Online Meeting of the European Society for Microcirculation (ESM)
J Vasc Res 2021;58:1 –23 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - August 10, 2021 Category: Research Source Type: research
Prelims
J Vasc Res 2021;58:I –IV (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - August 10, 2021 Category: Research Source Type: research
Plasmalemmal Vesicle-Associated Protein Is Associated with Endothelial Cells Sprouting from the Peribiliary Capillary Plexus in Human Cirrhotic Liver
Conclusion: PLVAP was strongly expressed in the caveolae of proliferated capillaries directly connected with sinusoids linked with the PCP, suggesting that it plays a role in angiogenesis and sinusoidal remodeling in LC.J Vasc Res (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - July 19, 2021 Category: Research Source Type: research
Association of Circulating Extracellular Matrix Components with Central Hemodynamics and Arterial Distensibility of Peripheral Arteries
Conclusion: High circulating Col IV level indexes were associated with stiffer peripheral arteries whereas increased MMP-9 and TIMP-1 concentrations were associated with more compliant ones.J Vasc Res (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - July 12, 2021 Category: Research Source Type: research
Gleevec and Rapamycin Synergistically Reduce Cell Viability and Inhibit Proliferation and Angiogenic Function of Mouse Bone Marrow-Derived Endothelial Progenitor Cells
Conclusions: Gleevec and rapamycin synergistically suppress cell proliferation and tube formation of EPCs by inducing cell apoptosis and endothelial differentiation. Mechanistically, it is likely that rapamycin enhances the proapoptotic and antiangiogenic effects of Gleevec by promoting the endothelial differentiation of EPCs. Given that EPCs are involved in the pathogenesis of some cardiovascular diseases and critical to angiogenesis, pharmacological inhibition of EPC proliferation by combined Gleevec and rapamycin therapy may be a promising approach for suppressing cardiovascular disease pathologies associated with angio...
Source: Journal of Vascular Research - July 9, 2021 Category: Research Source Type: research
The Protective Effect of Tetrahydroxystilbene Glucoside on High Glucose-Induced Injury in Human Umbilical Vein Endothelial Cells through the PI3K/Akt/eNOS Pathway and Regulation of Bcl-2/Bax
Endothelial dysfunction plays a central role in the patho genesis of diabetic vascular complications. 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside (TSG), an active component extracted from the roots of Polygonum multiflorum Thunb, has been shown to have strong antioxidant and antiapoptotic activities. In the present study, we investigated the pro tective effect of TSG on apoptosis induced by high glucose in human umbilical vein endothelial cells (HUVECs) and the possible mechanisms. Our data demonstrated that TSG significantly reversed the high glucose-induced decrease in cell viability, suppressed high glucose-i...
Source: Journal of Vascular Research - July 2, 2021 Category: Research Source Type: research
Effect of Sex on Vascular Adaptations to Isometric Handgrip Training in Elderly Patients with Peripheral Artery Disease: A Randomized Controlled Trial
Conclusions: There are no effects of sex on vascular adaptation after 8 weeks of IHT in older adults with symptomatic PAD.J Vasc Res (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - June 29, 2021 Category: Research Source Type: research
Automated Detection and Diameter Estimation for Mouse Mesenteric Artery Using Semantic Segmentation
Conclusion: The U-Net-based image analysis method could streamline the experimental approach.J Vasc Res (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - June 28, 2021 Category: Research Source Type: research
Possible Mechanism of Human Recombinant Leptin-Induced VEGF A Synthesis via PI3K/Akt/mTOR/S6 Kinase Signaling Pathway while Inducing Angiogenesis: An Analysis Using Chicken Chorioallantoic Membrane Model
Conclusion: Synthesis of VEGF A, followed by the growth of new blood vessels, by human recombinant leptin via the activation of the PI3K/Akt/mTOR/S6 kinase signaling pathway reflects mechanistic therapeutic application of human recombinant leptin. The data also signify the role of mTOR and S6 kinase molecules in angiogenesis under a physiological environment.J Vasc Res (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - June 24, 2021 Category: Research Source Type: research
Platelets Do Not Alter Flow-Mediated Dilation or Arterial Conduction in vivo
The aim of this study was to investigate whether platelets contribute to shear stress and vascular conductance in the iliac vascular bed in vivo. Flow-mediated dilation of pig iliac was induced by downstream injection of acetylcholine (50 μg), and separately, conductance (ΔF/ΔP) was calculated. This was carried out before and after removal of 1 L of arterial blood in 240 mL increments, and each 240 mL was spun in a centrifuge (1,500 rcf for 7 min); platelet-rich plasma was replaced with equal volume of heparinised saline and reinj ected. The circulating platelet count fell from 369 × 109/L (n = 5) to 165 × 109/L (p = ...
Source: Journal of Vascular Research - May 19, 2021 Category: Research Source Type: research
Maternal Anti-HPA-1a Antibodies Increase Endothelial Cell Apoptosis and Permeability
We examined the effect of anti-HPA-1a antibodies on EC function using 2 EC lines from different vascular beds, HMVEC of dermal origin and hCMEC/D3 of cerebral origin. Anti-HPA-1a sera significantly increased apoptosis in both HMVEC and hCMEC/D3 cells and p ermeability in hCMEC/D3 cells only. This increase in both apoptosis and permeability was significantly inhibited by a monoclonal anti-β3 antibody (SZ21) binding to the HPA-1a epitope. Our results indicate that (1) maternal anti-HPA-1a antibodies impair EC function by increasing apoptosis and permea bility and (2) ECs from different vascular beds vary in their susceptibi...
Source: Journal of Vascular Research - May 11, 2021 Category: Research Source Type: research
Can Myogenic Tone Protect Endothelial Function? Integrating Myogenic Activation and Dilator Reactivity for Cerebral Resistance Arteries in Metabolic Disease
The obese Zucker rat (OZR) manifests multiple risk factors for impaired cerebrovascular function, including hypertension and insulin resistance although how they combine to produce integrated vascular function is unclear. As studies have suggested that myogenic activation (MA) severity for middle cerebral arteries (MCAs) may be proportional to hypertension severity, we hypothesized that MA will negatively correlate with dilator reactivity in OZR. MA of MCA from OZR was divided into low, medium, and high based on the slope of MA, while MCA reactivity and vascular metabolite bioavailability were assessed in all groups. Endot...
Source: Journal of Vascular Research - May 10, 2021 Category: Research Source Type: research
Adapter Protein RapGEF1 Is Required for ERK1/2 Signaling in Response to Elevated Phosphate in Vascular Smooth Muscle Cells
In this study, we tested the hypothesis that RapGEF1 is a critical component of the SLC20A1-mediated Pi-induced ERK1/2 phosphorylation pathway. Co-localization of SLC20A1 and RapGEF1, knockdown of RapGEF1 with siRNA, and small molecule inhibitors of Rap1, B-Raf, and Mek1/2 were investigated. SLC20A1 and RapGEF1 were co-localized in peri-membranous structures in VSMCs. Knockdown of RapGEF1 and small molecule inhibitors against Rap1, B-Raf, and Mek1/2 eliminated elevated Pi-induced ERK1/2 phosphorylation. Knockdown of RapGEF1 inhibited SM22 α mRNA expression and blocked elevated Pi-induced downregulation of SM22α mRNA. Tog...
Source: Journal of Vascular Research - May 5, 2021 Category: Research Source Type: research
Protective Effects of 1,25 Dihydroxyvitamin D < sub > 3 < /sub > against High-Glucose-Induced Damage in Human Umbilical Vein Endothelial Cells Involve Activation of Nrf2 Antioxidant Signaling
Conclusions: 1,25(OH)2D3 attenuates high-glucose-induced endothelial oxidative injury through upregulation of the Nrf2 antioxidant pathway in a VDR-dependent manner.J Vasc Res (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - May 4, 2021 Category: Research Source Type: research
Cystamine Treatment Fails to Prevent the Development of Pulmonary Hypertension in Chronic Hypoxic Rats
Conclusions: Cystamine inhibited TG2 transamidase activity, but cystamine failed to prevent pulmonary hypertension, right ventricular hypertrophy, and pulmonary arterial muscularization in the chronic hypoxic rat.J Vasc Res (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - April 28, 2021 Category: Research Source Type: research
