β-Adrenoceptor Blockade for Infantile Hemangioma Therapy: Do β < sub > 3 < /sub > -Adrenoceptors Play a Role?
Infantile hemangiomas (IH) are frequent (4 –5% of the childhood population) benign vascular tumors that involve accumulation, proliferation, and differentiation of aberrant vascular cells. Typically, IH are innocuous and spontaneously disappear, but they represent a potential risk for harmful effects in the body (e.g., permanent disfigurem ent) and health (e.g., ulcerations) in some patients. From a serendipitous discovery, the nonselective β-adrenoceptor blocker propranolol (which blocks β1-adrenoceptors, β2-adrenoceptors, and β3-adrenoceptors) emerged as an alternative therapy to treat this pathology and it quickly...
Source: Journal of Vascular Research - June 22, 2018 Category: Research Source Type: research
Differential Stiffening between the Abdominal and Thoracic Aorta: Effect of Salt Loading in Stroke-Prone Hypertensive Rats
This study demonstrates the pro-stiffening effect of salt in addition to hypertension; it shows that only the abdominal aorta presents a specific pressure-independent stiffening, in which elastin disarray is likely a key mechanism.J Vasc Res 2018;55:144 –158 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - June 8, 2018 Category: Research Source Type: research
A Novel ex vivo Mouse Mesometrium Culture Model for Investigating Angiogenesis in Microvascular Networks
Conclusion: These results introduce a novel culture model for investigating multicellular dynamics during angiogenesis in real-time ex vivo microvascular networks.J Vasc Res 2018;55:125 –135 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - May 30, 2018 Category: Research Source Type: research
Intraoperative Incident Dark Field Imaging of the Human Peritoneal Microcirculation
Conclusion: The peritoneal microcirculation was characterized by a low capillary density and a distinctive angioarchitecture. The possibility of peri toneal microcirculatory assessment offers promise for the study of peritoneal (patho-)physiology and (monitoring or detection of) associated diseases.J Vasc Res 2018;55:136 –143 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - May 30, 2018 Category: Research Source Type: research
Conference Calendar
J Vasc Res 2018;55:124 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - May 30, 2018 Category: Research Source Type: research
RANKL Inhibits the Production of Osteoprotegerin from Smooth Muscle Cells under Basal Conditions and following Exposure to Cyclic Strain
This study characterizes the production of OPG/RANKL from human aortic endothelial and smooth muscl e cells (HAECs and HASMCs) under various conditions. HAECs and HASMCs were exposed to inflammatory stimuli (tumor necrosis factor-α or hyperglycemia) or physiological levels of hemodynamic (cyclic) strain. After 72 h, both cells and supernatant media were harvested for assessment of OPG/RANKL produ ction. Based on initial findings, the experiments involving HASMCs were then repeated in the presence of exogenous RANKL. OPG was produced and secreted by HASMCs and (to a considerably lesser degree) HAECs under basal conditions....
Source: Journal of Vascular Research - April 10, 2018 Category: Research Source Type: research
Absence of Nicotinamide Nucleotide Transhydrogenase in C57BL/6J Mice Exacerbates Experimental Atherosclerosis
Conclusion: These data indicate that loss of NNT increases vascular ROS production and exacerbates atherosclerotic plaque development.J Vasc Res 2018;55:98 –110 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - February 16, 2018 Category: Research Source Type: research
Remodeling of Wall Mechanics and the Myogenic Mechanism of Rat Intramural Coronary Arterioles in Response to a Short-Term Daily Exercise Program: Role of Endothelial Factors
Conclusions: A short-term daily exercise program induces remodeling of rat intramural coronary arterioles, likely resulting in a greater range of coronary autoregulatory function (constrictor and dilator reserves) and more effective protection against great changes in intraluminal pressure, contributing thereby to the optimization of coronary blood flow during exercise.J Vasc Res 2018;55:87 –97 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - February 14, 2018 Category: Research Source Type: research
Ligand-Activated Peroxisome Proliferator-Activated Receptor δ Attenuates Vascular Oxidative Stress by Inhibiting Thrombospondin-1 Expression
In this study, we found that peroxisome proliferator-activated receptor δ (PPARδ) inhibited oxidative stress-induced TSP-1 expression and migration in vascular smooth muscle cells (VSMCs). Activation of PPARδ by GW501516, a specific ligand for PPARδ, significantly attenuated hydrogen peroxide (H2O2)-induced expression of TSP-1 in VSMCs. Small interfering RNA-mediated knockdown of PPAR δ and treatment with GSK0660, a selective PPARδ antagonist, reversed the effect of GW501516 on H2O2-induced expression of TSP-1, suggesting that PPAR δ is associated with GW501516 activity. Furthermore, JNK (c-Jun N-terminal kinase), b...
Source: Journal of Vascular Research - February 6, 2018 Category: Research Source Type: research
The Effect of a High-Fat Diet on the Development of Abdominal Aortic Aneurysm in a Vascular Hypoperfusion-Induced Animal Model
In this study, we evaluated the effects of a high-fat diet on the development of AAA in a vascular hypoperfusion-induced animal model. The risk of AAA rupture and AAA diameter in the high-fat group significantly increased compared with those in the control group. The number and size of adipocytes in the vascular wall in the high-fat group significantly increased as compared with those in the control group. Additionally, the collagen-positive sections in the areas with adipocytes significantly decreased as compared with those without adipocytes. The protein levels of matrix metalloproteinase (MMP)-2, MMP-9, and MMP-12, and ...
Source: Journal of Vascular Research - January 29, 2018 Category: Research Source Type: research
Membership of the ESM
J Vasc Res 2018;55:62 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - January 23, 2018 Category: Research Source Type: research
Conference Calendar
J Vasc Res 2018;55:61 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - January 23, 2018 Category: Research Source Type: research
Cooperative Effects of Q10, Vitamin D < sub > 3 < /sub > , and < smlcap > L < /smlcap > -Arginine on Cardiac and Endothelial Cells
This work demonstrates the cooperative effect of Q10, vitamin D3, andL-arginine on both cardiac and endothelial cells. The effects of Q10,L-arginine, and vitamin D3 alone or combined on cell viability, nitric oxide, and reactive oxygen species productions in endothelial and cardiac cells were studied. Moreover, the involvement of PI3K/Akt and ERK/MAPK pathways leading to eNOS activation as well as the involvement of vitamin D receptor were also investigated. The same agents were tested in an animal model to verify vasodilation, nitric oxide, and reactive oxygen species production. The data obtained in this work demonstrate...
Source: Journal of Vascular Research - January 4, 2018 Category: Research Source Type: research
Progressive Development of Aberrant Smooth Muscle Cell Phenotype in Abdominal Aortic Aneurysm Disease
Abdominal aortic aneurysm (AAA) is a silent, progressive disease with a high mortality and an increasing prevalence with aging. Smooth muscle cell (SMC) dysfunction contributes to gradual dilatation and eventual rupture of the aorta. Here we studied phenotypic characteristics in SMC cultured from end-stage human AAA ( ≥5 cm) and cells cultured from a porcine carotid artery (PCA) model of early and end-stage aneurysm. Human AAA-SMC presented a secretory phenotype and expressed elevated levels of the differentiation marker miR-145 (2.2-fold,p (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - December 12, 2017 Category: Research Source Type: research
Conference Calendar
J Vasc Res 2017;54:388 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - December 7, 2017 Category: Research Source Type: research
