How 3,4,5-Trihydroxycinnamic Acid Targets Vascular Leakage: Potential Targeted Sepsis Treatment
J Vasc Res (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - June 29, 2020 Category: Research Source Type: research
3,4,5-Trihydroxycinnamic Acid Inhibits LPS-Induced Inflammatory Response by Increasing SIRT1 Expression in Human Umbilical Vein Endothelial Cells
In conclusion, the results clearly demonstrate that THC possesses anti-inflammatory properties by increasing SIRT1 expression and subsequent suppres sion of p53 activation in LPS-challenged HUVECs.J Vasc Res (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - June 19, 2020 Category: Research Source Type: research
Disparate Effect of Antioxidant Supplements on the Basal Tone and Vascular Remodeling of the Aorta in Hypertensive Rats
Conclusions: Tempol decreased calcium-dependent basal aortic tone and improved vascular homeostasis in L-NAME rats. Vit-C did not lead to a similar effect, suggesting that alterations in the superoxide dismutase pathway may play a role in the basal aortic tone.J Vasc Res (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - June 18, 2020 Category: Research Source Type: research
Publisher's Note
J Vasc Res 2020;57:177 –177 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - June 18, 2020 Category: Research Source Type: research
Vasoreactivity of the Murine External Jugular Vein and Carotid Artery
Conclusion: Vasorelaxation and vasocontraction can be reliably assessed in the external jugular vein in C57BL/6 mice using isometric procedures.J Vasc Res (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - June 15, 2020 Category: Research Source Type: research
Pathophysiologic Role of Molecules Determining Arteriovenous Differentiation in Adult Life
The structural differences between arteries and veins are genetically predetermined. Vascular identity markers, the molecular markers specific to veins and arteries, determine the differential development of vessels during embryogenesis and their expression persists in adult vessels. It is revealed that they can be reactivated under various pathophysiologic conditions even after vessel differentiation. Thus, once considered as quiescent in adults, vascular identity markers may actually play significant roles in vascular remodeling. Manipulation of vascular identity and the underlying molecular mechanisms might be a novel s...
Source: Journal of Vascular Research - June 12, 2020 Category: Research Source Type: research
Effect and Molecular Mechanisms of Collateral Vessel Growth Mediated by Activation of Transient Receptor Potential Vanilloid Type 1
Information on the function of transient receptor potential vanilloid 1 (TRPV1) in arteriogenesis is limited. We aimed to verify whether TRPV1 is involved in collateral vessel growth in rat hind limbs and elucidate the possible subcellular action mechanisms. Adult Sprague Dawley rats were chosen to establish the hind limb ischemic model and treatment with capsaicin. Angiographies were performed, and tissue was isolated for immunohistochemistry. In vitro, rat aortic endothelial cells (RAECs) were treated with capsaicin and antagonist capsazepine. The RAEC proliferation was determined, and the protein and mRNA levels of Ca2+...
Source: Journal of Vascular Research - June 11, 2020 Category: Research Source Type: research
The Release of Cyclophilin A from Rapamycin-Stimulated Vascular Smooth Muscle Cells Mediated by Myosin II Activation: Involvement of Apoptosis but Not Autophagy
Conclusions: Rapamycin induced the release of CyPA from apoptotic RASMCs but did not affect exocytosis through autophagosomes. ROCK, actin remodelling, and synaptic vesicles were not involved in the apoptosis-related release of CyPA. Myosin II activation modulated the apoptosis of vascular smooth muscle cells and the release of CyPA from rapamycin-induced apoptotic cell death.J Vasc Res (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - June 11, 2020 Category: Research Source Type: research
Effects of Iliac Stenosis on Abdominal Aortic Aneurysm Formation in Mice and Humans
Reduced lower-limb blood flow has been shown to lead to asymmetrical abdominal aortic aneurysms (AAAs) but the mechanism of action is not fully understood. Therefore, small animal ultrasound (Vevo2100, FUJIFILM VisualSonics) was used to longitudinally study mice that underwent standard porcine pancreatic elastase (PPE) infusion (n = 5), and PPE infusion with modified 20% iliac artery stenosis in the left (n = 4) and right (n = 5) iliac arteries. Human AAA computed tomography images were obtained from patients with normal (n = 9) or stenosed left (n = 2), right (n = 1), and bilateral (n = 1) iliac arteries. We observed rapi...
Source: Journal of Vascular Research - July 4, 2019 Category: Research Source Type: research
The Significance of Vascular Alterations in Acute and Chronic Rejection for Vascularized Composite Allotransplantation
Vascularized composite allotransplantation (VCA) has emerged as a useful reconstructive option for patients suffering from major tissue defects and functional deficits. While the technical feasibility has been optimized and more than 130 VCAs have been performed during the last two decades, hurdles such as acute and chronic allograft rejection, graft deterioration, and eventual functional impairment need to be addressed. Recently, chronic graft rejection and progressive failure have been linked to vascular alterations observed in the allografts. Graft vasculopathy (GV) may play a pivotal role in long-term graft deteriorati...
Source: Journal of Vascular Research - July 2, 2019 Category: Research Source Type: research
Silencing of GPR82 with Interference RNA Improved Metabolic Profiles in Rats with High Fructose Intake
Metabolic syndrome (MS) is a clinical condition, constituted by alterations that lead to the onset of type II diabetes and cardiovascular disease. It has been reported that orphan G-protein-coupled receptor 82 (GPR82) participates in metabolic processes. The aim of this study was to evaluate the function of GPR82 in MS using a small interfering RNA (siRNA) against this receptor. We used Wistar rats of 10–12 weeks of age fed with a high-fructose solution (70%) for 9 weeks to induce MS. Subsequently, the rats were treated with an intrajugular dose of an siRNA against GPR82 and the effects were evaluated on day 3 and 7 af...
Source: Journal of Vascular Research - July 2, 2019 Category: Research Source Type: research
An Inhibitor of Activated Blood Coagulation Factor X Shows Anti-Endothelial Senescence and Anti-Atherosclerotic Effects
Conclusion: Rivaroxaban prevents replicative senescence in HUVECs and aortic endothelial cells in dyslipidemic diabetic mice. It restores endothelial function and prevents the progression of atherosclerosis.J Vasc Res (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - July 2, 2019 Category: Research Source Type: research
Conference Calendar
J Vasc Res 2019;56:107 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - June 24, 2019 Category: Research Source Type: research
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J Vasc Res 2019;56:107 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - June 24, 2019 Category: Research Source Type: research
Beraprost Upregulates K < sub > V < /sub > Channel Expression and Function via EP < sub > 4 < /sub > Receptor in Pulmonary Artery Smooth Muscle Cells Obtained from Rats with Hypoxia-Induced Pulmonary Hypertension
The reduced expression and function of voltage-dependent potassium (KV) channels have been involved in the pathogenesis of hypoxia-induced pulmonary hypertension (HPH), leading to pulmonary vasoconstriction and vascular remodeling, while the upregulation of KV channels is of therapeutic significance for pulmonary hypertension. Beraprost sodium (BPS) has been shown to be effective in patients with pulmonary hypertension. However, the effect of BPS on O2-sensitive KV channels in pulmonary artery smooth muscle cells (PASMCs) remains unclear. In the present study, the effect of BPS on rats with HPH was observed, and the influe...
Source: Journal of Vascular Research - June 12, 2019 Category: Research Source Type: research
