Extra- and Intraluminal Elastase Induce Morphologically Distinct Abdominal Aortic Aneurysms in Mice and Thus Represent Specific Subtypes of Human Disease
This study, therefore, compares matrix remodeling, inflammation, and angiogenesis as distinct features of aneurysms in two models treated with intra-/extraluminal elastase. C57BL/6 mice underwent intra-/extraluminal elastase application via laparotomy and were followed up for 4 weeks. Basic histology and immunohistochemistry were performed at different time points along with transmission electron microscopy, PCR analysis, TUNEL assays, and blood analysis. Both models did not differ in aneurysm growth rate, but they showed distinct features and results depending on the way of elastase application. Extraluminal aneurysm indu...
Source: Journal of Vascular Research - August 17, 2016 Category: Research Source Type: research
C-Reactive Protein and Inflammatory Cytokines during Percutaneous Coronary Intervention
Conclusions: The current study provides evidence that increased serum IL-6, IL-1 β, and CRP levels around PCI are not different between different postdilation pressure and stent number groups. The combination of IL-6 and IL-1β at concentrations associated with PCI cannot induce CRP expression in human VSMCs, but they can augment mechanical strain-induced CRP synthesis via the SAC-NF-#x03BA;B pathway in human IMAs.J Vasc Res 2016;53:39-48 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - August 3, 2016 Category: Research Source Type: research
Altered PPAR γ Coactivator-1 Alpha Expression in Abdominal Aortic Aneurysm: Possible Effects on Mitochondrial Biogenesis
Conclusion: < /i > < /b > Our results suggest that mitochondrial biogenesis is impaired in AAA in synthetic SMCs in the media, with the exception of newly formed supporting vessels in the adventitia where the mitochondrial markers seem to be intact. To our knowledge, this is the first study investigating PGC1 α and mitochondria biogenesis in AAA. < br / > J Vasc Res 2016;53:17-26 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - July 22, 2016 Category: Research Source Type: research
Increment of HFABP Level in Coronary Artery In-Stent Restenosis Segments in Diabetic and Nondiabetic Minipigs: HFABP Overexpression Promotes Multiple Pathway-Related Inflammation, Growth and Migration in Human Vascular Smooth Muscle Cells
Conclusion: HFABP expression is significantly higher in ISR tissue than in non-ISR tissue from diabetic and nondiabetic minipigs. Overexpression of HFABP induces multiple pathway-related promotion of inflammation, growth and migration in vascular SMCs, suggesting a potential role in coronary artery ISR.J Vasc Res 2016;53:27-38 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - July 1, 2016 Category: Research Source Type: research
Altered PPARγ Coactivator-1 Alpha Expression in Abdominal Aortic Aneurysm: Possible Effects on Mitochondrial Biogenesis
Conclusion: Our results suggest that mitochondrial biogenesis is impaired in AAA in synthetic SMCs in the media, with the exception of newly formed supporting vessels in the adventitia where the mitochondrial markers seem to be intact. To our knowledge, this is the first study investigating PGC1α and mitochondria biogenesis in AAA.J Vasc Res 2016;53:17-26 (Source: Journal of Vascular Research)
Source: Journal of Vascular Research - June 29, 2016 Category: Research Source Type: research
