Digoxin Attenuates Receptor Activation of NF- κB Ligand-Induced Osteoclastogenesis in Macrophages

Conclusions: These results show that digoxin attenuates OCG. By inhibition of HIF-1 α, digoxin decreases OCG through the downregulation of the RANK/RANKL signaling pathway. Therefore, digoxin is a potential candidate for medical treatment of AAAs.J Vasc Res

Source: Journal of Vascular Research - May 14, 2019 Category: Research Source Type: research