Journal of the American Society of Nephrology : JASN This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Acute Kidney Injury Associates with Long-Term Increases in Plasma TNFR1, TNFR2, and KIM-1: Findings from the CRIC Study
Conclusions Among patients with CKD, AKI during hospitalization was associated with increases in plasma TNFR1, TNFR2, and KIM-1 several months after their hospitalization. These results highlight a potential mechanism by which AKI may contribute to more rapid loss of kidney function months to years after the acute insult. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - May 31, 2022 Category: Urology & Nephrology Authors: McCoy, I. E., Hsu, J. Y., Bonventre, J. V., Parikh, C. R., Go, A. S., Liu, K. D., Ricardo, A. C., Srivastava, A., Cohen, D. L., He, J., Chen, J., Rao, P. S., Hsu, C.-y., on behalf of the Chronic Renal Insufficiency Cohort (CRIC) Study Investigators, Chron Tags: Acute Kidney Injury Source Type: research

Tumor Lysis Syndrome and AKI: Beyond Crystal Mechanisms
Conclusion This study sheds new light on the pathophysiology of TLS-induced AKI and suggests that extracellular histones may constitute a novel target for therapeutic intervention in TLS when endothelial dysfunction occurs. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - May 31, 2022 Category: Urology & Nephrology Authors: Arnaud, M., Loiselle, M., Vaganay, C., Pons, S., Letavernier, E., Demonchy, J., Fodil, S., Nouacer, M., Placier, S., Frere, P., Arrii, E., Lion, J., Mooney, N., Itzykson, R., Djediat, C., Puissant, A., Zafrani, L. Tags: Acute Kidney Injury Source Type: research

Factor H-Related Protein 1 Drives Disease Susceptibility and Prognosis in C3 Glomerulopathy
Conclusions Our findings explain how FHR-1 mutants with duplicated dimerization domains result in predisposition to C3G. They also provide a pathogenic mechanism that may be shared by other diseases, such as IgA nephropathy or age-related macular degeneration, and identify FHR-1 as a potential novel therapeutic target in C3G. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - May 31, 2022 Category: Urology & Nephrology Authors: Marquez-Tirado, B., Gutierrez-Tenorio, J., Tortajada, A., Lucientes Continente, L., Caravaca-Fontan, F., Malik, T. H., Roldan Montero, R., Elias, S., Saiz Gonzalez, A., Fernandez-Juarez, G., Sanchez-Corral, P., Pickering, M. C., Praga, M., Rodriguez de Co Tags: Glomerulonephritis and Interstitial Nephritis Source Type: research

Reduced Glomerular Filtration in Diabetes Is Attributable to Loss of Density and Increased Resistance of Glomerular Endothelial Cell Fenestrations
Conclusions This study demonstrates the critical role of GEnC fenestrations in renal filtration function and suggests EHD3 may be a key regulator, loss of which may contribute to declining glomerular filtration function through aberrant GEnC fenestration regulation. This points to EHD3 as a novel therapeutic target to restore filtration function in disease. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - May 31, 2022 Category: Urology & Nephrology Authors: Finch, N. C., Fawaz, S. S., Neal, C. R., Butler, M. J., Lee, V. K., Salmon, A. J., Lay, A. C., Stevens, M., Dayalan, L., Band, H., Mellor, H. H., Harper, S. J., Shima, D. T., Welsh, G. I., Foster, R. R., Satchell, S. C. Tags: Chronic Kidney Disease Source Type: research

Intestinal Bacterial Translocation Contributes to Diabetic Kidney Disease
Conclusions Impaired MAVS signaling both in the kidney and intestine contributes to the disrupted homeostasis, leading to diabetic kidney disease progression. Controlling intestinal homeostasis may offer a novel therapeutic approach for this condition. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - May 31, 2022 Category: Urology & Nephrology Authors: Linh, H. T., Iwata, Y., Senda, Y., Sakai-Takemori, Y., Nakade, Y., Oshima, M., Nakagawa-Yoneda, S., Ogura, H., Sato, K., Minami, T., Kitajima, S., Toyama, T., Yamamura, Y., Miyagawa, T., Hara, A., Shimizu, M., Furuichi, K., Sakai, N., Yamada, H., Asanuma, Tags: Chronic Kidney Disease Source Type: research

Protein Kinase A Downregulation Delays the Development and Progression of Polycystic Kidney Disease
Conclusions PKA-I is the main PKA isozyme promoting cystogenesis. Direct PKA inhibition may be an effective strategy to treat PKD and other conditions where PKA signaling is upregulated. By acting directly on PKA, the inhibition may be more effective than or substantially increase the efficacy of treatments that only affect PKA activity by lowering cAMP. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - May 31, 2022 Category: Urology & Nephrology Authors: Wang, X., Jiang, L., Thao, K., Sussman, C. R., LaBranche, T., Palmer, M., Harris, P. C., McKnight, G. S., Hoeflich, K. P., Schalm, S., Torres, V. E. Tags: Genetic Disease of the Kidney Source Type: research

Arginase-1 Is Required for Macrophage-Mediated Renal Tubule Regeneration
Conclusions GM-CSF–induced, proreparative macrophages express arginase-1, which is required for the S3 tubular cell proliferative response that promotes renal repair after ischemia-reperfusion injury. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - May 31, 2022 Category: Urology & Nephrology Authors: Shin, N. S., Marlier, A., Xu, L., Doilicho, N., Linberg, D., Guo, J., Cantley, L. G. Tags: Acute Kidney Injury Source Type: research

Empagliflozin Changes Urine Supersaturation by Decreasing pH and Increasing Citrate
Clinical Trial registry name and registration number: Empagliflozin and Renal Oxygenation in Healthy Volunteers (EMPA-REIN), NCT03093103 (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - May 31, 2022 Category: Urology & Nephrology Authors: Harmacek, D., Pruijm, M., Burnier, M., Muller, M.-E., Ghajarzadeh-Wurzner, A., Bonny, O., Zanchi, A. Tags: Chronic Kidney Disease Source Type: research

Cost Barriers to More Widespread Use of Peritoneal Dialysis in the United States
The United States Department of Health and Human Services launched the Advancing American Kidney Health Initiative in 2019, which included a goal of transforming dialysis care from an in-center to a largely home-based dialysis program. A substantial motivator for this transition is the potential to reduce costs of ESKD care with peritoneal dialysis. Studies demonstrating that peritoneal dialysis is less costly than in-center hemodialysis have often focused on the perspective of the payer, whereas less consideration has been given to the costs of those who are more directly involved in treatment decision making, including p...
Source: Journal of the American Society of Nephrology : JASN - May 31, 2022 Category: Urology & Nephrology Authors: Baerman, E. A., Kaplan, J., Shen, J. I., Winkelmayer, W. C., Erickson, K. F. Tags: Review Source Type: research

The Advancing American Kidney Health Initiative: The Challenge of Measuring Success
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - May 31, 2022 Category: Urology & Nephrology Authors: Quinn, R. R., Lam, N. N., Ravani, P., Oliver, M. J., Blake, P. G., Tonelli, M. Tags: Perspective Source Type: research

Molecular Characterization of Membranous Nephropathy: Quo Vadis?
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - May 31, 2022 Category: Urology & Nephrology Authors: Fervenza, F. C., Glassock, R. J. Tags: Editorial Source Type: research

Crystals or His(stones): Rethinking AKI in Tumor Lysis Syndrome
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - May 31, 2022 Category: Urology & Nephrology Authors: Basile, D. P. Tags: Editorial Source Type: research

Of Mice and MAVS-Diabetic Kidney Disease and the Leaky Gut
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - May 31, 2022 Category: Urology & Nephrology Authors: Farre, R., Dejongh, S., Meijers, B. Tags: Editorial Source Type: research

More than a Marker: Arginase-1 in Kidney Repair
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - May 31, 2022 Category: Urology & Nephrology Authors: von Vietinghoff, S., Schmitt, R. Tags: Editorial Source Type: research

This Month's Highlights
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - May 31, 2022 Category: Urology & Nephrology Tags: This Month ' s Highlights Source Type: research