Protein Kinase A Downregulation Delays the Development and Progression of Polycystic Kidney Disease

Conclusions
PKA-I is the main PKA isozyme promoting cystogenesis. Direct PKA inhibition may be an effective strategy to treat PKD and other conditions where PKA signaling is upregulated. By acting directly on PKA, the inhibition may be more effective than or substantially increase the efficacy of treatments that only affect PKA activity by lowering cAMP.

Source: Journal of the American Society of Nephrology : JASN - May 31, 2022 Category: Urology & Nephrology Authors: Wang, X., Jiang, L., Thao, K., Sussman, C. R., LaBranche, T., Palmer, M., Harris, P. C., McKnight, G. S., Hoeflich, K. P., Schalm, S., Torres, V. E. Tags: Genetic Disease of the Kidney Source Type: research