Reduced Glomerular Filtration in Diabetes Is Attributable to Loss of Density and Increased Resistance of Glomerular Endothelial Cell Fenestrations

Conclusions This study demonstrates the critical role of GEnC fenestrations in renal filtration function and suggests EHD3 may be a key regulator, loss of which may contribute to declining glomerular filtration function through aberrant GEnC fenestration regulation. This points to EHD3 as a novel therapeutic target to restore filtration function in disease.

http://jasn.asnjournals.org/cgi/content/short/33/6/1120?rss=1

Source: Journal of the American Society of Nephrology : JASN - May 31, 2022 Category: Urology & Nephrology Authors: Finch, N. C., Fawaz, S. S., Neal, C. R., Butler, M. J., Lee, V. K., Salmon, A. J., Lay, A. C., Stevens, M., Dayalan, L., Band, H., Mellor, H. H., Harper, S. J., Shima, D. T., Welsh, G. I., Foster, R. R., Satchell, S. C. Tags: Chronic Kidney Disease Source Type: research