Tumor Lysis Syndrome and AKI: Beyond Crystal Mechanisms

Conclusion
This study sheds new light on the pathophysiology of TLS-induced AKI and suggests that extracellular histones may constitute a novel target for therapeutic intervention in TLS when endothelial dysfunction occurs.

Source: Journal of the American Society of Nephrology : JASN - May 31, 2022 Category: Urology & Nephrology Authors: Arnaud, M., Loiselle, M., Vaganay, C., Pons, S., Letavernier, E., Demonchy, J., Fodil, S., Nouacer, M., Placier, S., Frere, P., Arrii, E., Lion, J., Mooney, N., Itzykson, R., Djediat, C., Puissant, A., Zafrani, L. Tags: Acute Kidney Injury Source Type: research