Factor H-Related Protein 1 Drives Disease Susceptibility and Prognosis in C3 Glomerulopathy

Conclusions Our findings explain how FHR-1 mutants with duplicated dimerization domains result in predisposition to C3G. They also provide a pathogenic mechanism that may be shared by other diseases, such as IgA nephropathy or age-related macular degeneration, and identify FHR-1 as a potential novel therapeutic target in C3G.

http://jasn.asnjournals.org/cgi/content/short/33/6/1137?rss=1

Source: Journal of the American Society of Nephrology : JASN - May 31, 2022 Category: Urology & Nephrology Authors: Marquez-Tirado, B., Gutierrez-Tenorio, J., Tortajada, A., Lucientes Continente, L., Caravaca-Fontan, F., Malik, T. H., Roldan Montero, R., Elias, S., Saiz Gonzalez, A., Fernandez-Juarez, G., Sanchez-Corral, P., Pickering, M. C., Praga, M., Rodriguez de Co Tags: Glomerulonephritis and Interstitial Nephritis Source Type: research