Journal of the American Society of Nephrology : JASN This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Genome-Wide Mapping of DNA Accessibility and Binding Sites for CREB and C/EBP{beta} in Vasopressin-Sensitive Collecting Duct Cells
Conclusions The analysis identified two enhancer regions pertinent to transcriptional regulation of the Aqp2 gene and showed C/EBPβ (but not CREB) binding. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - April 30, 2018 Category: Urology & Nephrology Authors: Jung, H. J., Raghuram, V., Lee, J. W., Knepper, M. A. Tags: Basic Research Source Type: research

Gpr97 Exacerbates AKI by Mediating Sema3A Signaling
Conclusions Gpr97 is an important mediator of AKI, and pharmacologic targeting of Gpr97-mediated Sema3A signaling at multiple levels may provide a novel approach for the treatment of AKI. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - April 30, 2018 Category: Urology & Nephrology Authors: Fang, W., Wang, Z., Li, Q., Wang, X., Zhang, Y., Sun, Y., Tang, W., Ma, C., Sun, J., Li, N., Yi, F. Tags: Basic Research Source Type: research

Nephrin-Binding Ephrin-B1 at the Slit Diaphragm Controls Podocyte Function through the JNK Pathway
Conclusions Through interactions with nephrin, ephrin-B1 maintains the structure and barrier function of the slit diaphragm. Moreover, phosphorylation of ephrin-B1 and, consequently, JNK are involved in the development of podocyte injury. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - April 30, 2018 Category: Urology & Nephrology Authors: Fukusumi, Y., Zhang, Y., Yamagishi, R., Oda, K., Watanabe, T., Matsui, K., Kawachi, H. Tags: Basic Research Source Type: research

Intracellular Chloride and Scaffold Protein Mo25 Cooperatively Regulate Transepithelial Ion Transport through WNK Signaling in the Malpighian Tubule
Conclusions Cooperative interactions between chloride and Mo25 regulate WNK signaling in a transporting renal epithelium. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - April 30, 2018 Category: Urology & Nephrology Authors: Sun, Q., Wu, Y., Jonusaite, S., Pleinis, J. M., Humphreys, J. M., He, H., Schellinger, J. N., Akella, R., Stenesen, D., Krämer, H., Goldsmith, E. J., Rodan, A. R. Tags: Basic Research Source Type: research

Lipoxins Regulate the Early Growth Response-1 Network and Reverse Diabetic Kidney Disease
Conclusions These data demonstrate that LXs can reverse established diabetic complications and support a therapeutic paradigm to promote the resolution of inflammation. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - April 30, 2018 Category: Urology & Nephrology Authors: Brennan, E. P., Mohan, M., McClelland, A., Tikellis, C., Ziemann, M., Kaspi, A., Gray, S. P., Pickering, R., Tan, S. M., Ali-Shah, S. T., Guiry, P. J., El-Osta, A., Jandeleit-Dahm, K., Cooper, M. E., Godson, C., Kantharidis, P. Tags: Basic Research Source Type: research

Laminin-521 Protein Therapy for Glomerular Basement Membrane and Podocyte Abnormalities in a Model of Pierson Syndrome
Conclusions These studies show that GBM composition and function can be altered in vivo via vascular delivery of even very large proteins, which may advance therapeutic options for patients with abnormal GBM composition, whether genetic or acquired. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - April 30, 2018 Category: Urology & Nephrology Authors: Lin, M.-H., Miller, J. B., Kikkawa, Y., Suleiman, H. Y., Tryggvason, K., Hodges, B. L., Miner, J. H. Tags: Basic Research Source Type: research

Mechanism of Hyperkalemia-Induced Metabolic Acidosis
Conclusions Hyperkalemia decreases proximal tubule ammonia generation and collecting duct ammonia transport, leading to impaired ammonia excretion that causes metabolic acidosis. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - April 30, 2018 Category: Urology & Nephrology Authors: Harris, A. N., Grimm, P. R., Lee, H.-W., Delpire, E., Fang, L., Verlander, J. W., Welling, P. A., Weiner, I. D. Tags: Basic Research Source Type: research

Protein S Protects against Podocyte Injury in Diabetic Nephropathy
Conclusions Our results support a protective role of PS against glomerular injury in DN progression. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - April 30, 2018 Category: Urology & Nephrology Authors: Zhong, F., Chen, H., Xie, Y., Azeloglu, E. U., Wei, C., Zhang, W., Li, Z., Chuang, P. Y., Jim, B., Li, H., Elmastour, F., Riyad, J. M., Weber, T., Chen, H., Wang, Y., Zhang, A., Jia, W., Lee, K., He, J. C. Tags: Basic Research Source Type: research

Renal Interstitial Platelet-Derived Growth Factor Receptor-{beta} Cells Support Proximal Tubular Regeneration
Conclusions Ablated tubular cells are exclusively replaced by resident tubular cell proliferation in a process dependent on PDGFRβ-mediated communication between the renal interstitium and the tubular system. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - April 30, 2018 Category: Urology & Nephrology Authors: Schiessl, I. M., Grill, A., Fremter, K., Steppan, D., Hellmuth, M.-K., Castrop, H. Tags: Basic Research Source Type: research

The Ebb and Flow of Echocardiographic Cardiac Function Parameters in Relationship to Hemodialysis Treatment in Patients with ESRD
Cardiovascular disease is the leading cause of mortality in patients receiving hemodialysis. Cardiovascular events in these patients demonstrate a day-of-week pattern; i.e., they occur more commonly during the last day of the long interdialytic interval and the first session of the week. The hemodialysis process causes acute decreases in cardiac chamber size and pulmonary circulation loading and acute diastolic dysfunction, possibly through myocardial stunning and other non–myocardial-related mechanisms; systolic function, in contrast, is largely unchanged. During interdialytic intervals volume overload, acid-base, a...
Source: Journal of the American Society of Nephrology : JASN - April 30, 2018 Category: Urology & Nephrology Authors: Loutradis, C., Sarafidis, P. A., Papadopoulos, C. E., Papagianni, A., Zoccali, C. Tags: Reviews Source Type: research

HDL in CKD--The Devil Is in the Detail
The picture of HDL cholesterol (HDL-C) as the "good" cholesterol has eroded. This is even more surprising because there exists strong evidence that HDL-C is associated with cardiovascular disease (CVD) in the general population as well as in patients with impairment of kidney function and/or progression of CKD. However, drugs that dramatically increase HDL-C have mostly failed to decrease CVD events. Furthermore, genetic studies took the same line, as genetic variants that have a pronounced influence on HDL-C concentrations did not show an association with cardiovascular risk. For many, this was not surprising, given that ...
Source: Journal of the American Society of Nephrology : JASN - April 30, 2018 Category: Urology & Nephrology Authors: Kronenberg, F. Tags: Reviews Source Type: research

The Quest for Better Biomarkers of Bone Turnover in CKD
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - April 30, 2018 Category: Urology & Nephrology Authors: Nickolas, T. L. Tags: Editorials Source Type: research

Using Large Datasets to Understand CKD
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - April 30, 2018 Category: Urology & Nephrology Authors: Drysdale, T. A. Tags: Editorials Source Type: research

Insights into CKD from Metabolite GWAS
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - April 30, 2018 Category: Urology & Nephrology Authors: Liu, L., Kiryluk, K. Tags: Editorials Source Type: research

WNKs on the Fly
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - April 30, 2018 Category: Urology & Nephrology Authors: Welling, P. A. Tags: Editorials Source Type: research