Hypomagnesemia, Hypocalcemia, and Tubulointerstitial Nephropathy Caused by Claudin-16 Autoantibodies
Conclusions Pathogenic claudin-16 autoantibodies represent a novel autoimmune cause of specific renal tubular transport disturbances and tubulointerstitial nephropathy. Screening for autoantibodies targeting claudin-16, and potentially other magnesium transporters or channels in the kidney, may be warranted in patients with acquired unexplained hypomagnesemia. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - June 30, 2022 Category: Urology & Nephrology Authors: Figueres, L., Bruneau, S., Prot-Bertoye, C., Brideau, G., Neel, M., Griveau, C., Cheval, L., Bignon, Y., Dimitrov, J., Dejoie, T., Ville, S., Kandel-Aznar, C., Moreau, A., Houillier, P., Fakhouri, F. Tags: Glomerulonephritis and Interstitial Nephritis Source Type: research

Association of Proximal Tubular Secretory Clearance with Long-Term Decline in Cognitive Function
Conclusions Lower kidney clearances of secreted solutes are associated with incident global cognitive decline in a prospective study of CKD, independent of eGFR. Further work is needed to determine the domains of cognition most affected by decreased secretory clearance and the mechanisms of these associations. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - June 30, 2022 Category: Urology & Nephrology Authors: Lidgard, B., Bansal, N., Zelnick, L. R., Hoofnagle, A., Chen, J., Colaizzo, D., Dobre, M., Mills, K. T., Porter, A. C., Rosas, S. E., Sarnak, M. J., Seliger, S., Sondheimer, J., Tamura, M. K., Yaffe, K., Kestenbaum, B., the CRIC Study Investigators, The C Tags: Chronic Kidney Disease Source Type: research

The Association of Excess Body Weight with Risk of ESKD Is Mediated Through Insulin Resistance, Hypertension, and Hyperuricemia
Conclusions TyG index, MAP, and UA, but not TC, mediate the association of BMI with ESKD in middle-aged adults. Our findings highlight that in addition to weight reduction, the control of metabolic risk factors might be essential in mitigating the adverse effects of BMI on kidney function. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - June 30, 2022 Category: Urology & Nephrology Authors: Fritz, J., Brozek, W., Concin, H., Nagel, G., Kerschbaum, J., Lhotta, K., Ulmer, H., Zitt, E. Tags: Chronic Kidney Disease Source Type: research

Aqp2+ Progenitor Cells Maintain and Repair Distal Renal Segments
Conclusion Our study demonstrates that Aqp2+ B1B2+ cells behave as adult APs to maintain and repair DCT2/CNT1/CNT2/CD segments. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - June 30, 2022 Category: Urology & Nephrology Authors: Gao, C., Zhang, L., Chen, E., Zhang, W. Tags: Renal Repair Source Type: research

Brief Early Life Angiotensin-Converting Enzyme Inhibition Offers Renoprotection in Sheep with a Solitary Functioning Kidney at 8 Months of Age
Conclusions Brief and early ACEi in SFK is associated with reduced glomerular hyperfiltration–mediated kidney disease up to 8 months of age in a sheep model. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - June 30, 2022 Category: Urology & Nephrology Authors: McArdle, Z., Singh, R. R., Bielefeldt-Ohmann, H., Moritz, K. M., Schreuder, M. F., Denton, K. M. Tags: Hypertension Source Type: research

Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells
Conclusions These results suggest that, in addition to CaSR’s established role in the parathyroid-kidney-bone axis, expression of CaSR in vascular smooth muscle cells directly contributes to total body mineral ion homeostasis. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - June 30, 2022 Category: Urology & Nephrology Authors: Schepelmann, M., Ranieri, M., Lopez-Fernandez, I., Webberley, T. S., Brennan, S. C., Yarova, P. L., Graca, J., Hanif, U.-K., Müller, C., Manhardt, T., Salzmann, M., Quasnichka, H., Price, S. A., Ward, D. T., Gilbert, T., Matchkov, V. V., Fenton, R Tags: Extra-Renal Effects of Kidney Disease Source Type: research

Single-Cell Chromatin and Gene-Regulatory Dynamics of Mouse Nephron Progenitors
Conclusion Mapping the regulatory landscape at single-cell resolution informs the regulatory hierarchy of nephrogenesis. Paired single-cell epigenomes and transcriptomes of nephron progenitors should provide a foundation to understand prenatal programming, regeneration after injury, and ex vivo nephrogenesis. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - June 30, 2022 Category: Urology & Nephrology Authors: Hilliard, S., Tortelote, G., Liu, H., Chen, C.-H., El-Dahr, S. S. Tags: Development of the Kidney Source Type: research

A Novel Soluble ACE2 Protein Provides Lung and Kidney Protection in Mice Susceptible to Lethal SARS-CoV-2 Infection
Conclusions This study demonstrates the preclinical efficacy of a novel soluble ACE2 protein, termed ACE2–1-618-DDC-ABD, in a lethal mouse model of SARS-CoV-2 infection that develops severe lung injury and variable degrees of moderate kidney proximal tubular injury. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - June 30, 2022 Category: Urology & Nephrology Authors: Hassler, L., Wysocki, J., Gelarden, I., Sharma, I., Tomatsidou, A., Ye, M., Gula, H., Nicoleascu, V., Randall, G., Pshenychnyi, S., Khurram, N., Kanwar, Y., Missiakas, D., Henkin, J., Yeldandi, A., Batlle, D. Tags: Acute Kidney Injury Source Type: research

Maturation of GFR in Term-Born Neonates: An Individual Participant Data Meta-Analysis
Conclusions These reference values for healthy, term-born neonates show a biphasic increase in GFR, with the largest increase between days 1 and 5. Together with the re-examined Schwartz equation, this can help identify altered GFR in term-born neonates. To enable widespread implementation of our proposed eGFR equation, validation in a large cohort of neonates is required. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - June 30, 2022 Category: Urology & Nephrology Authors: Smeets, N. J. L., IntHout, J., van der Burgh, M. J. P., Schwartz, G. J., Schreuder, M. F., de Wildt, S. N. Tags: Development of the Kidney Source Type: research

Transplantation Mediates Much of the Racial Disparity in Survival from Childhood-Onset Kidney Failure
Conclusions Equalizing time with a functioning transplant for Black patients may equalize survival of childhood-onset ESKD with White patients. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - June 30, 2022 Category: Urology & Nephrology Authors: Becerra, A. Z., Chan, K. E., Eggers, P. W., Norton, J., Kimmel, P. L., Schulman, I. H., Mendley, S. R. Tags: Special Series on Addressing Racial and Ethnic Disparities in Kidney Disease Source Type: research

Lack of Cultural and Language Concordant Nutrition Education for Hispanic/Latinx Individuals with CKD: A Call to Action
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - June 30, 2022 Category: Urology & Nephrology Authors: Perez, L. M., Biruete, A. Tags: Special Series on Addressing Racial and Ethnic Disparities in Kidney Disease Source Type: research

Racial and Ethnic Disparities in Home Dialysis Use in the United States: Barriers and Solutions
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - June 30, 2022 Category: Urology & Nephrology Authors: Rizzolo, K., Cervantes, L., Shen, J. I. Tags: Special Series on Addressing Racial and Ethnic Disparities in Kidney Disease Source Type: research

Recognizing the Potential Importance of Religion and Spirituality in the Care of Black Americans with Kidney Failure
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - June 30, 2022 Category: Urology & Nephrology Authors: Gelfand, S. L., Fitchett, G., Moss, A. H. Tags: Special Series on Addressing Racial and Ethnic Disparities in Kidney Disease Source Type: research

Culturally Concordant Community-Health Workers: Building Sustainable Community-Based Interventions that Eliminate Kidney Health Disparities
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - June 30, 2022 Category: Urology & Nephrology Authors: Cervantes, L., Robinson, B. M., Steiner, J. F., Myaskovsky, L. Tags: Special Series on Addressing Racial and Ethnic Disparities in Kidney Disease Source Type: research

Looking Upstream-The Role of Primary Care in Addressing US Race Inequities in Kidney Health
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - June 30, 2022 Category: Urology & Nephrology Authors: Boulware, L. E. Tags: Special Series on Addressing Racial and Ethnic Disparities in Kidney Disease Source Type: research