Journal of the American Society of Nephrology : JASN This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Gabapentin and Pregabalin Use and Association with Adverse Outcomes among Hemodialysis Patients
Conclusions Gabapentin and pregabalin should be used judiciously in patients on hemodialysis, and research to identify the most optimal dosing is warranted. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - June 29, 2018 Category: Urology & Nephrology Authors: Ishida, J. H., McCulloch, C. E., Steinman, M. A., Grimes, B. A., Johansen, K. L. Tags: Clinical Epidemiology Source Type: research

Clinical and Pathology Findings Associate Consistently with Larger Glomerular Volume
Conclusions Characteristics associated with glomerular volume are consistent between patient populations with low and high levels of comorbidity. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - June 29, 2018 Category: Urology & Nephrology Authors: Denic, A., Mathew, J., Nagineni, V. V., Thompson, R. H., Leibovich, B. C., Lerman, L. O., Lieske, J. C., Alexander, M. P., Augustine, J. J., Kremers, W. K., Rule, A. D. Tags: Clinical Epidemiology Source Type: research

ESRD among Immigrants to Ontario, Canada: A Population-Based Study
Conclusions Among immigrants in Canada, those from sub-Saharan Africa and the Caribbean have the highest ESRD-D risk. Tailored kidney-protective interventions should be developed for these susceptible populations. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - June 29, 2018 Category: Urology & Nephrology Authors: Perl, J., McArthur, E., Tan, V. S., Nash, D. M., Garg, A. X., Harel, Z., Li, A. H., Sood, M. M., Ray, J. G., Wald, R. Tags: Clinical Epidemiology Source Type: research

Serum 6-Bromotryptophan Levels Identified as a Risk Factor for CKD Progression
Conclusions Serum 6-bromotryptophan is a consistent and novel risk factor for CKD progression. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - June 29, 2018 Category: Urology & Nephrology Authors: Tin, A., Nadkarni, G., Evans, A. M., Winkler, C. A., Bottinger, E., Rebholz, C. M., Sarnak, M. J., Inker, L. A., Levey, A. S., Lipkowitz, M. S., Appel, L. J., Arking, D. E., Coresh, J., Grams, M. E. Tags: Clinical Epidemiology Source Type: research

Blocking Properdin Prevents Complement-Mediated Hemolytic Uremic Syndrome and Systemic Thrombophilia
Conclusions These results contrast with the detrimental effect of P inhibition observed in a murine model of C3 glomerulopathy and suggest that P contributes critically to aHUS pathogenesis. Inhibition of P in aHUS may be of therapeutic benefit. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - June 29, 2018 Category: Urology & Nephrology Authors: Ueda, Y., Miwa, T., Gullipalli, D., Sato, S., Ito, D., Kim, H., Palmer, M., Song, W.-C. Tags: Basic Research Source Type: research

A NOX4/TRPC6 Pathway in Podocyte Calcium Regulation and Renal Damage in Diabetic Kidney Disease
Conclusions These data reveal a novel signaling mechanism involving NOX4 and TRPC6 in podocytes that could be pharmacologically targeted to abate the development of DKD. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - June 29, 2018 Category: Urology & Nephrology Authors: Ilatovskaya, D. V., Blass, G., Palygin, O., Levchenko, V., Pavlov, T. S., Grzybowski, M. N., Winsor, K., Shuyskiy, L. S., Geurts, A. M., Cowley, A. W., Birnbaumer, L., Staruschenko, A. Tags: Basic Research Source Type: research

Caspase-3 Is a Pivotal Regulator of Microvascular Rarefaction and Renal Fibrosis after Ischemia-Reperfusion Injury
Conclusions These results establish the pivotal importance of caspase-3 in regulating microvascular endothelial cell apoptosis and renal fibrosis after IRI. These findings also demonstrate the predominant role of microvascular over tubular injury as a driver of progressive renal damage and fibrosis after IRI. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - June 29, 2018 Category: Urology & Nephrology Authors: Yang, B., Lan, S., Dieude, M., Sabo-Vatasescu, J.-P., Karakeussian-Rimbaud, A., Turgeon, J., Qi, S., Gunaratnam, L., Patey, N., Hebert, M.-J. Tags: Basic Research Source Type: research

Epithelial and Endothelial Pannexin1 Channels Mediate AKI
Conclusions Panx1 is involved in regulating ATP release from hypoxic cells, and reducing this ATP release may protect kidneys from AKI. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - June 29, 2018 Category: Urology & Nephrology Authors: Jankowski, J., Perry, H. M., Medina, C. B., Huang, L., Yao, J., Bajwa, A., Lorenz, U. M., Rosin, D. L., Ravichandran, K. S., Isakson, B. E., Okusa, M. D. Tags: Basic Research Source Type: research

Mechanisms of Crystalloid versus Colloid Osmosis across the Peritoneal Membrane
Conclusions These data cast light on the molecular mechanisms involved in colloid versus crystalloid osmosis and characterize novel osmotic agents. Dialysis solutions combining crystalloid and colloid particles may help restore fluid balance in patients treated with peritoneal dialysis. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - June 29, 2018 Category: Urology & Nephrology Authors: Morelle, J., Sow, A., Fustin, C.-A., Fillee, C., Garcia-Lopez, E., Lindholm, B., Goffin, E., Vandemaele, F., Rippe, B., Öberg, C. M., Devuyst, O. Tags: Basic Research Source Type: research

Cellular Origin and Functional Relevance of Collagen I Production in the Kidney
Conclusions Our data show that hematopoietic cells are a major source of collagen and that antifibrotic therapies need to be carefully considered depending on the type of disease and the underlying cause of fibrosis. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - June 29, 2018 Category: Urology & Nephrology Authors: Buchtler, S., Grill, A., Hofmarksrichter, S., Stöckert, P., Schiechl-Brachner, G., Rodriguez Gomez, M., Neumayer, S., Schmidbauer, K., Talke, Y., Klinkhammer, B. M., Boor, P., Medvinsky, A., Renner, K., Castrop, H., Mack, M. Tags: Basic Research Source Type: research

Glycine Amidinotransferase (GATM), Renal Fanconi Syndrome, and Kidney Failure
Conclusions In this novel genetic disorder, fully penetrant heterozygous missense mutations in GATM trigger intramitochondrial fibrillary deposition of GATM and lead to elongated and abnormal mitochondria. We speculate that this renal proximal tubular mitochondrial pathology initiates a response from the inflammasome, with subsequent development of kidney fibrosis. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - June 29, 2018 Category: Urology & Nephrology Authors: Reichold, M., Klootwijk, E. D., Reinders, J., Otto, E. A., Milani, M., Broeker, C., Laing, C., Wiesner, J., Devi, S., Zhou, W., Schmitt, R., Tegtmeier, I., Sterner, C., Doellerer, H., Renner, K., Oefner, P. J., Dettmer, K., Simbuerger, J. M., Witzgall, R. Tags: Basic Research Source Type: research

The Calcium-Sensing Receptor Increases Activity of the Renal NCC through the WNK4-SPAK Pathway
Conclusions Activation of CaSR can increase NCC activity via the WNK4-SPAK pathway. It is possible that activation of CaSR by Ca2+ in the apical membrane of the DCT increases NaCl reabsorption by NCC, with the consequent, well known decrease of Ca2+ reabsorption, further promoting hypercalciuria. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - June 29, 2018 Category: Urology & Nephrology Authors: Bazua-Valenti, S., Rojas-Vega, L., Castaneda-Bueno, M., Barrera-Chimal, J., Bautista, R., Cervantes-Perez, L. G., Vazquez, N., Plata, C., Murillo-de-Ozores, A. R., Gonzalez-Mariscal, L., Ellison, D. H., Riccardi, D., Bobadilla, N. A., Gamba, G. Tags: Basic Research Source Type: research

IL-10 Receptor Signaling Empowers Regulatory T Cells to Control Th17 Responses and Protect from GN
Conclusions IL-10R engagement optimizes Treg-mediated suppression of Th17 immunity. We hypothesize a feed-forward loop, in which IL-10Ra signaling reinforces IL-10 secretion by Tregs which potently controls Th17 development via direct and indirect mechanisms. IL-10R thus may be a promising therapeutic target for the treatment of GN. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - June 29, 2018 Category: Urology & Nephrology Authors: Diefenhardt, P., Nosko, A., Kluger, M. A., Richter, J. V., Wegscheid, C., Kobayashi, Y., Tiegs, G., Huber, S., Flavell, R. A., Stahl, R. A. K., Steinmetz, O. M. Tags: Basic Research Source Type: research

The Complexity and Heterogeneity of Monoclonal Immunoglobulin-Associated Renal Diseases
Monoclonal gammopathies are characterized by the overproduction of monoclonal Ig (MIg) detectable in the serum or urine resulting from a clonal proliferation of plasma cells or B lymphocytes. The underlying hematologic conditions range from malignant neoplasms of plasma cells or B lymphocytes, including multiple myeloma and B-cell lymphoproliferative disorders, to nonmalignant small clonal proliferations. The term MGUS implies presence of an MIg in the setting of a "benign" hematologic condition without renal or other end organ damage. The term MGRS was recently introduced to indicate monoclonal gammopathy with MIg-associa...
Source: Journal of the American Society of Nephrology : JASN - June 29, 2018 Category: Urology & Nephrology Authors: Sethi, S., Rajkumar, S. V., DAgati, V. D. Tags: Reviews Source Type: research

Sirtuins in Renal Health and Disease
Sirtuins belong to an evolutionarily conserved family of NAD+-dependent deacetylases that share multiple cellular functions related to proliferation, DNA repair, mitochondrial energy homeostasis, and antioxidant activity. Mammalians express seven sirtuins (SIRT1–7) that are localized in different subcellular compartments. Changes in sirtuin expression are critical in several diseases, including metabolic syndrome, diabetes, cancer, and aging. In the kidney, the most widely studied sirtuin is SIRT1, which exerts cytoprotective effects by inhibiting cell apoptosis, inflammation, and fibrosis together with SIRT3, a cruc...
Source: Journal of the American Society of Nephrology : JASN - June 29, 2018 Category: Urology & Nephrology Authors: Morigi, M., Perico, L., Benigni, A. Tags: Reviews Source Type: research