Journal of the American Society of Nephrology : JASN This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Acid Stimulation of the Citrate Transporter NaDC-1 Requires Pyk2 and ERK1/2 Signaling Pathways
Conclusions Acid stimulation of NaDC-1 activity involves Pyk2/c-Src and Raf1-ERK1/2-p90RSK signaling pathways, but these pathways are not downstream of ET-1/ETB in this process. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - May 31, 2018 Category: Urology & Nephrology Authors: Zacchia, M., Tian, X., Zona, E., Alpern, R. J., Preisig, P. A. Tags: Basic Research Source Type: research

The Role of Intercalated Cell Nedd4-2 in BP Regulation, Ion Transport, and Transporter Expression
Conclusions IC Nedd4–2 regulates Cl–/HCO3– exchange in ICs., Nedd4–2 gene ablation increases BP in part through its action in these cells. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - May 31, 2018 Category: Urology & Nephrology Authors: Nanami, M., Pham, T. D., Kim, Y. H., Yang, B., Sutliff, R. L., Staub, O., Klein, J. D., Lopez-Cayuqueo, K. I., Chambrey, R., Park, A. Y., Wang, X., Pech, V., Verlander, J. W., Wall, S. M. Tags: Basic Research Source Type: research

Interleukin-1{beta} Activates a MYC-Dependent Metabolic Switch in Kidney Stromal Cells Necessary for Progressive Tubulointerstitial Fibrosis
Conclusions Our findings define a connection between IL-1β and metabolic switch in fibrosis initiation and progression and highlight IL-1β and MYC as potential therapeutic targets in tubulointerstitial diseases. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - May 31, 2018 Category: Urology & Nephrology Authors: Lemos, D. R., McMurdo, M., Karaca, G., Wilflingseder, J., Leaf, I. A., Gupta, N., Miyoshi, T., Susa, K., Johnson, B. G., Soliman, K., Wang, G., Morizane, R., Bonventre, J. V., Duffield, J. S. Tags: Basic Research Source Type: research

Depletion of Gprc5a Promotes Development of Diabetic Nephropathy
Conclusions Gprc5a has an important role in the pathogenesis of DN, and further study of the podocyte-specific signaling activity of this protein is warranted. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - May 31, 2018 Category: Urology & Nephrology Authors: Ma, X., Schwarz, A., Sevilla, S. Z., Levin, A., Hultenby, K., Wernerson, A., Lal, M., Patrakka, J. Tags: Basic Research Source Type: research

The Role of Palladin in Podocytes
Conclusions Palladin has an important role in podocyte function in vitro and in vivo. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - May 31, 2018 Category: Urology & Nephrology Authors: Artelt, N., Ludwig, T. A., Rogge, H., Kavvadas, P., Siegerist, F., Blumenthal, A., van den Brandt, J., Otey, C. A., Bang, M.-L., Amann, K., Chadjichristos, C. E., Chatziantoniou, C., Endlich, K., Endlich, N. Tags: Basic Research Source Type: research

An Engineered Complement Factor H Construct for Treatment of C3 Glomerulopathy
Conclusions FH1–5^18–20^R1–2 may have utility as a treatment option for C3G or other complement-mediated diseases. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - May 31, 2018 Category: Urology & Nephrology Authors: Yang, Y., Denton, H., Davies, O. R., Smith-Jackson, K., Kerr, H., Herbert, A. P., Barlow, P. N., Pickering, M. C., Marchbank, K. J. Tags: Basic Research Source Type: research

Zinc Inhibits Phosphate-Induced Vascular Calcification through TNFAIP3-Mediated Suppression of NF-{kappa}B
Conclusions Zinc supplementation ameliorates phosphate-induced osteo-/chondrogenic transdifferentiation of VSMCs and vascular calcification through an active cellular mechanism resulting from GPR39-dependent induction of TNFAIP3 and subsequent suppression of the NF-B pathway. Zinc supplementation may be a simple treatment to reduce the burden of vascular calcification in CKD. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - May 31, 2018 Category: Urology & Nephrology Authors: Voelkl, J., Tuffaha, R., Luong, T. T. D., Zickler, D., Masyout, J., Feger, M., Verheyen, N., Blaschke, F., Kuro-o, M., Tomaschitz, A., Pilz, S., Pasch, A., Eckardt, K.-U., Scherberich, J. E., Lang, F., Pieske, B., Alesutan, I. Tags: Basic Research Source Type: research

Cooperation of Antiporter LAT2/CD98hc with Uniporter TAT1 for Renal Reabsorption of Neutral Amino Acids
Conclusions The LAT2/CD98hc and TAT1 transporters functionally cooperate in vivo, and y+LAT1/CD98hc may compensate for the loss of LAT2/CD98hc and TAT1, functioning as a neutral AA exporter at the expense of some urinary loss of cationic AAs. Cooperative and compensatory mechanisms of AA transporters may explain the lack of basolateral neutral aminoacidurias in humans. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - May 31, 2018 Category: Urology & Nephrology Authors: Vilches, C., Boiadjieva-Knöpfel, E., Bodoy, S., Camargo, S., Lopez de Heredia, M., Prat, E., Ormazabal, A., Artuch, R., Zorzano, A., Verrey, F., Nunes, V., Palacin, M. Tags: Basic Research Source Type: research

Hydroxyproline Metabolism and Oxalate Synthesis in Primary Hyperoxaluria
Conclusions Hyp metabolism differs among PH types and is a major source of oxalate synthesis in individuals with PH2 and PH3. In patients with PH1, who have the highest urinary excretion of oxalate, the major sources of oxalate remain to be identified. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - May 31, 2018 Category: Urology & Nephrology Authors: Fargue, S., Milliner, D. S., Knight, J., Olson, J. B., Lowther, W. T., Holmes, R. P. Tags: Basic Research Source Type: research

A Novel Method for Rapid Bedside Measurement of GFR
Conclusions The VFI-based approach allows for the rapid determination of mGFR at the bedside while maintaining patient safety and measurement accuracy and reproducibility. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - May 31, 2018 Category: Urology & Nephrology Authors: Rizk, D. V., Meier, D., Sandoval, R. M., Chacana, T., Reilly, E. S., Seegmiller, J. C., DeNoia, E., Strickland, J. S., Muldoon, J., Molitoris, B. A. Tags: Rapid Communication Source Type: research

Circulating Bacterial Fragments as Cardiovascular Risk Factors in CKD
Cardiovascular disease (CVD) is a major cause of mortality and morbidity in patients with CKD. In the past decade, intestinal dysbiosis and altered gut epithelial barrier function are increasingly recognized in CKD. Uremic patients have slow intestinal transit time, impaired protein assimilation, and decreased consumption of dietary fiber. The use of multiple medications also may contribute to the proliferation of dysbiotic bacteria, which affect the barrier function of intestinal epithelium. In addition, fluid overload and uremic toxins per se directly reduce the gut barrier function. The major consequence of these altera...
Source: Journal of the American Society of Nephrology : JASN - May 31, 2018 Category: Urology & Nephrology Authors: Szeto, C.-C., McIntyre, C. W., Li, P. K.-T. Tags: Reviews Source Type: research

Four-Dimensional Imaging of T Cells in Kidney Transplant Rejection
Kidney transplantation is the treatment of choice for ESRD but is complicated by the response of the recipient’s immune system to nonself histocompatibility antigens on the graft, resulting in rejection. Multiphoton intravital microscopy, referred to as four-dimensional imaging because it records dynamic events in three-dimensional tissue volumes, has emerged as a powerful tool to study immunologic processes in living animals. Here, we will review advances in understanding the complex mechanisms of T cell–mediated rejection made possible by four-dimensional imaging of mouse renal allografts. We will summarize r...
Source: Journal of the American Society of Nephrology : JASN - May 31, 2018 Category: Urology & Nephrology Authors: Hughes, A. D., Lakkis, F. G., Oberbarnscheidt, M. H. Tags: Reviews Source Type: research

Vascularizing the Kidney in the Embryo and Organoid: Questioning Assumptions about Renal Vasculogenesis
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - May 31, 2018 Category: Urology & Nephrology Authors: Munro, D. A. D., Davies, J. A. Tags: Perspectives Source Type: research

Does the Receipt of Antibiotics for Common Infectious Diseases Predispose to Kidney Stones? A Cautionary Note for All Health Care Practitioners
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - May 31, 2018 Category: Urology & Nephrology Authors: Nazzal, L., Blaser, M. J. Tags: Perspectives Source Type: research

Metabolomics Research in Chronic Kidney Disease
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - May 31, 2018 Category: Urology & Nephrology Authors: Grams, M. E., Shafi, T., Rhee, E. P. Tags: Perspectives Source Type: research