Independent association between prediabetes and future pancreatic fat accumulation: a 5-year Japanese cohort study
AbstractBackgroundThe association between pancreatic fat and glucose dysmetabolism has been reported in several cross-sectional studies; however, a recent longitudinal study showed that baseline pancreatic fat did not cause subsequent diabetes mellitus. We hypothesized that pancreatic fat is not a cause but a manifestation of glucose dysmetabolism and aimed to investigate the association between baseline prediabetes and future pancreatic fat accumulation.MethodsBetween 2008 and 2015, 198 nondiabetic participants, who underwent a health check-up via unenhanced computed tomography (CT) twice with CT intervals ≥ 5&nbs...
Source: Journal of Gastroenterology - December 13, 2017 Category: Gastroenterology Source Type: research

Gastrointestinal manifestation of immunoglobulin G4-related disease: clarification through a multicenter survey
ConclusionsIgG4-GID is found in the setting of IgG4-RD, often with ulceration or cancer. Characteristic histologic findings are observed in the muscularis propria and gastric mucosa. Cases with IPT may be heterogeneous, and there may be mimickers of IgG4-GID. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - December 8, 2017 Category: Gastroenterology Source Type: research

Correction to: Telomere length of gallbladder epithelium is shortened in patients with congenital biliary dilatation: measurement by quantitative fluorescence in situ hybridization
AbstractIn the original publication of this article, Fig.  5 was published with incorrect color of the approximate lines of CBD and Control. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - December 5, 2017 Category: Gastroenterology Source Type: research

Pharmacogenetics of thiopurines for inflammatory bowel disease in East Asia: prospects for clinical application of NUDT15 genotyping
AbstractThe thiopurine drugs 6-mercaptopurine (6-MP) and azathiopurine (AZA) are widely used to treat inflammatory bowel disease. However, the incidence of adverse reactions is high, particularly in Asia, and the mechanisms of toxicity in Asian populations remain unclear. ThiopurineS-methyltransferase (TPMT) is a well-known enzyme that inactivates AZA or 6-MP through methylation and is one of the few pharmacogenetic predictors used in clinical settings in Western countries. Individuals carrying TPMT-deficient genetic variants require reduced drug doses, but this treatment modification is are not applicable to East Asian po...
Source: Journal of Gastroenterology - November 30, 2017 Category: Gastroenterology Source Type: research

A nationwide population-based study of common bile duct stone recurrence after endoscopic stone removal in Korea
AbstractBackgroundThere is no consensus whether patients who underwent endoscopic common bile duct (CBD) stone removal should be followed up periodically and whether patients with gallbladder (GB) stones should undergo cholecystectomy. Thus, this study aimed to investigate the recurrence rate of CBD stones and the difference in recurrence rate according to cholecystectomy.MethodsWe conducted a population-based study using the National Health Insurance database. Patients diagnosed with CBD stones and with procedure registry of endoscopic stone removal were included. The primary outcome was the recurrence rate of CBD stones....
Source: Journal of Gastroenterology - November 30, 2017 Category: Gastroenterology Source Type: research

Efficacy and safety of twice-daily rabeprazole maintenance therapy for patients with reflux esophagitis refractory to standard once-daily proton pump inhibitor: the Japan-based EXTEND study
AbstractBackgroundRabeprazole at 10 or 20  mg twice daily (b.i.d.) has been reported to be highly effective in the treatment of proton pump inhibitor (PPI)-resistant reflux esophagitis (RE) that is refractory to the standard once-daily PPI regimen. We evaluated the efficacy and safety of rabeprazole maintenance therapy at 10 mg once daily (q.d.) or b.i.d. for longer than 8 weeks.MethodsPatients with RE refractory to standard PPI regimens for at least 8  weeks were enrolled. They were treated with rabeprazole at 10 or 20 mg b.i.d. for 8 weeks during the open-label treatment period. After endosc...
Source: Journal of Gastroenterology - November 29, 2017 Category: Gastroenterology Source Type: research

Clinical strategy of diagnosing and following patients with nonalcoholic fatty liver disease based on invasive and noninvasive methods
AbstractNonalcoholic fatty liver disease (NAFLD) is an important cause of chronic liver injury in many countries. The incidence of NAFLD is rising rapidly in both adults and children, because of the currently ongoing epidemics of obesity and type 2 diabetes. Notably, histological liver fibrosis is recognized as the main predictive factor for the overall long-term outcome of NAFLD, including cardiovascular disease and liver-related mortality. Thus, staging of liver fibrosis is essential in determining the prognosis and optimal treatment for patients with NAFLD and in guiding surveillance for the development of hepatocellula...
Source: Journal of Gastroenterology - November 24, 2017 Category: Gastroenterology Source Type: research

Telomere length of gallbladder epithelium is shortened in patients with congenital biliary dilatation: measurement by quantitative fluorescence in situ hybridization
ConclusionsOur findings indicate that telomere shortening in the gallbladder mucosa plays an important role in the process of carcinogenesis in patients with CBD. These results support the recommendation of established guidelines for prophylactic surgery in patients with CBD because CBD is a premalignant condition with excessive telomere shortening. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 15, 2017 Category: Gastroenterology Source Type: research

World trends for H. pylori eradication therapy and gastric cancer prevention strategy by H. pylori test-and-treat
AbstractHelicobacter pylori-associated gastritis leads to the development of gastric cancer. Kyoto global consensus report onH. pylori gastritis recommendedH. pylori eradication therapy to prevent gastric cancer. To manageH. pylori infection, it is important to choose the appropriate regimen considering regional differences in resistance to clarithromycin and metronidazole. Quinolones and rifabutin-containing regimens are useful as third- and fourth-line rescue therapies. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 14, 2017 Category: Gastroenterology Source Type: research

Is the incidence of esophageal adenocarcinoma increasing in Japan? Trends from the data of a hospital-based registration system in Akita Prefecture, Japan
We examined the data from a collaborative hospital-based registration system for cancer patients. Eleven of the main hospitals in Akita Prefecture participate in this system, which covers 90% of the cancer cases in the region and which provides near population-based data. Using this registration system, we examined the sequential trends in the percentage of adenocarcinoma cases in relation to total esophageal cancer cases in Akita Prefecture from 2007 to 2014.ResultsIn 2007 –2014, a total of 2527 esophageal cancer patients were registered in the system. Among these, only 43 (1.8%) had adenocarcinoma. However, the num...
Source: Journal of Gastroenterology - November 14, 2017 Category: Gastroenterology Source Type: research

Esophageal motility disorders: new perspectives from high-resolution manometry and histopathology
AbstractHigh-resolution manometry (HRM) and peroral endoscopic myotomy (POEM) have contributed significantly to the field of esophageal motility disorders in recent years. The development of HRM has categorized various esophageal motility disorders with a focus on a diverse range of manometric anomalies. Additionally, the Chicago classification criteria is widely used for manometric diagnosis. Moreover, POEM was introduced as a minimally invasive radical therapy for achalasia and shows promise for other spastic esophageal motility disorders as well. POEM has also enabled a transluminal endoscopic approach for determining t...
Source: Journal of Gastroenterology - November 13, 2017 Category: Gastroenterology Source Type: research

Correction to: Efficacy and safety of glecaprevir/pibrentasvir in HCV-infected Japanese patients with prior DAA experience, severe renal impairment, or genotype 3 infection
This article is an open access publication” and also the CC-BY description was not included. The description should be as follows. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 13, 2017 Category: Gastroenterology Source Type: research

A proposed severity classification system for hepatolithiasis based on an analysis of prognostic factors in a Japanese patient cohort
ConclusionsThe proposed hepatolithiasis severity classification system can be used to assess prognosis and thereby improve patient outcomes. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 8, 2017 Category: Gastroenterology Source Type: research

Safety of first-line triple therapy with a potassium-competitive acid blocker for Helicobacter pylori eradication in children
ConclusionsFirst-line triple therapy with a P-CAB forH. pylori eradication in children was found to be safe. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 7, 2017 Category: Gastroenterology Source Type: research

miR-324-3p promotes gastric cancer development by activating Smad4-mediated Wnt/beta-catenin signaling pathway
ConclusionsThe results suggested that miR-324-3p promoted GC through activating the Smad4-mediated Wnt/beta-catenin signaling pathway. The miR-324-3p/Smad4/Wnt signaling axis may be a potential therapeutic target to prevent GC progression. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 4, 2017 Category: Gastroenterology Source Type: research

Human hepatic stellate cell isolation and characterization
AbstractThe hepatic stellate cells (HSCs) localize at the space of Disse in the liver and have multiple functions. They are identified as the major contributor to hepatic fibrosis. Significant understanding of HSCs has been achieved using rodent models and isolated murine HSCs; as well as investigating human liver tissues and human HSCs. There is growing interest and need of translating rodent study findings to human HSCs and human liver diseases. However, species-related differences impose challenges on the translational research. In this review, we focus on the current information on human HSCs isolation methods, human H...
Source: Journal of Gastroenterology - November 1, 2017 Category: Gastroenterology Source Type: research

Association between alanine aminotransferase elevation and UGT1A1*6 polymorphisms in daclatasvir and asunaprevir combination therapy for chronic hepatitis C
ConclusionsThrough the analysis we suggest that the A allele inUGT1A1 rs4148323 (UGT1A1*6), which is highly prevalent in the Japanese population, should be considered a risk for the development of DCV/ASV therapy-induced ALT elevation. Pretreatment SNP testing ofUGT1A1*6 might be beneficial for the prediction of liver damage induced by DCV/ASV or even by DCV/ASV plus beclabuvir. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 1, 2017 Category: Gastroenterology Source Type: research

Activation of apoptosis inhibitor of macrophage is a sensitive diagnostic marker for NASH-associated hepatocellular carcinoma
ConclusionsOur observations suggest the activation of AIM in blood in the presence of NASH-HCC, with a significant increase in IgM-free AIM levels. IgM-free AIM serum levels appear to be a sensitive diagnostic marker for NASH-HCC. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - October 30, 2017 Category: Gastroenterology Source Type: research

Clinical importance of IL-22 cascade in IBD
AbstractIL-22 is a relatively new cytokine that is characterized by several unique biological properties. In the intestines, the effect of IL-22 is restricted mainly to non-lymphoid cells such as epithelial cells. Interestingly, the expression pattern and major cellular source of IL-22 have distinct difference between large and small intestines. IL-22 possesses an ability to constitutively activate STAT3 for promoting epithelial cell regeneration and reinforcing mucosal barrier integrity through stimulating the expression of anti-bacterial peptide and mucins. Of note, IL-22 is characterized as a two-faced cytokine that can...
Source: Journal of Gastroenterology - October 26, 2017 Category: Gastroenterology Source Type: research

Immunoglobulin A and liver diseases
AbstractImmunoglobulin A (IgA) is a major immunoglobulin isotype in the gut and plays a role in maintenance of gut homeostasis. Secretory IgA (SIgA) has multiple functions in the gut, such as to regulate microbiota composition, to protect intestinal epithelium from pathogenic microorganisms, and to help for immune-system development. The liver is the front-line organ that receives gut-derived products through the portal vein, implying that the liver could be severely affected by a disrupted intestinal homeostasis. Indeed, some liver diseases like alcoholic liver disease are associated with an altered composition of gut mic...
Source: Journal of Gastroenterology - October 26, 2017 Category: Gastroenterology Source Type: research

Endoscopic diagnosis of hiatus hernia under deep inspiration is not consistent with esophageal manometric diagnosis
ConclusionsEndoscopic diagnosis of HH under deep inspiration is not consistent with esophageal manometric diagnosis, leading to overdiagnosis. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - October 26, 2017 Category: Gastroenterology Source Type: research

Slow-metabolizing ADH1B and inactive heterozygous ALDH2 increase vulnerability to fatty liver in Japanese men with alcohol dependence
ConclusionsTheADH1B Arg/Arg genotype and theALDH2 Glu/Lys genotype were positive determinants of fatty liver in the subjects. These results suggest that slow ethanol and acetaldehyde metabolism accelerates the development of alcoholic fatty liver in heavy drinkers. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - October 23, 2017 Category: Gastroenterology Source Type: research

Efficacy and safety of glecaprevir/pibrentasvir in HCV-infected Japanese patients with prior DAA experience, severe renal impairment, or genotype 3 infection
AbstractBackgroundOnce-daily, orally administered, co-formulated glecaprevir (NS3/4A protease inhibitor) and pibrentasvir (NS5A inhibitor) (G/P) demonstrated pangenotypic activity and high sustained virologic response (SVR) rates in studies outside Japan. Here we report safety and efficacy in a subset of Japanese patients with chronic HCV infection who received G/P 300/120  mg in a phase 3, open-label, multicenter study (CERTAIN-1).MethodsThis analysis focuses on three difficult-to-treat subgroups: HCV GT1/2-infected patients who failed to achieve SVR after treatment with a direct acting antiviral (DAA)-containing reg...
Source: Journal of Gastroenterology - October 20, 2017 Category: Gastroenterology Source Type: research

Nationwide survey for acute liver failure and late-onset hepatic failure in Japan
ConclusionAlthough the clinical features, including the etiologies, of patients with ALF and LOHF have changed, the outcomes of patients have not improved in recent years. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - October 13, 2017 Category: Gastroenterology Source Type: research

Correction to: Complete mucosal healing of distal lesions induced by twice-daily budesonide 2-mg foam promoted clinical remission of mild-to-moderate ulcerative colitis with distal active inflammation: double-blind, randomized study
In Fig.  2(c) of this article, the length of the “95% CI difference bars” under the items labelled “Left-sided and Pancolitis” and “Left-sided” under the heading “Disease type” was corrected. The correct figure is shown in the following page. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - October 13, 2017 Category: Gastroenterology Source Type: research

Erratum to: Action and function of Wnt/ β-catenin signaling in the progression from chronic hepatitis C to hepatocellular carcinoma
Erratum to: J Gastroenterol (2017) 52:419 –431 DOI 10.1007/s00535-016-1299-5. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - October 11, 2017 Category: Gastroenterology Source Type: research

The role of maintenance therapy in eosinophilic esophagitis: who, why, and how?
AbstractIn patients with eosinophilic esophagitis (EoE) who do not respond to proton pump inhibitors, initial anti-inflammatory/anti-eosinophilic treatment is with either topical corticosteroids or dietary elimination. A large body of literature supports the efficacy of these approaches, with histologic response rates in the 50 –90% range for steroids and 70% range for the six-food elimination diet. However, these studies are almost all short-term and data evaluating long-term safety and efficacy of either treatment are limited. Nevertheless, because EoE is chronic, symptomatic, endoscopic, and histologic disease act...
Source: Journal of Gastroenterology - October 10, 2017 Category: Gastroenterology Source Type: research

Efficacy and safety of glecaprevir/pibrentasvir in Japanese patients with chronic genotype 1 hepatitis C virus infection with and without cirrhosis
ConclusionsCERTAIN-1 study results demonstrate high efficacy and favorable tolerability of G/P in GT1-infected Japanese patients including those with the NS5A Y93H polymorphism, with no virologic failures observed. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - September 25, 2017 Category: Gastroenterology Source Type: research

Erratum to: Proton pump inhibitors as risk factor for metabolic syndrome and hepatic steatosis in coeliac disease patients on gluten-free diet
Abstract Erratum to: J Gastroenterol DOI 10.1007/s00535-017-1381-7. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - September 19, 2017 Category: Gastroenterology Source Type: research

Basophils activated via TLR signaling may contribute to pathophysiology of type 1 autoimmune pancreatitis
In this study, we investigated basophils from the pancreatic tissue and peripheral blood of individuals with type 1 AIP.MethodsBy using immunohistochemistry, we investigated basophils in pancreatic tissue from 13 patients with type 1 AIP and examined expression of toll-like receptors (TLRs) by these cells. Additionally, we obtained peripheral blood samples from 27 healthy subjects, 40 patients with type 1 AIP, 8 patients with alcoholic chronic pancreatitis, 10 patients with bronchial asthma, and 10 patients with atopic dermatitis, and analyzed activation of basophils by stimulating them with ligands of TLR1 –9. We al...
Source: Journal of Gastroenterology - September 18, 2017 Category: Gastroenterology Source Type: research

Pouch functional outcomes after restorative proctocolectomy with ileal-pouch reconstruction in patients with ulcerative colitis: Japanese multi-center nationwide cohort study
ConclusionThe significant risk factor for a non-functional pouch was anastomotic leakage. The optimal staged surgical procedure should be selected according to a patient ’s condition to avoid anastomotic failure during RPC. Changes in diagnosis after RPC confer a substantial risk of pouch failure. Additional cohort studies are needed to obtain an understanding of the long-standing clinical course of and proper treatment for pouch failure. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - September 7, 2017 Category: Gastroenterology Source Type: research

Expression of ATF6 as a marker of pre-cancerous atypical change in ulcerative colitis-associated colorectal cancer: a potential role in the management of dysplasia
AbstractBackgroundDiagnosis of low-grade dysplasia (LGD) is important in the management of ulcerative colitis (UC), but it is often difficult to distinguish LGD from inflammatory regenerative epithelium. The unfolded protein response (UPR) is activated in inflammatory bowel disease and malignancies. We aimed to identify a UPR-related gene that is involved in the development of non-UC and UC-associated colorectal cancer (CRC), and to investigate whether the target gene is useful for the diagnosis of LGD.MethodsUsing our microarray gene expression database of 152 CRCs, we identified activating transcription factor 6 (ATF6) a...
Source: Journal of Gastroenterology - September 7, 2017 Category: Gastroenterology Source Type: research

Nationwide survey of hereditary pancreatitis in Japan
ConclusionsHP was characterized by early disease onset, frequent development of pancreatic exocrine insufficiency and diabetes mellitus, requirement of endoscopic treatment and/or surgery, and increased risk of pancreatic cancer.PRSS1 andSPINK1 mutations serve as genetic background for HP in Japan. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - August 31, 2017 Category: Gastroenterology Source Type: research

Mechanisms of curcumin-induced gastroprotection against ethanol-induced gastric mucosal lesions
ConclusionsCurcumin-induced protection against ethanol damage involves endogenous PG, NO, gastrin and CGRP released from sensory nerves due to activation of the vanilloid TRPV1 receptor. This protective effect can be attributed to the inhibition of HIF-1 α and Cdx-2 expression and the activation of HO-1 and SOD 2 expression. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - August 30, 2017 Category: Gastroenterology Source Type: research

Analysis of endoscopic brush samples identified mucosa-associated dysbiosis in inflammatory bowel disease
ConclusionsMucosa-associated dysbiosis was identified in IBD patients. CD and UC may be distinguishable from the mucosa-associated microbial community structure. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - August 29, 2017 Category: Gastroenterology Source Type: research

Serum Wisteria floribunda agglutinin-positive Mac-2 binding protein predicts hepatocellular carcinoma incidence and recurrence in nucleos(t)ide analogue therapy for chronic hepatitis B
ConclusionSerum WFA(+)-M2BP and HBcrAg are useful diagnostic tests for predicting the development and recurrence of HBV-related HCC during NA treatment. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - August 28, 2017 Category: Gastroenterology Source Type: research

Determining an optimal clinical dose of elobixibat, a novel inhibitor of the ileal bile acid transporter, in Japanese patients with chronic constipation: a phase II, multicenter, double-blind, placebo-controlled randomized clinical trial
ConclusionsOur study results suggest that 10  mg of elobixibat is a clinically optimal dose for Japanese patients with chronic constipation.Clinical trial registration numberJapicCTI-142608. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - August 24, 2017 Category: Gastroenterology Source Type: research

Proton pump inhibitors as risk factor for metabolic syndrome and hepatic steatosis in coeliac disease patients on gluten-free diet
This study aimed to evaluate the predictive factors for MS and HS in CD after 1  year of GFD.MethodsAll consecutive newly diagnosed CD patients were enrolled. We prospectively collected data about BMI; waist circumference; blood pressure; cholesterol; triglycerides, glucose and insulin blood levels; insulin resistance (through the homeostatic model assessment HOMA-IR) and treatment with proton pump inhibitors (PPI). Diagnosis of MS was made in accordance with current guidelines and HS was diagnosed by ultrasonography. The prevalence of MS and HS was re-assessed after 1  year of GFD. A logistic regression analysis...
Source: Journal of Gastroenterology - August 19, 2017 Category: Gastroenterology Source Type: research

Fusobacterium nucleatum as a prognostic marker of colorectal cancer in a Japanese population
ConclusionThese results suggest that determiningF. nucleatum levels may help predict clinical outcomes in colorectal cancer patients. Further confirmatory studies using independent datasets are required to confirm our findings. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - August 19, 2017 Category: Gastroenterology Source Type: research

Modifiable factors and esophageal cancer: a systematic review of published meta-analyses
This study aimed to summarize the current scientific knowledge on modifiable risk factors for EC, by histological type, through a systematic review of meta-analyses referenced in PubMed and ISI Web of Knowledge. We identified 100 meta-ana lyses on risk factors for ESCC (n = 54), EAC (n = 43), or EC (n = 51). ESCC risk significantly increased with alcohol and maté drinking, smoking, red and processed meat consumption and human papillomavirus infection, while it was negatively associated with body mass index and consumption of fruit, vegetables, white meat, folate, and some carotenoids. C...
Source: Journal of Gastroenterology - August 18, 2017 Category: Gastroenterology Source Type: research

Application of transcutaneous ultrasonography for the diagnosis of muscle mass loss in patients with liver cirrhosis
AbstractBackgroundTo propose an ultrasound-based parameter for the diagnosis of muscle mass loss (MML) in cirrhosis.MethodsThis is an IRB-approved cross-sectional study (October 2013 to January 2017) with written informed consent including 357 subjects —234 cirrhosis and 123 controls. MML was diagnosed using the skeletal muscle index at the L3 level (L3-SMI) on computed tomography (CT). Transcutaneous ultrasound was used to demonstrate a cross section of the right iliopsoas muscle, and the iliopsoas muscle index (IP index) was defined by the ili opsoas muscle area/height2 (mm2/m2). Receiver operating characteristic (...
Source: Journal of Gastroenterology - August 18, 2017 Category: Gastroenterology Source Type: research

The tumor-stromal ratio as a strong prognosticator for advanced gastric cancer patients: proposal of a new TSNM staging system
AbstractBackgroundInsufficient attention is paid to the underlying tumor microenvironment (TME) evolution, that resulting in tumor heterogeneity and driving differences in cancer aggressiveness and treatment outcomes. The morphological evaluation of the proportion of the stroma at the most invasive part of primary tumor (tumor-stromal ratio, TSR) in cancer is gaining momentum as evidence strengthens for the clinical relevance.MethodsTissue samples from the most invasive part of the primary gastric cancer (GC) of 494 patients were analyzed for their TSR, and a new TSNM (tumor-stromal node metastasis) staging system based on...
Source: Journal of Gastroenterology - August 16, 2017 Category: Gastroenterology Source Type: research

Efficacy and safety of ledipasvir/sofosbuvir with ribavirin in chronic hepatitis C patients who failed daclatasvir/asunaprevir therapy: pilot study
ConclusionLedipasvir/sofosbuvir with ribavirin is an effective retreatment option for patients with chronic hepatitis C who failed to respond to prior daclatasvir and asunaprevir therapy. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - August 16, 2017 Category: Gastroenterology Source Type: research

Skeletal muscle mass to visceral fat area ratio is an important determinant affecting hepatic conditions of non-alcoholic fatty liver disease
ConclusionsDecreased muscle mass coupled with increased visceral fat mass is closely associated with an increased risk for exacerbating NAFLD pathophysiology. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - August 8, 2017 Category: Gastroenterology Source Type: research

Complete mucosal healing of distal lesions induced by twice-daily budesonide 2-mg foam promoted clinical remission of mild-to-moderate ulcerative colitis with distal active inflammation: double-blind, randomized study
ConclusionsThis study confirmed for the first time complete mucosal healing with twice-daily budesonide 2-mg foam in mild-to-moderate ulcerative colitis with distal active inflammation. The results also indicated that complete mucosal healing of distal lesions by budesonide foam promotes clinical remission of ulcerative colitis.Clinical trial registration no.: Japic CTI-142704. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - August 4, 2017 Category: Gastroenterology Source Type: research

Meta-analysis: proton pump inhibitors moderately increase the risk of small intestinal bacterial overgrowth
AbstractThe use of proton pump inhibitors (PPIs) may potentially predispose to the development of small intestinal bacterial overgrowth (SIBO), but this association is controversial due to conflicting results from studies conducted to date. The aim of this meta-analysis was to evaluate the association between the use of PPIs and the risk of SIBO. We systematically searched the online PubMed, Embase, and Cochrane Library databases and Web of Science for relevant articles published up to November 2016. Two researchers identified and extracted data independent of each other. The pooled analysis was performed using the generic...
Source: Journal of Gastroenterology - August 2, 2017 Category: Gastroenterology Source Type: research

Transarterial chemoembolization with miriplatin vs. epirubicin for unresectable hepatocellular carcinoma: a phase III randomized trial
ConclusionsOS after TACE with miriplatin was not superior to that after TACE with epirubicin; however, hepatic AEs were less frequent with miriplatin.Clinical Trial Registration: JapicCTI-080632. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - August 1, 2017 Category: Gastroenterology Source Type: research

Combination of PNPLA3 and TLL1 polymorphism can predict advanced fibrosis in Japanese patients with nonalcoholic fatty liver disease
AbstractBackgroundHepatic fibrosis is an independent risk factor for mortality and liver-related events in patients with nonalcoholic fatty liver disease (NAFLD). PNPLA3 rs738409 has been associated with fibrosis in viral and non-viral hepatitis. TLL1 rs17047200 also has been associated with developing hepatocellular carcinoma probably via hepatic fibrogenesis. We estimated the impact of these genetic polymorphisms on hepatic fibrosis in Japanese patients with NAFLD.MethodsWe analyzed the association between these genetic variants and the backgrounds of 817 individuals who received health checkups (health check cohort) fro...
Source: Journal of Gastroenterology - July 25, 2017 Category: Gastroenterology Source Type: research

Magnitude and direction of the association between Clostridium difficile infection and proton pump inhibitors in adults and pediatric patients: a systematic review and meta-analysis
AbstractBackgroundClostridium difficile infection (CDI) is a cause of increased morbidity and health care costs among hospitalized patients. Proton pump inhibitors (PPIs) are mainly used for the treatment of acid-related upper gastrointestinal diseases. The aim of the study was to assess the risks associated with initial and recurrent CDI in adult and pediatric patients treated with PPIs.MethodsA systematic search was performed using PubMed (Medline), Embase, and Web of Science with the following search terms: ( “proton pump inhibitor,” “PPI,” or “acid suppression”) AND (“infection...
Source: Journal of Gastroenterology - July 25, 2017 Category: Gastroenterology Source Type: research

Erratum to: Virological and Clinical Characteristics of Hepatitis B Virus Genotype A
(Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - July 25, 2017 Category: Gastroenterology Source Type: research