CircDCBLD2 alleviates liver fibrosis by regulating ferroptosis via facilitating STUB1-mediated PARK7 ubiquitination degradation
ConclusionCircDCBLD2 overexpression increased PARK7 ubiquitination degradation by upregulating STUB1 through its interaction with HuR, inhibiting HSC activation and promoting HSC ferroptosis, ultimately enhancing liver fibrosis. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - February 3, 2024 Category: Gastroenterology Source Type: research
Medical treatment selection and outcomes for hospitalized patients with severe ulcerative colitis as defined by the Japanese criteria
ConclusionsTacrolimus and infliximab in addition to corticosteroids were used as first-line treatment in severe hospitalized patients. PRO2 on day 3 is a useful marker for switching to second-line therapy or colectomy. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - January 26, 2024 Category: Gastroenterology Source Type: research
Gastrointestinal symptoms in COVID-19 and disease severity: a Japanese registry-based retrospective cohort study
ConclusionsDiarrhea was associated with better clinical outcomes in COVID-19 patients. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - January 25, 2024 Category: Gastroenterology Source Type: research
Non-alcoholic fatty liver disease in patients with morbid obesity: the gut microbiota axis as a potential pathophysiology mechanism
ConclusionsWe established a link between gut microbiota alterations and histological injury in liver diagnosis using biopsy. Harmful products such as ethanol or succinate may be involved in the pathogenesis and progression of MAFLD. Thus, these alterations in gut microbiota patterns and their possible metabolic pathways could add information to the classical predictors of MAFLD severity and suggest novel metabolic targets. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - January 24, 2024 Category: Gastroenterology Source Type: research
Risk of gastric adenoma and adenocarcinoma in patients with familial adenomatous polyposis in Japan: a nationwide multicenter study
ConclusionCareful surveillance of the upper gastrointestinal tract in elderly patients with FAP, such as shortening the interval of follow-up according to age, may be helpful for early diagnosis of gastric cancer. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - January 23, 2024 Category: Gastroenterology Source Type: research
Clinical development of a blood biomarker using apolipoprotein-A2 isoforms for early detection of pancreatic cancer
ConclusionsThe clinical performance of ApoA2-ATQ/AT as a blood biomarker is equivalent to or better than that of CA19-9. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - January 23, 2024 Category: Gastroenterology Source Type: research
Risk of gastric adenoma and adenocarcinoma in patients with familial adenomatous polyposis in Japan: a nationwide multicenter study
ConclusionCareful surveillance of the upper gastrointestinal tract in elderly patients with FAP, such as shortening the interval of follow-up according to age, may be helpful for early diagnosis of gastric cancer. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - January 23, 2024 Category: Gastroenterology Source Type: research
Clinical development of a blood biomarker using apolipoprotein-A2 isoforms for early detection of pancreatic cancer
ConclusionsThe clinical performance of ApoA2-ATQ/AT as a blood biomarker is equivalent to or better than that of CA19-9. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - January 23, 2024 Category: Gastroenterology Source Type: research
Prevalence and risk factors for medication-refractory reflux esophagitis in patients with systemic sclerosis in Japan
ConclusionsPatients with persistent reflux symptoms and those with absent contractility and GEFV grade III or IV should receive maintenance therapy with strong acid inhibition to prevent medication-refractory RE. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - January 22, 2024 Category: Gastroenterology Source Type: research
A combination of bowel wall thickness and submucosa index is useful for estimating endoscopic improvement in ulcerative colitis: external validation of the Kyorin Ultrasound Criterion
ConclusionsExternal validation showed that the KUC-UC using only B mode findings without complicated calculations is a feasible and accurate sonographic criterion for estimating the EI of UC. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - January 21, 2024 Category: Gastroenterology Source Type: research
