N6-methyladenosine RNA methylation in liver diseases: from mechanism to treatment
AbstractEpigenetic modification occurring in RNA has become the hotspot of the field.N6-methyladenosine (m6A) methylation is the most abundant RNA internal modification mainly occurring at the consensus motif DR (m6A) CH (D = A/G/U,R = A/G,H = A/C/U) in the 3’-UTR particularly the region near stop codons. The life cycle of m6A methylation includes “writers,” “erasers,” and “readers”, which are responsible for the addition, removal, and recognition of m6A, respectively. m6A modification has been reported changing RNA s econdary structure or modulating the stability, localization, transport, and tra...
Source: Journal of Gastroenterology - June 28, 2023 Category: Gastroenterology Source Type: research
Association of ulcerative colitis symptom severity and proctocolectomy with multidimensional patient-reported outcomes: a cross-sectional study
ConclusionsUlcerative colitis was associated with reduced mood, quality of life, fatigue, and work productivity even in patients with mild symptoms, suggesting that management of active ulcerative colitis may improve patient-reported outcomes irrespective of disease severity. (UMIN Clinical Trials Registry: UMIN000031995,https://www.umin.ac.jp/ctr/index-j.htm). (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - June 23, 2023 Category: Gastroenterology Source Type: research
Endoscopic evaluation by the Kyoto classification of gastritis combined with serum anti-Helicobacter pylori antibody testing reliably risk-stratifies subjects in a population-based gastric cancer screening program
ConclusionsEndoscopic evaluation ofH. pylori status with the Kyoto classification of gastritis, especially combined with serum anti-Helicobacter pylori antibody testing, reliably risk-stratified subjects in a population-based gastric cancer screening program. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - June 21, 2023 Category: Gastroenterology Source Type: research
Standard versus delayed initiation of S-1 adjuvant chemotherapy after surgery for pancreatic cancer: a secondary analysis of a nationwide cohort by the Japan Pancreas Society
ConclusionsInitiation of S-1 adjuvant chemotherapy in resected PDAC patients within 10 weeks after surgery may offer survival benefit over later initiation. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - June 17, 2023 Category: Gastroenterology Source Type: research
Proton pump inhibitor use and risk of pneumonia: a self-controlled case series study
ConclusionsPPI-use seems to be associated with an increased risk of pneumonia. This finding highlights a need for caution in using PPIs in individuals with a history of pneumonia. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - June 14, 2023 Category: Gastroenterology Source Type: research
Anti-integrin αvβ6 autoantibodies in patients with primary sclerosing cholangitis
ConclusionsAutoantibodies against integrin αvβ6 were detected in most patients with PSC; anti-integrin αvβ6 antibody may serve as a potential diagnostic biomarker for PSC. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - June 13, 2023 Category: Gastroenterology Source Type: research
Hierarchical contribution of individual lifestyle factors and their interactions on adenomatous and serrated polyp risk
ConclusionsIndividual risk factors and their interactions for polyp formation along the adenomatous and serrated pathways are strongly heterogeneous. Our findings may facilitate tailored lifestyle recommendations and contribute to a better understanding of how risk factor combinations impact colorectal carcinogenesis. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - June 10, 2023 Category: Gastroenterology Source Type: research
