Clinical trajectory of intraductal papillary mucinous neoplasms progressing to pancreatic carcinomas during long-term surveillance: a prospective series of 100 carcinoma cases
ConclusionsThe usefulness of currently available blood biomarkers was limited in early detection of pancreatic carcinomas related to IPMNs. Morphological alterations were well correlated with long-term risk of IPMN-derived carcinomas, but not with that of concomitant carcinomas. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - July 29, 2023 Category: Gastroenterology Source Type: research
Exploring the challenge of early gastric cancer diagnostic AI system face in multiple centers and its potential solutions
ConclusionsGreat increase of false positives is a prominent challenge for applying EGC diagnostic AI in multiple centers due to high heterogeneity of negative cases. Optimizing AI by adding samples and using novel algorithms is promising to overcome this challenge. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - July 29, 2023 Category: Gastroenterology Source Type: research
Clinical trajectory of intraductal papillary mucinous neoplasms progressing to pancreatic carcinomas during long-term surveillance: a prospective series of 100 carcinoma cases
ConclusionsThe usefulness of currently available blood biomarkers was limited in early detection of pancreatic carcinomas related to IPMNs. Morphological alterations were well correlated with long-term risk of IPMN-derived carcinomas, but not with that of concomitant carcinomas. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - July 29, 2023 Category: Gastroenterology Source Type: research
Serum AKR1B10 as an indicator of unfavorable survival of hepatocellular carcinoma
ConclusionsSerum AKR1B10 is a new prognostic marker of HCC, better than AFP. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - July 27, 2023 Category: Gastroenterology Source Type: research
Correlation of mucosal healing endpoints with long-term clinical and patient-reported outcomes in ulcerative colitis
ConclusionsAchievement of HEMR or HEMI is clinically relevant with HEMR being associated with greater likelihood of improvement in long-term clinical and patient-reported outcomes.https://www.clinicaltrials.gov NCT02819635. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - July 25, 2023 Category: Gastroenterology Source Type: research
Partial splenic embolization combined with endoscopic therapies and vasoconstrictive drugs reduces rebleeding in cirrhosis patients with acute variceal bleeding and hypersplenism: a multicenter randomized controlled trial
ConclusionsThe rates of variceal re-bleeding and recurrence were significantly lower in cirrhosis patients with AVB and hypersplenism after combined endoscopic and PSE treatment compared to those who were provided endoscopic treatment only. The peripheral blood counts and liver function were also improved significantly in EP group (NCT02778425). (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - July 24, 2023 Category: Gastroenterology Source Type: research
Multicenter prospective registration study of efficacy and safety of capsule endoscopy in Crohn ’s disease in Japan (SPREAD-J study)
ConclusionSBCE is practical and safe in patients with CD. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - July 21, 2023 Category: Gastroenterology Source Type: research
A comprehensive analysis of tumor-stromal collagen in relation to pathological, molecular, and immune characteristics and patient survival in pancreatic ductal adenocarcinoma
ConclusionsTumor-stromal collagen deposition may play a crucial role in modulating tumor-immune microenvironment and determining response to adjuvant chemotherapy and patient survival outcomes. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - July 21, 2023 Category: Gastroenterology Source Type: research
Multicenter prospective registration study of efficacy and safety of capsule endoscopy in Crohn ’s disease in Japan (SPREAD-J study)
ConclusionSBCE is practical and safe in patients with CD. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - July 21, 2023 Category: Gastroenterology Source Type: research
A comprehensive analysis of tumor-stromal collagen in relation to pathological, molecular, and immune characteristics and patient survival in pancreatic ductal adenocarcinoma
ConclusionsTumor-stromal collagen deposition may play a crucial role in modulating tumor-immune microenvironment and determining response to adjuvant chemotherapy and patient survival outcomes. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - July 21, 2023 Category: Gastroenterology Source Type: research
Current status of molecular diagnostic approaches using liquid biopsy
AbstractPancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal cancers, and developing an efficient and reliable approach for its early-stage diagnosis is urgently needed. Precancerous lesions of PDAC, such as pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasms (IPMN), arise through multiple steps of driver gene alterations inKRAS,TP53,CDKN2A,SMAD4, orGNAS. Hallmark mutations play a role in tumor initiation and progression, and their detection in bodily fluids is crucial for diagnosis. Recently, liquid biopsy has gained attention as an approach to complement p...
Source: Journal of Gastroenterology - July 20, 2023 Category: Gastroenterology Source Type: research
MAFLD: an optimal framework for understanding liver cancer phenotypes
AbstractHepatocellular carcinoma has a substantial global mortality burden which is rising despite advancements in tackling the traditional viral risk factors. Metabolic (dysfunction) associated fatty liver disease (MAFLD) is the most prevalent liver disease, increasing in parallel with the epidemics of obesity, diabetes and systemic metabolic dysregulation. MAFLD is a major factor behind this sustained rise in HCC incidence, both as a single disease entity and often via synergistic interactions with other liver diseases. Mechanisms behind MAFLD-related HCC are complex but is crucially underpinned by systemic metabolic dys...
Source: Journal of Gastroenterology - July 20, 2023 Category: Gastroenterology Source Type: research
