Long-term outcomes after treatment for T1 colorectal carcinoma: a multicenter retrospective cohort study of Hiroshima GI Endoscopy Research Group
We examined T1 CRC patients treated during 1992 –2008 and who had ≥5 years of follow-up. Patients who did not meet the curative criteria after ER according to the Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines were defined as “non-endoscopically curable” and classified into three groups: ER alone (Group A: 121 pat ients), additional surgery after ER (Group B: 238 patients), and surgical resection alone (Group C: 342 patients). Long-term outcomes and predictors of recurrence were analyzed.ResultsOf the 882 patients with T1 CRC, 701 were non-endoscopically curable. Among thes...
Source: Journal of Gastroenterology - February 13, 2017 Category: Gastroenterology Source Type: research

Current status of achalasia management: a review on diagnosis and treatment
ConclusionsAchalasia should be considered when dysphagia is present, and not otherwise caused by an obstruction or inflammation, and when criteria is met as per the Chicago Classification ver 3.0. Lowering LES tone and disruption of LES can be accomplished by various methods, most notably pneumatic balloon dilatation and surgical myotomy. POEM has been gaining momentum as a first line therapy for achalasia symptoms, and can be considered an important tool for motility disorders of the esophagus. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - February 10, 2017 Category: Gastroenterology Source Type: research

Acknowledgments
(Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - February 10, 2017 Category: Gastroenterology Source Type: research

Natural history of chronic hepatitis B virus infection in children in Japan: a comparison of mother-to-child transmission with horizontal transmission
ConclusionsPatients with childhood-onset HBV infection with MTCT and horizontal transmission developed hepatitis and seroconverted to anti-HBe at any age and had a lifetime risk of developing HCC. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - February 9, 2017 Category: Gastroenterology Source Type: research

Age at onset is associated with the seasonal pattern of onset and exacerbation in inflammatory bowel disease
ConclusionsSeasonality of disease onset and exacerbation was observed especially in young-onset IBD patients. Underlying pathophysiologic triggers for disease initiation and exacerbation may be influenced by age at disease onset. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - February 6, 2017 Category: Gastroenterology Source Type: research

Epithelial barrier dysfunction in lymphocytic colitis through cytokine-dependent internalization of claudin-5 and -8
ConclusionsEpithelial barrier dysfunction in LC occurs through downregulation of claudin-4, -5, and -8, and redistribution of claudin-5 and -8 off the tight junction, which contributes to diarrhea by a leak-flux mechanism. The key effector cytokines TNF α and IFNγ turned out to be the trigger for redistribution of claudin-5 and -8. Thus, alongside sodium malabsorption, leak-flux is yet another important diarrheal mechanism in LC. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - January 30, 2017 Category: Gastroenterology Source Type: research

Treatment with sofosbuvir and ledipasvir without ribavirin for 12  weeks is highly effective for recurrent hepatitis C virus genotype 1b infection after living donor liver transplantation: a Japanese multicenter experience
ConclusionsSofosbuvir and ledipasvir treatment without ribavirin for 12  weeks was highly effective in achieving a sustained virological response in Japanese patients who developed recurrent HCV genotype 1b infection after living donor liver transplantation. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - January 30, 2017 Category: Gastroenterology Source Type: research

Nationwide epidemiological survey of early chronic pancreatitis in Japan
ConclusionsWe clarified the current status of early CP in Japan. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - January 27, 2017 Category: Gastroenterology Source Type: research

A novel prostanoid EP1 receptor antagonist, ONO-8539, reduces acid-induced heartburn symptoms in healthy male volunteers: a randomized clinical trial
AbstractBackgroundPatients with proton pump inhibitor (PPI)-refractory gastroesophageal reflux disease (GERD) have unmet clinical needs. Recently, we reported that esophageal prostaglandin E2 (PGE2) plays a crucial role in the generation of heartburn. In the present study, we focused on the PGE2 receptor, EP1, and investigated the effects of ONO-8539, a novel EP1 receptor antagonist, on heartburn symptoms in healthy male volunteers.MethodsThis prospective, double-blind, placebo-controlled, two-period crossover study was performed in 20 healthy male subjects. The novel prostanoid EP1 receptor antagonist, ONO-8539 (450  ...
Source: Journal of Gastroenterology - January 24, 2017 Category: Gastroenterology Source Type: research

Diagnostic accuracy of demarcation of undifferentiated-type early gastric cancer after Helicobacter pylori eradication
ConclusionsThis study suggests thatH. pylori eradication therapy aids the accurate delineation of UD-type EGC in ME-NBI. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - January 12, 2017 Category: Gastroenterology Source Type: research

Effects of estrogen on esophageal function through regulation of Ca 2+ -related proteins
ConclusionsThe regulation of E2 in the function of esophagus may be applied to treat esophageal diseases such as reflux esophagitis, achalasia, and esophageal cancer. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - January 11, 2017 Category: Gastroenterology Source Type: research

New resistance-associated substitutions and failure of dual oral therapy with daclatasvir and asunaprevir
We examined the characteristics of patients without these baseline RASs who did not achieve hepatitis C virus eradication with DCV and ASV combination therapy and identified new baseline NS5A RASs that are closely associated with failure of combination therapy.MethodsThree hundred thirty-five patients with hepatitis C virus genotype 1 infection with no NS5A L31, NS5A Y93, and NS3 D168 RASs before DCV and ASV combination therapy and no history of protease inhibitor therapy were enrolled. All RASs were evaluated by direct sequencing.ResultsSustained virologic response at 12  weeks (SVR12) was achieved in 297 patients (8...
Source: Journal of Gastroenterology - January 11, 2017 Category: Gastroenterology Source Type: research

Appropriate timing to start and optimal response evaluation of high-dose corticosteroid therapy for patients with acute liver failure
ConclusionsWe propose the appropriate timing to start high-dose corticosteroid therapy in patients with ALI/ALF; 40% of JHEPM probability, 1.53 of PT-INR, and 52% of PT because these values were theoretically discriminated at 98% coverage to the patients with coma. Because the study contained selection bias, the appropriate timing for therapy should be confirmed in a future prospective study. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - January 11, 2017 Category: Gastroenterology Source Type: research

Upregulated absorption of dietary palmitic acids with changes in intestinal transporters in non-alcoholic steatohepatitis (NASH)
AbstractBackgroundPalmitic acid is an important risk factor for the pathogenesis of non-alcoholic steatohepatitis (NASH), but changes in palmitic acid intestinal absorption in NASH are unclear. The aim of this study was to clarify changes in palmitic acid intestinal absorption and their association with the pathogenesis of NASH.MethodsA total of 106 participants were recruited to the study, of whom 33 were control subjects (control group), 32 were patients with NASH Brunt stage 1 –2 [early NASH (e-NASH)], and 41 were patients with NASH Brunt stage 3–4 [advanced NASH (a-NASH)].13C-labeled palmitate was administe...
Source: Journal of Gastroenterology - January 6, 2017 Category: Gastroenterology Source Type: research

Low-dose maintenance steroid treatment could reduce the relapse rate in patients with type 1 autoimmune pancreatitis: a long-term Japanese multicenter analysis of 510 patients
ConclusionsThe RR could continue to increase for 7  years even under MST. Based on our analysis of the side effects of steroid therapy, MST at 5 mg/day for 2 (total 4625 mg) to 3 (total 6425 mg) years might be a rational and safe therapeutic strategy in terms of keeping the RR to
Source: Journal of Gastroenterology - January 6, 2017 Category: Gastroenterology Source Type: research

Hepatic vagus nerve regulates Kupffer cell activation via α7 nicotinic acetylcholine receptor in nonalcoholic steatohepatitis
ConclusionsHepatic vagus activity regulates the inflammatory response of Kupffer cells via α7nAChR in NASH development. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - January 2, 2017 Category: Gastroenterology Source Type: research

Action and function of Wnt/ β-catenin signaling in the progression from chronic hepatitis C to hepatocellular carcinoma
AbstractHepatitis C virus (HCV) infection is one of the leading causes of hepatocellular carcinoma (HCC) worldwide but the mechanistic basis as to how chronic HCV infection furthers the HCC process remains only poorly understood. Accumulating evidence indicates that HCV core and nonstructural proteins provoke activation of the Wnt/ β-catenin signaling pathway, and the evidence supporting a role of Wnt/β-catenin signaling in the onset and progression of HCC is compelling. Convincing molecular explanations as to how expression of viral effectors translates into increased activity of the Wnt/β-catenin signaling...
Source: Journal of Gastroenterology - December 29, 2016 Category: Gastroenterology Source Type: research

What score should be used for evaluation of Crohn ’s disease severity using magnetic resonance imaging?
(Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - December 29, 2016 Category: Gastroenterology Source Type: research

Incidence and clinical outcomes of intestinal Beh çet’s disease in Korea, 2011–2014: a nationwide population-based study
AbstractBackgroundIntestinal Beh çet’s disease (BD) is very rare, and epidemiologic data regarding BD are scarce. Moreover, there have been no population-based studies focusing on intestinal BD. We conducted a nationwide population-based study to examine the incidence and clinical course of Korean patients with intestinal BD.MethodsWe collected data on 365 patients diagnosed with intestinal BD from 2011 to 2014 using the Health Insurance Review and Assessment Services claims database. We analyzed the incidence and clinical outcomes, including cumulative rates of bowel resection, hospitalization, and medication...
Source: Journal of Gastroenterology - December 27, 2016 Category: Gastroenterology Source Type: research

Diagnostic performance and factors influencing the accuracy of EUS-FNA of pancreatic neuroendocrine neoplasms
(Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - December 24, 2016 Category: Gastroenterology Source Type: research

Quantitative diagnosis of chronic pancreatitis using EUS elastography
AbstractBackgroundIt is difficult to diagnose chronic pancreatitis (CP) objectively because of a lack of standard diagnostic criteria. Endoscopic ultrasonography (EUS) has been used to assess the severity of CP, but the diagnosis of CP using EUS depends on an endosnonographer. The aim of this study was to establish an objective diagnostic method for CP using EUS elastography (EUS-EG).MethodsA retrospective study was designed and 96 patients underwent EUS-EG for follow-up of known CP, or who were clinically suspected as having CP. CP patients were categorized CP patients as 4 stages using the Rosemont classification (RC). E...
Source: Journal of Gastroenterology - December 19, 2016 Category: Gastroenterology Source Type: research

Evidence-based clinical practice guidelines for cholelithiasis 2016
This article preferentially describes the clinical management of cholelithiasis and its complications. Following description of the diagnosis performed stepwise through imaging modalities, t reatments of cholecystolithiasis, choledocholithiasis, and hepatolithiasis are introduced along with a flowchart. Since there have been remarkable improvements in endoscopic treatments and surgical techniques, the guidelines ensure flexibility in choices according to the actual clinical environment. The revised clinical practice guidelines are appropriate for use by clinicians in their daily practice. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - December 10, 2016 Category: Gastroenterology Source Type: research

The 2016 diagnostic criteria for primary sclerosing cholangitis
ConclusionThe diagnostic criteria for PSC are useful for general physicians in practice. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - December 5, 2016 Category: Gastroenterology Source Type: research

NS5A resistance-associated variants undermine the effectiveness of ledipasvir and sofosbuvir for cirrhotic patients infected with HCV genotype 1b
ConclusionsLDV/SOF for HCV genotype 1b was exceptionally effective, however, NS5A RAVs undermined the virological effect for cirrhosis patients. Moreover, LDV/SOF was shown to be safe, irrespective of age or fibrosis status. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - December 2, 2016 Category: Gastroenterology Source Type: research

A critical overview on the biological and molecular features of red and processed meat in colorectal carcinogenesis
AbstractA recent investigation by the World Health Organisation (WHO) has found that the consumption of processed meat and potentially red meat promotes carcinogenesis and can increase the risk of colorectal cancer. This literature review aims to summarise both the red and processed meat molecules associated with colorectal carcinogenesis and investigate their relationship with the pathogenic process of colorectal cancer. Literature relating to the carcinogenic effect of red and processed meat molecules was critically reviewed. There are multiple molecules present in red and processed meat with a potential carcinogenic eff...
Source: Journal of Gastroenterology - December 2, 2016 Category: Gastroenterology Source Type: research

Indigo Naturalis ameliorates murine dextran sodium sulfate-induced colitis via aryl hydrocarbon receptor activation
ConclusionsIN and indigo ameliorated murine colitis through AhR signaling activation, suggesting that AhR could be a promising therapeutic target for UC. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 29, 2016 Category: Gastroenterology Source Type: research

Ipragliflozin, a sodium –glucose cotransporter 2 inhibitor, ameliorates the development of liver fibrosis in diabetic Otsuka Long–Evans Tokushima fatty rats
ConclusionIn conclusion, our dataset suggests that an SGLT2 inhibitor could alleviate the development of liver fibrosis by improving IR in naturally diabetic rats. This may provide the basis for creating new therapeutic strategies for chronic liver injuries with IR. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 25, 2016 Category: Gastroenterology Source Type: research

Intestinal stem cell transplantation
Abstract Organoid technologies to expand intestinal epithelial cells are gaining increasing attention as a useful tool to investigate many aspects of intestinal epithelial biology and pathology. One important application of organoid systems would be to use intestinal epithelial cells expanded in culture for following transplantation experiments. In this article, we present a brief overview of the studies that have succeeded in generating new epithelial tissues in the surface of native intestines in mice by organoid transplantation. We also discuss possible applications of this experimental approach in basic research on t...
Source: Journal of Gastroenterology - November 25, 2016 Category: Gastroenterology Source Type: research

Erratum to: Effectiveness of adalimumab for the treatment of ulcerative colitis in clinical practice: comparison between anti-tumour necrosis factor-na ïve and non-naïve patients
(Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 24, 2016 Category: Gastroenterology Source Type: research

Oral branched-chain amino acid granules improve structure and function of human serum albumin in cirrhotic patients
ConclusionThis study describes structural alterations and functional disturbances of HSA in patients with chronic liver disease, and indicates that the levels of reduced HSA might reflect disease progression and the functional properties of HSA. Moreover, oral BCAA supplementation increases the amount of reduced HSA, thereby leading to the restoration of HSA function in cirrhotic patients. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 21, 2016 Category: Gastroenterology Source Type: research

The combination of elbasvir and grazoprevir for the treatment of chronic HCV infection in Japanese patients: a randomized phase II/III study
ConclusionTreatment with EBR in combination with GZR for 12  weeks is effective and well tolerated in Japanese patients with chronic HCV infection.ClinicalTrials.gov identifierNCT02203149. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 21, 2016 Category: Gastroenterology Source Type: research

Fatty acids in a high-fat diet potentially induce gastric parietal-cell damage and metaplasia in mice
ConclusionsDietary lipids induce parietal-cell damage and may lead to the development of precancerous metaplasia. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 21, 2016 Category: Gastroenterology Source Type: research

Sequential therapy consisting of glucocorticoid infusions followed by granulocyte –monocyte absorptive apheresis in patients with severe alcoholic hepatitis
ConclusionsSequential therapy combining glucocorticoid infusion and GMA was useful for attenuating liver injuries in patients with severe alcoholic hepatitis by preventing rebound increases in inflammatory reactions after discontinuation of glucocorticoid infusions, except in patients with bacterial infections and/or multiple organ failure. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 17, 2016 Category: Gastroenterology Source Type: research

Different effects of dietary factors on reflux esophagitis and non-erosive reflux disease in 11,690 Korean subjects
ConclusionsWhile many food groups affected NERD, reflux esophagitis was associated with BMI and total energy intake rather than dietary component. These results may suggest different approaches toward dietary management of NERD and reflux esophagitis. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 15, 2016 Category: Gastroenterology Source Type: research

Magnetic resonance evaluation for small bowel strictures in Crohn ’s disease: comparison with balloon enteroscopy
AbstractBackgroundMagnetic resonance (MR) imaging is the recommended technique for detection of small bowel lesions in Crohn ’s disease. We aimed to evaluate the impact of stricture findings obtained by MR imaging on patient outcomes using balloon-assisted enteroscopy (BAE) as a reference.MethodsTwo hundred Crohn ’s disease patients undergoing both MR enterocolonography and BAE were prospectively followed up for at least 1 year. The presence of strictures detected by MR enterocolonography was compared with endoscopic findings. Moreover, the relationship between MR findings and surgery was evaluated.Results...
Source: Journal of Gastroenterology - November 15, 2016 Category: Gastroenterology Source Type: research

Emerging biologics in inflammatory bowel disease
AbstractEarly biologic therapy is recommended in patients with inflammatory bowel disease and poor prognostic factors and in those refractory to conventional medications. Anti-tumor necrosis factor (anti-TNF) agents are the most commonly used biologic agents. However, some patients may not have an initial response to anti-TNF therapy, and one-third will develop loss of response over time. Anti-TNF drugs can also be associated with side effects. In addition, the use of biologics is currently limited by their cost, especially in developing countries. A number of new therapeutic targets, including novel small molecules, and c...
Source: Journal of Gastroenterology - November 10, 2016 Category: Gastroenterology Source Type: research

Risk factors of nonadherence to colonoscopy surveillance after polypectomy and its impact on clinical outcomes: a KASID multicenter study
ConclusionsWomen, having undergone the procedure in small-to-medium-sized cities and the presence of an HRA at the index colonoscopy were found to be independent risk factors for late surveillance colonoscopy. Late surveillance is significantly predictive of subsequent HRA or CRC. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 9, 2016 Category: Gastroenterology Source Type: research

ITPA polymorphism effects on decrease of hemoglobin during sofosbuvir and ribavirin combination treatment for chronic hepatitis C
AbstractBackgroundPolymorphisms in the inosine triphosphatase (ITPA) gene is associated with anemia induced by peg-interferon (PEG-IFN) plus ribavirin (RBV) treatment for patients with chronic hepatitis C virus (HCV) infection. However, the effect ofITPA polymorphism on sofosbuvir plus RBV treatment is unknown.MethodsTwo hundred and forty-four patients with chronic HCV genotype 2 infection without decompensated liver cirrhosis were treated with sofosbuvir plus RBV for 12  weeks. The effects ofITPA polymorphism on hemoglobin levels and RBV dose reduction and treatment response were analyzed.ITPA (rs1127354) was genotyp...
Source: Journal of Gastroenterology - November 7, 2016 Category: Gastroenterology Source Type: research

Strain elastography for assessment of liver fibrosis and prognosis in patients with chronic liver diseases
ConclusionsSE could estimate advanced liver fibrosis without influence of liver inflammation unlike other serological liver fibrosis markers. SE might be a prognostic factor in chronic liver diseases and HCC. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - October 27, 2016 Category: Gastroenterology Source Type: research

Procalcitonin is a useful biomarker to predict severe acute cholangitis: a single-center prospective study
ConclusionsProcalcitonin predicted severe acute cholangitis better than conventional biomarkers. Severe cases for which urgent biliary drainage is indicated might be identified on admission on the basis of the cutoff values for procalcitonin suggested in this study. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - October 25, 2016 Category: Gastroenterology Source Type: research

Risk of metastasis in adenocarcinoma of the esophagus: a multicenter retrospective study in a Japanese population
AbstractBackgroundLittle is known about the specific risks of metastasis in esophageal adenocarcinoma in relation to invasion depth or other pathologic factors.MethodsWe conducted a multicenter retrospective study in 13 high-volume centers in Japan from January 2000 to October 2014 to elucidate the risk of metastasis of esophageal adenocarcinoma. A total of 458 patients (217 surgically resected and 241 endoscopically resected) with esophageal adenocarcinoma or esophagogastric adenocarcinoma involving the esophagus were included. Metastasis was considered positive if there was histologically confirmed metastasis in the surg...
Source: Journal of Gastroenterology - October 18, 2016 Category: Gastroenterology Source Type: research

Factors influencing the accuracy of EUS FNA: do educational elements matter?
(Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - October 17, 2016 Category: Gastroenterology Source Type: research

Molecular pathological epidemiology: new developing frontiers of big data science to study etiologies and pathogenesis
AbstractMolecular pathological epidemiology (MPE) is an integrative field that utilizes molecular pathology to incorporate interpersonal heterogeneity of a disease process into epidemiology. In each individual, the development and progression of a disease are determined by a unique combination of exogenous and endogenous factors, resulting in different molecular and pathological subtypes of the disease. Based on “the unique disease principle,” the primary aim of MPE is to uncover an interactive relationship between a specific environmental exposure and disease subtypes in determining disease incidence and morta...
Source: Journal of Gastroenterology - October 13, 2016 Category: Gastroenterology Source Type: research

Efficacy and safety of single fecal microbiota transplantation for Japanese patients with mild to moderately active ulcerative colitis
AbstractBackgroundThe clinical utility of fecal microbiota transplantation (FMT) in patients with ulcerative colitis (UC) is still controversial. We investigated the efficacy and safety of single FMT for patients with mild to moderately active UC in a Japanese population.MethodsFifty-seven patients were evaluated for eligibility, and 16 patients were excluded. Forty-one patients with UC refractory to standard medical therapy were treated with single FMT by colonoscopic administration. Changes in the fecal microbiota were assessed by 16S ribosomal DNA based terminal restriction fragment length polymorphism analysis.ResultsA...
Source: Journal of Gastroenterology - October 11, 2016 Category: Gastroenterology Source Type: research

Effectiveness of adalimumab for the treatment of ulcerative colitis in clinical practice: comparison between anti-tumour necrosis factor-na ïve and non-naïve patients
ConclusionsIn clinical practice, ADA was effective in UC, especially in anti-TNF na ïve patients. FC and CRP could be predictors of treatment effectiveness. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - October 8, 2016 Category: Gastroenterology Source Type: research

Autoimmune hepatitis in Japan: trends in a nationwide survey
ConclusionsIn the present nationwide survey of AIH patients in Japan, patients with acute hepatitis had clinical features different from those of patients with chronic hepatitis. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - October 8, 2016 Category: Gastroenterology Source Type: research

Genetic basis of hepatitis virus-associated hepatocellular carcinoma: linkage between infection, inflammation, and tumorigenesis
AbstractHepatitis virus infection is a leading cause of chronic liver disease, including cirrhosis and hepatocellular carcinoma (HCC). Although anti-viral therapies against hepatitis B virus (HBV) and hepatitis C virus (HCV) have dramatically progressed during the past decade, the estimated number of people chronically infected with HBV and/or HCV is ~370 million, and hepatitis virus-associated hepatocarcinogenesis is a serious health concern worldwide. Understanding the mechanism of virus-associated carcinogenesis is crucial toward both treatment and prevention, and the recently developed whole genome/exome sequencing ana...
Source: Journal of Gastroenterology - October 6, 2016 Category: Gastroenterology Source Type: research

Analysis of molecular alterations in laterally spreading tumors of the colorectum
ConclusionCombined genetic and epigenetic data suggested that the molecular mechanisms of tumorigenesis were different between LST-Gs and LST-NGs. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - October 4, 2016 Category: Gastroenterology Source Type: research

Biliary carcinogenesis in pancreaticobiliary maljunction
AbstractPancreaticobiliary maljunction (PBM) is a congenital malformation in which the pancreatic and bile ducts join anatomically outside the duodenal wall. Because of the excessive length of the common channel in PBM, sphincter action does not directly affect the pancreaticobiliary junction, which allows pancreatic juice to reflux into the biliary tract. According to the results of a nationwide survey, bile duct and gallbladder cancers were found in 6.9 and 13.4  % of adult patients with congenital biliary dilatation, respectively, and in 3.1 and 37.4 % of those with PBM without biliary dilatation, respectively...
Source: Journal of Gastroenterology - October 4, 2016 Category: Gastroenterology Source Type: research

Phase 2 study of lenvatinib in patients with advanced hepatocellular carcinoma
AbstractBackgroundLenvatinib is an oral inhibitor of vascular endothelial growth factor receptor 1 –3, fibroblast growth factor receptor 1–4, platelet-derived growth factor receptor alpha, RET, and KIT. This phase 2, single-arm, open-label multicenter study evaluated lenvatinib in advanced hepatocellular carcinoma (HCC).MethodsPatients with histologically/clinically confirmed advanced HCC who did not qualify for surgical resection or local therapies received lenvatinib at a dosage of 12 mg once daily (QD) in 28-day cycles. The primary efficacy endpoint was time to progression (TTP) per modified Response Evaluat...
Source: Journal of Gastroenterology - October 4, 2016 Category: Gastroenterology Source Type: research