Changing Nomenclature for PBC from “Primary Biliary Cirrhosis” to “Primary Biliary Cholangitis”
(Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - May 26, 2016 Category: Gastroenterology Source Type: research

Involvement of herbal medicine as a cause of mesenteric phlebosclerosis: results from a large-scale nationwide survey
Conclusions The use of herbal medicine containing sanshishi is associated with the etiology of MP. Although it may not be the causative factor, it is necessary for gastroenterologists to be aware of the potential risk of herbal medicine containing sanshishi for the development of MP. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - May 24, 2016 Category: Gastroenterology Source Type: research

Increased IL-17A/IL-17F expression ratio represents the key mucosal T helper/regulatory cell-related gene signature paralleling disease activity in ulcerative colitis
Abstract Background T helper (Th) and regulatory T (Treg) cell-related cytokines are implicated in inflammatory bowel diseases, including ulcerative colitis (UC). While these cytokines are generally upregulated in inflamed mucosae, the key cytokine profile explaining disease severity has not been determined. Methods The Rachmilewitz endoscopic index (REI) was assessed in 61 UC patients undergoing colonoscopy. Biopsies obtained from inflamed (REI 3–12) and noninflamed (REI 0–2) areas were analyzed by quantitative PCR for expression of mRNAs en...
Source: Journal of Gastroenterology - May 13, 2016 Category: Gastroenterology Source Type: research

Efficacy of double-coated probiotics for irritable bowel syndrome: a randomized double-blind controlled trial
Conclusions Our result implies that dual-coating layers of probiotic supplement can be a candidate for treatment of diarrhea-predominant irritable bowel syndrome. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - May 13, 2016 Category: Gastroenterology Source Type: research

Clinical benefits of neoadjuvant chemoradiotherapy for adenocarcinoma of the pancreatic head: an observational study using inverse probability of treatment weighting
Conclusions These findings suggest that NACRT improves R0 rates and increases the survival of patients with BR-PV adenocarcinoma of the pancreatic head but not that of patients with R-PDAC. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - May 11, 2016 Category: Gastroenterology Source Type: research

Aberrant BLM cytoplasmic expression associates with DNA damage stress and hypersensitivity to DNA-damaging agents in colorectal cancer
Conclusions Taken together, the findings of this study provide the first evidence that cancer-linked DNA hypomethylation and cytosolic BLM mislocalization might reflect compromised levels of DNA-repair activity and enhanced hypersensitivity to DNA-damaging agents in CRC patients. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - May 11, 2016 Category: Gastroenterology Source Type: research

Indole compounds may be promising medicines for ulcerative colitis
Abstract Indole compounds are extracted from indigo plants and have been used as blue or purple dyes for hundreds of years. In traditional Chinese medicine, herbal agents in combination with Qing-Dai (also known as indigo naturalis) have been used to treat patients with ulcerative colitis (UC) and to remedy inflammatory conditions. Recent studies have noted that indole compounds can be biosynthesized from tryptophan metabolites produced by various enzymes derived from intestinal microbiota. In addition to their action on indole compounds, the intestinal microbiota produce various tryptophan metabolites that mediat...
Source: Journal of Gastroenterology - May 9, 2016 Category: Gastroenterology Source Type: research

Factors associated with poor therapeutic response in outpatients with irritable bowel syndrome: a multicenter study in Japan
Abstract Background Some patients with irritable bowel syndrome (IBS) show poor response to treatment. However, risk factors associated with poor therapeutic response have not been determined. Methods This multicenter trial evaluated consecutive outpatients with IBS undergoing treatment for more than 1 month. Mental health status and physical function were evaluated using the Japanese version of the SF-8. Therapeutic response was evaluated using the IBS severity index-Japanese version (IBS-SIJ). Patients with IBS-SIJ scores ≥175 were defined as p...
Source: Journal of Gastroenterology - April 29, 2016 Category: Gastroenterology Source Type: research

New endoscopic classification of cascade stomach, a risk factor for reflux esophagitis
Conclusions This endoscopic classification of cascade stomach showed acceptable inter-observer variation. Cascade stomach is a risk factor for reflux esophagitis. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 27, 2016 Category: Gastroenterology Source Type: research

Stem cell dynamics and pretumor progression in the intestinal tract
Abstract Colorectal carcinogenesis is a process that follows a stepwise cascade that goes from the normal to an invisible pretumor stage ultimately leading to grossly visible tumor progression. During pretumor progression, an increasing accumulation of genetic alterations occurs, by definition without visible manifestations. It is generally thought that stem cells in the crypt base are responsible for this initiation of colorectal cancer progression because they are the origin of the differentiated epithelial cells that occupy the crypt. Furthermore, they are characterized by a long life span that enables them to ...
Source: Journal of Gastroenterology - April 23, 2016 Category: Gastroenterology Source Type: research

Similarities and differences among eosinophilic esophagitis, proton-pump inhibitor-responsive esophageal eosinophilia, and reflux esophagitis: comparisons of clinical, endoscopic, and histopathological findings in Japanese patients
Abstract Background Esophageal eosinophilia is classified as either eosinophilic esophagitis (EoE) or proton-pump inhibitor-responsive esophageal eosinophilia (PPI-REE), depending on the response to PPI treatment. The aim of this study was to compare the clinical, endoscopic, and histopathological findings of EoE and PPI-REE in Japanese patients. In addition, the characteristics of these cases were compared with those of reflux esophagitis (RE) cases. Methods Eleven patients diagnosed with EoE, 16 with PPI-REE, and 39 with RE, who were all consecutively ...
Source: Journal of Gastroenterology - April 23, 2016 Category: Gastroenterology Source Type: research

Safety and efficacy of sorafenib in Japanese patients with hepatocellular carcinoma in clinical practice: a subgroup analysis of GIDEON
Conclusions Sorafenib was well tolerated by Japanese HCC patients in clinical settings. Patients with Child-Pugh B had shorter duration of treatment and higher incidence of SAEs. It is important to carefully evaluate patients’ conditions and assess the benefit and risk before making a decision to treat patients with sorafenib. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 22, 2016 Category: Gastroenterology Source Type: research

Is radical surgery necessary in all patients who do not meet the curative criteria for endoscopic submucosal dissection in early gastric cancer? A multi-center retrospective study in Japan
Abstract Background Although radical surgery is routinely performed for patients who do not meet the curative criteria for endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) due to the risk of lymph node metastasis (LNM), this standard therapeutic option may be excessive given the lower number of patients with LNM. Therefore, we aimed to investigate long-term outcomes and validate risk factors predicting recurrence after ESD. Methods Of 15,785 patients who underwent ESD for EGC at 19 institutions between 2000 and 2011, 1969 patients no...
Source: Journal of Gastroenterology - April 20, 2016 Category: Gastroenterology Source Type: research

Is a fecal occult blood test a useful tool for judging whether to perform capsule endoscopy in low-dose aspirin users with negative colonoscopy and esophagogastroduodenoscopy?
Conclusions Small bowel evaluation using CE is not recommended for FIT-negative, low-dose aspirin users. However, small bowel evaluation using CE should be considered in both FIT-positive and anemic low-dose aspirin users. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 19, 2016 Category: Gastroenterology Source Type: research

A prospective, multicenter survey on the validity of shorter periendoscopic cessation of antithrombotic agents in Japan
Conclusions With the new criteria in place for cessation of antithrombotic agents focused on prevention of periprocedural thrombosis, endoscopic procedures may be safely performed without substantially increasing bleeding in clinical practice in Japan. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 16, 2016 Category: Gastroenterology Source Type: research

Factors associated with exacerbation of newly diagnosed mild ulcerative colitis based on a nationwide registry in Japan
Conclusion Using data from the Japanese nationwide registry, we identified several factors, including body mass index and pathological findings, associated with disease exacerbation among patients with newly diagnosed mild UC. Our findings may lead to earlier recognition of exacerbation in patients with mild UC, thus enabling optimal care. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 13, 2016 Category: Gastroenterology Source Type: research

Psychological stress exacerbates NSAID-induced small bowel injury by inducing changes in intestinal microbiota and permeability via glucocorticoid receptor signaling
Conclusions This study demonstrated a relationship between NSAID enteropathy and psychological stress, and showed the utility of studying the intestinal microbiota in order to elucidate the pathophysiology of NSAID enteropathy. It also showed the impact of stress on the intestinal microbiota and the mucosal barrier in gastrointestinal diseases. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 13, 2016 Category: Gastroenterology Source Type: research

Lipopolysaccharide induces visceral hypersensitivity: role of interleukin-1, interleukin-6, and peripheral corticotropin-releasing factor in rats
Conclusions LPS induced visceral allodynia possibly through stimulating IL-1 and IL-6 release. In addition, this effect was mediated through peripheral CRF signaling. Since the LPS–cytokine system is thought to contribute to altered visceral sensation in the patients with irritable bowel syndrome, these results may further suggest that CRF plays a crucial role in the pathophysiology of this disease. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 13, 2016 Category: Gastroenterology Source Type: research

A population-based study examining the risk of malignancy in patients diagnosed with inflammatory bowel disease
Conclusions There was no increased risk of cancer overall in individuals with IBD compared to IBD-free individuals. Consistent with previous findings, a reduction in cancer risk was observed in IBD patients using aminosalicylates, with a substantial reduction in prostate cancer risk. Further large-scale studies examining the relationship between IBD therapy and cancer risk appear to be warranted. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 7, 2016 Category: Gastroenterology Source Type: research

Gastrointestinal mucosal barrier function and diseases
Abstract The gastrointestinal mucosal barrier plays an essential role in the separation of the inside of the body from the outside environment. Tight junctions (TJs) are the most important component for construction of a constitutive barrier of epithelial cells, and they regulate the permeability of the barrier by tightly sealing the cell–cell junctions. TJ proteins are represented by claudins, occludin, junctional adhesion molecules, and scaffold protein zonula occludens. Among these TJ proteins, claudins are the major components of TJs and are responsible for the barrier and the polarity of the epithelial ...
Source: Journal of Gastroenterology - April 5, 2016 Category: Gastroenterology Source Type: research

Periostin promotes hepatic fibrosis in mice by modulating hepatic stellate cell activation via α v integrin interaction
Conclusion Periostin exerts potent profibrotic activity mediated by αv integrin, suggesting the periostin–αv integrin axis as a novel therapeutic target for hepatic fibrosis. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 4, 2016 Category: Gastroenterology Source Type: research

SCHLAFEN 5 expression correlates with intestinal metaplasia that progresses to gastric cancer
Conclusion In this study population, elevated SLFN5 protein expression in patients with IM correlated with progression to GC. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 31, 2016 Category: Gastroenterology Source Type: research

Evaluation of the risk factors associated with rectal neuroendocrine tumors: a big data analytic study from a health screening center
Conclusion The findings of our study demonstrate the benefits of using big data analytics for research and clinical risk factor studies. Specifically, in this study, this analytical method was applied to identify higher levels of serum cholesterol and ferritin, metabolic syndrome, and family history of cancer as factors that may explain the increasing incidence and prevalence of rectal NET. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 30, 2016 Category: Gastroenterology Source Type: research

Ipragliflozin, a sodium–glucose cotransporter 2 inhibitor, ameliorates the development of liver fibrosis in diabetic Otsuka Long–Evans Tokushima fatty rats
Conclusion In conclusion, our dataset suggests that an SGLT2 inhibitor could alleviate the development of liver fibrosis by improving IR in naturally diabetic rats. This may provide the basis for creating new therapeutic strategies for chronic liver injuries with IR. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 29, 2016 Category: Gastroenterology Source Type: research

Sensitivity of 2-[ 18 F]fluoro-2-deoxyglucose positron emission tomography for advanced colorectal neoplasms: a large-scale analysis of 7505 asymptomatic screening individuals
Conclusions FDG-PET is believed to be difficult to use as a primary screening tool in population-based colorectal cancer screening because of its low sensitivity for advanced neoplasms. Even when it is used in opportunistic cancer screening, the limit of its sensitivity should be considered. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 28, 2016 Category: Gastroenterology Source Type: research

Inhibition of MMP activity can restore NKG2D ligand expression in gastric cancer, leading to improved NK cell susceptibility
Conclusion The present study is a comprehensive study demonstrating that upregulation of MMP activity can induce a downregulation of expression of NKG2D ligands in gastric cancer cells, leading to lower-level susceptibility to NK cells. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 22, 2016 Category: Gastroenterology Source Type: research

Gut microbiome diversity in acute infective and chronic inflammatory gastrointestinal diseases in North India
Abstract The disease profile in the Indian population provides a unique opportunity for studying the host microbiome interaction in both infectious (amebiasis) and autoimmune diseases like inflammatory bowel disease (IBD) from a similar environment and genetic background. Analysis of fecal samples from untreated amebic liver abscess (ALA) patients, Entamoeba histolytica (Eh)-negative and -positive asymptomatic individuals, and pus samples from naive ALA patients revealed a significant reduction in Lactobacillus in asymptomatic individuals (Eh +ve) and ALA patients. Two anaerobic genera, namely Bacteroides and...
Source: Journal of Gastroenterology - March 19, 2016 Category: Gastroenterology Source Type: research

Pancreatic cysts in general population on ultrasonography: Prevalence and development of risk score
Conclusions The prevalence of pancreatic cyst detected by US was 3.5 % in the general population, and increased with age, female sex, and the presence of GB-ADM. A new scoring system developed in the present study may help to identify better candidates for further examination when the pancreas is not visible by US. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 17, 2016 Category: Gastroenterology Source Type: research

Carcinoma of the colon and rectum with deregulation of insulin-like growth factor 2 signaling: clinical and molecular implications
Conclusions LOI of IGF2 is a frequent and early event in CRC that occurs both in the adenomatous polyposis coli (APC) gene-mutated and serrated route of carcinogenesis. LOI leads to overexpression of IGF2, activates IGF1R and AKT1, and is a powerful driver of cell proliferation. Moreover, our results suggest that IGF2 via AKT1 also contributes to non-canonical wnt signaling. Although LOI had no significant impact on major clinical parameters and outcome, its potential as a target for preventive and therapeutic interventions merits further investigation. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 17, 2016 Category: Gastroenterology Source Type: research

Serotonin disrupts esophageal mucosal integrity: an investigation using a stratified squamous epithelial model
Conclusions Serotonin disrupted esophageal squamous epithelial barrier function by modulating the levels of TJ proteins. Serotonin signaling pathways may mediate the pathogenesis of gastroesophageal reflux disease. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 16, 2016 Category: Gastroenterology Source Type: research

Utility of surrogate markers for the prediction of relapses in inflammatory bowel diseases
Abstract Patients with diagnosed inflammatory bowel disease (IBD) will commonly experience a clinical relapse in spite of a prolonged therapy-induced period of clinical remission. The current methods of assessing subclinical levels of low-grade inflammation which predispose patients to relapse are not optimal when considering both cost and patient comfort. Over the past few decades, much investigation has discovered that proteins such as calprotectin that are released from inflammatory cells are capable of indicating disease activity. Along with C-reactive protein and erythrocyte sedimentation rate, calprotectin h...
Source: Journal of Gastroenterology - March 14, 2016 Category: Gastroenterology Source Type: research

Low alcohol consumption increases the risk of impaired glucose tolerance in patients with non-alcoholic fatty liver disease
Conclusions A small amount of alcohol consumption is a significant risk factor for the onset of IFG in NAFLD patients; onset risk differs according to the amount of alcohol consumption. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 12, 2016 Category: Gastroenterology Source Type: research

Erratum to: Predictive value of serum HER2 ECD in patients with HER2-positive advanced gastric cancer treated with trastuzumab plus chemotherapy
(Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 8, 2016 Category: Gastroenterology Source Type: research

Erratum to: Safety and efficacy of dual direct-acting antiviral therapy (daclatasvir and asunaprevir) for chronic hepatitis C virus genotype 1 infection in patients on hemodialysis
(Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 7, 2016 Category: Gastroenterology Source Type: research

Clinical characteristics and molecular analysis of hepatitis B virus reactivation in hepatitis B surface antigen-negative patients during or after immunosuppressive or cytotoxic chemotherapy
Conclusions Reactivation risk factors included male sex, advanced age, and hematological malignancy. HBV S gene immune-escape mutants were frequently found in the HBsAg-negative reactivation patients during or after immunosuppressive or cytotoxic chemotherapy. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 4, 2016 Category: Gastroenterology Source Type: research

Antiviral effects of anti-HBs immunoglobulin and vaccine on HBs antigen seroclearance for chronic hepatitis B infection
Conclusion These results suggest that monthly HBIG injection might benefit patients with chronic hepatitis B whose HBsAg titer becomes lower following long-term nucleotide/nucleoside analogue treatment. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 4, 2016 Category: Gastroenterology Source Type: research

Hepatic sinusoids in liver injury, inflammation, and fibrosis: new pathophysiological insights
This article builds upon a seminar given at the recent 3rd JSGE International Topic Conference in Sendai, Japan, and reviews the areas outlined above. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 3, 2016 Category: Gastroenterology Source Type: research

Safety and effectiveness of sorafenib in Japanese patients with hepatocellular carcinoma in daily medical practice: interim analysis of a prospective postmarketing all-patient surveillance study
Conclusions In general, the safety and effectiveness findings in this PMS were consistent with findings from previous clinical studies. Sorafenib was well tolerated and clinically useful for Japanese patients. Clinical trial registration number: NCT01411436 (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 1, 2016 Category: Gastroenterology Source Type: research

Identification of a serum transglutaminase threshold value for the noninvasive diagnosis of symptomatic adult celiac disease patients: a retrospective study
Abstract Background A celiac disease (CD) diagnosis is based on duodenal histology, with the exception of children showing anti-tissue transglutaminase (anti-tTG) serum levels exceeding ten times the cut-off. Our aim was to reproduce this simplified approach in adults, identifying an anti-tTG threshold value useful to diagnose CD without endoscopic procedures. Methods A total of 671 adult CD patients were subjected to blood sampling to determine anti-tTG serum levels, as well as to endoscopy with biopsy to perform duodenal histology. The anti-tTG serum l...
Source: Journal of Gastroenterology - February 29, 2016 Category: Gastroenterology Source Type: research

Fecal calprotectin: its scope and utility in the management of inflammatory bowel disease
Abstract Gastrointestinal symptoms such as abdominal pain, dyspepsia, and diarrhea are relatively nonspecific and a common cause for seeking medical attention. To date, it is challenging for physicians to differentiate between functional and organic gastrointestinal conditions and it involves the use of serological and endoscopic techniques. Therefore, a simple, noninvasive, inexpensive, and effective test would be of utmost importance in clinical practice. Fecal calprotectin (FC) is considered to be a reliable biomarker that fulfills these criteria. FC can detect intestinal inflammation, and its level correlates ...
Source: Journal of Gastroenterology - February 20, 2016 Category: Gastroenterology Source Type: research

No weekend effect on outcomes of severe acute pancreatitis in Japan: data from the diagnosis procedure combination database
Conclusions A weekend effect in severe acute pancreatitis admissions was not evident. Adjustments to weekend staffing and selective hospital referral of patients admitted at weekends are not indicated for severe acute pancreatitis in current clinical practice in Japan. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - February 20, 2016 Category: Gastroenterology Source Type: research

Reply to the letter by Takeshi Yamada et al. concerning “Is serum HER2 ECD a predictive biomarker for response to trastuzumab in advanced gastric cancer?”
(Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - February 20, 2016 Category: Gastroenterology Source Type: research

Host–virus interactions in hepatitis B and hepatitis C infection
Abstract Hepatitis B virus (HBV) and hepatitis C virus (HCV) are among the most endemic pathogens worldwide, with more than 500 million people globally currently infected with these viruses. These pathogens can cause acute and chronic hepatitis that progress to liver cirrhosis or hepatocellular carcinoma. Both viruses utilize multifaceted strategies to evade the host surveillance system and fall below the immunological radar. HBV has developed specific strategies to evade recognition by the innate immune system and is acknowledged to be a stealth virus. However, extensive research has revealed that HBV is recogniz...
Source: Journal of Gastroenterology - February 19, 2016 Category: Gastroenterology Source Type: research

Is serum HER2 ECD a predictive biomarker for response to trastuzumab in advanced gastric cancer?
(Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - February 18, 2016 Category: Gastroenterology Source Type: research

Direct evidence for activated CD8+ T cell transmigration across portal vein endothelial cells in liver graft rejection
Conclusions We show for the first time direct evidence of T-cell transmigration across PV endothelial cells during hepatic allograft rejection. Interactions between VCAM-1 on endothelia and α4β1 integrin on recipient effector T-cells putatively play critical roles in adhesion and transmigration through endothelia. A chemokine axis of CXCL10 and CXCR3 also may be involved. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - February 18, 2016 Category: Gastroenterology Source Type: research

Risk stratification and predictive risk-scoring model for lymph node metastasis in early gastric cancer
Conclusions The present study revealed detailed LNM risk stratification data, and developed and validated an 11-point scoring model. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - February 16, 2016 Category: Gastroenterology Source Type: research

PKD signaling and pancreatitis
Conclusions These novel findings suggest that PKD signaling is a necessary modulator in key initiating pathobiologic processes of pancreatitis, and that it constitutes a novel therapeutic target for treatments of this disorder. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - February 15, 2016 Category: Gastroenterology Source Type: research

Evidence-based clinical practice guidelines for peptic ulcer disease 2015
Abstract The Japanese Society of Gastroenterology (JSGE) revised the evidence-based clinical practice guidelines for peptic ulcer disease in 2014 and has created an English version. The revised guidelines consist of seven items: bleeding gastric and duodenal ulcers, Helicobacter pylori (H. pylori) eradication therapy, non-eradication therapy, drug-induced ulcer, non-H. pylori, non-nonsteroidal anti-inflammatory drug (NSAID) ulcer, surgical treatment, and conservative therapy for perforation and stenosis. Ninety clinical questions (CQs) were developed, and a literature search was performed for the CQs using the Med...
Source: Journal of Gastroenterology - February 15, 2016 Category: Gastroenterology Source Type: research

A micro-RNA expression signature for human NAFLD progression
Conclusions Our analytical results suggest that NAFLD severity is associated with a specific pattern of altered hepatic microRNA expression that may drive the hallmark of this disorder: altered lipid and carbohydrate metabolism. The three identified miRNAs can potentially be used as biomarkers to access the severity of NAFLD. The persistence of this miRNA expression pattern in an external validation cohort of HCC samples suggests that specific microRNA expression patterns may permit and/or sustain NAFLD development to HCC. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - February 13, 2016 Category: Gastroenterology Source Type: research

Intestine-specific homeobox (ISX) induces intestinal metaplasia and cell proliferation to contribute to gastric carcinogenesis
Conclusions ISX expression induced by H. pylori infection may lead to IM and hyperproliferation of gastric mucosa through CDX1/2 and cyclinD1 expression, contributing to gastric carcinogenesis. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - February 12, 2016 Category: Gastroenterology Source Type: research