Marked intestinal trans-differentiation by autoimmune gastritis along with ectopic pancreatic and pulmonary trans-differentiation
ConclusionsAIG induces diverse trans-differentiation in the gastric mucosa, characterized by the transactivation of genes specific to the small intestine, pancreas, and lung. Increased environmental pH owing to AIG may cause abnormal differentiation of the gastric mucosa. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 14, 2023 Category: Gastroenterology Source Type: research
Induction of ferroptosis by photodynamic therapy and enhancement of antitumor effect with ferroptosis inducers
ConclusionThis study found that the mechanism underlying TS-PDT-induced ferroptosis constitutes direct lipid peroxidation by the generated ROS, and the inhibition of system xc−, and that the combination of a ferroptosis inducer with TS-PDT enhances the antitumor effect of TS-PDT. Our findings suggest that ferroptosis-inducing therapies combined with PDT may benefit cancer patients. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 10, 2023 Category: Gastroenterology Source Type: research
Three-dimensional chromatin landscapes in hepatocellular carcinoma associated with hepatitis B virus
ConclusionThis study demonstrates the crucial role of chromosomal structure variation in HCC oncogenesis and potential novel biomarkers of HCC, laying a foundation for cancer precision medicine development. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 5, 2023 Category: Gastroenterology Source Type: research
The magnetic resonance imaging and age-adjusted matrix metalloproteinase-7 assist the diagnosis of biliary atresia
ConclusionThe age-adjusted MMP-7 ratio and the LTPAR are both significant non-invasive predictors of BA. The consideration of both serum and imaging parameters may enhance BA diagnostic performance in cholestatic infants. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - October 30, 2023 Category: Gastroenterology Source Type: research
Clinicopathologic differences of gastric neoplasms between Helicobacter pylori-infected and -na ïve patients: a multicenter retrospective analysis
ConclusionsHpNGNs is recently on the increase but shows lower malignant nature regardless of histologic type than HpIGN. Endoscopic gastric cancer screening will be reviewed via cost effectiveness forHp-na ïve individuals in future. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - October 19, 2023 Category: Gastroenterology Source Type: research
MGAT5/TMEM163 variant is associated with prognosis in ursodeoxycholic acid-treated patients with primary biliary cholangitis
ConclusionsPBC patients carrying the rs661899 T allele are associated with poor prognosis and adverse outcomes after 1-year UDCA therapy. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - October 16, 2023 Category: Gastroenterology Source Type: research
A survey questionnaire evaluating physical activity patterns and determinants in patients with chronic liver disease
ConclusionsPatients with CLD are insufficiently active and need physical activity interventions, especially regarding walking. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - October 16, 2023 Category: Gastroenterology Source Type: research
Prediction of outcomes in patients with metabolic dysfunction-associated steatotic liver disease based on initial measurements and subsequent changes in magnetic resonance elastography
ConclusionsBoth initial LSM and ΔLSM can predict liver-related events in patients with MASLD, even for low initial LSM. This integrated assessment can allow more detailed risk stratification compared with single LSM assessments and identify high-risk patients with MASLD among those previously considered as low risk. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - October 16, 2023 Category: Gastroenterology Source Type: research
MGAT5/TMEM163 variant is associated with prognosis in ursodeoxycholic acid-treated patients with primary biliary cholangitis
ConclusionsPBC patients carrying the rs661899 T allele are associated with poor prognosis and adverse outcomes after 1-year UDCA therapy. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - October 16, 2023 Category: Gastroenterology Source Type: research
