Correlation between mismatch repair and survival of patients with gastric cancer after 5-FU-based adjuvant chemotherapy
ConclusionTo our knowledge, this is the first prospective study to specifically explore the correlation between MMR and survival of patients with gastric cancer after 5-FU-based adjuvant chemotherapy. The results showed that gastric cancer patients with pMMR can benefit from 5-FU-based adjuvant chemotherapy, but those with dMMR cannot. Among pMMR patients, lower PLR and SII values with surgery alone and lower NLRs in those receiving 5-FU-based adjuvant chemotherapy were associated with higher DFS and OS. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 10, 2023 Category: Gastroenterology Source Type: research
Genomic landscape and clinical features of rare subtypes of pancreatic cancer: analysis with the national database of Japan
ConclusionsACC clearly harbors different genomics compared with PDAC, possibly accounting for differences in treatment efficacy. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 7, 2023 Category: Gastroenterology Source Type: research
Serum osteopontin predicts the response to atezolizumab plus bevacizumab in patients with hepatocellular carcinoma
ConclusionHigh serum OPN levels were associated with poor response to Atez/Bev in patients with uHCC. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 30, 2023 Category: Gastroenterology Source Type: research
New insight on the correlation of immune landscapes with immune markers expression in different risk classification of gastrointestinal stromal tumors
ConclusionsWe first reported that GIST cells could express OX40L, patients with high OX40L experienced longer RFS. The colocalization of OX40L with immune cells indicates that OX40L could be a promising potential target for immunotherapy in GIST. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 24, 2023 Category: Gastroenterology Source Type: research
Correction: Characteristics of synchronous and metachronous duodenal tumors and association with colorectal cancer: a supplementary analysis
(Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 24, 2023 Category: Gastroenterology Source Type: research
Antidiabetic drugs for IBD: a long but promising road ahead for drug repositioning to target intestinal inflammation
(Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 24, 2023 Category: Gastroenterology Source Type: research
New insight on the correlation of immune landscapes with immune markers expression in different risk classification of gastrointestinal stromal tumors
ConclusionsWe first reported that GIST cells could express OX40L, patients with high OX40L experienced longer RFS. The colocalization of OX40L with immune cells indicates that OX40L could be a promising potential target for immunotherapy in GIST. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 24, 2023 Category: Gastroenterology Source Type: research
Correction: Characteristics of synchronous and metachronous duodenal tumors and association with colorectal cancer: a supplementary analysis
(Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 24, 2023 Category: Gastroenterology Source Type: research
Antidiabetic drugs for IBD: a long but promising road ahead for drug repositioning to target intestinal inflammation
(Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 24, 2023 Category: Gastroenterology Source Type: research
Splenectomy and azygoportal disconnection decreases the risk of hepatocellular carcinoma for cirrhosis patients with portal hypertension bleeding: a 10-year retrospective follow-up study based on the inverse probability of treatment weighting method
ConclusionsConsidering the better postoperative survival and the ability to prevent HCC in CPH patients with gastroesophageal variceal bleeding and secondary hypersplenism, LSD is worth popularization in situations where liver donors are scarce. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 21, 2023 Category: Gastroenterology Source Type: research
plenectomy and azygoportal disconnection decreases the risk of hepatocellular carcinoma for cirrhosis patients with portal hypertension bleeding: a 10-year retrospective follow-up study based on the inverse probability of treatment weighting method
ConclusionsConsidering the better postoperative survival and the ability to prevent HCC in CPH patients with gastroesophageal variceal bleeding and secondary hypersplenism, LSD is worth popularization in situations where liver donors are scarce. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 21, 2023 Category: Gastroenterology Source Type: research
