International Journal of Clinical Chemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Electrochemical biosensors for early diagnosis of glioblastoma
Clin Chim Acta. 2024 Mar 15:117878. doi: 10.1016/j.cca.2024.117878. Online ahead of print.ABSTRACTGlioblastoma (GBM) is a highly aggressive and life-threatening neurological malignancy of predominant astrocyte origin. This type of neoplasm can develop in either the brain or the spine and is also known as glioblastoma multiforme. Although current diagnostic methods such as magnetic resonance imaging (MRI) and positron emission tomography (PET) facilitate tumor location, these approaches are unable to assess disease severity. Furthermore, interpretation of imaging studies requires significant expertise which can have substan...
Source: International Journal of Clinical Chemistry - March 17, 2024 Category: Chemistry Authors: Hamid Vatankhahan Farnaz Esteki Mohammad Amin Jabalameli Pouria Kiani Sajad Ehtiati Ahmad Movahedpour Omid Vakili Seyyed Hossein Khatami Source Type: research

A method for measuring serum levels of melanin-associated indole metabolites using LC-MS/MS and its application to malignant melanoma
CONCLUSION: We successfully established measurement methods for serum 5H6MI2C and 6H5MI2C levels using LC-MS/MS. Serum 6H5MI2C levels offer a potential marker for MM.PMID:38493943 | DOI:10.1016/j.cca.2024.117873 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - March 17, 2024 Category: Chemistry Authors: Masaki Takiwaki Hiroshi Umemura Yoshikuni Kikutani Seketsu Fukuzawa Kentaro Abe Kiyotaka Fujino Satoru Sugihara Kota Tachibana Shin Morizane Mamoru Satoh Tomohiro Nakayama Osamu Yamasaki Source Type: research

Breast cancer derived exosomes: Theragnostic perspectives and implications
Clin Chim Acta. 2024 Mar 15:117875. doi: 10.1016/j.cca.2024.117875. Online ahead of print.ABSTRACTBreast cancer (BC) is the most prevalent malignancy affecting women worldwide. Although conventional treatments such as chemotherapy, surgery, hormone therapy, radiation therapy, and biological therapy are commonly used, they often entail significant side effects. Therefore, there is a critical need to investigate more cost-effective and efficient treatment modalities in BC. Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, play a crucial role in modulating recipient cell behaviour and driv...
Source: International Journal of Clinical Chemistry - March 17, 2024 Category: Chemistry Authors: Ram Mohan Ram Kumar Logesh Rajan Suresh Joghee Source Type: research

External quality assurance in the era of standardization
Clin Chim Acta. 2024 Mar 15:117876. doi: 10.1016/j.cca.2024.117876. Online ahead of print.ABSTRACTMetrology in clinical chemistry aims to ensure the equivalence of measurement results from different in-vitro diagnostic measurement devices (IVD MD) for use in healthcare. The metrological traceability of measurement results to higher-order references is the cornerstone to achieving equivalent results. However, other fundamentals are also needed, including the commutability of reference materials and external quality assessment (EQA) materials for monitoring the equivalence of measurement results at the end-user level. This m...
Source: International Journal of Clinical Chemistry - March 17, 2024 Category: Chemistry Authors: Theodorsson Elvar Meijer Piet Badrick Tony Source Type: research

ALISTER - Application for lipid stability evaluation and research
CONCLUSION: ALISTER is available for use under https://itmp.shinyapps.io/alister/. The application enables and simplifies data-driven decision making concerning pre-analytic blood sample handling and fits the needs of clinical investigations from multiple perspectives.PMID:38492658 | DOI:10.1016/j.cca.2024.117858 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - March 16, 2024 Category: Chemistry Authors: Samuel Rischke Robert Gurke Alexandre Bennett Frank Behrens Gerd Geisslinger Lisa Hahnefeld Source Type: research

Epigenetics of Diabetes: A bioinformatic approach
Clin Chim Acta. 2024 Mar 13;557:117856. doi: 10.1016/j.cca.2024.117856. Online ahead of print.ABSTRACTThe adaptability of epigenetics offers a compelling research avenue, notably in the context of Type 2 Diabetes Mellitus (T2DM) biomarkers and provides a nuanced approach to managing biological systems for diagnosis. However, challenges such as DNA degradation during methylation studies are prominent, especially with cell-free DNA (cfDNA) which is present in small quantities in plasma, calling for innovative solutions. To tackle these challenges, four methodological approaches have been identified: firstly, selecting an app...
Source: International Journal of Clinical Chemistry - March 15, 2024 Category: Chemistry Authors: Sulistyo Emantoko Dwi Putra Farizky Martriano Humardani Yulanda Antonius Jonathan Jonathan Lisa Thalia Mulyanata Source Type: research

Comprehensive metabolomics analysis reveals novel biomarkers and pathways in falsely suspected glutaric aciduria Type-1 newborns
CONCLUSIONS: A distinct metabolic pattern linked to the transient C5DC elevation in newborns was reported to enhance the prediction of the falsely positive cases, which could help avoiding unnecessary medical treatments and minimizing the financial burdens in the health sector.PMID:38490341 | DOI:10.1016/j.cca.2024.117861 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - March 15, 2024 Category: Chemistry Authors: Essa M Sabi Maha AlMogren Rajaa Sebaa Khalid M Sumaily Reem AlMalki Ahmad Mujammami Anas Abdel Rahman Source Type: research

A novel method for simultaneous detection of hematological tumors and infectious pathogens by metagenomic next generation sequencing of plasma
CONCLUSIONS: Concurrent CNV analysis alongside mNGS for infection diagnosis is promising for detecting malignant tumors. We recommend adopting a CNV region of 10Mbp over 5Mbp for our model, because of the lower false-positive rate (FPR).PMID:38484907 | DOI:10.1016/j.cca.2024.117874 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - March 14, 2024 Category: Chemistry Authors: Pingping Song Yaxian Tian Shuai Chen Sheng Zhang Xuan Li Zhiqing You Juanjuan Fu Wenbin Xu Zhen Li Jing Luan Qigang Zhao Chengtan Wang Feng Pang Source Type: research

Identification of potential serum biomarkers associated with HbA1c levels in Indian type 2 diabetic subjects using NMR-based metabolomics
CONCLUSION: We propose that the identified metabolite panel can be used in the future as a biomarker for clinical diagnosis, patient surveillance, and for predicting individuals at risk for developing diabetes.PMID:38484908 | DOI:10.1016/j.cca.2024.117857 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - March 14, 2024 Category: Chemistry Authors: Saleem Yousf Hitender S Batra Rakesh M Jha Devika M Sardesai Kalyani Ananthamohan Jeetender Chugh Shilpy Sharma Source Type: research

The biological variation of serum 1,25-dihydroxyvitamin D and parathyroid hormone, and plasma fibroblast growth factor 23 in healthy individuals
CONCLUSIONS: We report for the first time BV estimates for 1,25(OH)2D and enhance existing data about iFGF23-BV and PTH 1-84-BV through cutting-edge immunometric methods.PMID:38471629 | DOI:10.1016/j.cca.2024.117863 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - March 12, 2024 Category: Chemistry Authors: Francesca Iannone Elvira Angotti Fortunata Lucia Luisa Martino Giulio Cesare Antico Francesco Galato Ilenia Aversa Raffaella Gallo Caterina Giordano Antonio Abatino Serafina Mancuso Lorenza Giaquinto Carinci Maria Martucci Consuelo Teti Francesco Costanzo Source Type: research

A comprehensive Exdia TRF-LFIA for simultaneous quantification of GFAP and NT-proBNP in distinguishing ischemic and hemorrhagic stroke
Clin Chim Acta. 2024 Mar 11;557:117872. doi: 10.1016/j.cca.2024.117872. Online ahead of print.ABSTRACTThe goal of this study is to create a highly sensitive time-resolved fluorescence lateral flow immunoassay (TRF-LFIA) capable of concurrently measuring glial fibrillary acidic protein (GFAP) and the N-terminal fragment of B-type natriuretic peptide precursor (NT-proBNP). This assay is designed as a diagnostic tool and aims to provide an algorithm for stroke management, specifically for distinguishing between Ischemic stroke (IS) and Hemorrhagic stroke (HS). However, LFIA to quantify simultaneous serum NT-proBNP and GFAP ar...
Source: International Journal of Clinical Chemistry - March 12, 2024 Category: Chemistry Authors: Minki Lee Danishmalik Rafiq Sayyed Hyejeong Kim Jean-Charles Sanchez Sung Sik Hong Sehee Choi Hyunghoon Kim Eunhee Han Hye Won Kang Jeong Min Kim Montaner Joan Hanshin Kim Hyojin Chae Jong-Myeon Park Source Type: research