International Journal of Clinical Chemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Asymptomatic elevation of parathyroid hormone levels by antibodies against reagent alkaline phosphatase
CONCLUSION: PTH was falsely evaluated due to anti-bovine ALP antibodies (antibodies against reagent ALP). Anti-bovine ALP antibody should be considered in assays that use ALP as a signal generator.PMID:38342424 | DOI:10.1016/j.cca.2024.117821 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - February 11, 2024 Category: Chemistry Authors: Danchen Wang Yicong Yin Jin Cheng Yingying Hu Wei Su Wei Ji Xinqi Cheng Songlin Yu Ling Qiu Source Type: research

The European biological variation study (EuBIVAS): Biological variation data for testosterone, follicle stimulating hormone, prolactin, luteinizing hormone and dehydroepiandrosterone sulfate in men
CONCLUSIONS: In this study, we have used samples from the highly powered EuBIVAS study to derive BV estimates for testosterone, FSH, prolactin, LH and DHEA-S in men. Our data confirm previously published BV estimates of testosterone, FSH and LH. For prolactin and DHEA-S BV data for men are reported for the first time.PMID:38341016 | DOI:10.1016/j.cca.2024.117806 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - February 10, 2024 Category: Chemistry Authors: Outi Itkonen Niels Jonker Aasne K Aarsand Sverre Sandberg Jorge Diaz-Garzon Pilar Fernandez-Calle Abdurrahman Coskun William A Bartlett Massimo Locatelli Anna Carobene Source Type: research

An unusual case of trisomy 8 mosaicism complicated by coexistence of phenylketonuria
Clin Chim Acta. 2024 Feb 8;555:117794. doi: 10.1016/j.cca.2024.117794. Online ahead of print.ABSTRACTTrisomy 8 syndrome, also known as " Warkany syndrome type 2 ", was first reported in 1971. Complete trisomy 8 are mostly aborted spontaneouslyinthe first trimester. Trisomy 8 mosaicism (T8M), predominated in the current cases reported. Itisahighlyheterogeneous Chromosome disorder. We know little about its effects on fertility. In this case, a patient with T8M combined with phenylketonuria was diagnosed. She's mentally retarded. After evaluating the anatomy and function of the reproductive system, the patient conceived throu...
Source: International Journal of Clinical Chemistry - February 10, 2024 Category: Chemistry Authors: Yanan Wang Lina Hu Yuqiong Chai Xiaofei Liu Source Type: research

Identification of molecular markers for predicting the severity of heart failure after AMI: An Olink precision proteomic study
CONCLUSIONS: Neutrophil count, GDF-15, TNF-R2, TNF-R1 and TFF3 were closely related to the Killip classification of HF after AMI, which suggests that the inflammatory response plays an important role in the severity of HF after AMI and that regulating inflammation might become a new target for controlling HF.PMID:38331209 | DOI:10.1016/j.cca.2024.117825 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - February 8, 2024 Category: Chemistry Authors: Tianxing Zhang Xuexue Han Hao Zhang Xue Li Xingzhu Zhou Shuhui Feng Chenglong Guo Fei Song Tianqi Tao Chunlin Yin Jinggang Xia Source Type: research

Metabolomics and lipidomics in non-small cell lung cancer
Clin Chim Acta. 2024 Feb 5;555:117823. doi: 10.1016/j.cca.2024.117823. Online ahead of print.ABSTRACTDue to its insidious nature, lung cancer remains a leading cause of cancer-related deaths worldwide. Therefore, there is an urgent need to identify sensitive/specific biomarkers for early diagnosis and monitoring. The current study was designed to provide a current metabolic profile of non-small cell lung cancer (NSCLC) by systematically reviewing and summarizing various metabolomic/ lipidomic studies based on NSCLC blood samples, attempting to find biomarkers in human blood that can predict or diagnose NSCLC, and investiga...
Source: International Journal of Clinical Chemistry - February 7, 2024 Category: Chemistry Authors: Wei Shi Yizhen Cheng Haihua Zhu Longshan Zhao Source Type: research

Molecular characterization and functional roles of circulating cell-free extrachromosomal circular DNA
Clin Chim Acta. 2024 Feb 5:117822. doi: 10.1016/j.cca.2024.117822. Online ahead of print.ABSTRACTCircular DNA segments isolated from chromosomes are known as extrachromosomal circular DNA (eccDNA). Its distinct structure and characteristics, along with the variations observed in different disease states, makes it a promising biomarker. Recent studies have revealed the presence of eccDNAs in body fluids, indicating their involvement in various biological functions. This finding opens up avenues for utilizing eccDNAs as convenient and real-time biomarkers for disease diagnosis, treatment monitoring, and prognosis assessment ...
Source: International Journal of Clinical Chemistry - February 7, 2024 Category: Chemistry Authors: Dandan Li Xia Qian Yingjie Wang Yicong Yin Huishan Sun Haitao Zhao Jie Wu Ling Qiu Source Type: research

Prostate cancer: Novel genetic and immunologic biomarkers
Clin Chim Acta. 2024 Feb 3;555:117824. doi: 10.1016/j.cca.2024.117824. Online ahead of print.ABSTRACTProstate cancer (PCa) is considered one of the most prevalent male malignancies worldwide with a global burden estimated to increase over the next two decades. Due to significant mortality and debilitation of survival, early diagnosis has been described as key. Unfortunately, current diagnostic serum-based strategies have low specificity and sensitivity. Histologic examination is invasive and not useful for treatment and monitoring purposes. Hence, a plethora of studies have been conducted to identify and validate an effici...
Source: International Journal of Clinical Chemistry - February 5, 2024 Category: Chemistry Authors: Mohammad Samare-Najaf Hosein Kouchaki Seyed Moein Mahini Masoumeh Saberi Rounkian Yasaman Tavakoli Ali Samareh Mohammad Karim Azadbakht Navid Jamali Source Type: research

Lipidomic profiles in serum and urine in children with steroid sensitive nephrotic syndrome
CONCLUSIONS: Untargeted lipidomic analysis successfully identified specific lipid class changes in patients with SSNS, providing a deeper understanding of lipid alterations and underlying mechanisms associated with SSNS.PMID:38316288 | DOI:10.1016/j.cca.2024.117804 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - February 5, 2024 Category: Chemistry Authors: Lidan Hu Zhaoyang Peng Guannan Bai Haidong Fu Danny Junyi Tan Jingjing Wang Wei Li Zhongkai Cao Guoping Huang Fei Liu Yi Xie Li Lin Jingmiao Sun Langping Gao Yixuan Chen Ruihan Zhu Jianhua Mao Source Type: research

Validation of SMA screening kits with SMN1 gene analysis in a Turkish cohort
CONCLUSIONS: The qRT-PCR method proved to be a rapid, cost-effective, and accurate technique, aligning well with the demands of routine SMA screening, suggesting its general suitability for application in SMA screening programs. This research highlights the importance of improving molecular methodologies and the value of collaborations between government and relevant sectors to overcome rare diseases, particularly through the enhancement of screening initiatives which is the first and most effective strategy to protect the public health.PMID:38309554 | DOI:10.1016/j.cca.2024.117793 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - February 3, 2024 Category: Chemistry Authors: Murat G ülşen Ahmet Cevdet Ceylan Taha Bahsi Hikmet Can Çubukçu Onur Burak Dursun Source Type: research

Soluble signal inhibitory receptor on leukocyte-1 reflects disease activity and assists diagnosis of patients with rheumatoid arthritis
CONCLUSION: The expression pattern of sSIRL-1 in RA, coupled with its correlation with disease activity, underscores its potential clinical utility for both diagnosis and disease monitoring in RA patients. This study offers valuable insights into the evolving diagnostic landscape of RA.PMID:38309555 | DOI:10.1016/j.cca.2024.117808 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - February 3, 2024 Category: Chemistry Authors: Zhen Xv Xuejing Xv Nianzhen Chen Jiayi Yuan Jing Li Lan Wang Shanshan Yu Gen Li Menglei Ding Ming Zong Lieying Fan Source Type: research

Metabolomics study reveals blood biomarkers for early diagnosis of chronic kidney disease and IgA nephropathy: A retrospective cross-sectional study
CONCLUSIONS: This study provides promising plasma biomarkers for early diagnosis of CKD and IgAN.PMID:38309556 | DOI:10.1016/j.cca.2024.117815 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - February 3, 2024 Category: Chemistry Authors: Xian Fu Zhi-Xiao Luo Hou-Hua Yin Ya-Nan Liu Xiao-Gang Du Wei Cheng Jun-Yan Liu Source Type: research

Recommendations on the measurement and use of the alcohol consumption biomarker CDT. A position paper from the IFCC Working Group on CDT standardisation
CONCLUSION: The relationship between alcohol intake versus resulting CDT is discussed as well as the cutoff and measurement uncertainty. Concerning the application in practice, potential pitfalls are considered and recommendations handling both analytical and preanalytical caveats are given. Finally, some examples of serious misunderstandings in publications about CDT are addressed.PMID:38309557 | DOI:10.1016/j.cca.2024.117800 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - February 3, 2024 Category: Chemistry Authors: J P M Wielders N M Porpiglia F Schellenberg J Deenmamode J Delanghe R F Anton F Bortolotti C Siebelder F Tagliaro C Weykamp A Helander Source Type: research

Association of circulating fibroblast growth factor 21 levels with all-cause and cardiovascular mortality: The multi-ethnic study of atherosclerosis
CONCLUSIONS: In subjects without clinically-evident CVD at baseline, over 17.7 years follow-up there is a modest association of baseline FGF21 levels with all-cause mortality. The finding that this is driven primarily by a significant association with non-CVD mortality over almost two decades merits further investigation.PMID:38309558 | DOI:10.1016/j.cca.2024.117799 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - February 3, 2024 Category: Chemistry Authors: William J Tucker Bradley Tucker Andrzej S Januszewski Alicia J Jenkins Anthony C Keech Bryan R Kestenbaum Matthew A Allison Kerry-Anne Rye Kwok Leung Ong Source Type: research

Evaluating the efficacy of a long-read sequencing-based approach in the clinical diagnosis of neonatal congenital adrenocortical hyperplasia
Clin Chim Acta. 2024 Feb 1;555:117820. doi: 10.1016/j.cca.2024.117820. Online ahead of print.ABSTRACTCongenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders predominantly characterized by impaired corticosteroid synthesis. Clinical phenotypes include hypoadrenocorticism, electrolyte disturbances, abnormal gonadal development, and short stature, of which severe hyponadrenocorticism and salt wasting can be life-threatening. Genetic analysis can help in the clinical diagnosis of CAH. However, the 21-OHD-causing gene CYP21A2 is arranged in tandem with the highly homologous CYP21A1P pseudogene, making i...
Source: International Journal of Clinical Chemistry - February 2, 2024 Category: Chemistry Authors: Ruixue Zhang Di Cui Chengrong Song Xiaoping Ma Na Cai Yan Zhang Mei Feng Yanlin Cao Libao Chen Rong Qiang Source Type: research

Performance of the digital cell morphology analyzer MC-100i in a multicenter study in tertiary hospitals in China
CONCLUSIONS: The MC-100i is an accurate and reliable digital cell morphology analyzer, offering another intelligent option for hematology laboratories.PMID:38296220 | DOI:10.1016/j.cca.2024.117801 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - January 31, 2024 Category: Chemistry Authors: Hong Jiang Wei Xu Wei Chen Jun He Haoqin Jiang Zhigang Mao Min Liu Mianyang Li Dandan Liu Yuling Pan Chenxue Qu Linlin Qu Ziyong Sun Dehua Sun Xuefeng Wang Jianbiao Wang Wenjing Wu Ying Xing Shihong Zhang Chi Zhang Lei Zheng Ming Guan Source Type: research