Reference interval establishment and correlation research of urine thromboxane metabolites: Unveiling new possibilities in platelet activation
CONCLUSION: The establishment of RI provides a reference for diseases related to platelet activation and the use of drugs, and the first discovery of the correlation between 11dhTxB2 and 11dh23dinorTxB2 in urine provides a new possibilitie for the diagnostic and prognostic of cardiovascular diseases.PMID:38621589 | DOI:10.1016/j.cca.2024.119672 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - April 15, 2024 Category: Chemistry Authors: Yunfeng Cao Furong Zhao Shuang Wang Ying Li Shuainan Li Xueting Cui Source Type: research

C. difficile biomarkers, pathogenicity and detection
CONCLUSION: To overcome the deficiencies of conventional methods, the potential of advanced methods for C. difficile diagnosis, their direction, perspective, and challenges ahead were discussed.PMID:38621586 | DOI:10.1016/j.cca.2024.119674 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - April 15, 2024 Category: Chemistry Authors: Sepideh Ziaei Chamgordani Abbas Yadegar Hedayatollah Ghourchian Source Type: research

A machine learning algorithm based on circulating metabolic biomarkers offers improved predictions of neurological diseases
CONCLUSION: The performance of the model based on circulating NMR spectroscopy-detected metabolic biomarkers was better than that of the clinical model in the prediction of dementia, AD, and PD.PMID:38621587 | DOI:10.1016/j.cca.2024.119671 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - April 15, 2024 Category: Chemistry Authors: Liyuan Han Xi Chen Wang Yue Ruijie Zhang Tian Zhao Liyuan Pu Yi Huang Hongpeng Sun Source Type: research

Space research to explore novel biochemical insights on Earth
Clin Chim Acta. 2024 Apr 13:119673. doi: 10.1016/j.cca.2024.119673. Online ahead of print.ABSTRACTTravel to space has overcome unprecedent technological challenges and this has resulted in transfer of these technological results on Earth to better our lives. Health technology, medical devices, and research advancements in human biology are the first beneficiaries of this transfer. The real breakthrough came with the International Space Station, which endorsed multidisciplinary international scientific collaborations and boosted the research on pathophysiological adaptation of astronauts to life on space. These studies evid...
Source: International Journal of Clinical Chemistry - April 15, 2024 Category: Chemistry Authors: Simona Ferraro Anilkumar Dave Cristina Cereda Elvira Verduci Santica Marcovina Gianvincenzo Zuccotti Source Type: research

Reference interval establishment and correlation research of urine thromboxane metabolites: Unveiling new possibilities in platelet activation
CONCLUSION: The establishment of RI provides a reference for diseases related to platelet activation and the use of drugs, and the first discovery of the correlation between 11dhTxB2 and 11dh23dinorTxB2 in urine provides a new possibilitie for the diagnostic and prognostic of cardiovascular diseases.PMID:38621589 | DOI:10.1016/j.cca.2024.119672 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - April 15, 2024 Category: Chemistry Authors: Yunfeng Cao Furong Zhao Shuang Wang Ying Li Shuainan Li Xueting Cui Source Type: research

Cancer risk and male Infertility: Unravelling predictive biomarkers and prognostic indicators
Clin Chim Acta. 2024 Apr 11:119670. doi: 10.1016/j.cca.2024.119670. Online ahead of print.ABSTRACTIn recent years, there has been a global increase in cases of male infertility. There are about 30 million cases of male infertility worldwide and male reproductive health is showing rapid decline in last few decades. It is now recognized as a potential risk factor for developing certain types of cancer, particularly genitourinary malignancies like testicular and prostate cancer. Male infertility is considered a potential indicator of overall health and an early biomarker for cancer. Cases of unexplained male factor infertilit...
Source: International Journal of Clinical Chemistry - April 13, 2024 Category: Chemistry Authors: Prabhakar Tiwari Anjali Yadav Meenakshi Kaushik Rima Dada Source Type: research

Cancer risk and male Infertility: Unravelling predictive biomarkers and prognostic indicators
Clin Chim Acta. 2024 Apr 11:119670. doi: 10.1016/j.cca.2024.119670. Online ahead of print.ABSTRACTIn recent years, there has been a global increase in cases of male infertility. There are about 30 million cases of male infertility worldwide and male reproductive health is showing rapid decline in last few decades. It is now recognized as a potential risk factor for developing certain types of cancer, particularly genitourinary malignancies like testicular and prostate cancer. Male infertility is considered a potential indicator of overall health and an early biomarker for cancer. Cases of unexplained male factor infertilit...
Source: International Journal of Clinical Chemistry - April 13, 2024 Category: Chemistry Authors: Prabhakar Tiwari Anjali Yadav Meenakshi Kaushik Rima Dada Source Type: research

Diagnostic and prognostic value of mannan-binding lectin associated protein (MAp19) for functionally relevant coronary artery disease
CONCLUSION: MAp19 demonstrated an association with the risk of myocardial infarction. Increases in MAp19 concentration were observed during bicycle and combined stress-tests.PMID:38599540 | DOI:10.1016/j.cca.2024.119668 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - April 10, 2024 Category: Chemistry Authors: Ganna Isayeva Klara Rumora Eliska Potlukova Jan-Philipp Leibfarth Ibrahim Sch äfer Zsofia Bartha Michael J Zellweger Marten Trendelenburg Trine Korsgaard Hejlesen Annette Gudmann Hansen Steffen Thiel Christian Mueller Source Type: research

Decreased serum tryptophan levels in patients with MOGAD:a cross-sectional survey
CONCLUSION: This study manifested decreased serum tryptophan levels and serum tryptophan may be the potential marker to predict the short-term outcome in MOGAD patients.PMID:38599541 | DOI:10.1016/j.cca.2024.119669 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - April 10, 2024 Category: Chemistry Authors: Haoxiao Chang Jiali Sun Jia Ma Yaobo Zhao Tianshu Guo Yuzhen Wei Hengri Cong Linlin Yin Xinghu Zhang Huabing Wang Source Type: research

Diagnostic and prognostic value of mannan-binding lectin associated protein (MAp19) for functionally relevant coronary artery disease
CONCLUSION: MAp19 demonstrated an association with the risk of myocardial infarction. Increases in MAp19 concentration were observed during bicycle and combined stress-tests.PMID:38599540 | DOI:10.1016/j.cca.2024.119668 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - April 10, 2024 Category: Chemistry Authors: Ganna Isayeva Klara Rumora Eliska Potlukova Jan-Philipp Leibfarth Ibrahim Sch äfer Zsofia Bartha Michael J Zellweger Marten Trendelenburg Trine Korsgaard Hejlesen Annette Gudmann Hansen Steffen Thiel Christian Mueller Source Type: research

Decreased serum tryptophan levels in patients with MOGAD:a cross-sectional survey
CONCLUSION: This study manifested decreased serum tryptophan levels and serum tryptophan may be the potential marker to predict the short-term outcome in MOGAD patients.PMID:38599541 | DOI:10.1016/j.cca.2024.119669 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - April 10, 2024 Category: Chemistry Authors: Haoxiao Chang Jiali Sun Jia Ma Yaobo Zhao Tianshu Guo Yuzhen Wei Hengri Cong Linlin Yin Xinghu Zhang Huabing Wang Source Type: research

Diagnostic and prognostic value of mannan-binding lectin associated protein (MAp19) for functionally relevant coronary artery disease
CONCLUSION: MAp19 demonstrated an association with the risk of myocardial infarction. Increases in MAp19 concentration were observed during bicycle and combined stress-tests.PMID:38599540 | DOI:10.1016/j.cca.2024.119668 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - April 10, 2024 Category: Chemistry Authors: Ganna Isayeva Klara Rumora Eliska Potlukova Jan-Philipp Leibfarth Ibrahim Sch äfer Zsofia Bartha Michael J Zellweger Marten Trendelenburg Trine Korsgaard Hejlesen Annette Gudmann Hansen Steffen Thiel Christian Mueller Source Type: research

Decreased serum tryptophan levels in patients with MOGAD:a cross-sectional survey
CONCLUSION: This study manifested decreased serum tryptophan levels and serum tryptophan may be the potential marker to predict the short-term outcome in MOGAD patients.PMID:38599541 | DOI:10.1016/j.cca.2024.119669 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - April 10, 2024 Category: Chemistry Authors: Haoxiao Chang Jiali Sun Jia Ma Yaobo Zhao Tianshu Guo Yuzhen Wei Hengri Cong Linlin Yin Xinghu Zhang Huabing Wang Source Type: research

Diagnostic value of isolated plasma biomarkers and its combination in neurodegenerative dementias: A multicenter cohort study
CONCLUSIONS: Our results confirmed the diagnostic performance of individual plasma biomarkers Aβ42/Aβ40, p-tau181, NfL, and GFAP in Chinese dementia patients and noted that a combination of these biomarkers may be more accurate in identifying FTD/PSP patients and distinguishing AD from non-AD dementia.PMID:38588788 | DOI:10.1016/j.cca.2024.118784 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - April 8, 2024 Category: Chemistry Authors: Yi Chen Yunyun Wang Qingqing Tao Peilin Lu Fanxia Meng Liying Zhuang Song Qiao Ying Zhang Benyan Luo Yang Liu Guoping Peng Source Type: research

Diagnostic value of isolated plasma biomarkers and its combination in neurodegenerative dementias: A multicenter cohort study
CONCLUSIONS: Our results confirmed the diagnostic performance of individual plasma biomarkers Aβ42/Aβ40, p-tau181, NfL, and GFAP in Chinese dementia patients and noted that a combination of these biomarkers may be more accurate in identifying FTD/PSP patients and distinguishing AD from non-AD dementia.PMID:38588788 | DOI:10.1016/j.cca.2024.118784 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - April 8, 2024 Category: Chemistry Authors: Yi Chen Yunyun Wang Qingqing Tao Peilin Lu Fanxia Meng Liying Zhuang Song Qiao Ying Zhang Benyan Luo Yang Liu Guoping Peng Source Type: research