International Journal of Clinical Chemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Anti-phosphatidyl-serine/prothrombin (aPS/PT) antibodies are superior predictors of LAC presence and APS diagnoses: A single Center Study
CONCLUSION: Anti-phosphatidyl-serine/prothrombin (aPS/PT) antibodies are superior predictors of LAC presence and APS diagnoses.PMID:38195020 | DOI:10.1016/j.cca.2024.117761 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - January 9, 2024 Category: Chemistry Authors: Abdulrahman Saadalla Vijayalakshmi Nandakumar Source Type: research

Evaluation of insulin secretion and insulin sensitivity in pregnant women: Application value of simple indices
This article reviews the progress in the application of simple indices to help clinicians better understand their potential application in detecting GDM.PMID:38185282 | DOI:10.1016/j.cca.2023.117753 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - January 7, 2024 Category: Chemistry Authors: Shuying Ren Dan Wu Ping Li Source Type: research

Pseudo-targeted Metabolic Profile Differences between Emergency Patients with Type 1 and Type 2 Myocardial Infarction Diagnosed by Optical Coherence Tomography
CONCLUSIONS: There are significant metabolic profile differences between T1MI and T2MI. Several candidate metabolic biomarkers can effectively distinguish the two groups.PMID:38185283 | DOI:10.1016/j.cca.2023.117745 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - January 7, 2024 Category: Chemistry Authors: Jifei Wang Zhaoying Li Guang Yang Chao Fang Yanwei Yin Zhilei Zheng Hongwei Wang Shaohong Fang Jiannan Dai Shanjie Wang Shuang Yang Bo Yu Source Type: research

Liquid chromatography-tandem mass spectrometry methods for quantification of total and free antibiotic concentrations in serum and exudate from patients with post-sternotomy deep sternal wound infection receiving negative pressure wound therapy
CONCLUSION: This method can accurately quantify the total and free concentrations of 16 antibiotics. Comparison of concentration ratios between serum and exudates allows for monitoring individual antibiotics' penetration capacity in patients receiving NPWT.PMID:38185284 | DOI:10.1016/j.cca.2023.117704 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - January 7, 2024 Category: Chemistry Authors: Hana Brozmanov á Pavel Šištík Jana Ďuricová Ivana Kac ířová Kl ára Kaňková Martin Kolek Source Type: research

Myocarditis: A multi-omics approach
Clin Chim Acta. 2024 Jan 4;554:117752. doi: 10.1016/j.cca.2023.117752. Online ahead of print.ABSTRACTMyocarditis, an inflammatory condition of weakened heart muscles often triggered by a variety of causes, that can result in heart failure and sudden death. Novel ways to enhance our understanding of myocarditis pathogenesis is available through newer modalities (omics). In this review, we examine the roles of various biomolecules and associated functional pathways across genomics, transcriptomics, proteomics, and metabolomics in the pathogenesis of myocarditis. Our analysis further explores the reproducibility and variabili...
Source: International Journal of Clinical Chemistry - January 6, 2024 Category: Chemistry Authors: Lulu Wang Tao Sun Xiaolan Liu Yan Wang Xiaorong Qiao Nuo Chen Fangqian Liu Xiaoxiang Zhou Hua Wang Hongxing Shen Source Type: research

Combined Z-scores to assess the impact of rare autosomal trisomies that results in non-invasive prenatal screening on pregnancy outcomes
CONCLUSIONS: Clinicians should pay more attention to the RATs results when the Z-score is ≥ 15. The data are available for clinicians to guide the prenatal diagnosis of RATs and pregnancy management.PMID:38184139 | DOI:10.1016/j.cca.2023.117758 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - January 6, 2024 Category: Chemistry Authors: Xinxin Tang Zhiwei Wang Min Chen Yue Zhang Yunqiu Du Fang Zhang Juan Tan Ting Yin Leilei Wang Source Type: research

Evaluation of diagnostic performance of SARS-CoV-2 infection using digital droplet polymerase chain reaction in individuals with or without COVID-19 symptoms
CONCLUSIONS: Detecting SARS-CoV-2 in samples with low viral loads using RT-qPCR can be challenging. However, our study suggests that RT-ddPCR, with its higher sensitivity and accuracy, is better suited for detecting low viral copies in samples, particularly those from close contacts and convalescent patients.PMID:38184140 | DOI:10.1016/j.cca.2023.117759 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - January 6, 2024 Category: Chemistry Authors: Yoonjung Kim Eunyoung Lee Boyeon Kim Jinhee Cho Sook-Won Ryu Kyung-A Lee Source Type: research

Liquid biopsy in lung cancer
This article critically examines the significant role and potential clinical implications of liquid biopsy in the diagnosis, treatment, and prognosis of lung cancer.PMID:38184141 | DOI:10.1016/j.cca.2023.117757 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - January 6, 2024 Category: Chemistry Authors: Lan Li Haixia Jiang Bingjie Zeng Xianzhao Wang Yunxia Bao Changqiang Chen Lifang Ma Jin Yuan Source Type: research

Quality and composition of archived nucleic acids after use in SARS-CoV-2 molecular testing
CONCLUSIONS: Archived NA quality after SARS-CoV-2 rRT-PCR was guaranteed for subsequent molecular research using human or bacterial DNA, especially for short targets.PMID:38182077 | DOI:10.1016/j.cca.2023.117755 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - January 5, 2024 Category: Chemistry Authors: Ho Hyun Song Jong Cheul Choi Ran Lee Sook Kyung Yoon Hye Jeong Park Young Hee Shin Jeong Won Shin Jieun Kim Source Type: research

Quality and composition of archived nucleic acids after use in SARS-CoV-2 molecular testing
CONCLUSIONS: Archived NA quality after SARS-CoV-2 RT-PCR was guaranteed for subsequent molecular use, especially for short targets and human or bacterial DNA.PMID:38182077 | DOI:10.1016/j.cca.2023.117755 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - January 5, 2024 Category: Chemistry Authors: Ho Hyun Song Jong Cheul Choi Ran Lee Sook Kyung Yoon Hye Jeong Park Young Hee Shin Jeong Won Shin Jieun Kim Source Type: research

Establishment of portable Pseudomonas aeruginosa detection platform based on one-tube CRISPR/Cas12a combined with recombinase polymerase amplification technology
This study successfully combined RPA and CRISPR/Cas12a techniques. Through a series of experiments involving the design and screening of lasB crRNA, the creation of lasB RPA primers, and the establishment of a streamlined RPA-CRISPR/Cas12a assay, the study developed a one-tube detection method targeting P. aeruginosa's lasB gene. The assay demonstrated inclusive behavior across standard and 21 isolates, while specifically discerning P. aeruginosa from diverse strains. Sensitivity reached 15.9 CFU/reaction. Clinical validation revealed a 97.62% concordance with traditional methods. The one-tube assay's protocol mitigated ae...
Source: International Journal of Clinical Chemistry - January 4, 2024 Category: Chemistry Authors: Haitao Yang Aibo Liu Fenfen Ma Xuzhu Gao Kun Wang Yan Wang Source Type: research

Autoimmune inflammatory myopathy biomarkers
Clin Chim Acta. 2024 Jan 2:117742. doi: 10.1016/j.cca.2023.117742. Online ahead of print.ABSTRACTThe autoimmune inflammatory myopathy disease spectrum, commonly known as myositis, is a group of systemic diseases that mainly affect the muscles, skin and lungs. Biomarker assessment helps in understanding disease mechanisms, allowing for the implementation of precise strategies in the classification, diagnosis, and management of these diseases. This review examines the pathogenic mechanisms and highlights current data on blood and tissue biomarkers of autoimmune inflammatory myopathies.PMID:38176522 | DOI:10.1016/j.cca.2023.1...
Source: International Journal of Clinical Chemistry - January 4, 2024 Category: Chemistry Authors: Mickael Essouma Source Type: research