Profiling of the genetic features of patients with breast, ovarian, colorectal and extracolonic cancers: Association to CHEK2 and PALB2 germline mutations
CONCLUSIONS: Multigene panel testing improves the chance of finding PVs in actionable genes in families with HCS. In addition, the coexistence of variants should be recorded to implement a polygenic risk algorithm that might explain the missing heritability in the aforementioned families.PMID:38061684 | DOI:10.1016/j.cca.2023.117695 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - December 7, 2023 Category: Chemistry Authors: Mar Infante M ónica Arranz-Ledo Enrique Lastra Amaya Olaverri Raquel Ferreira Marta Orozco Lara Hern ández Noem í Martínez Mercedes Dur án Source Type: research

Profiling of the genetic features of patients with breast, ovarian, colorectal and extracolonic cancers: Association to CHEK2 and PALB2 germline mutations
CONCLUSIONS: Multigene panel testing improves the chance of finding PVs in actionable genes in families with HCS. In addition, the coexistence of variants should be recorded to implement a polygenic risk algorithm that might explain the missing heritability in the aforementioned families.PMID:38061684 | DOI:10.1016/j.cca.2023.117695 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - December 7, 2023 Category: Chemistry Authors: Mar Infante M ónica Arranz-Ledo Enrique Lastra Amaya Olaverri Raquel Ferreira Marta Orozco Lara Hern ández Noem í Martínez Mercedes Dur án Source Type: research

Tumor-educated platelets
Clin Chim Acta. 2023 Dec 6;552:117690. doi: 10.1016/j.cca.2023.117690. Online ahead of print.ABSTRACTBeyond traditional roles in homeostasis and coagulation, growing evidence suggests that platelets also reflect malignant transformation in cancer. Platelets are present in the tumor microenvironment where they interact with cancer cells. This interaction results in direct and indirect "education" as evident by platelet alterations in adhesion molecules, glycoproteins, nucleic acids, proteins and various receptors. Subsequently, these tumor-educated platelets (TEPs) circulate throughout the body and play pivotal roles in pro...
Source: International Journal of Clinical Chemistry - December 6, 2023 Category: Chemistry Authors: Sajad Najafi Yahya Asemani Jamal Majidpoor Reza Mahmoudi Seyed Mohsen Aghaei-Zarch Keywan Mortezaee Source Type: research

Next-generation sequencing for genetic testing of hearing loss populations
CONCLUSION: Our findings expand the mutation spectrum of hearing loss and highlight the importance of genetic diagnosis and prenatal diagnosis to allow accurate and personalized guidance for those at high risk of deafness.PMID:38056549 | DOI:10.1016/j.cca.2023.117693 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - December 6, 2023 Category: Chemistry Authors: Lulu Wang Gang Liu Dingyuan Ma Huasha Zeng Yuguo Wang Chunyu Luo Jingjing Zhang Zhengfeng Xu Source Type: research

Dried blood spot analysis for the quantification of vancomycin and creatinine using liquid chromatography - tandem mass spectrometry: method development and validation
CONCLUSION: Hence, we successfully validated a quantification method for the simultaneous determination of creatinine and vancomycin in DBS.PMID:38052384 | DOI:10.1016/j.cca.2023.117689 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - December 5, 2023 Category: Chemistry Authors: Soma Bahmany Moska Hassanzai Robert B Flint Hein A W van Onzenoort Brenda C M de Winter Birgit C P Koch Source Type: research

Dried blood spot analysis for the quantification of vancomycin and creatinine using liquid chromatography - tandem mass spectrometry: method development and validation
CONCLUSION: Hence, we successfully validated a quantification method for the simultaneous determination of creatinine and vancomycin in DBS.PMID:38052384 | DOI:10.1016/j.cca.2023.117689 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - December 5, 2023 Category: Chemistry Authors: Soma Bahmany Moska Hassanzai Robert B Flint Hein A W van Onzenoort Brenda C M de Winter Birgit C P Koch Source Type: research

Effect size and inferential statistical techniques coupled with machine learning for assessing the association between prolactin concentration and metabolic homeostasis
CONCLUSION: A strong correlation was identified between mean prolactin concentrations and the results of metabolism tests below the gray zones associated with inflection points, indicating the potential role of prolactin in the appearance of metabolic disorders. Mean prolactin results can provide deeper insight into metabolic balance.PMID:38049046 | DOI:10.1016/j.cca.2023.117688 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - December 4, 2023 Category: Chemistry Authors: Alan Carvalho Dias Rafael Henriques J ácomo Lidia Freire Abdalla Nery Luciana Ansaneli Naves Source Type: research

Effect size and inferential statistical techniques coupled with machine learning for assessing the association between prolactin concentration and metabolic homeostasis
CONCLUSION: A strong correlation was identified between mean prolactin concentrations and the results of metabolism tests below the gray zones associated with inflection points, indicating the potential role of prolactin in the appearance of metabolic disorders. Mean prolactin results can provide deeper insight into metabolic balance.PMID:38049046 | DOI:10.1016/j.cca.2023.117688 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - December 4, 2023 Category: Chemistry Authors: Alan Carvalho Dias Rafael Henriques J ácomo Lidia Freire Abdalla Nery Luciana Ansaneli Naves Source Type: research

Development and validation of equilibrium dialysis UHPLC-MS/MS measurement procedures for total and unbound concentrations of bictegravir, dolutegravir, darunavir and doravirine in human plasma. Application to patients with HIV
CONCLUSIONS: The UHPLC-MS/MS procedures developed could be used for research purposes and therapeutic drug monitoring of antiretrovirals in routine clinical practice.PMID:38042460 | DOI:10.1016/j.cca.2023.117678 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - December 2, 2023 Category: Chemistry Authors: Ra úl Rigo-Bonnin Laura Garc ía-Tejada Virg ínia Mas-Bosch Arkaitz Imaz Juan Manuel Tiraboschi Sof ía Scévola Jordi Niub ó Antonio Navarro-Alcaraz Daniel Podzamczer Source Type: research

Longitudinal Impact of COVID-19 Pandemic on the Utilization of Hemoglobin A1c Testing in Outpatients
CONCLUSION: Given the propensity for healthcare disruptions to widen disparities, it is reassuring that we did not observe a worsening of disparities in rates of HbA1c testing during the COVID-19 pandemic.PMID:38042461 | DOI:10.1016/j.cca.2023.117686 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - December 2, 2023 Category: Chemistry Authors: Li Zha Sara MacLeod Tanzy Love Robert J Fortuna Y Victoria Zhang Source Type: research

Development and validation of equilibrium dialysis UHPLC-MS/MS measurement procedures for total and unbound concentrations of bictegravir, dolutegravir, darunavir and doravirine in human plasma. Application to patients with HIV
CONCLUSIONS: The UHPLC-MS/MS procedures developed could be used for research purposes and therapeutic drug monitoring of antiretrovirals in routine clinical practice.PMID:38042460 | DOI:10.1016/j.cca.2023.117678 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - December 2, 2023 Category: Chemistry Authors: Ra úl Rigo-Bonnin Laura Garc ía-Tejada Virg ínia Mas-Bosch Arkaitz Imaz Juan Manuel Tiraboschi Sof ía Scévola Jordi Niub ó Antonio Navarro-Alcaraz Daniel Podzamczer Source Type: research

Longitudinal Impact of COVID-19 Pandemic on the Utilization of Hemoglobin A1c Testing in Outpatients
CONCLUSION: Given the propensity for healthcare disruptions to widen disparities, it is reassuring that we did not observe a worsening of disparities in rates of HbA1c testing during the COVID-19 pandemic.PMID:38042461 | DOI:10.1016/j.cca.2023.117686 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - December 2, 2023 Category: Chemistry Authors: Li Zha Sara MacLeod Tanzy Love Robert J Fortuna Y Victoria Zhang Source Type: research

Effect of Hyperin and Icariin on steroid hormone secretion in rat ovarian granulosa cells (Erratum)
Clin Chim Acta. 2023 Nov 29:117681. doi: 10.1016/j.cca.2023.117681. Online ahead of print.NO ABSTRACTPMID:38040048 | DOI:10.1016/j.cca.2023.117681 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - December 1, 2023 Category: Chemistry Authors: Xiaowei Nie Wenjie Sheng Daorong Hou Qiang Liu Ronggen Wang Yong Tan Source Type: research

Effect of Hyperin and Icariin on steroid hormone secretion in rat ovarian granulosa cells (Erratum)
Clin Chim Acta. 2023 Nov 29:117681. doi: 10.1016/j.cca.2023.117681. Online ahead of print.NO ABSTRACTPMID:38040048 | DOI:10.1016/j.cca.2023.117681 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - December 1, 2023 Category: Chemistry Authors: Xiaowei Nie Wenjie Sheng Daorong Hou Qiang Liu Ronggen Wang Yong Tan Source Type: research

Genetics of congenital heart disease
Clin Chim Acta. 2023 Nov 28;552:117683. doi: 10.1016/j.cca.2023.117683. Online ahead of print.ABSTRACTDuring embryonic development, the cardiovascular system and the central nervous system exhibit a coordinated developmental process through intricate interactions. Congenital heart disease (CHD) refers to structural or functional abnormalities that occur during embryonic or prenatal heart development and is the most common congenital disorder. One of the most common complications in CHD patients is neurodevelopmental disorders (NDD). However, the specific mechanisms, connections, and precise ways in which CHD co-occurs with...
Source: International Journal of Clinical Chemistry - November 29, 2023 Category: Chemistry Authors: Yuanqin Zhao Wei Deng Zhaoyue Wang Yanxia Wang Hongyu Zheng Kun Zhou Qian Xu Le Bai Huiting Liu Zhong Ren Zhisheng Jiang Source Type: research