Cytoplasmic HSP90α expression is associated with perineural invasion in pancreatic cancer.
Cytoplasmic HSP90α expression is associated with perineural invasion in pancreatic cancer. Int J Clin Exp Pathol. 2014;7(6):3305-11 Authors: Jiang H, Duan B, He C, Geng S, Shen X, Zhu H, Sheng H, Yang C, Gao H Abstract Pancreatic cancer (PC) is an aggressive and devastating disease with a dismal prognosis. The study aimed to investigate the role of HSP90α and PDIA3 in patients with PC. Immunohistochemistry was performed on tissue microarrays containing 186 pairs of PC and normal pancreatic tissues to assess the expression levels of HSP90α and PDIA3. The expression levels of cytoplasm...
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Jiang H, Duan B, He C, Geng S, Shen X, Zhu H, Sheng H, Yang C, Gao H Tags: Int J Clin Exp Pathol Source Type: research

Phosphorylation status of Akt and caspase-9 in gastric and colorectal carcinomas.
In this study, we investigated the expression of phosphorylated (p)-Akt and phosphorylated (p)-caspase-9 in gastric and colorectal carcinoma and the relationship between p-Akt and p-caspase-9 expression and clinicopathological parameters of gastric and colorectal cancer patients. In total, 75 samples of advanced gastric adenocarcinoma (37 well-to-moderately differentiated and 38 poorly differentiated) and 76 samples of advanced colorectal adenocarcinoma (69 well-to-moderately differentiated and 7 poorly differentiated) were analyzed for p-Akt and p-caspase-9 expression by immunohistochemistry. Our results reveal a correlat...
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Sangawa A, Shintani M, Yamao N, Kamoshida S Tags: Int J Clin Exp Pathol Source Type: research

Up-regulation of miR-630 in clear cell renal cell carcinoma is associated with lower overall survival.
Abstract INTRODUCTION: MicroRNAs (miRNAs) are noncoding RNAs that regulate multiple cellular processes during cancer progression. MiR-630 has recently been identified to be involved in tumorigenesis of several cancers such as lung cancer and gastric cancer. However, the regulation of miR-630 in clear cell renal cell carcinoma (ccRCC) has not yet been reported before. METHODS: Expression of miR-630 was evaluated by quantitative real-time PCR in tumour and their normal matched tissues in n = 92 ccRCC patients, and its association with overall survival of patients was analyzed by statistical analysis. RESUL...
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Zhao JJ, Chen PJ, Duan RQ, Li KJ, Wang YZ, Li Y Tags: Int J Clin Exp Pathol Source Type: research

Protective effects of bifidobacterial adhesin on intestinal mucosa of stressed male rats via modulation of inflammation.
This study aimed to assess BA impact on inflammation markers and repair of intestinal mucosa. Forty-eight rats were randomly divided into stress (n = 24) and BA (n = 24) groups. Stress was induced by fettering in all animals, fed enterally with 125.4 kJ/kg/d and 0.2 g/kg/d nitrogen. Then, rats were treated for 8 days with 5 mg/kg/d BA (BA group) or 5 mg/kg/d saline (Stress group). Levels of NF-κB, IL-10, TNF-α, and IFN-γ were measured at different time points, in plasma and intestinal mucosa samples. Changes in intestinal mucosa morphology were observed by electron microscopy. Plasma and/or mucosal levels...
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Shu XL, Yu TT, Kang K, Xu H, Lei T Tags: Int J Clin Exp Pathol Source Type: research

Small cell carcinoma of the endometrium: a case report with emphasis on the cytological features.
PMID: 25031757 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Ishida M, Iwamoto N, Nakagawa T, Kaku S, Iwai M, Kagotani A, Takahashi K, Murakami T, Okabe H Tags: Int J Clin Exp Pathol Source Type: research

Three-year follow-up results for non-surgical root canal therapy of idiopathic external root resorption on a maxillary canine with MTA: a case report.
Abstract External root resorption (ERR) is an uncommon and intractable disease. Treatment alternatives are case-dependant and aim for the repair of the resorptive lesion and long-term retention of the tooth. A forty-year-old Asian female was diagnosed with idiopathic ERR on tooth #11 (the left maxillary canine) by CBCT. Non-surgical root canal therapy was completed with the aid of an operating microscope. The apical third of the root canal was filled with warm gutta-percha and the resorption defect was filled with mineral trioxide aggregate (MTA). The periapical radiographs were taken immediately after operation, ...
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Huang Z, Chen LL, Wang CY, Dai L, Cheng B, Sun J, Sun J Tags: Int J Clin Exp Pathol Source Type: research

Intraneural perineurioma affecting multiple nerves: a case report and literature review.
We describe the clinical presentation, magnetic resonance (MR) neurography characteristics, and pathological characteristics. The differential diagnosis with other diseases, such as neurofibroma, Schwannomatosis and HNPP, will also be discussed. We also review the literature in efforts to highlight recent studies on intraneural perineurioma and heighten and awareness for the possible presentations of this disorder. PMID: 25031759 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Wang LM, Zhong YF, Zheng DF, Sun AP, Zhang YS, Dong RF, Pan Y Tags: Int J Clin Exp Pathol Source Type: research

An autopsy case of infantile-onset vanishing white matter disease related to an EIF2B2 mutation (V85E) in a hemizygous region.
We report a rare autopsy case of early infantile-onset vanishing white matter disease, with a submicroscopic deletion of 14q24.3, which included EIF2B2 and a missense mutation of EIF2B2 (V85E) of the remaining allele. The patient was a 4-year-old boy, who was found to have suddenly died during sleep. Physical and mental development began to deteriorate after convulsions at 10 month of age, and did not recover to baseline measurements. At autopsy, the brain showed a marked decrease in volume of white matter, with no typical cystic rarefaction. Histopathologically, the affected white matter showed diffuse loss of myelin fibe...
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Hata Y, Kinoshita K, Miya K, Hirono K, Ichida F, Yoshida K, Nishida N Tags: Int J Clin Exp Pathol Source Type: research

Intravascular large B-cell lymphoma with pontine involvement successfully treated with R-CHOP therapy and intrathecal administration: a case report and review of literature.
Abstract A 46-year-old man developed a fever and cough, and computed tomography showed multiple, nodular infiltrative shadows in lungs. He was diagnosed as having intravascular large B-cell lymphoma (IVLBCL). Brain magnetic resonance imaging (MRI, T2W1) showed an abnormal signal area in the pons, which was IVLBCL involvement. R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) therapy and intrathecal (I.T.) injection of methotrexate, cytarabine and prednisolone were selected. Complete remission (CR) was achieved and pontine involvement disappeared. A total of 8 courses of R-CHOP therap...
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Sekiguchi Y, Shimada A, Imai H, Wakabayashi M, Sugimoto K, Nakamura N, Sawada T, Komatsu N, Noguchi M Tags: Int J Clin Exp Pathol Source Type: research

Perineal lipoblastoma: a case report and review of literature.
We describe a case of 3-year-old girl with a lipoblastoma arising from perineum. An approximately 4.5 cm × 3.5 cm × 2.5 cm nodule was resected in left perineum with satisfied results. Pathological examination showed that it was composed of small lobules of mature and immature fat cells, separated by fibrous septa containing small dilated blood vessels. The left perineal lipoblastoma, although rare, should be differentiated from some other mesenchymal tumors with similar histologic and cytological features. PMID: 25031762 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Liu Q, Xu Z, Mao S, Zeng R, Chen W, Lu Q, Guo Y, Liu J Tags: Int J Clin Exp Pathol Source Type: research

Pseudomembranous trigonitis in a male with Klinefelter syndrome: a case report and evidence of a hormonal etiology.
We report a 16 year old boy with Klinefelter syndrome presenting to our institution with gross hematuria. Cystoscopy and biopsy revealed the diagnosis of pseudomembranous trigonitis. Immunohistochemical stains showed an increase in estrogen and progesterone receptors in the trigone area but not in the rest of the bladder. In view of the patient's mildly raised estrogen levels and the histological findings, we postulate that estrogen is the driver of the development of pseudomembranous trigonitis. This is the first reported case of pseudomembranous trigonitis seen in association with Klinefelter syndrome, and also the first...
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Lian DW, Li FX, Ong CC, Kuick Ch, Chang KT Tags: Int J Clin Exp Pathol Source Type: research

Gastroblastoma in a 12-year-old Chinese boy.
Abstract Gastrablastoma is a rare epitheliomesenchymal biphasic tumor of stomach in children and young adults first reported by Miettinen et al in 2009. Five cases have been reported up to date including only one case with the nodal metastasis and distant metastases. With little atypism gastroblastoma is suggested to be a low-grade malignancy. Here we report one case of gastroblastoma in a 12-year-old boy with review of the literature. This is the first case of gastroblastoma in Chinese to our knowledge. PMID: 25031764 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Ma Y, Zheng J, Zhu H, Dong K, Zheng S, Xiao X, Chen L Tags: Int J Clin Exp Pathol Source Type: research

Primary multiple clear cell variant urothelial carcinomas of urinary bladder: a rare case report.
Abstract Clear cell variant urothelial carcinoma of urinary bladder was very rare. There were only 6 report articles included by Pubmed and total 8 cases had been described till now. All of the past reports described single tumor of urinary bladder, but multiple carcinomas had not been reported. Here we reported a 65-years-old Chinese man who complained of intermittent gross hematuria and odynuria for more than 2 months in January 2013. Only one cauliflower-like tumor was detected approximately in the left wall of the urinary bladder with cystoscopy and the biopsy specimen was diagnosed as "urothelial carcino...
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Zhang Y, Huang J, Feng H, Tang Y Tags: Int J Clin Exp Pathol Source Type: research

Expression of autophagy related proteins in invasive lobular carcinoma: comparison to invasive ductal carcinoma.
Abstract The aim of this study is to compare the expression of autophagy related proteins in invasive lobular carcinoma (ILC) with that of autophagy related proteins in invasive ductal carcinoma (IDC), and to determinate its implication. Tissue microarray containing 114 ILC and 692 IDC was constructed, and immunohistochemistry was performed for autophagy related protein (beclin-1, LC3A, LC3B, p62) and Ki-67. No significant difference in expression of autophagy-related proteins between pleomorphic type (n = 12) and classic type (n = 102) of ILC was observed, whereas ILC and IDC showed distinguished features that tu...
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Cha YJ, Kim YH, Cho NH, Koo JS Tags: Int J Clin Exp Pathol Source Type: research

Features of intraventricular tanycytic ependymoma: report of a case and review of literature.
We report here another case of tanycytic ependymoma arising from the third ventricle completed with immunohistochemical, ultrastructural, and molecular pathology study. The patient was a 44 year-old male who presented with headache, nausea and visual disturbances of a few months duration. Neuroradiological findings showed a well-defined mass arising from the posterolateral wall of third ventricle. Histologically the tumor was composed of monotonous spindle cells arranged in fascicles without definitive perivascular rosettes. The tumor cells were diffusely positive for glial fibrillary acidic protein and epithelial membrane...
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Agarwal S, Stevenson ME, Sughrue ME, Wartchow EP, Mierau GW, Fung KM Tags: Int J Clin Exp Pathol Source Type: research

Rosai-Dorfman disease of the pericardium: a case report and review of literature.
We describe here a unique case of extranodal RDD manifesting as a pericardial mass in a 69-year-old man. The lesion was detected by computed tomography during a periodic examination of the chest. Subsequently positron emission tomography scan showed mild increase of flurodeoxyglucose uptake. Clinically, it was supposed to be a mesothelioma. Histological examination showed the typical features of RDD confirmed by the staining of S100 protein, which highlighted the emperipolesis of the characteristic histiocytes. To the best of our knowledge, pericardial RDD represents an extremely rare condition and should be included in th...
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Lao IW, Dong Y, Wang J Tags: Int J Clin Exp Pathol Source Type: research

HHV-6-associated acute lymphadenitis in immunocompetent patients: a case report and review of literature.
We report an immunocompetent adult with HHV-6-associated acute lymphadenitis. The patient was an elderly man who presented with fever and generalized lymphadenopathy. Microscopically, the lymph node showed diffuse paracortical expansion and scattered large atypical lymphoid cells with large nucleus and eosinophilic nucleoli, resembled immunoblasts. Intranuclear eosinophilic viral inclusions can be found. Immunohistochemical study showed that the large atypical lymphoid cells were positive for CD3 and CD4, but negative for CD8, CD20, CD79a, CD30, ALK, CK, EBV-LMP, and CD56. The antibody against HHV-6 envelope glycoprotein h...
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Bai Y, Wang Z, Sun K, Yao H Tags: Int J Clin Exp Pathol Source Type: research

Multilocular bronchogenic cyst of the bilateral adrenal: report of a rare case and review of literature.
CONCLUSIONS: This report confirms the bronchogenic cyst that can be involved bilateral joint in the adrenal gland. And we demonstrated retroperitoneoscopic surgical management is effective in the treatment of the disease. PMID: 25031770 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Cao DH, Zheng S, Lv X, Yin R, Liu LR, Yang L, Huang Y, Wei Q Tags: Int J Clin Exp Pathol Source Type: research

Six cases of aggressive natural killer-cell leukemia in a Chinese population.
In conclusion, four cases experienced an aggressive clinical course whereas two demonstrated an indolent manifestation of their disease. New therapeutic regimens including allo-BMT should be optimized in order to improve outcomes of this disease. PMID: 25031771 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Zhang Q, Jing W, Ouyang J, Zeng H, George SK, Liu Z Tags: Int J Clin Exp Pathol Source Type: research

Development of angioimmunoblastic T-cell lymphoma after treatment of diffuse large B-cell lymphoma: a case report and review of literature.
Abstract Cases of diffuse large B-cell lymphoma (DLBCL) arising after the initial diagnosis of angioimmunoblastic T-cell lymphoma (AITL) and DLBCL synchronous with AITL have been reported. To date, there is no report on the subsequent development of AITL in patients with DLBCL. Here we presented a rare case of AITL developing six months after the initial diagnosis of DLBCL. In order to investigate the clinical and molecular features of patients with AITL and DLBCL, we also reviewed the literature on AITL patients developing DLBCL, and patients with composite AITL and DLBCL. PMID: 25031772 [PubMed - in process...
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Wang Y, Xie B, Chen Y, Huang Z, Tan H Tags: Int J Clin Exp Pathol Source Type: research

Mast cell leukemia with prolonged survival on PKC412/midostaurin.
We report a MCL case in a 71 year-old woman with high tumor load at the initial presentation in 2005, who did not respond to either interleukin-2 or dasatinib therapy. After enrolled in a clinical trial of PKC412 (or Midostaurin) with a daily dose of 100 mg, the patient responded well to PKC412 and became transfusion independent in three months. Since then, her disease had been stably controlled. This is the first report of a high-tumor-load MCL case which achieved prolonged survival (101 months) by PKC 412. The 101-month overall survival is the longest among reported MCL cases in the English literature. PMID: 2503177...
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Xu X, Kreisel FH, Frater JL, Hassan A Tags: Int J Clin Exp Pathol Source Type: research

Solitary fibrous tumor of the central nervous system: report of 2 cases and review of literature.
Abstract Solitary fibrous tumors (SFTs) rarely occur in the central nervous system (CNS). Involvement of the brainstem and pineal gland is rarely recorded. Herein, we represent 2 cases of SFTs and firstly report SFT of the pineal gland. Cranial MR imaging showed isointense to hypointense signal intensity, and marked enhancement. Microscopically, the tumors showed characteristic "patternless-pattern" architecture. Elongated tumour cells formed fascicles alternating with hypocellular densely collagenous stroma. Immunohistochemistry for CD34, BCL2, and CD99 favors the definitive diagnosis of SFT. It is diff...
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Wen G, Li M, Xu L, Hu P, Liao X, Lin C, Zhao L Tags: Int J Clin Exp Pathol Source Type: research

Pulmonary mucormycosis with embolism: two autopsied cases of acute myeloid leukemia.
Abstract Mucormycosis is an increasingly important cause of morbidity and mortality for patients with hematological malignancies. The diagnosis of mucormycosis usually requires mycological evidence through tissue biopsy or autopsy because the signs and symptoms are nonspecific and there are currently no biomarkers to identify the disease. We herein present two autopsied cases of acute myeloid leukemia with prolonged neutropenia who developed invasive mucormycosis accompanied by pulmonary artery embolism. Our cases were featured by unexplained fever and rapidly progressive dyspnea. Computed tomography scan detected...
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Kogure Y, Nakamura F, Shinozaki-Ushiku A, Watanabe A, Kamei K, Yoshizato T, Nannya Y, Fukayama M, Kurokawa M Tags: Int J Clin Exp Pathol Source Type: research

Paneth cell-like change in benign prostate can account for P504S (AMACR) reactivity.
Abstract Paneth cell-like neuroendocrine metaplasia of benign and cancerous prostate was described in 1992. Here, we note that P504S (AMACR), the cytoplasmic marker for prostate cancer used alone or in concert with basal cell markers, can be strongly reactive in benign prostatic acini with Paneth cell-like change. PMID: 25031776 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Iczkowski KA Tags: Int J Clin Exp Pathol Source Type: research

Pigmented anal squamous intraepithelial neoplasia: a case report and review of literature.
PMID: 25031777 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Ishida M, Iwai M, Kagotani A Tags: Int J Clin Exp Pathol Source Type: research

Blocking TRAIL-DR5 signaling with soluble DR5 alleviates acute kidney injury in a severely burned mouse model.
Abstract Acute kidney injury (AKI) predicts high mortality in severely burned patients. Apoptosis plays a significant role during AKI; however, the apoptotic mechanisms underlying AKI induced by burn injury are not clear. Here, we report a critical role for tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-Death receptor 5 (DR5) signaling in the pathogenesis of AKI. C57BL/6 male mice were subjected to full thickness scald burn. Apoptosis was significantly up-regulated in mouse kidney 24 h after the burn. Meanwhile, the TRAIL and DR5 expression levels were significantly increased in the kidney 2...
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Leng X, Zhang Q, Chen Z, Wang D Tags: Int J Clin Exp Pathol Source Type: research

MT2-MMP expression associates with tumor progression and angiogenesis in human lung cancer.
Abstract Matrix metalloproteinases (MMPs) are a family of important proteolytic enzymes that play an important role in the remodeling of the tumor microenvironment and associate with tumorigenesis and metastasis. We previously reported that membrane type-2 MMP (MT2-MMP) is highly expressed in human esophageal cancer tissues, and its expression level is positively correlated to tumor size and intratumoral angiogenesis. In order to reveal whether MT2-MMP expression is operative in human lung cancer and its underlying physio-pathological role, in the present study, we examined both mRNA and protein expression levels ...
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Chen L, Zhou Q, Xu B, Liu J, Shi L, Zhu D, Wu C, Jiang J Tags: Int J Clin Exp Pathol Source Type: research

miR-21 inhibitor suppresses proliferation and migration of nasopharyngeal carcinoma cells through down-regulation of BCL2 expression.
This study is to investigate the expression of miR-21 in nasopharyngeal carcinoma (NPC) cells, and the effect of miR-21 in the biological behavior and expression of B-cell lymphoma 2 (BCL2) in NPC cells. Paired NPC and adjacent non-tumor tissues were obtained from 53 patients who underwent primary surgical resection of NPC tissues. Luciferase reporter assay was performed to test whether BCL2 is a direct target of miR-21. Methylthiazolyl blue tetrazolium assay and colony assay were used to evaluate the effect of miR-21 on NPC cell proliferation. Transwell and wound-healing assays were carried out to test the effect of low e...
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Li Y, Yan L, Zhang W, Wang H, Chen W, Hu N, Ou H Tags: Int J Clin Exp Pathol Source Type: research

Analysis of male reproductive parameters in a murine model of mucopolysaccharidosis type I (MPS I).
Abstract Mucopolysaccharidosis (MPS) I is a lysosomal storage disorder (LSD) that is characterised by alpha-L-iduronidase (Idua) deficiency and continuous deposition of glycosaminoglycans (GAGs), which consequently interferes with cell signalling mechanisms and results in multisystemic and progressive symptoms. The animal model of MPS I (Idua-/-) has been widely studied to elucidate the consequences and progression of the disorder; however, studies specifically assessing the male reproductive tract are lacking. The aim of this study was to evaluate some of the reproductive characteristics of male MPS I mice in two...
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: do Nascimento CC, Junior OA, D'Almeida V Tags: Int J Clin Exp Pathol Source Type: research

Increased expression of miRNA-182 in colorectal carcinoma: an independent and tissue-specific prognostic factor.
In this study, we investigated the status of miR-182 expression in colorectal carcinoma (CRC) by in situ hybridization and its underlying clinicopathologic significance for patients with CRC. We found that 79/138 (57.25%) CRCs had high-level expression of miR-182, while 17/67 (25.37%) normal mucosa tissues had high-level expression of miR-182. The expression level of miR-182 was remarkably up-regulated in CRC tissues compared with non-neoplastic normal tissues (P
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Wang S, Yang MH, Wang XY, Lin J, Ding YQ Tags: Int J Clin Exp Pathol Source Type: research

"Int J Clin Exp Pathol"[ta]; +101 new citations
101 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[ta] These pubmed results were generated on 2014/06/28PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 28, 2014 Category: Pathology Tags: Report Source Type: research

Screening, management and surveillance for the sessile serrated adenomas/polyps.
Abstract The incidence and mortality rates from right-sided colorectal cancers (CRCs) have not decreased, compared with the significant reduction of CRCs in the left colon in recent years. It is likely that a significant proportion of right-sided CRCs evolve from undetected sessile serrated adenomas/polyps (SSA/Ps) in the primary colonoscopy. Increasing evidences suggest that SSA/Ps are high-risk lesions, with 15% of the SSA/P patients developing subsequent CRCs or adenomas with high-grade dysplasia. However, there are many issues in the screening, management and surveillance of SSA/Ps. Based on new evidences, thi...
Source: International Journal of Clinical and Experimental Pathology - May 15, 2014 Category: Pathology Authors: Fu X, Qiu Y, Zhang Y Tags: Int J Clin Exp Pathol Source Type: research

Long non-coding RNAs as novel biomarkers and therapeutic targets in head and neck cancers.
Abstract Long non-coding RNAs (lncRNAs) are generally defined as RNA molecules greater than 200 nt in length and without protein-coding property that different from housekeeping RNAs such as tRNAs, rRNAs, and snRNAs, and independent from small RNAs with specific molecular processing machinery such as micro- or piwi-RNAs. LncRNAs are a novel class of mRNA-like transcripts which contribute to cancer development and progression and accelerate cancer cells proliferation, invasion, metastasis, and apoptosis. These research results indicate the potential of lncRNAs as prospective novel biomarkers for diagnosis, therapeu...
Source: International Journal of Clinical and Experimental Pathology - May 15, 2014 Category: Pathology Authors: Yang QQ, Deng YF Tags: Int J Clin Exp Pathol Source Type: research

Clarifying the nomenclature of intervertebral disc degeneration and displacement: from bench to bedside.
Abstract As a significant determinant of low back pain, intervertebral disc degeneration (IDD) has attracted more and more attention of both investigators and physicians. Disc herniation, termed as intervertebral disc displacement, is amongst the most prevalent spinal diseases closely linked with IDD. Due to the same origins and similar pathophysiology, the ambiguity regarding the similarity and difference of IDD and intervertebral disc displacement thus remains. The aim of this study was to clarify the nomenclature of IDD and disc herniation in terms of molecular etiology, pathophysiology, nature history and clin...
Source: International Journal of Clinical and Experimental Pathology - May 15, 2014 Category: Pathology Authors: Wang HQ, Samartzis D Tags: Int J Clin Exp Pathol Source Type: research

Valproic acid overcomes transforming growth factor-β-mediated sorafenib resistance in hepatocellular carcinoma.
Valproic acid overcomes transforming growth factor-β-mediated sorafenib resistance in hepatocellular carcinoma. Int J Clin Exp Pathol. 2014;7(4):1299-313 Authors: Matsuda Y, Wakai T, Kubota M, Osawa M, Hirose Y, Sakata J, Kobayashi T, Fujimaki S, Takamura M, Yamagiwa S, Aoyagi Y Abstract Sorafenib is a multi-kinase inhibitor approved for hepatocellular carcinoma, but rarely causes tumor regression in patients with chronic liver diseases. To investigate whether growth factor-mediated signaling is involved in sorafenib resistance, HepG2 and PLC/PRF/5 hepatoma cells were exposed to epidermal growth ...
Source: International Journal of Clinical and Experimental Pathology - May 15, 2014 Category: Pathology Authors: Matsuda Y, Wakai T, Kubota M, Osawa M, Hirose Y, Sakata J, Kobayashi T, Fujimaki S, Takamura M, Yamagiwa S, Aoyagi Y Tags: Int J Clin Exp Pathol Source Type: research

Cardiac troponin I is abnormally expressed in non-small cell lung cancer tissues and human cancer cells.
Abstract Cardiac troponin I (cTnI) is the only sarcomeric protein identified to date that is expressed exclusively in cardiac muscle. Its expression in cancer tissues has not been reported. Herein, we examined cTnI expression in non-small cell lung cancer (NSCLC) tissues, human adenocarcinoma cells SPCA-1 (lung) and BGC 823 (gastric) by immunohistochemistry, western blot analysis and real-time PCR. Immunopositivity for cTnI was demonstrated in 69.4% (34/49) NSCLC tissues evaluated, and was strong intensity in 35.3% (6/17) lung squamous cell carcinoma cases. The non-cancer-bearing lung tissues except tuberculosis (...
Source: International Journal of Clinical and Experimental Pathology - May 15, 2014 Category: Pathology Authors: Chen C, Liu JB, Bian ZP, Xu JD, Wu HF, Gu CR, Shi Y, Zhang JN, Chen XJ, Yang D Tags: Int J Clin Exp Pathol Source Type: research

Expression profiling of long noncoding RNAs and the dynamic changes of lncRNA-NR024118 and Cdkn1c in angiotensin II-treated cardiac fibroblasts.
In conclusion, the expression profile of lncRNAs was significantly altered in the Ang II-treated cardiac fibroblasts and Ang II dynamically regulated the expression of lncRNA-NR024118 and Cdkn1c in cardiac fibroblasts, indicating the potential role of NR024118 in cardiac fibroblasts. PMID: 24817929 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - May 15, 2014 Category: Pathology Authors: Jiang XY, Ning QL Tags: Int J Clin Exp Pathol Source Type: research

Increasing the cytotoxicity of doxorubicin in breast cancer MCF-7 cells with multidrug resistance using a mesoporous silica nanoparticle drug delivery system.
Abstract Resistance to cytotoxic chemotherapy is the main cause of therapeutic failure and death in women with breast cancer. Overexpression of various members of the superfamily of adenosine triphosphate binding cassette (ABC)-transporters has been shown to be associated with multidrug resistance (MDR) phenotype in breast cancer cells. MDR1 protein promotes the intracellular efflux of drugs. A novel approach to address cancer drug resistance is to take advantage of the ability of nanocarriers to sidestep drug resistance mechanisms by endosomal delivery of chemotherapeutic agents. Doxorubicin (DOX) is an anthracyc...
Source: International Journal of Clinical and Experimental Pathology - May 15, 2014 Category: Pathology Authors: Wang X, Teng Z, Wang H, Wang C, Liu Y, Tang Y, Wu J, Sun J, Wang H, Wang J, Lu G Tags: Int J Clin Exp Pathol Source Type: research

SERPINA3 promotes endometrial cancer cells growth by regulating G2/M cell cycle checkpoint and apoptosis.
Abstract Endometrial carcinoma (EC) is the most common gynecologic cancer worldwide and is one of the leading causes of death in women. Therefore, it is urgent to elucidate the pathological mechanisms of EC. SERPINA3 is a member of the serpin super-family of protease inhibitors. Its aberrant expression has been observed in various tumor cells. However, its clinical significance and biological function in endometrial cancer remains unknown. In the present study, we demonstrated that SERPINA3 expression was significantly up-regulated in EC samples and was closely correlated with lower differentiation, higher stage, ...
Source: International Journal of Clinical and Experimental Pathology - May 15, 2014 Category: Pathology Authors: Yang GD, Yang XM, Lu H, Ren Y, Ma MZ, Zhu LY, Wang JH, Song WW, Zhang WM, Zhang R, Zhang ZG Tags: Int J Clin Exp Pathol Source Type: research

WNT3A gene expression is associated with isolated Hirschsprung disease polymorphism and disease status.
Abstract WNT3A has been regarded as an activator of the canonical Wnt signaling pathway. It has been found Wnt signaling pathway is closely related with embrionic development and Hirschsprung disease (HSCR). A common haplotype consisting of minor SNPs alleles located in the WNT3A gene has been described as a risk factor for various genetic disorders. However, whether WNT3A contributes to the onset of HSCR has not been identified. The present study aims to detect the interactions of genetic variations in the WNT3A gene and examine the biological expression levels with Hirschsprung disease (HSCR) in the Chinese peop...
Source: International Journal of Clinical and Experimental Pathology - May 15, 2014 Category: Pathology Authors: Chen D, Mi J, Liu X, Zhang J, Wang W, Gao H Tags: Int J Clin Exp Pathol Source Type: research

Early articular cartilage degeneration in a developmental dislocation of the hip model results from activation of β-catenin.
The objective of this study was to verify the relationship between β-catenin and DDH cartilage degeneration. We used a DDH model that was established by modification of swaddling position in newborn Wistar rats. The hips were isolated from the DDH model rats and untreated control group at the age of 2, 4, 6 and 8 weeks. β-Catenin gene and protein were investigated by quantitative (q)RT-PCR and immunohistochemistry. Collagen X and matrix metalloproteinase (MMP)-13, markers of early cartilage degeneration, were assessed by qRT-PCR. Primary chondrocytes were cultured from cartilage of two groups at the age of 8 week...
Source: International Journal of Clinical and Experimental Pathology - May 15, 2014 Category: Pathology Authors: Ning B, Sun J, Yuan Y, Yao J, Wang P, Ma R Tags: Int J Clin Exp Pathol Source Type: research

Cyclosporine A improves adhesion and invasion of mouse preimplantation embryos via upregulating integrin β3 and matrix metalloproteinase-9.
In conclusion, CsA in low dosage up-regulates itgβ3 and MMP-9 expression, and enhances embryonic adhesion and invasion, which is beneficial to the embryo implantation. PMID: 24817934 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - May 15, 2014 Category: Pathology Authors: Huang YH, Ma YL, Ma L, Mao JL, Zhang Y, Du MR, Li DJ Tags: Int J Clin Exp Pathol Source Type: research

Heterogeneity of microRNAs expression in cervical cancer cells: over-expression of miR-196a.
oacute;mez-Gutiérrez G, Román-Bassaure E, Salcedo M Abstract In recent years, the study of microRNAs associated with neoplastic processes has increased. Patterns of microRNA expression in different cell lines and different kinds of tumors have been identified; however, little is known about the alterations in regulatory pathways and genes involved in aberrant set of microRNAs. The identification of these altered microRNAs in several cervical cancer cells and potentially deregulated pathways involved constitute the principal goals of the present study. In the present work, the expression profiles of c...
Source: International Journal of Clinical and Experimental Pathology - May 15, 2014 Category: Pathology Authors: Villegas-Ruiz V, Juárez-Méndez S, Pérez-González OA, Arreola H, Paniagua-García L, Parra-Melquiadez M, Peralta-Rodríguez R, López-Romero R, Monroy-García A, Mantilla-Morales A, Gómez-Gutiérrez G, Román-Bassaure E, Salcedo M Tags: Int J Clin Exp Pathol Source Type: research

NCAM and FGFR1 coexpression and colocalization in renal tumors.
ski J Abstract Neural cell adhesion molecule (NCAM) and fibroblast growth factor receptor (FGFR) have a role in epithelial-mesenchymal transformation during tumor genesis. Interplay between both molecules activates FGFR signaling and it could be responsible for tumor development. Renal epithelial tumors were analyzed for FGFR1 and NCAM coexpression by immunohistochemistry and for colocalization of these molecules on the particular tumor cells by triple immunofluorescence. Detection of NCAM isoforms in renal tumors was evaluated by RT-PCR. Applying immunohistochemistry we revealed that the majority of analyzed rena...
Source: International Journal of Clinical and Experimental Pathology - May 15, 2014 Category: Pathology Authors: Cirović S, Vještica J, Mueller CA, Tatić S, Vasiljević J, Milenković S, Mueller GA, Marković-Lipkovski J Tags: Int J Clin Exp Pathol Source Type: research

Comparison of the efficacy of bone marrow mononuclear cells and bone mesenchymal stem cells in the treatment of osteoarthritis in a sheep model.
Abstract OBJECTIVE: To evaluate the therapeutic efficacy of uncultured bone marrow mononuclear cells (BMMCs) and bone mesenchymal stem cells in an osteoarthritis (OA) model of sheep. METHODS: Induction of sheep OA was performed surgically through anterior cruciate ligament transection and medial meniscectomy. After 12 weeks, concentrated BMMCs obtained from autologous bone marrow harvested from anterior iliac crest or a single dose of 10 million autologous bone mesenchymal stem cells (BMSCs) suspended in phosphate-buffered saline (PBS) was delivered to the injured knee via direct intra-articular injection. An...
Source: International Journal of Clinical and Experimental Pathology - May 15, 2014 Category: Pathology Authors: Song F, Tang J, Geng R, Hu H, Zhu C, Cui W, Fan W Tags: Int J Clin Exp Pathol Source Type: research

Pregnancy-associated plasma protein A up-regulated by progesterone promotes adhesion and proliferation of trophoblastic cells.
Abstract Embryo implantation and development is a complex biological process for the establishment of the successful pregnancy. Progesterone is a critical factor in the regulation of embryo adhesion to uterine endometrium and proliferation. Although it has been reported that pregnancy-associated plasma protein A (PAPPA) is increased in pregnant women, the relationship between progesterone and PAPPA, and the effects of PAPPA on embryo adhesion and proliferation are still not clear. The present results showed that the serum level of progesterone and PAPPA was closely correlated by ELISA assay (p
Source: International Journal of Clinical and Experimental Pathology - May 15, 2014 Category: Pathology Authors: Wang J, Liu S, Qin HM, Zhao Y, Wang XQ, Yan Q Tags: Int J Clin Exp Pathol Source Type: research

Features of gastric glomus tumor: a clinicopathologic, immunohistochemical and molecular retrospective study.
Abstract Glomus tumor (GT) of the stomach is a rare mesenchymal tumor. There have been few detailed studies on these tumors. A total of 1894 cases of resected gastric mesenchymal tumors were collected and eleven confirmed gastric GTs were studied. The clinical, pathological, immunohistochemical, ultrastructural and molecular characteristics of the tumors were analyzed through a retrospective study. Histologically, most tumors had gastric smooth muscle immediately adjacent and surrounding the tumor. Tumor cells around blood vessels were small, uniform, and round. Foci of hyaline and myxoid changes were observed. Pr...
Source: International Journal of Clinical and Experimental Pathology - May 15, 2014 Category: Pathology Authors: Wang ZB, Yuan J, Shi HY Tags: Int J Clin Exp Pathol Source Type: research

AKT/ERK activation is associated with gastric cancer cell resistance to paclitaxel.
Abstract Paclitaxel (PTX) has shown encouraging activity in the treatment of advanced gastric cancer (GC). However, the fact that more than half of GC patients respond poorly to PTX-based chemotherapies demonstrates the urgent need for biomarkers of PTX sensitivity in GC patients. In the present work, three GC cell lines (BGC-823, HGC-27 and NCI-N87) with different sensitivities to PTX were subjected to DNA microarray analysis. The significantly differentially expressed genes and microRNAs (miRs) were identified and pathway signatures for PTX sensitivity were proposed. Ingenuity Pathway Analysis results showed tha...
Source: International Journal of Clinical and Experimental Pathology - May 15, 2014 Category: Pathology Authors: Wu G, Qin XQ, Guo JJ, Li TY, Chen JH Tags: Int J Clin Exp Pathol Source Type: research

Lepidic and micropapillary growth pattern and expression of Napsin A can stratify patients of stage I lung adenocarcinoma into different prognostic subgroup.
Abstract Histologic categories and related growth pattern proposed by IASLC/ATS/ERS classification has been reported to be prognostically important in lung adenocarcinoma. Thyroid transcription factor-1 (TTF1) and Napsin A have been investigated as potential prognostic parameters with conflicting results. A total of 211 cases with stage I lung adenocarcinoma were analyzed according to the IASLC/ATS/ERS classification with slight modifications. Expression levels of TTF1 and Napsin A were evaluated by immunohistochemistry. In univariate analyses, we found female sex (p=0.009), lepidic growth pattern (P=0.011) and la...
Source: International Journal of Clinical and Experimental Pathology - May 15, 2014 Category: Pathology Authors: Yang X, Liu Y, Lian F, Guo L, Wen P, Liu XY, Lin DM Tags: Int J Clin Exp Pathol Source Type: research

Ultrastructural features of endometrial-myometrial interface and its alteration in adenomyosis.
In conclusions, there are significant ultrastructural differences between the myocytes from EMI and OM. The myocytes in women with adenomyosis were significantly different to the control subjects, primarily because the normal cyclical changes were absent. PMID: 24817942 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - May 15, 2014 Category: Pathology Authors: Zhang Y, Zhou L, Li TC, Duan H, Yu P, Wang HY Tags: Int J Clin Exp Pathol Source Type: research