Effect of prostaglandin reductase 1 (PTGR1) on gastric carcinoma using lentivirus-mediated system [Retraction].
Authors: Abstract [This retracts the article on p. 14493 in vol. 8, PMID: 26823768.]. PMID: 29874340 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 7, 2018 Category: Pathology Tags: Int J Clin Exp Pathol Source Type: research

Inhibitory effect of chloroquine derivatives on presenilin 1 and ubiquilin 1 expression in Alzheimer's disease [Retraction].
Authors: Abstract [This retracts the article on p. 7640 in vol. 8, PMID: 26261684.]. PMID: 29874341 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 7, 2018 Category: Pathology Tags: Int J Clin Exp Pathol Source Type: research

Primary parotid adenocarcinoma metastasis to the spleen with PIK3CA mutation: cytological findings and review of the literature.
Conclusion: Based on our review of the literature, we believe that this is the first report of such a case. Accurate diagnosis and molecular characterization of the splenic metastasis have a critical impact on the clinical management of the patient. PMID: 29263768 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - December 22, 2017 Category: Pathology Authors: Inouye CM, Anagnostou V, Li QK Tags: Int J Clin Exp Pathol Source Type: research

"Int J Clin Exp Pathol"[ta]; +229 new citations
229 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[ta] These pubmed results were generated on 2016/01/30PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - January 30, 2016 Category: Pathology Tags: Report Source Type: research

"Int J Clin Exp Pathol"[ta]; +230 new citations
230 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[ta] These pubmed results were generated on 2016/01/13PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - January 14, 2016 Category: Pathology Tags: Report Source Type: research

Altered expression profile of apoptosis-related molecules correlated with clinicopathological factors in non-small-cell lung cancer.
This study was aimed to observe the expression patterns of apoptosis-related molecules in lung cancer and paired non-cancerous tissues, and to observe if there is a correlation between the expression of these apoptotic molecules and clinicopathologic parameters. Immunohistochemistry (IHC) was performed to analyze the expression level of CASP3, CASP8, CASP9, PARP1, Cleaved CASP3 (C-CASP3), Cleaved PARP1 (C-PARP1), XIAP, BIRC5 (Survivin) and BCL2 in lung cancer and paired non-cancerous tissues. We found that apoptosis-related molecules CASP3, CASP9, BCL2, BIRC5 and PARP1 are abnormally expressed in lung cancer cells and thei...
Source: International Journal of Clinical and Experimental Pathology - December 12, 2015 Category: Pathology Authors: Huang JQ, Liang HL, Jin TE, Xie Z Tags: Int J Clin Exp Pathol Source Type: research

"Int J Clin Exp Pathol"[ta]; +269 new citations
269 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[ta] These pubmed results were generated on 2015/12/02PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - December 2, 2015 Category: Pathology Tags: Report Source Type: research

"Int J Clin Exp Pathol"[ta]; +135 new citations
135 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[ta] These pubmed results were generated on 2015/10/16PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - October 17, 2015 Category: Pathology Tags: Report Source Type: research

"Int J Clin Exp Pathol"[ta]; +127 new citations
127 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[ta] These pubmed results were generated on 2015/09/06PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 7, 2015 Category: Pathology Tags: Report Source Type: research

"Int J Clin Exp Pathol"[ta]; +208 new citations
208 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[ta] These pubmed results were generated on 2015/08/12PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 13, 2015 Category: Pathology Tags: Report Source Type: research

"Int J Clin Exp Pathol"[ta]; +215 new citations
215 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[ta] These pubmed results were generated on 2015/07/21PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - July 21, 2015 Category: Pathology Tags: Report Source Type: research

Preventing effects of joint contracture by high molecular weight hyaluronan injections in a rat immobilized knee model.
CONCLUSIONS: This study demonstrated that HMWHA injections suppressed inflammatory, fibrotic, and hypoxic conditions observed in the immobilized joint capsule. PMID: 26097527 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Kanazawa K, Hagiwara Y, Tsuchiya M, Yabe Y, Sonofuchi K, Koide M, Sekiguchi T, Itaya N, Ando A, Saijo Y, Itoi E Tags: Int J Clin Exp Pathol Source Type: research

3,4-dihydroxyphenylethanol suppresses irradiation-induced pulmonary fibrosis in adult rats.
Abstract The present study demonstrates the effect of DHPEA on suppression of irradiation-induced pulmonary fibrosis. A (60)Co irradiator was used to induce pulmonary fibrosis in a rat model at a dose of 22 Gy. The rats of the treatment and positive control group were intraperitoneally injected DHPEA (10 mg/kg) or dexamethasone (DEX; 5 mg/kg) daily for 30 days. Hydroxyproline assay was used to evaluate the fibrosis of pulmonary and lung tissue sections after irradiation. Hematoxylin and eosin (H&E) and Masson's trichrome stained lung section were used for alveolitis and fibrosis score analyses, respectively. I...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Liu ZH, Fan W, Chen RC Tags: Int J Clin Exp Pathol Source Type: research

An enterovirus 71 strain causes skeletal muscle damage in infected mice.
CONCLUSION: The EV71 clinical isolate used in this study presented evident myotropism. Skeletal muscles are important target organs for EV71 in the infected suckling mice. To clarify the relationship between EV71 infection and muscle diseases may contribute to a better understanding of the pathogenesis of EV71. PMID: 26097530 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Lin P, Gao L, Huang Y, Chen Q, Shen H Tags: Int J Clin Exp Pathol Source Type: research

Possible antiosteoporotic mechanism of Cicer arietinum extract in ovariectomized rats.
CONCLUSION: The ongoing study speculates that the CAE exerts its action through regulation of RANK/RANKL/OPG system. As, CAE not only promotes osteoblast differentiation, but also up-regulates OPG and downregulates RANKL secretion in osteoblasts, subsequently prevents bone loss and osteoporosis. PMID: 26097532 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Fahmy SR, Soliman AM, Sayed AA, Marzouk M Tags: Int J Clin Exp Pathol Source Type: research

CB2R orchestrates fibrogenesis through regulation of inflammatory response during the repair of skeletal muscle contusion.
In this study, we used selective agonist or antagonist of CB2R to observe the role of CB2R on inflammation and fibrogenesis during the repair of contused skeletal muscles in rats. Our results revealed that treatment with Gp1a, a selective CB2R agonist, significantly decreased the infiltration of neutrophils and macrophages, the expression of pro-inflammatory cytokines MCP-1, TNF-α, IL-1β and IL-6, the expression of pro-fibrotic cytokines IL-4, IL-13, TGF-β and P-Smad3 while increased anti-fibrotic cytokine IL-10 production as compared with Vehicle. The opposite results were observed in the CB2R inhibition g...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Zhang M, Jiang SK, Tian ZL, Wang M, Zhao R, Wang LL, Li SS, Liu M, Li JY, Zhang MZ, Guan DW Tags: Int J Clin Exp Pathol Source Type: research

Protective effects of calcitriol on diabetic nephropathy are mediated by down regulation of TGF-β1 and CIP4 in diabetic nephropathy rat.
Protective effects of calcitriol on diabetic nephropathy are mediated by down regulation of TGF-β1 and CIP4 in diabetic nephropathy rat. Int J Clin Exp Pathol. 2015;8(4):3503-12 Authors: Yu R, Mao J, Yang Y, Zhang Y, Tian Y, Zhu J Abstract OBJECTIVE: To explore the protective effects of calcitriol on diabetic nephropathy by modulating the expressions of transforming growth factor-beta 1 (TGF-β1) and Cdc42 interacting protein-4 (CIP4). METHODS: Streptozotocin-induced diabetic nephropathy rats (n=36) were randomly divided into control group (control-H, control-M, control-L) and calcitriol...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Yu R, Mao J, Yang Y, Zhang Y, Tian Y, Zhu J Tags: Int J Clin Exp Pathol Source Type: research

Combined cancer testis antigens enhanced prediction accuracy for prognosis of patients with hepatocellular carcinoma.
Abstract Cancer testis antigens (CTAs) are selectively expressed in malignant cells and can serve as ideal targets for immunotherapy. We investigated the expressions of MAGE-A3, MAGE-A4, MAGE-C2 and NY-ESO-1 to determine if combinatorial expressions of CTAs might be as potential prognostic markers for patients with hepatocellular carcinoma (HCC). In tumor tissues of 142 HCC patients, the mRNA expressions of MAGE-A3, MAGE-A4, MAGE-C2 and NY-ESO-1 were 78.9%, 33.8%, 74.6% and 14.1% respectively. Furthermore, the expressions of MAGE-A3, MAGE-A4 and combination of MAGE-A3, MAGE-A4 and NY-ESO-1 (CTAs-A3/A4/NY) showed p...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Wang M, Li J, Wang L, Chen X, Zhang Z, Yue D, Ping Y, Shi X, Huang L, Zhang T, Yang L, Zhao Y, Ma X, Li D, Fan Z, Zhao L, Tang Z, Zhai W, Zhang B, Zhang Y Tags: Int J Clin Exp Pathol Source Type: research

Inhibition of 4-nitroquinoline-1-oxide-induced oral carcinogenesis by dietary calcium.
Abstract Calcium is a strong inducer of keratinocyte differentiation. We have previously demonstrated that extracellular calcium promotes keratinocyte differentiation via E-cadherin-catenin complex-mediated phospholipase C-γ1 (PLC-γ1) activation in the plasma membrane. However, it is unclear whether dietary calcium regulates keratinocyte proliferation, differentiation or carcinogenesis. To address this issue, the rates of oral tumor and levels of proliferation and differentiation in the oral epithelium were assessed in mice on different calcium diets and the carcinogen 4-nitroquinoline-1-oxide. The res...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Jiang Y, Liao L, Shrestha C, Li D, Li M, Mu Y, Crumrine D, Wang L, Xie Z Tags: Int J Clin Exp Pathol Source Type: research

Anti-neoplastic activities of sepia officinalis ink and coelatura aegyptiaca extracts against Ehrlich ascites carcinoma in Swiss albino mice.
CONCLUSION: Both IE and CE were effective in inhibiting the tumor growth in ascitic tumor models. The biochemical, antioxidants and histopathological studies were also supported their antitumor properties. PMID: 26097537 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Soliman AM, Fahmy SR, El-Abied SA Tags: Int J Clin Exp Pathol Source Type: research

Expression of MMP14 in invasive pituitary adenomas: relationship to invasion and angiogenesis.
Abstract Pituitary adenomas (PAs) are noncancerous tumors, and about 35% of those reported to be invasive have been classified as "invasive pituitary adenomas (IPAs)". In clinical, operative complications, total resection failures, and high relapse rates result from invasive features during the therapeutic process. Invasive mechanism is a complex process, including metalloproteases, inhibitors and tumor microenvironment factors etc. Thus, studying invasive mechanism of PAs might contribute to understanding its biological behavior. In our research, three type tissue samples of human, pituitaries, PAs, IPA...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Hui P, Xu X, Xu L, Hui G, Wu S, Lan Q Tags: Int J Clin Exp Pathol Source Type: research

Enhanced circulating ILC2s accompany by upregulated MDSCs in patients with asthma.
In this study, we sought to determine whether MDSCs are also participation in immune imbalance and its relationship with ILC2s in asthma. The data showed that the circulatory ILC2s or MDSCs and their characteristic cytokines or transcription factors were significantly enhanced in asthmatic patients, as well as in chronic obstructive pulmonary disease (COPD) or respiratory viral infections (RVI). Meanwhile, a Th2-dominated phenotype was found in patients with asthma which closely related to the expression levels of ILC2s and MDSCs associated moleculars. These findings indicated that Th2 polarization was close related to syn...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Wu Y, Yan Y, Su Z, Bie Q, Wu J, Wang S, Yu Y, Ding H, Lu P, Xu H Tags: Int J Clin Exp Pathol Source Type: research

LRIG1 enhances the radiosensitivity of radioresistant human glioblastoma U251 cells via attenuation of the EGFR/Akt signaling pathway.
Abstract The radiotherapy as a local and regional modality is widely applied in treatment of glioma, but most glioblastomas are commonly resistant to irradiation treatment. It remains challengeable to seek out efficient strategies to conquer the resistance of human glioblastoma cells to radiotherapy. Leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1) is a newly discovered tumor suppressor which involved in regulation of chemosensitivity in various human cancer cells. In the present study, we established a radioresistant U251 cell line (U251R) to investigate the role of LRIG1 in regulation of ra...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Yang JA, Liu BH, Shao LM, Guo ZT, Yang Q, Wu LQ, Ji BW, Zhu XN, Zhang SQ, Li CJ, Chen QX Tags: Int J Clin Exp Pathol Source Type: research

Elevated DNA polymerase iota (Poli) is involved in the acquisition of aggressive phenotypes of human esophageal squamous cell cancer.
Abstract DNA polymerase iota (Polι) can repair several types of DNA damage but has extremely low fidelity. Previous studies have shown an aberrantly elevated Polι expression in human esophageal squamous cell cancer tissues. However, there were few reports describing the role of Polι in esophageal cancer progression. Based on Real-time PCR assay, we found Polι expression was up-regulated in esophageal cancer tissues compared to adjacent normal tissues and overexpression of Polι was correlated to lymph node metastasis. Clonogenic assay and transwell chamber assay showed that overexpression o...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Sun H, Zou S, Zhang S, Liu B, Meng X, Li X, Yu J, Wu J, Zhou J Tags: Int J Clin Exp Pathol Source Type: research

Effects of nicotine on a rat model of early stage osteoarthritis.
In conclusion, nicotine prevented cartilage damage and had an anti-inflammatory effect in a rat model of early stage OA. Thus nicotine may have potential as a therapeutic strategy for early stage OA. PMID: 26097542 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Gu Q, Li D, Wei B, Guo Y, Yan J, Mao F, Zhang X, Wang L Tags: Int J Clin Exp Pathol Source Type: research

HOXA10 controls proliferation, migration and invasion in oral squamous cell carcinoma.
Abstract Although HOX genes are best known for acting in the regulation of important events during embryogenesis, including proliferation, differentiation and migration, alterations in their expression patterns have been frequently described in cancers. In previous studies we analyzed the expression profile of the members of the HOX family of homeobox genes in oral samples of normal mucosa and squamous cell carcinoma (OSCC) and identified differently expressed genes such as HOXA10. The present study aimed to validate the increased expression of HOXA10 in OSCCs, and to investigate the effects arising from its knock...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Carrera M, Bitu CC, de Oliveira CE, Cervigne NK, Graner E, Manninen A, Salo T, Coletta RD Tags: Int J Clin Exp Pathol Source Type: research

Effects of early and late adverse experiences on morpho-quantitative characteristics of Sprague-Dawley rat spleen subjected to stress during adulthood.
Sol M Abstract Morpho-quantitative studies of the spleen indicate that the proportions of the compartments and sub-compartments are stable in normal conditions. However, disorders due to stress can influence the number and function of the immune cells in this organ. The aim of this study was to determine, through the model of altering the early mother-infant bond and altering the late social bond through isolation, the effect on the morpho-quantitative characteristics of the spleen in adult Sprague-Dawley rats subjected to intermittent chronic stress in adulthood. Twenty-five newborn female rats were used, kept un...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Vásquez B, Sandoval C, Smith RL, Del Sol M Tags: Int J Clin Exp Pathol Source Type: research

Chromosomal imbalances revealed in primary renal cell carcinomas by comparative genomic hybridization.
Abstract Renal cell carcinoma (RCC) accounts for approximately 3% of all new cancer cases. Although the classification of RCC is based mainly on histology, this method is not always accurate. We applied comparative genomic hybridization (CGH) to determine genomic alterations in 46 cases of different RCC histological subtypes [10 cases of clear cell RCC (CCRCC), 13 cases of papillary RCC (PRCC), 12 cases of chromophobe RCC (CRCC), 9 cases of Xp11.2 translocation RCC (Xp11.2RCC), 2 cases of undifferentiated RCC (unRCC)], and investigated the relationships between clinical parameters and genomic aberrations. Changes ...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Kang XL, Zou H, Pang LJ, Hu WH, Zhao J, Qi Y, Liu CX, Hu JM, Tang JX, Li HA, Liang WH, Yuan XL, Li F Tags: Int J Clin Exp Pathol Source Type: research

Intestinal mucosal barrier dysfunction participates in the progress of nonalcoholic fatty liver disease.
Abstract Intestinal mucosal barrier dysfunction is closely related to liver diseases, which implies impaired gut-liver axis may play a role in the pathogenesis of NAFLD. In our study, rats were divided into three groups: normal chow diet (NCD) group, high-fat diet (HFD) group and TNBS-induced colitis with high-fat diet (C-HFD) group. Liver tissues were obtained for histological observation and TNF-α, IL-6 mRNA determination and blood samples were collected for liver enzymes and LPS analysis. Ultrastructural changes of jejuna epithelium, SIBO and amounts of CD103(+)MHCII(+)DCs and CD4(+)CD25(+)FoxP3(+)T-regs ...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Mao JW, Tang HY, Zhao T, Tan XY, Bi J, Wang BY, Wang YD Tags: Int J Clin Exp Pathol Source Type: research

Abnormal immunomodulatory ability on memory T cells in humans with severe aplastic anemia.
In this study we investigate the quantities and functions of memory T cells in SAA patients before and after immunosuppressive therapy (IST) to further clarify the mechanism of SAA apoptosis of bone marrow hematopoietic cells. Results showed that the percentage of CD4+ effector T cells in peripheral blood and bone marrow lymphocytes was decreased in SAA patients. The ratio of CD4+ memory T lymphocytes to CD8+ memory T subsets (CD4+/CD8+TM) in SAA patients was also lower. The percentage of CD8+ effector T cells in peripheral blood and CD8+ central memory T cells in the bone marrow lymphocytes was significantly higher in new...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Zheng M, Liu C, Fu R, Wang H, Wu Y, Li L, Liu H, Ding S, Shao Z Tags: Int J Clin Exp Pathol Source Type: research

Role of cd56 and e-cadherin expression in the differential diagnosis of papillary thyroid carcinoma and suspected follicular-patterned lesions of the thyroid: the prognostic importance of e-cadherin.
ın A Abstract INTRODUCTION: The pathological diagnosis of papillary thyroid carcinoma (PTC) is generally easy on routine sections stained with hematoxylin and eosin (H&E). However, the differentiation of the follicular variant of PTC (FVPTC) from other suspected follicular-patterned lesions of the thyroid is highly difficult. Among these, the lesions for which FVPTC cannot be excluded are classified as well-differentiated tumors of uncertain malignant potential (WDT-UMP). The most common immunohistochemical (IHC) markers used in the differential diagnosis include HBME-1, galectin-3, and CK19. However, none of...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Ceyran AB, Şenol S, Şimşek BÇ, Sağıroğlu J, Aydın A Tags: Int J Clin Exp Pathol Source Type: research

Ursolic acid derivative ameliorates streptozotocin-induced diabestic bone deleterious effects in mice.
CONCLUSIONS: These results demonstrated that UAD could ameliorate STZ-induced bone deterioration through improving adipocyte dysfunction and enhancing new bone formation and inhibiting absorptive function of osteoclast in the bone of diabetic mice. PMID: 26097549 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Yu SG, Zhang CJ, Xu XE, Sun JH, Zhang L, Yu PF Tags: Int J Clin Exp Pathol Source Type: research

Krüppel-like factors 4 and 5 expression and their involvement in differentiation of oral carcinomas.
This study examined expression of KLF4 and KLF 5 in the carcinomas by immunohistochemistry (n = 67) and the involvement in proliferation and differentiation of carcinoma cells. KLF4 was detected in keratinizing carcinoma cells and KLF5 in non-keratinizing cells. KLF4 staining declined in the patient with lymph node metastasis (P
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Shibata M, Chiba T, Matsuoka T, Mihara N, Kawashiri S, Imai K Tags: Int J Clin Exp Pathol Source Type: research

Decreased SATB2 expression is associated with metastasis and poor prognosis in human clear cell renal cell carcinoma.
This study provides the first evidence of the expression and clinical significance of SATB2 in ccRCC. Our data suggest that SATB2 functions as a tumor suppressor in the development and progression of ccRCC, and is thereby implicated as a valuable prognostic marker for ccRCC patients. PMID: 26097552 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Guo C, Xiong D, Yao X, Gu W, Zhang H, Yang B, Peng B, Liu M, Zheng J Tags: Int J Clin Exp Pathol Source Type: research

HGF/MET signaling promotes glioma growth via up-regulation of Cox-2 expression and PGE2 production.
Abstract Cyclooxygenase2 (Cox-2) is well known for glioma growth through up-regulation of prostaglandin E2 (PGE2) levels. MET, a hepatocyte growth factor (HGF) receptor, is also frequently high expressed in glioma, which promotes glioma growth and invasion. Here, we demonstrate that HGF/MET signaling can promote PGE2 production in glioma cells via Cox-2 up-regulation. RNA inhibition of MET suggested that MET signaling is essential for Cox-2 up-regulation. Moreover, HGF could enhance Cox-2 expression and PGE2 release. Knockdown of Cox-2 inhibited growth-promoting effects of HGF, suggesting that HGF/MET functioned v...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Zhao Y, Sun Y, Zhang H, Liu X, Du W, Li Y, Zhang J, Chen L, Jiang C Tags: Int J Clin Exp Pathol Source Type: research

Spatiotemporal expression of BMP7 in the development of anorectal malformations in fetal rats.
Abstract The aim of this study was to determine the expression patterns of bone morphogenetic protein 7 (BMP7) during anorectal development in normal rat embryos and in embryos with anorectal malformations (ARM), and to investigate the possible role of BMP7 in the pathogenesis of ARM. ARM was induced by treating rat embryos with ethylenethiourea on the 10th gestational day (GD10). Embryos were harvested by Cesarean delivery and the spatiotemporal expression of BMP7 was evaluated in normal (n=168) and ARM embryos (n=171) from GD13 to GD16 using immunohistochemistry staining and western blot analysis. Immunohistoche...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Zhang J, Tang XB, Wang WL, Yuan ZW, Bai YZ Tags: Int J Clin Exp Pathol Source Type: research

Trimetazidine protects against hypoxia-reperfusion-induced cardiomyocyte apoptosis by increasing microRNA-21 expression.
In conclusion, this study revealed the mechanism that TMZ up-regulated miR-21 expression, then miR-21 targeted PTEN increasing the PI3K pathway and finally the activation of this pathway counteracted the apoptotic effect of hypoxia/reperfusion. PMID: 26097555 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Yang Q, Yang K, Li AY Tags: Int J Clin Exp Pathol Source Type: research

Expression of androgen receptor in coronary artery in the cases of sudden coronary death.
Abstract To study the expression of androgen receptor (AR) in the cases of sudden death caused by coronary heart disease (CHD) and relationship between AR and sudden coronary death (SCD) to explore the mechanism of the development of coronary atherosclerosis and provide references for the prevent and treatment of CHD and medicolegal identification of SCD. 53 cases selected from the autopsied cases in our department from 2011 to 2012 were divided into 3 groups: 18 case of SCD, including 11 males and 7 females, as experimental group, another 18 cases, including 11 males and 7 females, with CHD but died of mechanical...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Liu K, Shen C, Chen X Tags: Int J Clin Exp Pathol Source Type: research

Predictors for contralateral prophylactic mastectomy in breast cancer patients.
CONCLUSION: Younger age, lower TN stage, requiring only SLNB and high risk family history predict contralateral prophylactic mastectomy. Tissue expander/implant-based reconstructions were more frequently chosen by patients with BM. PMID: 26097557 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Fu Y, Zhuang Z, Dewing M, Apple S, Chang H Tags: Int J Clin Exp Pathol Source Type: research

Decreased expression of long non-coding RNA NBAT-1 is associated with poor prognosis in patients with clear cell renal cell carcinoma.
CONCLUSIONS: NBAT-1 is a novel molecular correlated with ccRCC progression; and it may represent a prognostic biomarker and therapeutic target in renal cancer diagnosis and treatment. PMID: 26097558 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Xue S, Li QW, Che JP, Guo Y, Yang FQ, Zheng JH Tags: Int J Clin Exp Pathol Source Type: research

Targeting eradication of chronic myeloid leukemia using chimeric oncolytic adenovirus to drive IL-24 expression.
In this study, we explore whether chimeric oncolytic adenovirus-mediated transfer of human interleukin-24 (IL-24) gene induce the enhanced antitumor potency. Our results showed that chimeric oncolytic adenovirus carrying hIL-24 (AdCN205-11-IL-24) could produce high levels of hIL-24 in CML cancer cells, as compared with constructed double-regulated oncolytic adenovirus expressing hIL-24 (AdCN205-IL-24). AdCN205-11-IL-24 could specifically induce cytotoxocity to CML cancer cells, but little or no effect on normal cell lines. AdCN205-11-IL-24 exhibited remarkable anti-tumor activities and induce higher antitumor activity to C...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Wei X, Liu L, Wang G, Li W, Xu K, Hu X, Qian C, Shao J Tags: Int J Clin Exp Pathol Source Type: research

β-arrestin1 over-expression is associated with an unfavorable prognosis in lung adenocarcinomas and correlated with vascular endothelial growth factor.
β-arrestin1 over-expression is associated with an unfavorable prognosis in lung adenocarcinomas and correlated with vascular endothelial growth factor. Int J Clin Exp Pathol. 2015;8(4):3785-93 Authors: Qiu C, Zheng C, Zhu L, Qu X, Shen H, Du J Abstract The aim of this study was to examine β-arrestin1 expression in patients with lung adenocarcinoma (ADC) and explore the relationship of β-arrestin1 protein with clinicopathologic factors, vascular endothelial growth factor (VEGF) and prognosis. A total of 105 surgically resected lung adenocarcinoma patients were recruited for the study. Th...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Qiu C, Zheng C, Zhu L, Qu X, Shen H, Du J Tags: Int J Clin Exp Pathol Source Type: research

PABPC1 exerts carcinogenesis in gastric carcinoma by targeting miR-34c.
Abstract As one of the common malignant tumors that threaten human health severely, gastric carcinoma is the second highest cause of cancer death and the fourth most common cancer globally. However, the mechanism underling gastric cancer is still not fully understood. PABPC1 plays an important role in translation, control the rate of mRNA deadenylation and participates in mRNA decay, which is involved in carcinogenesis. Here in present study, we reported that PABPC1 is an oncogenic protein in gastric carcinoma. The results showed that PABPC1 is upregulated in gastric carcinoma tissues, and high PABPC1 expression p...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Zhu J, Ding H, Wang X, Lu Q Tags: Int J Clin Exp Pathol Source Type: research

Carboplatin-docetaxel-induced activity against ovarian cancer is dependent on up-regulated lncRNA PVT1.
Abstract Ovarian cancer is the fourth most ordinary cause of cancer-related deaths in women. In recent, combination chemotherapy with carboplatin and docetaxel was developed as first-line drug to treat ovarian carcinoma. However, the detailed molecular mechanism, which accounts for the cells to apoptosis induced by administration of carboplatin and docetaxel, was unrecognized. In present study, we provide the mechanistic link between mixture of carboplatin plus docetaxel and its anticancer activity. Primarily, a majority of 30 cancer-related long non-coding RNA (lncRNA) showed differential alteration in carboplati...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Liu E, Liu Z, Zhou Y Tags: Int J Clin Exp Pathol Source Type: research

Combinatorial effects of miR-20a and miR-29b on neuronal apoptosis induced by spinal cord injury.
In conclusion, altered expression of miR-20a and miR-29b may cooperatively contribute to the neuronal cell death of SCI through down-regulating anti-apoptotic myeloid cell leukemia sequence-1 (Mcl-1) and up-regulating pro-apoptotic BH3-only proteins. PMID: 26097563 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Liu XJ, Zheng XP, Zhang R, Guo YL, Wang JH Tags: Int J Clin Exp Pathol Source Type: research

Upregulated expression of N-methyl-D-aspartate receptor 1 and nitric oxide synthase during form-deprivation myopia in guinea pigs.
In conclusion, FDM upregulates the expression of NMDAR1 and ncNOS and increases cGMP content in the retina. NMDAR1/NO-cGMP pathway may contribute to abnormal visual signals during myopic progression. PMID: 26097564 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Wen D, Song W, Liu S, Tan X, Liu F Tags: Int J Clin Exp Pathol Source Type: research

Endogenous neural stem cells in central canal of adult rats acquired limited ability to differentiate into neurons following mild spinal cord injury.
Abstract Endogenous neural stem cells in central canal of adult mammalian spinal cord exhibit stem cell properties following injury. In the present study, the endogenous neural stem cells were labeled with Dil to track the differentiation of cells after mild spinal cord injury (SCI). Compared with 1 and 14 days post mild injury, the number of endogenous neural stem cells significantly increased at the injured site of spinal cord on 3 and 7 days post-injury. Dil-labeled βIII-tublin and GFAP expressing cells could be detected on 7 days post-injury, which indicated that the endogenous neural stem cells in centra...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Liu Y, Tan B, Wang L, Long Z, Li Y, Liao W, Wu Y Tags: Int J Clin Exp Pathol Source Type: research

Nitric oxide donor, NOC7, reveals dose dependently and cGMP pathway independently biphasic effects on contractile force of isolated rat heart after global ischemia.
CONCLUSION: NOC7 has biphasic effect on isolated rat heart after ischemia and reperfusion myocardial contractility. This biphasic effect shows neither concentration-dependent nor the cGMP-dependent characteristics. PMID: 26097567 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Liu L, Yue H, Guo B, He X, Wang J, Li JC Tags: Int J Clin Exp Pathol Source Type: research

Mesothelial/monocytic incidental cardiac excrescences (cardiac MICE) associated with acute aortic dissection: a study of two cases.
Abstract Acute aortic dissection is a life-threatening condition mainly caused by hypertension, atherosclerotic disease and other degenerative diseases of the connective tissue of the aortic wall. Mesothelial/monocytic incidental cardiac excrescences (cardiac MICE) is a rare benign reactive tumor-like lesion composed of admixture of histiocytes, mesothelial cells, and inflammatory cells set within a fibrinous meshwork without a vascular network or supporting stroma. Cardiac MICE occurring in association with aortic dissection is exceptionally rare (only one such case reported to date). We herein report on the surg...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Strecker T, Bertz S, Wachter DL, Weyand M, Agaimy A Tags: Int J Clin Exp Pathol Source Type: research

Increased expression of metastasis-associated in colon cancer-1 in renal cell carcinoma is associated with poor prognosis.
This study aimed to investigate MACC1 expression in renal cell carcinoma via immunohistochemical analysis and determine the relationship between MACC1 expression and cancer prognosis. Positive MACC1 expression was found to significantly correlate with distant metastasis and TNM stage (P
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Jin Z, Xu N, Guo K, Xu P, Li P, Zhang Y, Li X, Zheng S, Liu C, Xu A, Huang P Tags: Int J Clin Exp Pathol Source Type: research