High expression of CRAM correlates with poor prognosis in patients with cervical carcinoma.
Abstract AIMS: Atypical chemokine receptors (ACRs) have been reported to scavenge or alter the localization of their chemokine ligands. However, CRAM, a newly identified ACR member, is lack of ligand scavenging properties. The present study was to investigate the clinical significance of CRAM in cervical carcinoma. METHODS: The expression of CRAM in primary cervical cancer and paired normal tissues from adjacent regions was examined using Real time PCR. Moreover, CRAM protein expression was analyzed in 272 cervical specimens including 50 normal cervical tissues, 40 cases of carcinoma in situ of cervix (CIS), ...
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Hou T, Liang D, Yang D, He J, Huang Y, Zhang Y Tags: Int J Clin Exp Pathol Source Type: research

Liofilchem(®) O.A. Listeria agar and direct CAMP test provided sooner Listeria monocytogenes identification from neonatal bacteremia.
Liofilchem(®) O.A. Listeria agar and direct CAMP test provided sooner Listeria monocytogenes identification from neonatal bacteremia. Int J Clin Exp Pathol. 2014;7(3):1172-5 Authors: Savini V, Marrollo R, Serio A, Paparella A, Argentieri AV, D'Antonio M, Coclite E, Fusilli P, Fazii P Abstract Listeria monocytogenes infection in pregnant women and newborns is a cause for serious concern, and invasive disease outcome strongly depends on prompt antibiotic therapy. To provide sooner identification from neonatal bacteremia we performed a CAMP test directly on positive blood aliquots and inoculated the ...
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Savini V, Marrollo R, Serio A, Paparella A, Argentieri AV, D'Antonio M, Coclite E, Fusilli P, Fazii P Tags: Int J Clin Exp Pathol Source Type: research

Collision tumor of the esophagus: report of a case with mixed squamous cell carcinoma and gastrointestinal stromal tumor.
This study together with a literature review indicates that esophageal collision tumors have been increasingly reported in recent years. Histology and immunohistochemistry are needed to make a differential diagnosis. The exact oncogenic mechanism or the interaction of two independent neoplasms still remains to be determined, and further investigation, such as electron microscopy and genetic analysis, may help to elucidate the pathogenesis of the colliding tumors. PMID: 24695797 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Qian T, Gao F, Chen MZ, Meng FH, Li XJ, Liu YJ, Yin HB Tags: Int J Clin Exp Pathol Source Type: research

Morules in fundic gland polyposis: a case report.
We report the formation of morules in a case of sporadic fundic gland polyposis with low grade dysplasia in a 47 year old woman that underwent total gastrectomy. The immunophenotype of the morules was CD10, CDX2, Beta-catenin nuclear positive; p63, Ki67, chromogranin, synaptophysin, Ck20 negative. The presence of morules in a neoplasm know to be associated with the disruption of wnt/β-catenin pathway is discussed. The report provides the first description of the immunophenotype of morules in the stomach and hypothesizes the biological similitude of fundic gland polyposis to other tumors characterized by morules format...
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Petris GD, Chen L Tags: Int J Clin Exp Pathol Source Type: research

Well-differentiated cerebellum within a mature cystic teratoma of the ovary.
PMID: 24695848 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Ishida M, Iwai M, Yoshida K, Kagotani A, Okabe H Tags: Int J Clin Exp Pathol Source Type: research

Advances in serous tubal intraepithelial carcinoma: correlation with high grade serous carcinoma and ovarian carcinogenesis.
Abstract Early serous carcinoma in fallopian tube or serous tubal intraepithelial carcinoma (STIC), an early lesion limited to the epithelium of the fallopian tube and firstly identified from specimen obtained by prophylactic salpingo-oophorectomy, has provided insight into pelvic high grade serous carcinoma (HGSC). Increasing evidence indicates that STIC is a likely precursor for HGSC and several studies have focused on this lesion and its clinical significance. This review addresses recent advances in recognizing STIC and its correlation with HGSC and ovarian carcinogenesis. It also describes evidence regarding ...
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Li HX, Lu ZH, Shen K, Cheng WJ, Malpica A, Zhang J, Wei JJ, Zhang ZH, Liu J Tags: Int J Clin Exp Pathol Source Type: research

Coxsackievirus-induced acute neonatal central nervous system disease model.
Abstract Coxsackievirus B (CVB) is a significant pathogen that causes pediatric central nervous system disease with acute syndromes commonly. The onset of its infection was abrupt, and after recovery there usually will be severe mental sequelae. The disease model for research was not established by the way of natural infection, although there are various investigations about the CVB-induced central nervous system (CNS) diseases. Thus, we have established an acute neonatal CNS disease mice model by CVB orally infecting. This model imitated the natural infection route and focuses the onset of CNS disease, inducing s...
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Wang L, Dong C, Chen DE, Song Z Tags: Int J Clin Exp Pathol Source Type: research

Silencing SATB1 influences cell invasion, migration, proliferation, and drug resistance in nasopharyngeal carcinoma.
Abstract Special AT rich sequence binding protein 1 (SATB1) play an important role in many cancers, but the role of SATB1 in nasopharyngeal carcinoma (NPC) is still not full understand. Immunofluorescence staining showed that SATB1 was mainly localized in the nuclei in CNE-2 cell. After successful down-regulation of SABT1 in NPC cell line CNE-2 by shRNA, compared to parental CNE-2 and control shRNA group, the capacity of the proliferation, migration, invasion and drug resistance of CNE-2 cell was reduced, which indicated that SATB1 may be involved in NPC development and progression. SATB1 may be a promising therap...
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Ye CS, Zhou DN, Yang QQ, Deng YF Tags: Int J Clin Exp Pathol Source Type: research

Risk factors for central lymph node metastasis of patients with papillary thyroid microcarcinoma: a meta-analysis.
CONCLUSION: The papillary thyroid microcarcinoma should be considered central lymph node metastasis when tumor size ≥0.5 cm, multifocality and have capsular invasion. PMID: 24696711 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Liu Z, Wang L, Yi P, Wang CY, Huang T Tags: Int J Clin Exp Pathol Source Type: research

Apolipoprotein E pathology in vascular dementia.
Abstract Vascular dementia (VaD) is the second most common form of dementia and is currently defined as a cerebral vessel vascular disease leading to ischemic episodes. Apolipoprotein E (apoE) gene polymorphism has been proposed as a risk factor for VaD, however, to date there are few documented post-mortem studies on apoE pathology in the VaD brain. To investigate a potential role for the apoE protein, we analyzed seven confirmed cases of VaD by immunohistochemistry utilizing an antibody that specifically detects the amino-terminal fragment of apoE. Application of this antibody, termed N-terminal, apoE cleavage f...
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Rohn TT, Day RJ, Sheffield CB, Rajic AJ, Poon WW Tags: Int J Clin Exp Pathol Source Type: research

RNAs specifically affect gene expression in a length, position and sequence dependent manner.
Abstract We aim to explore if RNA regulating gene expression is affected by length, sequence and position of RNA. HeLa cells were co-transfected with modulator plasmids (derived from pcDNA3.1 vector containing different length regulating sequences that produce RNAs) and reporter plasmids (derived from pEGFP-C1 vector); In addition, HeLa cells were transfected with plasmids that possess different sequences of downstream or adjacent genes of GFP reporter gene. We found that long inserting sequences of modulator plasmids induced stronger GFP gene activation than short inserting sequences. Changing of downstream seque...
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Cheng J, Wang X, Cai N, Ma Z, Zhang L, Lv Z Tags: Int J Clin Exp Pathol Source Type: research

HLJ1 is a novel biomarker for colorectal carcinoma progression and overall patient survival.
Abstract The implication of HLJ1, a member of the heat shock protein-40 chaperone family, in colorectal carcinoma (CRC) remains unclear. The aim of this study was to determine the dynamic changes of HLJ1 in CRC both in vitro and in vivo, and the relationship between its level and the survival rate of CRC patients. Both real-time RT-PCR and Western blot were used to detect the expression of HLJ1 in CRC cells, while the distribution of HLJ1 in CRC and its adjacent normal mucosa tissues from CRC patients was determined with immunohistochemistry. Moreover, MTT and in vitro invasive assays were performed to determine t...
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Liu Y, Zhou J, Zhang C, Fu W, Xiao X, Ruan S, Zhang Y, Luo X, Tang M Tags: Int J Clin Exp Pathol Source Type: research

Co-expression of perforin and granzyme B genes induces apoptosis and inhibits the tumorigenicity of laryngeal cancer cell line Hep-2.
Abstract Granzyme B and perforin, two of the most important components, have shown anticancer properties in various cancers, but their effects in laryngeal cancer remain unexplored. Here we decided to examine the effects of Granzyme B and perforin in Hep-2 cells and clarify the role of perforin and granzyme B in the tumorigenicity of laryngeal cancer cell line. Hep-2 cells were transfected with pVAX1-PIG co-expression vector (comprising perforin and granzyme B genes), and then the growth and apoptosis of these Hep-2 cells were evaluated. The tumorigenicity of Hep-2 cell line co-expressing perforin and granzyme B g...
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Li XY, Li Z, An GJ, Liu S, Lai YD Tags: Int J Clin Exp Pathol Source Type: research

Wnt5a involved in regulation of the biological behavior of hepatocellular carcinoma.
CONCLUSION: Overexpression of Wnt5a in Huh7 cells was associated with decrease of cell proliferation and migration. Wnt5a may act as a tumor-suppressor gene in HCC, which works through the non-canonical Wnt signaling pathway by binding to the Ror2 and E-cadherin receptor. PMID: 24696716 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Bi L, Liu X, Wang C, Cao Y, Mao R, Li P, Geng M Tags: Int J Clin Exp Pathol Source Type: research

CT features and pathologic characteristics of lymphoepithelial carcinoma of salivary glands.
CONCLUSION: In most cases, LEC was primary and occurred in the parotid glands. The probable diagnosis could be made based upon Dual-phase contrast-enhanced CT scan findings combined with positive expression of EBV. PMID: 24696717 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Zhang G, Tang J, Pan Y, Zhuang Q, Wu C Tags: Int J Clin Exp Pathol Source Type: research

Prognostic value of CD117 in cancer: a meta-analysis.
CONCLUSIONS: CD117 expression might be a predictive factor of poor prognosis in some surgically treated cancers, particularly in renal carcinoma. PMID: 24696718 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Zhao F, Chen Y, Wu Q, Wang Z, Lu J Tags: Int J Clin Exp Pathol Source Type: research

VE-statin/Egfl7 expression in malignant glioma and its relevant molecular network.
This study investigated VE-statin/Egfl7 expression and its role and regulatory mechanism in malignant glioma progression. Forty-five paraffin-embedded glioma (grade I-II: n=24; grade III-IV: n=21) were examined. VE-statin/Egfl7 protein expression was detected via immunohistochemistry, and its correlation with pathological grade was evaluated. Three-dimensional cell culture was then performed to investigate the influence of VE-statin/Egfl7 on the angiogenesis of umbilical vein endothelial cells. Microarray detection was used to molecularly profile VE-statin/Egfl7 and relevant signaling pathways in malignant glioma (U251 cel...
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Huang C, Yuan X, Wan Y, Liu F, Chen X, Zhan X, Li X Tags: Int J Clin Exp Pathol Source Type: research

Mantle cell lymphoma with in situ or mantle zone growth pattern: a study of five cases and review of literature.
In conclusion, the "in situ MCL" is associated with incidental finding, indolent clinical course and lower tumor burden. The predominant usage of kappa light chain and frequent CD5-negativity observed in our cases are unusual. We review the clinical and laboratory features of "in situ MCL" cases in the literature. PMID: 24696721 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Hsu P, Yang T, Sheikh-Fayyaz S, Brody J, Bandovic J, Roy S, Laser J, Kolitz JE, Devoe C, Zhang X Tags: Int J Clin Exp Pathol Source Type: research

Uterine tumors resembling ovarian sex cord tumors (UTROSCT) with metastasis: clinicopathological study of two cases.
Abstract Uterine tumors with sex cord-like elements are divided in two groups; uterine tumors resembling ovarian sex cord tumors (UTROSCT), and endometrial stromal tumors with sex cord-like elements (ESTSCLE). UTROSCT is currently defined as the neoplasm predominantly or exclusively composed of sex cord-like elements, and generally behaves in a benign fashion. We studied two unusual cases of UTROSCT with metastasis. One case was a 38-year-old multiparous woman presented with hypermenorrhea. The tumor grew as an intramural mass, and metastasized to a pelvic lymph node. Another case was a 57-year-old woman presented...
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Umeda S, Tateno M, Miyagi E, Sakurai K, Tanaka R, Tateishi Y, Tokinaga A, Ohashi K, Furuya M Tags: Int J Clin Exp Pathol Source Type: research

Altered expression of fibroblast growth factor receptor 2 isoform IIIc: relevance to endometrioid adenocarcinoma carcinogenesis and histological differentiation.
In this study, we identified roles for FGFR2IIIc in EEC carcinogenesis and demonstrated its diagnostic and prognostic values in EEC. FGFR2IIIc expression was compared between 10 normal endometrium, 10 atypical endometrial hyperplasias, and 47 EEC specimens using immunohistochemistry and quantitative real-time PCR. Atypical hyperplasia, Grade 1 (G1), and Grade 2 (G2) differentiated EEC tissues showed significantly higher FGFR2IIIc expression than normal endometrium tissue. However, as compared to G1 and G2 EECs, Grade 3 (G3) differentiated EEC tissue showed lower FGFR2IIIc expression (P
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Peng WX, Kudo M, Fujii T, Teduka K, Naito Z Tags: Int J Clin Exp Pathol Source Type: research

VE-statin/Egfl7 siRNA inhibits angiogenesis in malignant glioma in vitro.
This study investigated the role of VE-statin/Egfl7 and its mechanism in angiogenesis in malignant glioma. Transwell culture plates were used to establish an U251-HUVEC co-culture system, which was used to mimic the interaction between malignant glioma and endothelial cells. Lentiviral vectors expressing VE-statin/Egfl7 siRNA were constructed, and U251 cells and HUVECs were transfected to inhibit VE-statin/Egfl7 expression. The proliferation, adherence, migration, and lumen formation of endothelial cells were assayed to investigate the influence of VE-statin/Egfl7 on angiogenesis in malignant glioma in vitro. Data showed t...
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Huang C, Yuan X, Li Z, Tian Z, Zhan X, Zhang J, Li X Tags: Int J Clin Exp Pathol Source Type: research

RNAi screening with shRNAs against histone methylation-related genes reveals determinants of sorafenib sensitivity in hepatocellular carcinoma cells.
Abstract Sorafenib is the first drug currently approved to treat advanced hepatocellular carcinoma (HCC). However, very low response rate and acquired drug resistance makes rare patients benefit from sorafenib therapy, therefore it is urgent to find biomarkers for sorafenib sensitivity. Histone modifications, including histone methylation, have been demonstrated to influence the initiation and progression of HCC. It is of great interest to elicit the possibility whether histone methylation plays a role in regulation of sorafenib sensitivity. In present work, a high throughput RNAi screening with 176 shRNA pools ag...
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Li GM, Wang YG, Pan Q, Wang J, Fan JG, Sun C Tags: Int J Clin Exp Pathol Source Type: research

Prognostic factors of hepatocellular carcinoma patients treated by transarterial chemoembolization.
Abstract We aim to investigate the clinical characteristics and prognostic factors of Hepatocellular Carcinoma (HCC) patients treated by transarterial chemoembolization (TACE) in Chinese cohort. A total of 2,493 HCC patients treated by TACE were included in this retrospective study. Patients were divided into the younger group (n=1,877) or the elderly group (n=616) based upon their ages (cut-off value of 60 y/o). Chi-square test or Wilcoxon rank-sum test was used to compare patients' characteristics. Univariate and multivariate analysis were used to determine prognostic factors. When compared with the younger grou...
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Xiao J, Li G, Lin S, He K, Lai H, Mo X, Chen J, Lin Y Tags: Int J Clin Exp Pathol Source Type: research

Cathepsin K in the immunohistochemical diagnosis of melanocytic lesions.
Abstract Recent studies have demonstrated that cathepsin K seems to be a powerful marker in identifying the microphthalmia associated transcription factor (MITF) family tumors such as renal perivascular epithelioid cell neoplasms (PEComas), alveolar soft part sarcoma, and translocation-associated renal cell carcinomas. However, the expression of cathepsin K in melanocytic lesions has not been well characterized. Our aim was to investigate the expression of cathepsin K in a wide histological spectrum of melanocytic lesions and to evaluate its potential diagnostic and molecular target therapy usefulness in compariso...
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Rao Q, Wang Y, Xia QY, Shi SS, Shen Q, Tu P, Shi QL, Zhou XJ, Wu B Tags: Int J Clin Exp Pathol Source Type: research

STAT3 activation in tumor cell-free lymph nodes predicts a poor prognosis for gastric cancer.
The objective of the current study was to investigate the role of STAT3 activity in tumor cell-free lymph nodes in tumor progression and prognosis for gastric cancer patients. Immunohistochemical analyses for p-STAT3, Ki-67, CD68 and Bcl-xL were performed in tumor cell-free lymph nodes from 60 gastric cancer patients. Survival analysis was conducted by using the Kaplan-Meier method. Immunohistochemical analyses showed that hyperactivity of STAT3 in tumor cell-free lymph nodes was significantly associated with tumor recurrence, and STAT3 activation pattern coincides with expression Ki-67, CD68, Bcl-xL. Survival analysis rev...
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Wu LJ, Li HX, Luo XT, Lu RZ, Ma YF, Wang R, Zhang J, Yang DQ, Yu H, Liu J Tags: Int J Clin Exp Pathol Source Type: research

Vitrification of in vitro matured oocytes: effects on meiotic spindle configuration and mitochondrial function.
CONCLUSION: In vitro maturation (IVM) has an adverse effect on the organization of spindle and chromosome, and no significantly effect on spindle and chromosome was discovered after vitrification-thaw cycle, while there was obvious damage of oocyte mitochondrial function of in vitro-matured oocyte detected after warming, which may be the reason of the low following developmental potential. PMID: 24696732 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Lei T, Guo N, Liu JQ, Tan MH, Li YF Tags: Int J Clin Exp Pathol Source Type: research

Sertoli-Leydig cell tumor with heterologous element: a case report and a review of the literature.
Abstract The patient was a 19-year-old female who presented with a chief complaint of progressive pelvic pain. Preoperative ultrasound of the right ovary revealed an ovarian torsion as the cause of the patient's progressive pain. Laparoscopy confirmed the torsion and revealed a right ovary measuring 10 cm in greatest diameter. Intraoperative incision into the ovary revealed a simple ovarian cystic mass measuring 3.0 x 1.5 x 0.8 cm. A solid component within the cyst was identified. Histological sections of the cystic mass demonstrated mononuclear and hyperchromatic Sertoli cells with a trabecular growth pattern. Cl...
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Chen L, Tunnell CD, Petris GD Tags: Int J Clin Exp Pathol Source Type: research

Brain metastasis of ALK positive anaplastic large cell lymphoma after a long-term disease free survival in an old adult.
Abstract Anaplastic large cell lymphoma (ALCL) is a subtype of non-Hodgkin lymphoma composed of CD30-positive cells and now recognized as three different entities: primary cutaneous ALCL, primary systemic anaplastic lymphoma kinase (ALK)-positive (ALK+) ALCL and primary ALK-negative (ALK-) ALCL. ALK+ ALCL is supposed to have a better prognosis than ALK- ALCL. It is rarely metastasized to other sites, especially to the central nervous system (CNS). Herein, we present a rare case of systemic ALK+ ALCL which metastasized to the brain after a long-term disease free survival in an adult. Neuroimaging revealed a well-en...
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Wang CX, Wang H, Li J, Ma HH, Yu B, Shi SS, Zhou XJ, Shi QL Tags: Int J Clin Exp Pathol Source Type: research

Primary cardiac angiosarcoma confirmed by multimodality imaging guided liver biopsy.
We report a case presented with bloody pericardial effusion, in which the final diagnosis was confirmed by multiple imaging modalities such as echocardiography, computed tomography, magnetic resonance imaging and fluorine-18-fluorodeoxyglucose positron emission tomography, as well as ultrasound-guided liver biopsy. PMID: 24696736 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Qiu ZX, Zhang Q Tags: Int J Clin Exp Pathol Source Type: research

Primary cutaneous B-cell lymphoma with abundant reactive gamma/delta T-cells within the skin lesion and peripheral blood.
Abstract T-cell/histiocyte-rich diffuse large B-cell lymphoma is characterized by abundant reactive T-cell and histiocyte infiltration within nodal diffuse large B-cell lymphoma, and only limited cases of primary cutaneous T-cell-rich B-cell lymphoma have been documented. These reactive T-cells usually show a T-helper phenotype. Gamma/delta T-cell is a functionally distinct T-cell lineage, which constitutes on average 5% of all T-cells in the peripheral blood. Herein, we report the first documented case of primary cutaneous malignant B-cell lymphoma with abundant reactive gamma/delta(+) T-cells within the skin les...
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Ishida M, Iwai M, Yoshida K, Kagotani A, Okabe H Tags: Int J Clin Exp Pathol Source Type: research

Tumor rupture as an initial manifestation of malignant mesonephric mixed tumor: a case report and review of the literature.
We report a case of MMMT of the uterine cervix in a patient who presented with tumor rupture, instead of the common presentation, vaginal bleeding. This unusual presentation has not been reported in the literature. It implies that MMMT may progress rapidly without any prodrome and pose a surgical emergency. Unlike most cervical adenocarcinomas, both mesonephric adenocarcinoma and MMMT are not related to human papilloma virus (HPV) infection. Because mesonephric neoplasms have a different etiology, their prevention, screening, and treatment should be further investigated. Thirteen cases of MMMT reported in the literature ar...
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Tseng CE, Chen CH, Chen SJ, Chi CL Tags: Int J Clin Exp Pathol Source Type: research

Invasive ductal carcinoma of the breast associated with extensive melanin melanosis: a case report and review of the literature.
Abstract Extensive melanosis of breast tissue due to melanin in the absence of involvement by melanoma either primary or secondary has been rarely encountered. Herein we report a first and unique case of extensive macroscopic and microscopic melanosis of mammary parenchyma between carcinoma cells due to melanin in a patient with a poorly differentiated invasive ductal carcinoma of the breast with no evidence of melanocytic differentiation or melanoma. In contrast to previously reported cases in the literature, there is no breach of dermal-epidermal junction and there is no dermal infiltrate in the skin overlying t...
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Zhang X, Liang Y, Wang HY Tags: Int J Clin Exp Pathol Source Type: research

Progesterone receptor expression in sinonasal leiomyoma: a case report and review of the literature.
We describe the case of a 48 year-old woman with a leiomyoma arising from right inferior nasal turbinate. Transnasal endoscopic excision was performed with satisfied result. The tumor was found to be progesterone receptor positive on immunohistochemical analysis. The clinical findings are addressed with a review of the literature. To the best of our knowledge, this is the third reported case that supports the growth of the tumor may be hormone-dependent. PMID: 24696741 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Tseng PY, Lai YS, Chen MK, Shen KH Tags: Int J Clin Exp Pathol Source Type: research

Ultrasonographic features of Langerhans cell histiocytosis of the thyroid.
Abstract Langerhans cell histiocytosis (LCH) is a rare disease, especially when it involves the thyroid gland. Awareness of ultrasonic features will be helpful for a clinician who should consider this disease in the differential diagnosis from other more common thyroid disorders, especially prior to surgery. Here, we report two patients who have histologically confirmed LCH of the thyroid and summarize the reported cases with ultrasonographic scans from the last 10 years (n=10). Ultrasonograms showed isolated or multiple hypoechoic nodules in unilateral or bilateral thyroid gland. Internal acoustic features of mos...
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Chen ED, Cheng P, Cai YF, Xiang YY, Zheng HM, Xing HX, Li Q Tags: Int J Clin Exp Pathol Source Type: research

Hilus cell heterotopia accompanying bilateral ovarian serous cystadenomas: a case report and review of the literature.
In this report, we described a patient having bilateral serous cystadenomas with an incidental finding of hilus cells in the fallopian tube. PMID: 24696744 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: He HL, Lee YE, Chang CC Tags: Int J Clin Exp Pathol Source Type: research

IgD plasmablastic myeloma: a case report with emphasis on the cytological features.
PMID: 24696745 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Ishida M, Hodohara K, Okuno H, Yoshii M, Horinouchi A, Shirakawa A, Harada A, Iwai M, Yoshida K, Kagotani A, Yoshida T, Okabe H Tags: Int J Clin Exp Pathol Source Type: research

Parachordoma/myoepithelioma of the kidney: first report of a myxoid mimicry in an unusual location.
We report a case of parachordoma (or myoepithelioma) of the right upper kidney in a 56 year-old male patient. Light microscopic features of the tumor exhibited epithelioid, glomoid, and spindle cells with eosinophilic and vacuolated cytoplasm as well as round to oval nuclei. These cells were embedded in a myxoid and hyaline stroma separated by a fibrous tissue with minimal cellular atypia and a few small nucleoli. Immunohistochemically, the tumor cells were immunoreactive for epithelial membrane antigen, calponin, vimentin, S-100, and type-IV collagen. All kidney and adrenal were resected, and the patient was carefully fol...
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Gao HX, Liu CX, Zou H, Chun CP, Cui X, Chen Y, Zhang W, Qi Y, Wang N, Liang W, Jiang J, Li F Tags: Int J Clin Exp Pathol Source Type: research

Treg cells: a potential regulator for IL-22 expression?
Abstract Inteleurkin-22 (IL-22) is a IL-10 family cytokine member and is mainly produced by innate lymphoid cells (ILCs), Th17 cells, and Th22 cells. Previous studies have indicated that IL-23 and several transcription factors, including STAT3, RORγt, and the AhR are important stimulus. Recently, there is emerging evidence that Tregs can regulate IL-22 expression. In the review, we discuss the updated advancement on Tregs function and its regulatory role on IL-22 expression. PMID: 24551268 [PubMed - as supplied by publisher] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - February 23, 2014 Category: Pathology Authors: Lin S, Yang X, Liang D, Zheng SG Tags: Int J Clin Exp Pathol Source Type: research

Requirement for TLR2 in the development of albuminuria, inflammation and fibrosis in experimental diabetic nephropathy.
Abstract Inflammation and fibrosis are essential elements of diabetic nephropathy (DN). We tested the hypothesis that these elements are dependent upon Toll-like receptor 2 (TLR2) signalling by examining WT and TLR2(-/-) mice in an experimental model of DN. Diabetes was induced in WT and TLR2(-/-) mice by i.p. injection of streptozotocin. Kidney injury was assessed at 6, 12 and 24 weeks after induction of diabetes. Gene expression of TLR2, its endogenous ligands and downstream cytokines, chemokines and fibrogenic molecules were upregulated in kidneys from WT mice with streptozotocin diabetes. TLR2(-/-) mice were p...
Source: International Journal of Clinical and Experimental Pathology - February 23, 2014 Category: Pathology Authors: Ma J, Wu H, Zhao CY, Panchapakesan U, Pollock C, Chadban SJ Tags: Int J Clin Exp Pathol Source Type: research

Osteo-radio-necrosis (ORN) and bisphosphonate-related osteonecrosis of the jaws (BRONJ): the histopathological differences under the clinical similarities.
CONCLUSIONS: The demonstrated differences in the bone architecture and in the bone collagen content between the two pathological conditions most likely reflect underlying pathophysiological differences. PMID: 24551270 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - February 23, 2014 Category: Pathology Authors: Mitsimponas KT, Moebius P, Amann K, Stockmann P, Schlegel KA, Neukam FW, Wehrhan F Tags: Int J Clin Exp Pathol Source Type: research

Tim-1-Fc suppresses chronic cardiac allograft rejection and vasculopathy by reducing IL-17 production.
Abstract Previously, we demonstrated that Tim-1-Fc prevents acute cardiac graft rejection by inhibiting Th1 response. In the present report, we tackled the impact of Tim-1-Fc on Th17 cells in a model of cardiac chronic rejection. Administration of Tim-1-Fc did not result in a detectable impact on innate immunity and regulatory T cells, while it provided protection for Bm12-derive cardiac grafts against chronic rejection in B6 recipients, as manifested by the reduction of inflammatory infiltration along with less severity of vasculopathy. Studies in T-bet(-/-) recipients by implanting Bm12-derived cardiac grafts fu...
Source: International Journal of Clinical and Experimental Pathology - February 23, 2014 Category: Pathology Authors: Shi X, Zhang M, Liu F, Wang Z, Zhang L, Cheng H, Zhang S, Fei T, Guo M, Bian J, Wang Q, Ding G Tags: Int J Clin Exp Pathol Source Type: research

Potential biomarkers for sensitivity of gallbladder cancer cells to gemcitabine.
Abstract Gemcitabine (Gem)-based chemotherapies are the main therapeutic regimens for patients with unresectable advanced or metastatic gallbladder cancer (GBC). However, the modest ORR and mild benefit on survival demonstrates the need for finding biomarkers for sensitivity to Gem and hence improving the therapy. In present work, two GBC cell lines with vast difference in sensitivity to Gem were subjected to DNA microarray analysis. Dramatic expression difference was found in protein kinase A signaling, P2Y purigenic receptor signaling, ErbB signaling and p70S6K signaling. Predicted low expression of KRAS and ina...
Source: International Journal of Clinical and Experimental Pathology - February 23, 2014 Category: Pathology Authors: Yang C, Xu M, Shen HJ, Zhu HY, Li F, He M, Chen T, Wang J, Shi WJ, Ji F Tags: Int J Clin Exp Pathol Source Type: research

Expression analysis of BMP2, BMP5, BMP10 in human colon tissues from Hirschsprung disease patients.
CONCLUSIONS: BMP2, BMP5 and BMP10 are elevated in the stenotic colon segment of HSCR, and BMPs signaling plays a pivotal role in the development of HSCR. PMID: 24551273 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - February 23, 2014 Category: Pathology Authors: Wu M, Chen W, Mi J, Chen D, Wang W, Gao H Tags: Int J Clin Exp Pathol Source Type: research

NOX1 is responsible for cell death through STAT3 activation in hyperoxia and is associated with the pathogenesis of Acute Respiratory Distress Syndrome.
This study demonstrates that NOX1 is involved in human ARDS pathophysiology and is responsible for the damage occurring in alveolar epithelial cells at least in part via STAT3 signalling pathways. PMID: 24551274 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - February 23, 2014 Category: Pathology Authors: Carnesecchi S, Dunand-Sauthier I, Zanetti F, Singovski G, Deffert C, Donati Y, Cagarelli T, Pache JC, Krause KH, Reith W, Barazzone-Argiroffo C Tags: Int J Clin Exp Pathol Source Type: research

Alveolar epithelial cells in idiopathic pulmonary fibrosis display upregulation of TRAIL, DR4 and DR5 expression with simultaneous preferential over-expression of pro-apoptotic marker p53.
In this study, we investigated expression of a panel of pro-apoptotic and cell cycle regulatory proteins in 21 IPF and 19 control lung tissue samples. We reveal significant upregulation of the apoptosis-inducing ligand TRAIL and its cognate receptors DR4 and DR5 in AEC within active lesions of IPF lungs. This upregulation was accompanied by pro-apoptotic protein p53 overexpression. In contrast, myofibroblasts within the fibroblastic foci of IPF lungs exhibited high TRAIL, DR4 and DR5 expression but negligible p53 expression. Similarly, p53 expression was absent or negligible in IPF and control alveolar macrophages and lymp...
Source: International Journal of Clinical and Experimental Pathology - February 23, 2014 Category: Pathology Authors: Akram KM, Lomas NJ, Forsyth NR, Spiteri MA Tags: Int J Clin Exp Pathol Source Type: research

microRNA-21 promotes cardiac fibrosis and development of heart failure with preserved left ventricular ejection fraction by up-regulating Bcl-2.
Abstract The morbidity and mortality of heart failure with preserved left ventricular ejection fraction (HFpEF) were similar to those of systolic heart failure, but the pathogenesis of HFpEF remains poorly understood. It was demonstrated that, in systolic heart failure, microRNA-21 (miR-21) could inhibit the apoptosis of cardiac fibroblasts, leading to cardiac hypertrophy and myocardial fibrosis, but the role of miR-21 in HFpEF remains unknown. By employing cell culture technique, rat myocardiocytes and cardiac fibroblasts were obtained. The expression of miR-21 in the two cell types under different conditions was...
Source: International Journal of Clinical and Experimental Pathology - February 23, 2014 Category: Pathology Authors: Dong S, Ma W, Hao B, Hu F, Yan L, Yan X, Wang Y, Chen Z, Wang Z Tags: Int J Clin Exp Pathol Source Type: research

Hypoxia promotes the proliferation of cervical carcinoma cells through stimulating the secretion of IL-8.
Abstract To explore whether hypoxia and interleukin 8 (IL-8) regulate the viability and apoptosis of cervical carcinomas cells and the possible mechanism. We evaluated the expression of hypoxia inducible factor-1α (HIF-1α), IL-8 and its receptors (CXCR1 and CXCR2) in cervical cancer and cervicitis tissues by immunohistochemistry. Then the effects of hypoxia and IL-8 on the viability and apoptosis of HeLa and SiHa cells were detected by the SRB and apoptosis assays. Here we observed that the expression of HIF-1α, IL-8 and CXCR1 in cervical cancer tissues was significantly higher than that in cervi...
Source: International Journal of Clinical and Experimental Pathology - February 23, 2014 Category: Pathology Authors: Liu LB, Xie F, Chang KK, Li MQ, Meng YH, Wang XH, Li H, Li DJ, Yu JJ Tags: Int J Clin Exp Pathol Source Type: research

Depleting ABCE1 expression induces apoptosis and inhibits the ability of proliferation and migration of human esophageal carcinoma cells.
This study aims to explore the clinical characteristics of ABCE1 in esophageal cancers and its roles in the proliferation, invasiveness, migration and apoptosis of the esophageal carcinoma Eca109 cell line. METHODS: The expression of ABCE1 and its target protein-RNase L, were first studied in tumor tissues of esophageal carcinoma and adjacent non-tumor tissues. The siRNA green fluorescent protein (GFP) expression vector of ABCE1 was prepared and transfected into the esophageal carcinoma Eca109 cells, then the fluorescence microscope was used to study the transfection efficiency. The MTT assay, cell invasion, the trans...
Source: International Journal of Clinical and Experimental Pathology - February 23, 2014 Category: Pathology Authors: Huang B, Gong X, Zhou H, Xiong F, Wang S Tags: Int J Clin Exp Pathol Source Type: research

Overexpression of periostin is significantly correlated to the tumor angiogenesis and poor prognosis in patients with esophageal squamous cell carcinoma.
This study aimed to examine the expression of PN in patients with esophageal squamous cell carcinoma (ESCC) and explore the relationship of PN expression with clinicopathologic factors, tumor angiogenesis and prognosis. The results showed that increased PN protein expression was prevalent in ESCC and was significantly associated with lymphatic metastasis (P=0.008), tumor differentiation (P=0.04), venous invasion (P=0.014) and TNM stage (P=0.001). Additionally, expression of PN was found to be an independent prognostic factor in ESCC patients. High expression of PN protein is closely correlated to the tumor progression and ...
Source: International Journal of Clinical and Experimental Pathology - February 23, 2014 Category: Pathology Authors: Wang W, Sun QK, He YF, Ma DC, Xie MR, Ji CS, Hu B Tags: Int J Clin Exp Pathol Source Type: research

microRNA-155 acts as an oncogene by targeting the tumor protein 53-induced nuclear protein 1 in esophageal squamous cell carcinoma.
Abstract MicroRNA-155 (miR-155) is overexpressed in many human cancers; however, the function of miR-155 is largely unknown in esophageal squamous cell carcinoma (ESCC). In the present study, we found that miR-155 is dramatically increased in ESCC tissues compared with the paired adjacent normal tissues, which suggested that miR-155 acts as an oncogene in ESCC. We predicted that tumor protein p53-induced nuclear protein 1 (TP53INP1) is a candidate target gene of miR-155 given that miR-155 expression decreased mRNA and protein levels of TP53INP1 as determined by RT-PCR and Western blot analysis. In addition, miR-15...
Source: International Journal of Clinical and Experimental Pathology - February 23, 2014 Category: Pathology Authors: Zhang J, Cheng C, Yuan X, He JT, Pan QH, Sun FY Tags: Int J Clin Exp Pathol Source Type: research