SOX9 was involved in TKIs resistance in renal cell carcinoma via Raf/MEK/ERK signaling pathway.
Abstract Renal cell carcinoma (RCC) is common genitourinary malignancy in human, 30-40% of patients with RCC would be diagnosed with metastatic RCC (mRCC). Even in the era of targeted therapy, patients with mRCC would inevitably progress due to drug resistance. Herein, exploration of the mechanisms of resistance is noteworthy to study. In the present study, we firstly reported the expression profile of SOX9 in renal carcinoma cells and tissues, and found that its expression was significantly associated with Fuhrman grading. Dual luciferase analysis confirmed that Raf/MEK/ERK pathway could directly be regulated by ...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Li XL, Chen XQ, Zhang MN, Chen N, Nie L, Xu M, Gong J, Shen PF, Su ZZ, Weng X, Tan JY, Zhao T, Zeng H, Zhou Q Tags: Int J Clin Exp Pathol Source Type: research

LOXL4 is downregulated in hepatocellular carcinoma with a favorable prognosis.
Abstract Lysyl oxidase like 4 (LOXL4), a member of the secreted copper-dependent amine oxidases that contribute to the assemble and maintenance of the extracellular matrix (ECM), was found to be up-regulated or down-regulated in different cancer types, suggesting its paradoxical roles in cancer. The specific role of LOXL4 in hepatocellular carcinoma (HCC), however, is still yet to be defined. Twenty-eight pairs of HCC specimens were used for LOXL4 mRNA expression analysis. The mRNA expression in HCC cell lines was examined, and HepG2 was selected for LOXL4 small interfering RNA (siRNA) interference to investigate ...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Tian M, Liu W, Jin L, Jiang X, Yang L, Ding Z, Shen Y, Peng Y, Gao D, Li L, Zhou J, Qiu S, Dai Z, Fan J, Shi Y Tags: Int J Clin Exp Pathol Source Type: research

Epithelioid angiosarcoma: a clinicopathological study of 16 Chinese cases.
CONCLUSIONS: EA is highly aggressive and carries a very poor prognosis. Therefore, the clinical recognition and correct diagnosis of EA are essential. PMID: 26097574 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Wu J, Li X, Liu X Tags: Int J Clin Exp Pathol Source Type: research

Vascular invasion as an independent predictor of poor prognosis in nonmetastatic gastric cancer after curative resection.
Abstract The prognostic significance of vascular invasion (VI) in nonmetastatic gastric cancer (GC) remains a matter of controversy. The purpose of this study was to assess the impact of VI on survival in this group of GC patients. We enrolled 361 GC patients without metastasis who underwent curative gastrectomy between 1996 and 2009 in Sun Yat-sen University Cancer Center. A retrospective analysis of the clinicopathological data was performed, focusing on the impact of VI detected by routine H&E staining on disease-free survival (DFS) and cancer-specific survival (CSS). The presence of VI was detected in 13.9...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Li P, Ling YH, Zhu CM, Hu WM, Zhang XK, Luo RZ, He JH, Yun JP, Li YF, Cai MY Tags: Int J Clin Exp Pathol Source Type: research

High expression of Zinc-finger protein X-linked is associated with reduced E-cadherin expression and unfavorable prognosis in nasopharyngeal carcinoma.
In this study, quantitative real-time polymerase chain reaction, Western blot and Immunohistochemistry were performed to detect ZFX expression in NPC and normal nasopharyngeal tissues. As a result, we found ZFX expression was significantly elevated in NPC tissues compared with that in normal nasopharyngeal tissues. The statistical analysis based on immunohistochemical staining demonstrated that ZFX expression was significantly correlated with lymph node stage and clinical stage. Furthermore, we found NPC patients with high ZFX expression had lower 5-year overall survival rates, progression-free survival rates, loco-regiona...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Li Y, Yan X, Yan L, Shan Z, Liu S, Chen X, Zou J, Zhang W, Jin Z Tags: Int J Clin Exp Pathol Source Type: research

Associations between the properties of the cartilage matrix and findings from quantitative MRI in human osteoarthritic cartilage of the knee.
Abstract The aim of this study was to investigate the associations between the properties of the cartilage matrix and the results of T2 mapping and delayed gadolinium-enhanced magnetic resonance imaging (dGEMRIC) in human knee osteoarthritic cartilage. Osteochondral samples were harvested from the middle part of the femoral condyle and tibial plateaus of 20 patients with knee osteoarthritis (OA) during total knee arthroplasty. Sagittal T2 mapping, T1pre, and T1Gd were performed using 7.0T magnetic resonance imaging (MRI). Gycosaminoglycan (GAG) distribution was evaluated by OARSI, collagen anisotropy was assessed ...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Wei B, Du X, Liu J, Mao F, Zhang X, Liu S, Xu Y, Zang F, Wang L Tags: Int J Clin Exp Pathol Source Type: research

Bronchogenic cyst of the conus medullaris with spinal cord tethering: a case report and review of the literature.
Abstract Bronchogenic cysts (BCs) are congenital malformations that originate from remnants of the primitive foregut. Intraspinal BCs, especially those of the conus medullaris are rare with only one case reported until now. To date, a bronchogenic cyst with spinal cord tethering has not been previously reported. We reviewed the clinical course of a 44-year-old woman, who presented with low back pain and leg weaknesss as well as sphincter disturbance. Magnetic resonance imaging showed an intradural oval mass located at the conus medullaris. A tethered cord was also observed, as well as a dermal sinus tract. The mas...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Zou MX, Hu JR, Kang YJ, Li J, Lv GH, She XL Tags: Int J Clin Exp Pathol Source Type: research

Evaluation of oxidative events and copper accumulatıon in oral tissues of patients wıth Wilson's disease: three case report.
Abstract Wilson's disease (WD), also known as hepatolenticular degeneration, was first described in 1912 by Kinnear Wilson. It is an autosomal recessive disorder caused by mutations in the ATP7B gene, a membrane-bound copper transporting ATPase. The disorder is caused by impairment of the copper transporting ATPase, ATP7B, in the liver, which disturbs copper transport, excretion into the bile, and incorporation into apoceruloplasmin. WD is an inherited copper metabolism disorder with pathological copper accumulation in many tissues, but especially in brain and liver. We conducted this study because copper accumula...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Ozturk M, Karacelebi E, Gungor K, Coskun S, Boysan E Tags: Int J Clin Exp Pathol Source Type: research

Selection of reference genes for expression analyses in liver of rats with impaired glucose metabolism.
ar LA Abstract Hepatic gene expression studies are vital for identification of molecular factors involved in insulin resistance. However, the need of normalized gene expression data has led to the search of stable genes which are useful as a reference in specific experimental conditions. The aim of this study was to evaluate expression stability of potential reference genes for real-time PCR gene expression studies, in rats with insulin resistance, early programmed in intrauterine environment of maternal insulin resistance and triggered by exposure to a high sucrose and fat diet in adult life. Male rats coming fro...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Hernández AH, Curi R, Salazar LA Tags: Int J Clin Exp Pathol Source Type: research

Large palpable ductal carcinoma in situ is Her-2 positive with high nuclear grade.
Abstract Ductal carcinoma in situ (DCIS) of the breast is a heterogeneous group with variable clinical presentation. The exact molecular mechanism is not known why some ductal carcinomas may reach to such a large size but still remains in situ. Although, molecular classification of DCIS lesions and nuclear grading are important for identification of more aggressive lesions but it is not sufficient. Our aim was to examine the expression pattern of immunohistochemical (IHC) markers of ER, PR, HER-2 in palpable DCIS lesions and compare with clinicopathological findings. Our center is referral hospital from South of I...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Monabati A, Sokouti AR, Noori SN, Safaei A, Talei AR, Omidvari S, Azarpira N Tags: Int J Clin Exp Pathol Source Type: research

Effects of Smad decoy ODN on shear stress-induced atherosclerotic ApoE-/-mouse.
We examined the effect of cast placement on the development of atherosclerosis, and the carotid artery was harvested at the sacrifice to observe histological changes. Also, we evaluated the impact of Smad decoy ODN in the regulation of genes expression related to atherosclerosis, including TGF-β1, PAI-1, and α-SMA. Our results showed that western diet with cast placement developed atherosclerosis in ApoE-/-mouse. Also, administration of Smad decoy ODN decreases the expression of TGF-β1, PAI-1, and α-SMA. These results demonstrate the potential of Smad decoy ODN to prevent the progression of atheroscle...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: An HJ, Lee WR, Kim KH, Kim JY, Kim WH, Park KK, Youn SW Tags: Int J Clin Exp Pathol Source Type: research

Differential expression of FOXA1, DUSP6, and HA117 in colon segments of Hirschsprung's disease.
Abstract OBJECTIVE: To describe the expression profiles of FOXA1, DUSP6, and HA117 in different portions of the colon of patients diagnosed with Hirschsprung's disease (HSCR). METHODS: Colon specimens were collected from34 HSCR patients and grouped into 3 segments: proximal anastomosis, dilated segment and stenotic segment. Levels of FOXA1, DUSP6, and HA117 RNA were evaluated by real-time PCR. Levels of FOXA1 and DUSP6 protein were analyzed by immunohistochemistry and Western blotting. RESULTS: The levels of FOXA1 and DUSP6 RNA were significantly lower in the stenotic segment compared to proximal anastomosis (P
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Luo Y, Li S, Teng Y, Wang N, Li L, Liu H, Jin X Tags: Int J Clin Exp Pathol Source Type: research

miR-144 regulates transforming growth factor-β1 iduced hepatic stellate cell activation in human fibrotic liver.
miR-144 regulates transforming growth factor-β1 iduced hepatic stellate cell activation in human fibrotic liver. Int J Clin Exp Pathol. 2015;8(4):3994-4000 Authors: Liu Z, Yi J, Ye R, Liu J, Duan Q, Xiao J, Liu F Abstract OBJECTIVES: Activation of hepatic stellate cells (HSCs) into collagen producing myofibroblasts is critical for pathogenesis of liver fibrosis. Transforming growth factor-β1 (TGF-β1) is one of the main profibrogenic mediators for HSC transdifferentiation. Recent studies have shown effect of microRNAs (miRNAs) on regulating TGF-β1-induced HSC activation during liver...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Liu Z, Yi J, Ye R, Liu J, Duan Q, Xiao J, Liu F Tags: Int J Clin Exp Pathol Source Type: research

Cullin1 is up-regulated and associated with poor patients' survival in hepatocellular carcinoma.
Abstract Cullin1 (Cul1) is a scaffold protein of the ubiquitin E3 ligase Skp1/Cullin1/Rbx1/F-box protein complex, which ubiquitinates a broad range of proteins involved in cell-cycle progression, signal transduction, and transcription. To investigate the role of Cul1 in the development of hepatocellular carcinoma (HCC), we evaluated the Cul1 expression by immunohistochemistry using a tissue microarray (TMA) containing 90 cases HCC tissues and paired adjacent non-cancerous tissues. We analyzed the correlation between Cul1 expression and clinicopathologic variables and patients survival using two independent HCC coh...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Liu W, Wang Y, Zhang C, Huang B, Bai J, Tian L Tags: Int J Clin Exp Pathol Source Type: research

Up-regulation of long non-coding RNA Sox2ot promotes hepatocellular carcinoma cell metastasis and correlates with poor prognosis.
Abstract BACKGROUND: Long non-coding RNAs (lncRNAs) have been shown to have important regulatory roles in cancer biology, and the lncRNA Sox2ot is up-regulated in some tumors. However, the contributions of Sox2ot to hepatocellular carcinoma (HCC) remain largely unknown. METHODS: In the present study, expression of lncRNA Sox2ot was evaluated by quantitative real-time PCR in tumor tissues and adjacent non-tumor tissues in 84 HCC patients. The association of lncRNA Sox2ot expression with clinicopathological features and the prognosis of HCC patients were also analyzed. Survival analysis was performed using the ...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Shi XM, Teng F Tags: Int J Clin Exp Pathol Source Type: research

NKD1 down-regulation is associated with poor prognosis in breast invasive ductal carcinoma.
In this study, we performed western blotting and immunohistochemistry to evaluate the expression of NKD1 and relevance with clinicopathological factors in the breast invasive ductal carcinoma. Reduction of NKD1 was significantly correlated with lymph node metastasis, histological grade and ER expression in breast cancer. Patients with negative NKD1 expression had significantly lower cumulative postoperative 5 year survival rate than those with positive NKD1 expression. This interpretation is in keeping with the results obtained from our in vitro experiments on MDA-MB-231 cells, we demonstrated that upregulation of NKD1 exp...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Lv ZD, Zhang L, Liu XP, Jin LY, Dong Q, Li FN, Wang HB, Kong B Tags: Int J Clin Exp Pathol Source Type: research

Combination of CD4(+)CD25(+)CD127(-) regulatory T cells with MLC-BE and BE-Ab2: an efficient evaluation of the therapy of paternal lymphocyte induced immunization in unexplained recurrent spontaneous abortion patients.
Abstract The aim of this retrospective study was to compare the immune tolerance status of patients suffered from unexplained spontaneous abortion (URSA) before and after treatment with paternal lymphocyte induced immunization (PLII) four times, and its relationship to the pregnancy outcome. 168 URSA patients were included in the present study. Among 168 couples, 138 couples were conceived again, of whom 86 were successfully pregnant till 20 gestational weeks, 31 cases again failed in the first trimester, 21 cases were still under follow-up, another 30 cases still had not conceived. Both the level of one way mixed...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Yuan MM, Du MR, Wang MY, Duan ZL, Meng Y, Jin LP, Li MQ, Li DJ Tags: Int J Clin Exp Pathol Source Type: research

Erythropoietin and erythropoietin receptor in hepatocellular carcinoma: correlation with vasculogenic mimicry and poor prognosis.
Abstract To evaluate erythropoietin (Epo) and erythropoietin receptor (EpoR) expression, its relationship with vasculogenic mimicry (VM) and its prognostic value in human hepatocellular carcinoma (HCC), we examined Epo/EpoR expression and VM formation using immunohistochemistry and CD31/PAS (periodic acid-Schiff) double staining on 92 HCC specimens. The correlation between Epo/EpoR expression and VM formation was analyzed using two-tailed Chi-square test and Spearman correlation analysis. Survival curves were generated using Kaplan-Meier method. Multivariate analysis was performed using Cox regression model to ass...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Yang Z, Sun B, Zhao X, Shao B, An J, Gu Q, Wang Y, Dong X, Zhang Y, Qiu Z Tags: Int J Clin Exp Pathol Source Type: research

HK2 is a radiation resistant and independent negative prognostic factor for patients with locally advanced cervical squamous cell carcinoma.
Abstract The mechanism by which overexpression of hexokinase 2 (HK2) indicates locally advanced cervical squamous cell carcinoma (LACSCC) with radio-resistance is still unknown despite being an independent biomarker of poor prognosis. Here, we retrospectively analyzed 132 female patients receiving radiotherapy for cervical squamous cell carcinoma including 85 radiation-sensitive cases and 47 radiation-resistant cases. The expression of HK2 was examined by immunohistochemistry. The percentage of high HK2 expression in the radiation-resistant group differed from the radiation-sensitive group with statistical significance (P
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Huang X, Liu M, Sun H, Wang F, Xie X, Chen X, Su J, He Y, Dai Y, Wu H, Shen L Tags: Int J Clin Exp Pathol Source Type: research

Differential expression of GSK3β and pS9GSK3β in normal human tissues: can pS9GSK3β be an epithelial marker?
Differential expression of GSK3β and pS9GSK3β in normal human tissues: can pS9GSK3β be an epithelial marker? Int J Clin Exp Pathol. 2015;8(4):4064-73 Authors: Lee H, Ro JY Abstract Glycogen synthase kinase 3β (GSK3β) and phosphorylated GSK3β at Ser9 (pS9GSK3β) are crucial in cellular proliferation and metabolism. GSK3β and pS9GSK3β are deregulated in many diseases including tumors. Data on altered expression of GSK3β and pS9GSK3β are mainly limited to tumor tissues, thus the expression of GSK3β and pS9GSK3β in normal human tissue has bee...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Lee H, Ro JY Tags: Int J Clin Exp Pathol Source Type: research

Significance of serum levels of vitamin D and some related minerals in breast cancer patients.
CONCLUSION: It is not only the deficient levels of Vit D and other related minerals, but the combination of the abnormal levels of all the studied parameters that might contribute to the development of cancer. Further studies with larger number of patient are needed. PMID: 26097595 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Abdelgawad IA, El-Mously RH, Saber MM, Mansour OA, Shouman SA Tags: Int J Clin Exp Pathol Source Type: research

FRZB up-regulation is correlated with hepatic metastasis and poor prognosis in colon carcinoma patients with hepatic metastasis.
Abstract Frizzled-related protein (FRZB) was up-regulated in hepatic metastasis samples compared with primary colon cancer samples in our previous work. However, the clinical relevance of FRZB in colon cancer hepatic metastasis remains uncertain. The aim of this study was to assess the prognostic value of FRZB in patients with colon carcinoma hepatic metastasis after hepatic resection. FRZB expression was evaluated by immunohistochemistry in formalin-fixed paraffin embedded (FFPE) primary colon carcinoma and paired hepatic metastasis tissues from 136 patients with liver metastasis from colon carcinoma that underwe...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Shen Y, Zhang F, Lan H, Chen K, Zhang Q, Xie G, Teng L, Jin K Tags: Int J Clin Exp Pathol Source Type: research

Interleukin-10 promotor -592A/C polymorphism is associated with slow coronary flow in Han Chinese.
Abstract An accumulating body of evidence suggests that slow coronary flow (SCF) phenomenon seems to be an early-form of atherosclerosis and low-grade inflammation plays a major role in the atherosclerotic vascular processes. Interleukin (IL)-10 is a multifunctional cytokine involved in both innate and adaptive immune response. The aim of the present study is to investigate the association of IL-10 gene -592A/C polymorphism with SCF in Han Chinese. 250 patients who underwent coronary angiography and had angiographically normal coronary arteries of varying coronary flow rates without any atherosclerotic lesion were...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Shi GL, Cai XX, Su YM, Chen C, Deng XT, Pan HY, Fan MK, Zhu JH, Pan M Tags: Int J Clin Exp Pathol Source Type: research

Effects of storage conditions on the stability of serum CD163, NGAL, HMGB1 and MIP2.
In this study, potential utility of serum samples of a CHB cohort was evaluated to investigate several processes that might impact cytokine profiles such as temperature, storage time and number of freeze-thaw cycles. Blood samples collected from 100 patients with CHB were separated immediately and divided into two groups. In one group, samples (n=50) stored at -80°C were subject to 1-3 freeze-thaw cycles. In the other group, samples (n=50) were stored at 4°C and 25°C for 3 h, 9 h, 24 h, 48 h, 72 h, and 7 d time points, respectively. To assess the influence of different storage conditions on cytokines, the level...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Wang J, Zhu HH, Xue JH, Wu SS, Chen Z Tags: Int J Clin Exp Pathol Source Type: research

Genetic variability of DNA repair mechanisms influences chemotherapy outcome of gastric cancer.
In conclusion, ERCC1 rs11615, rs2298881 and ERCC2 rs1799793 polymorphism play an important role in the treatment outcome of gastric cancer. PMID: 26097599 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Yu H, Wu X, Zhang Y, Jin Z, Li G, Zhao H Tags: Int J Clin Exp Pathol Source Type: research

Whether Alzheimer's diseases related genes also differently express in the hippocampus of Ts65Dn mice?
CONCLUSIONS: There are differential expressed genes in the hippocampus of Ts65Dn mice that may be closely related to Alzheimer's disease. PCR array technology was used in the screening and identification of these genes. PMID: 26097601 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Zhang B, Wang Q, Miao T, Yu B, Yuan P, Kong J, Lu B Tags: Int J Clin Exp Pathol Source Type: research

Prognostic significance of long non-coding RNA PCAT-1 expression in human hepatocellular carcinoma.
We examined the expression of PCAT-1 in 117 HCC tissues and adjacent non-tumor tissues using quantitative real-time-PCR and analyzed its correlation with the clinical parameters. RESULTS: Our data showed that PCAT-1 expression in HCC tissues was significantly increased compared with adjacent non-tumor tissues (P
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Yan TH, Yang H, Jiang JH, Lu SW, Peng CX, Que HX, Lu WL, Mao JF Tags: Int J Clin Exp Pathol Source Type: research

Increased expression of microRNA-196a predicts poor prognosis in human ovarian carcinoma.
In this study, we investigated the expression of miR-196a in ovarian carcinoma and its relationship with tumor progression and clinical prognosis. METHODS: The expression level of miR-196a was examined by quantitative Real-time PCR (qRT-PCR) in surgically removed ovarian cancer tissues and ovarian cancer cell lines. The correlation between miR-196a expression and clinical features and prognosis were statistically analyzed. RESULTS: The results showed that the miR-196a expression was significantly upregulated in tumor tissues and ovarian cancer cell lines compared with that in normal ovarian surface tissues and no...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Fan Y, Fan J, Huang L, Ye M, Huang Z, Wang Y, Li Q, Huang J Tags: Int J Clin Exp Pathol Source Type: research

Stereological evaluation of fibronectin in the periurethral region of the transitional zone from normal human prostates compared with benign prostatic hyperplasia.
Abstract The aim of this study was to assess the volumetric density (Vv) of the fibronectin in the periurethral region of patients with benign prostatic hyperplasia (BPH) and compare with a control group. Prostatic periurethral tissue samples were obtained from ten patients (age range 65 to 79 years, mean 66) with clinical symptoms of bladder outlet obstruction who had undergone open prostatectomy. The control group samples (periurethral tissue samples from the transitional zone) were collected from prostates obtained during autopsy of accidental death adults of less than 25 years. The volumetric density (Vv) of t...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Manaia JH, Cardoso GP, Babinski MA Tags: Int J Clin Exp Pathol Source Type: research

Clinical experience of uterine tumors resembling ovarian sex cord tumors: a clinicopathological analysis of 6 cases.
CONCLUSION: These UTROSCTs are polymorphic neoplasms with true sex cord differentiation and uncertain malignant potential, which possess a distinct biology from ESTSCLEs. PMID: 26097607 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Liu CY, Shen Y, Zhao JG, Qu PP Tags: Int J Clin Exp Pathol Source Type: research

Interactions of central obesity with rs3918242 on risk of non-alcoholic fat liver disease: a preliminary case-control study.
Abstract NAFLD is a complex disease characterized by inflammation and insulin resistance which is determined by an interaction of genetics and environmental factors. MMP gene has been implicated in relation to inflammation and insulin resistance. The preliminary case-control study aimed to investigate the association between Matrix metalloproteinase (MMP)-9-1562C/T (rs3918242), MMP-2-1306C/T (rs243865) and risk of NAFLD and to further evaluate the interactions of central obesity with rs3918242 and rs243865. Two variants, rs3918242 and rs243865, were genotyped by polymerase chain reaction -restriction fragment leng...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Wu P, Hua Y, Tan S, Li M, Shu Y, Fang G Tags: Int J Clin Exp Pathol Source Type: research

Association of -308G/A and -238G/A polymorphisms of TNF-α and osteosarcoma risk.
CONCLUSION: The AA genotype of -308G/A locus of TNF-α gene was a risk factor for OS, however there was no correlation between -238G/A of TNF-α and OS. PMID: 26097610 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Zhao Z, Tang X, Song K, Li X, Zhang Y Tags: Int J Clin Exp Pathol Source Type: research

Association of IL-1α rs17561 and IL-1 RN rs315952 polymorphisms with Tourette syndrome: a family-based study.
CONCLUSION: Our results suggest that IL-1α rs17561 and IL-1RN rs315952 polymorphisms may not be associated with susceptibility to TS in Chinese Han population. However, the results still need to be replicated in a larger sample size and different populations. PMID: 26097611 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: He F, Shao X, Yi M, Wang Y, Wang CY, Liu S Tags: Int J Clin Exp Pathol Source Type: research

Peripheral T cell lymphoma, not otherwise specified with myelofibrosis: report of a case with review of the literature.
Abstract A 68-year-old man presented to us with pancytopenia, erythroderma, and multiple lymphadenopathies. Lymph node biopsy led to the diagnosis of peripheral T-Cell lymphoma-not otherwise specified (PTCL-NOS). Immunostaining of the lymph node biopsy specimens for cytokines revealed that the tumor cells were positive for plated-derived growth factor (PDGF), basic fibroblast growth factor (b-FGF), vascular endothelial growth factor (VEGF), tumor necrosis factor α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), interleukin-2 (IL-2), and transforming growth factor-β (TG...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Sekiguchi Y, Shirane S, Shimada A, Ichikawa K, Wakabayashi M, Sugimoto K, Tomita S, Izumi H, Nakamura N, Sawada T, Ohta Y, Komatsu N, Noguchi M Tags: Int J Clin Exp Pathol Source Type: research

P120 catenin attenuates lipopolysaccharide-induced blood-brain barrier dysfunction and inflammatory responses in human brain microvascular endothelial cells.
In this study, we found that p120ctn expression was correlated with an increase in the permeability of BBB and a decrease in the expression of tight-junction proteins in human brain microvascular endothelial cells (HBMECs) after LPS challenge. Transfection with p120ctn small interfering RNA (siRNA) induced disruption of BBB integrity, monocyte migration across BBB and inflammatory responses at basal level and after LPS treatment. Conversely, over-expression of p120ctn with adenovirus significantly ameliorated BBB disruption and inflammatory responses in LPS-treated cells. Mechanistically, up-regulation of p120ctn inhibited...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Liu N, Li AL, Zhou XP, Chen Q, Cao W Tags: Int J Clin Exp Pathol Source Type: research

Epithelioid inflammatory myofibroblastic sarcoma in abdominal cavity: a case report and review of literature.
In this study, we present a rare and difficult case of epithelioid inflammatory myofibroblastic sarcoma (EIMS) in abdominal cavity. A 47-year-old female presented as left upper abdominal pain for 6 months and abdominal distention for 1 month. CT examination showed a solid mass in the left upper intra-abdomen. Grossly, the tumor was found in the mesenterium of colon with the size of 7.5 × 6.5 × 3.5 cm, and was solid and gray-yellowish in the cut surface. Focal myxomatous appearance was observed. Microscopically, stromal myxoid change together with prominant infiltrated lymphocytes, neutrophils and eosinophils we...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Wu H, Meng YH, Lu P, Ning HY, Hong L, Kang XL, Duan MG Tags: Int J Clin Exp Pathol Source Type: research

Transient elastography-derived liver stiffness measurements were found to be useful for predicting liver infiltration in a case of mature T-cell neoplasm involving liver dysfunction.
Abstract Transient elastography (TE) is a novel, non-invasive imaging technique for measuring liver stiffness (LS). It is considered to be useful for predicting the severity of fibrosis and the risk of cirrhosis or hepatocellular carcinoma. However, the association between the presence of diffuse regions of increased cell density in the liver and elevated LS values has not been assessed. We experienced a case in which a mature T-cell neoplasm had invaded the liver, but the infiltrating lesion was not detected by contrast-enhanced computed tomography (CT) or fluorodeoxyglucose positron emission tomography/CT scans....
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Ichikawa K, Narita Y, Ota Y, Komatsu N, Koike M Tags: Int J Clin Exp Pathol Source Type: research

Fibrosarcoma arising from gouty tophi: report of a unique case and review of literature.
Abstract Fibrosarcoma is a malignant mesenchymal tumor. To the author's best knowledge, no previous case of fibrosarcoma arising from gouty tophi has been reported. Here we reported the first case of fibrosarcoma arising from gouty tophi. A case of 58-year-old man was presented with a mass with ulcer and infection in the second joint of left middle finger for 2 months, with long standing gouty tophi. The tumor was biopsied and the biopsy showed complete excision of the tumor. With the pathological and immunohistochemical features considered, the diagnosis of fibrosarcoma associated with gouty tophi was made. The c...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Wang JJ, Wang HY, Cheng K, Wang X, Yu B, Shi SS, Zhou XJ, Shi QL Tags: Int J Clin Exp Pathol Source Type: research

A case report of sclerosing thymoma of the anterior mediastinum: an exceedingly rare morphology.
Abstract The morphology of thymoma is diverse, although 5 basic subtypes are recognized in the World Health Organization classification system. Sclerosing thymoma was first documented in 1994 and to date only 13 cases have been reported. Sclerosis itself is considered to be an ancient change and can occur in various histological subtypes. Herein, we present a case of a 62-year-old woman incidentally found to have an anterior mediastinal mass, 31 × 24 × 17 mm in size, without an associated autoimmune disease such as myasthenia gravis. The mass was finally diagnosed as sclerosing thymoma derived from typ...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Tajima S, Koda K Tags: Int J Clin Exp Pathol Source Type: research

Endogenous lipoid pneumonia in a cachectic patient after brain injury.
Abstract Endogenous lipoid pneumonia (EnLP) is an uncommon non-life-threatening inflammatory lung disease that usually occurs in patients with conditions such as lung cancers, primary sclerosing cholangitis, and undifferentiated connective tissue disease. Here we report a case of EnLP in a paralytic and cachectic patient with bronchopneumonia after brain injury. A 40-year-old man experienced a severe brain injury in an automobile accident. He was treated for 1 month and his status plateaued. However, he became paralyzed and developed cachexia and ultimately died 145 days after the accident. Macroscopically, multif...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Zhang J, Mu J, Lin W, Dong H Tags: Int J Clin Exp Pathol Source Type: research

Articular nodular fasciitis of the right shoulder joint: report of an unusual case with focus on immunohistochemical differential diagnosis.
Abstract The mesenchymal lesion nodular fasciitis (NF) can affect various sites of the body but usually arises in subcutaneous tissue or occasionally skeletal muscle. NF is not commonly known to arise in joints, and articular NF is extremely rare. Herein, we present a case of a 54-year-old woman with articular NF. No sign of recurrence was observed after surgical piecemeal removal with a suspected positive surgical margin. In our case, a differential diagnosis of NF, desmoid-type fibromatosis, and low-grade myofibroblastic sarcoma was considered. Stromal hyalinization, a characteristic of articular NF, made the di...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Tajima S, Zuki T, Koda K Tags: Int J Clin Exp Pathol Source Type: research

Porokeratosis with follicular involvement: report of three cases and review of literatures.
Abstract Porokeratosis is characterized clinically by annular plaques with a distinct peripheral keratotic ridge and histologically by the cornoid lamella. Porokeratosis with follicular involvement is rarely reported. To provide the basis of that follicular porokeratosis is a clinical variant or not. Biopsy was taken from three patients who were diagnosed porokeratosis. Routine stain was made and reviewed the literatures about well-documented cases of porokeratosis with follicular involvement. Porokeratosis with follicular involvement may have some clinical features: asymptomatic, erythematous, brownish or skin-co...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Zhao M, Sanusi T, Zhao Y, Huang C, Chen S Tags: Int J Clin Exp Pathol Source Type: research

Death by aortoesophageal fistula due to disseminated tuberculosis: a case study.
Abstract Tuberculosis remains a serious public health problem worldwide, especially in Korea. Although tuberculosis is generally considered a non-fatal chronic disease, deaths have occurred. In this case study, a 68-year-old man was admitted to the hospital with dyspepsia, vomiting, and abdominal pain. Nine hours later, he suffered severe hematemesis and died despite cardiopulmonary resuscitation. A medico-legal autopsy was performed and an external examination revealed no external injuries. However, an internal examination revealed an aortoesophageal fistula and a large amount of blood in the stomach. A histologi...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Na JY, Kim YS, Choi YD, Kim HS, Park JT Tags: Int J Clin Exp Pathol Source Type: research

Primary adrenal leiomyosarcoma: a case report and review of literature.
Abstract Primary adrenal leiomyosarcoma (PAL) is an extremely rare mesenchymal tumors and originates from the smooth muscle wall of the central adrenal vein and its branches. Herein we report a case of a 49-year-old female suffering from PAL. Computed tomography revealed a well-circumscribed heterogeneously mass measuring 6×5×5 cm located in the left suprarenal areal, and a left laparoscopic adrenalectomy was underwent. Microscopic examination showed a hypercellular tumor with intersecting fascicled of spindled cells. Immunohistochemical staining showed that the cells were positive for desmin, smooth m...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Zhou Y, Tang Y, Tang J, Deng F, Gong G, Dai Y Tags: Int J Clin Exp Pathol Source Type: research

A rare occurrence of lymphoepithelial cyst in the palatine tonsil: a case report and discussion of the etiopathogenesis.
ro LA Abstract Lymphoepithelial cysts are uncommon benign lesions that present as painless yellowish nodules arising from various sites in the oral cavity and other parts of the body. Their etiopathogenesis is controversial, but most authors have assumed that they develop from obstruction of crypts in oral lymphoid aggregates, thus they are not true cysts but pseudocysts of retention. This paper describes a case of a large lymphoepithelial cyst located in the tonsil of a 21-year-old man complaining of a lump in the throat for four months. The patient underwent excisional biopsy, and the histopathological features ...
Source: International Journal of Clinical and Experimental Pathology - June 26, 2015 Category: Pathology Authors: Castro JG, Ferreira GM, Mendonça EF, Castro LA Tags: Int J Clin Exp Pathol Source Type: research

"Int J Clin Exp Pathol"[ta]; +147 new citations
147 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[ta] These pubmed results were generated on 2015/06/08PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - June 8, 2015 Category: Pathology Tags: Report Source Type: research

"Int J Clin Exp Pathol"[ta]; +143 new citations
143 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[ta] These pubmed results were generated on 2015/05/17PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - May 17, 2015 Category: Pathology Tags: Report Source Type: research

"Int J Clin Exp Pathol"[ta]; +136 new citations
136 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[ta] These pubmed results were generated on 2015/03/13PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - March 13, 2015 Category: Pathology Tags: Report Source Type: research

"Int J Clin Exp Pathol"[ta]; +123 new citations
123 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[ta] These pubmed results were generated on 2015/01/05PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - January 6, 2015 Category: Pathology Tags: Report Source Type: research

"Int J Clin Exp Pathol"[ta]; +110 new citations
110 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[ta] These pubmed results were generated on 2014/11/21PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - November 21, 2014 Category: Pathology Tags: Report Source Type: research