Prokaryotic expression and identification of B- and T-cell combined epitopes of Em95 antigen of Echinococcus multilocularis.
CONCLUSION: Three B- and T-cell combined epitopes were successfully cloned with good immunogenicity and antigenicity. Our data suggest that B- and T-cell combined epitopes predicted from the Em95 antigen may be used for the construction of high-valence vaccines and as targets for prevention of echinococcosis. PMID: 25197385 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Wang H, Zhang F, Ma X, Ma H, Zhu Y, Liu X, Zhu M, Wen H, Ding J Tags: Int J Clin Exp Pathol Source Type: research

Establishing a rapid animal model of osteoporosis with ovariectomy plus low calcium diet in rats.
The objective of this study was to rapidly develop osteoporotic model animals by combining ovariectomy with a low calcium diet in rats. Thirty, eight-week-old, female, Sprague-Dawley rats were either sham-operated (Sham) or ovariectomized (Ovx) and divided into three groups: Sham, Ovx, and Ovx + low calcium diet. Rats in the Sham and Ovx groups were fed a standard diet containing 1.1% w/w calcium while rats in the Ovx + low calcium diet group were fed a diet containing 0.1% w/w calcium. Serum osteocalcin and bone mineral density (BMD) of the lumbar vertebrae were measured 4 and 8 weeks after surgery. The rats were euthaniz...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Gao X, Ma W, Dong H, Yong Z, Su R Tags: Int J Clin Exp Pathol Source Type: research

Antepartum or immediate postpartum renal biopsies in preeclampsia/eclampsia of pregnancy: new morphologic and clinical findings.
CONCLUSION: Endotheliosis, vacuolation of podocytes, proliferation of mesangial cells, and protein casts in the tubule lumens were found in the kidneys of women with PE/eclampsia. Immune depositions of C4 and IgM are major contributors to renal lesions in preeclamptic patients, whose neonates can generally survive. Eclampsia can occur without increased blood pressure. PMID: 25197387 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Han L, Yang Z, Li K, Zou J, Li H, Han J, Zhou L, Liu X, Zhang X, Zheng Y, Yu L, Li L Tags: Int J Clin Exp Pathol Source Type: research

Clinicopathological correlation and prognostic significance of sonic hedgehog protein overexpression in human gastric cancer.
This study investigated the expression of Sonic Hedgehog (Shh) protein in gastric cancer, and correlated it with clinicopathological parameters. The prognostic significance of Shh protein was analyzed. METHODS: Shh protein expression was evaluated in 113 cases of gastric cancer and 60 cases of normal gastric mucosa. The immunoreactivity was scored semi quantitatively as: 0 = absent; 1 = weak; 2 = moderate; and 3 = strong. All cases were further classified into two groups, namely non-overexpression group with score 0 or 1, and overexpression group with score 2 or 3. The overexpression of Shh protein was correlated with...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Niu Y, Li F, Tang B, Shi Y, Hao Y, Yu P Tags: Int J Clin Exp Pathol Source Type: research

Association of single nucleotide polymorphisms in ADAM12 gene with susceptibility to knee osteoarthritis: a case-control study in a Chinese Han population.
This study tried to examine the single-nucleotide polymorphisms (SNPs) of ADAM12 for their association with knee OA susceptibility in a Chinese Han population. METHODS: The rs3740199, rs1871054, rs1278279, and rs1044122 SNPs in ADAM12 gene were genotyped in 152 subjects who were diagnosed as knee osteoarthritis and in 179 healthy controls. RESULTS: Rs1871054 was found to be significantly associated with increased risk of OA (C vs. T, OR 1.802 (1.308 to 2.483), P
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Lou S, Zhao Z, Qian J, Zhao K, Wang R Tags: Int J Clin Exp Pathol Source Type: research

Clinical features of acute corpus callosum infarction patients.
In conclusion, CC infarction has the highest incidence in the stroke of high-risk group; neck color Doppler and TCD examination can be found as early as possible to explore the pathogenic factors. Prognosis is usually much better by treatment according to the location and risk factors. PMID: 25197390 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Yang LL, Huang YN, Cui ZT Tags: Int J Clin Exp Pathol Source Type: research

Feasibility of fine-needle aspiration biopsy and its applications in superficial cervical lesion biopsies.
Abstract The aim of the study was to investigate the feasibility and value of clinical application of fine-needle aspiration histological biopsy via ultrasound-guided thyroid nodule and enlarged cervical lymph node fine-needle aspiration histological biopsy. Fine-needle aspiration cytological and histological biopsies and surgical treatments were performed on 982 patients with thyroid nodule and 1435 patients with enlarged cervical lymph nodes. A comparative study of the histological and cytological examination results and post-surgical etiology results was subsequently conducted. Among the 982 thyroid nodule pati...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Xu D, Xu HM, Li MK, Chen LY, Wang LJ Tags: Int J Clin Exp Pathol Source Type: research

Relationship of the changes of cervical MRI, TCD and BAEP in patients with "isolated" vertigo.
Relationship of the changes of cervical MRI, TCD and BAEP in patients with "isolated" vertigo. Int J Clin Exp Pathol. 2014;7(8):5171-6 Authors: Ji W, Zhang X Abstract OBJECTIVE: To study the relationship and changes of cervical MRI, TCD and BAEP in patients with "isolated" vertigo. METHODS: The relationship and changes of cervical MRI, TCD and BAEP were investigated respectively in 125 patients with "isolated" vertigo and 100 healthy controls. RESULTS: There were statistically significant differences between two groups for overall abnormalities of TCD (X(2) = 61.96, P
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Ji W, Zhang X Tags: Int J Clin Exp Pathol Source Type: research

Synchronous double cancers of colonic large cell neuroendocrine carcinoma and gastric squamous-cell carcinoma: a case report and review of literature.
Abstract Either colonic large cell neuroendocrine carcinoma (LCNEC) or gastric squamous-cell carcinoma (SCC) is extremely rare, with a very poor prognosis due to the high rate of distant metastases. Here, we report the first case of synchronous double malignancies in form of colonic LCNEC and gastric SCC. A 66-year male underwent a right hemicolectomy for a mass obstructing the ascending colon and an emergent gastroscopic hemostasis for another hemorrhagic stomach mass. Histopathological examination confirmed colonic LCNEC displaying the characteristic of large, vesicular nuclei with variable amounts of cytoplasm ...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Xu F, Feng GS, Wang ZJ, Zhang KN Tags: Int J Clin Exp Pathol Source Type: research

A case of primary spindle cell variant of embryonal rhabdomyosarcoma of the prostate.
Abstract We treated a rare case of spindle cell variant of embryonal rhabdomyosarcoma (RMS) of the prostate of a patient referred to our hospital for gross hematuria. Computed tomography and magnetic resonance imaging revealed a 4-cm-diameter mass with focal cystic change. Transurethral resection (TUR) of the prostate was performed to diagnosis and treat for complete urinary retention. Microscopically, the TUR specimen almost comprised a fascicular proliferation of spindle-shaped tumor cells, leading to the diagnosis of spindle cell sarcoma. The consequent total prostatectomy revealed the presence of rhabdomyoblas...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Asahina M, Saito T, Arakawa A, Suehara Y, Takagi T, Hisasue S, Kaneko K, Horie S, Yao T Tags: Int J Clin Exp Pathol Source Type: research

Fine needle aspiration cytology of a granular cell tumor arising in the thyroid gland: a case report and review of literature.
Abstract Granular cell tumor (GCT) is an uncommon tumor of soft tissue, and rarely occurs in thyroid. In this article, we report the FNAC results and pathological analysis of a 14-year-old female who presented with a painless mass in the right lobe of thyroid gland. A resection of the right lobe and isthmus of thyroid were applied after cells with abundant strong eosinophilic cytoplasma, indistinct border and inconspicuous nucleolus were found in the FNAC of the mass. Postoperative pathology and immunohistology helped diagnosis the lesion as thyroid GCT. Differential diagnosis from five diseases and cell types wer...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Chen Q, Li Q, Guo L, Li S, Jiang Y Tags: Int J Clin Exp Pathol Source Type: research

Successful off-label use of the Cepheid Xpert GBS in a late-onset neonatal meningitis by Streptococcus agalactiae.
We report the case of a late-onset neonatal meningitis by Streptococcus agalactiae (group B Streptococcus - GBS) that was diagnosed with a latex agglutination assay (on cerebrospinal fluid, CSF), as well as by using, for the first time, Xpert GBS (Cepheid, US) on CSF. Due to empirical antibiotics given before sampling, both CSF and blood culture were negative, so the abovementioned diagnostics was crucial. Moreover, the Xpert GBS assay, performed according to an off-label, modified protocol (the system is designed for GBS-carriage intrapartum screening, based on a completely automated real time-Polymerase Chain Reaction) q...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Savini V, Marrollo R, Coclite E, Fusilli P, D'Incecco C, Fazii P Tags: Int J Clin Exp Pathol Source Type: research

Occult thyroid carcinoma: a rare case report and review of literature.
Abstract Occult thyroid carcinoma is very common in the clinic and is generally divided into four groups. Here, we proposed two types of occult thyroid carcinoma as the fifth group. The first type was locoregional lymph node metastases from thyroid carcinoma, and the second type was distant organ metastases from thyroid carcinoma. The unique aspect of the fifth group was that the primary carcinoma of the fifth group was not finally found by pathological examination. To better understand the fifth group, we reported a typical case. Furthermore, we discussed the diagnostic criteria and procedures and the management ...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Liu H, Lv L, Yang K Tags: Int J Clin Exp Pathol Source Type: research

Pleomorphic carcinoma of breast: a case report and review of literature.
Abstract Pleomorphic carcinoma of the breast is a rare variant of invasive breast carcinoma. Here, we report a case in a 45-year-old woman presenting a lesion composed microscopically of predominantly pleomorphic giant cells, squamous metaplastic component and focal conventional ductal carcinoma. Immunohistochemical assay showed different immunologic manifestation in respective malignant components. Despite positive lymph node metastasis, the patient has been well without evidence of recurrence or metastasis two years after operation. The implication of this report is to provide insights into further understanding...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Tang H, Liu F, Li H, Huang X, Zhao T Tags: Int J Clin Exp Pathol Source Type: research

Nodal involvement by marginal zone B-cell lymphoma harboring t(14;22)(q32;q11) involving immunoglobulin heavy chain and light chain lambda as the sole karyotypically recognizable abnormality in a patient with systemic lupus erythematosus.
Abstract Recurrent non-random balanced chromosomal translocation, usually involving the immunoglobulin heavy chain (IgH) gene or an immunoglobulin light chain gene and a proto-oncogene, which results in the overexpression of the latter under the control of an enhancer or promoter of the former, is a hallmark of many types of non-Hodgkin lymphoma (NHL) of B-cell origin. However, translocations between IgH and the immunoglobulin (Ig) light chain lambda gene (IgL), namely, a t(14;22)(q32;q11), have rarely been described in B-cell NHL. Herein we report the first case of marginal zone B-cell lymphoma harboring a t(14;2...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Li K, Johnson RL, Li S, Thorson JA, Mulroney CM, Dell'Aquila ML, Wang HY Tags: Int J Clin Exp Pathol Source Type: research

A case of chronic hepatitis C patient of myocardial ischemia accompanied with interstitial pneumonia induced by pegylated interferon alpha-2a.
Abstract After 3 months of combination treatment using interferon α-2a and Ribavirin, a case of 59-year-old female patient with chronic viral hepatitis C demonstrated symptoms such as headache, dizziness accompanied by nausea, vomiting, dry cough, breathing difficulty, and shortness of breath. Dynamic electrocardiogram showed occasional atrial premature beats, paroxysmal tachycardia, and abnormal ST-T (T wave inversion and prolongation of the QT interval). Ambulatory blood pressure indicated that mean blood pressure was elevated than before. Myocardial radionuclide scan showed focal myocardial ischemia in le...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Qu C, Zheng Z, Liu W, Jiao J, Zhu J Tags: Int J Clin Exp Pathol Source Type: research

Pathological examinations of an enterovirus 71 infection: an autopsy case.
We report an 8-month-old female infant with the fatal enterovirus 71 infection here. Clinically, she developed respiratory failure and severe pulmonary edema rapidly. Histologically, the lung specimen showed diffuse, severe pulmonary congestion and edema with focal intra-alveolar hemorrhage and typical features of acute encephalitis were easily identified under light microscope. Immunohistochemically, enterovirus 71 antigen was positive in the cerebella and brainstem. We measured the viral loads of different tissues and found that the brainstem and mesenteric lymph nodes showed the highest viral loads among all tissues. We...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Gao L, Lin P, Liu S, Lei B, Chen Q, Yu S, Shen H Tags: Int J Clin Exp Pathol Source Type: research

Absence of 19 known hotspot oncogenic mutations in soft tissue clear cell sarcoma: two cases report with review of the literature.
In this study, two cases of CCS were presented: (1) left thumb and (2) jejunum. Case 1 manifested the characteristic CCS morphology. Case 2 was morphologically unusual and difficult to diagnose. Immunohistochemically, the two cases of tumor cells were diffusely positive for S100, vimentin, NSE protein, focal expression of CgA, and CAM2.5 protein. In case 1, the tumor cells were diffusely positive for HMB45, focal expression of CD56, and melan A antigen. Reverse transcriptase-polymerase chain reaction (RT-PCR) results confirmed the presence of the EWS/ATF1 translocation (type 1) in the two cases. Then, we detected 19 hotspo...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Liu C, Ren Y, Li X, Cao Y, Chen Y, Cui X, Li L, Li F Tags: Int J Clin Exp Pathol Source Type: research

Infectious crystalline keratopathy predominantly affecting the posterior cornea.
Abstract A case of infectious crystalline keratopathy that affects mainly the posterior stroma is presented. Crystalline infiltrates presented after multiple epithelial defects and chronic topical steroid use following a penetrating keratoplasty in this patient. His epithelial defects persisted and given the deep location of the crystalline infiltrates, a penetrating keratoplasty was performed again. Slit-lamp photo demonstrates the crystalline plaque. Confocal microscopy also documents the aggregates of crystal-like structures. Histology slides are also presented that show the disruption of the stromal-Descemet i...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Mesiwala NK, Chu CT, Raju LV Tags: Int J Clin Exp Pathol Source Type: research

Spindle cell rhabdomyosarcoma in the hypopharynx of an adult.
Abstract We herein present the first-reported case in the English-language literature of a spindle cell rhabdomyosarcoma in the hypopharynx of an adult. A 58-year-old male presented with a progressive, 7-month history of discomfort during swallowing, accompanied by hoarseness for 1 month. Computed tomography and magnetic resonance imaging revealed a tumor in the left pyriform sinus; frozen section evaluation suggested that it was rhabdomyosarcoma. The tumor was removed completely via left lateral cervical incision. Section margins were negative, and laryngeal function was preserved. The postoperative pathological ...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Wu TT, Wang QY, Zhou SH, Zheng ZJ Tags: Int J Clin Exp Pathol Source Type: research

Unclassified mixed germ cell-sex cord-stromal tumor with multiple malignant cellular elements in a young woman: a case report and review of the literature.
We report the case of a 28 year-old female with a right adnexal mass measuring 8 cm in greatest dimension, containing areas with both germ cell and sex cord components. The germ cell portion contained multiple growth patterns with a malignant appearance, while the sex cord element consisted mainly of annular tubules. Within the malignant germ cell elements was a dysgerminoma that accounted for approximately 75% of the tumor volume. Other malignant germ cell elements included yolk sac tumor, embryonal carcinoma, and choriocarcinoma, which comprised about 15% of the tumor volume. The annular tubule structures comprised about...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Pang S, Zhang L, Shi Y, Liu Y Tags: Int J Clin Exp Pathol Source Type: research

Huge juxtacortical brown tumor in two patients with secondary hyper-parathyroidism due to chronic renal failure.
We reported two cases of juxtacortical brown tumor in patients with HPT secondary to chronic renal insufficiency which has never been reported previously. PMID: 25197408 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Shen J, Zhang J, Zhu G Tags: Int J Clin Exp Pathol Source Type: research

Uretheral invagination of multilocular cystic nephroma; a case report of a new pathologic variant.
CONCLUSION: The etiology, pathogenesis, and genetic basis of multilocular cystic nephroma are currently unknown. This tumor is confused with cystic partially differentiated nephroblastoma and cystic Wilms tumor in childhood, and multilocular cystic renal cell carcinoma, clear cell papillary renal cell carcinoma, and tubulocystic carcinoma in adults. The association of this tumor with pleuropulmonary blastoma in children exhibits genetic inheritance. US control is particularly recommended in siblings of these children. Albeit rare, the disease can occur as a bilateral synchronous or metachronous lesion. There are four repor...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Ozturk H, Karaaslan S Tags: Int J Clin Exp Pathol Source Type: research

Primary extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue type with malakoplakia in the urinary bladder: a case report.
Abstract Primary malignant lymphoma of the urinary bladder is a rare disease constituting less than 1% of neoplasms of the urinary bladder. The most prevalent histological subtype is extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue type (MALT lymphoma). It is frequently associated with chronic cystitis and predominantly occurs in females. On the other hand, malakoplakia is thought to be a reactive granulomatous lesion occurring most prevalently in the genitourinary tracts. It is frequently found in females and often associated with bacterial infection in immunosuppressive status. Here we repo...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Matsuda I, Zozumi M, Tsuchida YA, Kimura N, Liu NN, Fujimori Y, Okada M, Hashimoto T, Yamamoto S, Hirota S Tags: Int J Clin Exp Pathol Source Type: research

Lung intravascular large B-cell lymphoma with ground glass opacities on chest computed tomography: a case report.
Abstract Intravascular large B-cell lymphoma (IVLBCL) is a rare type of extranodal large B-cell lymphoma characterized by the selective growth of lymphoma cells within the lumina of vessels, particularly within capillaries, with exception of larger arteries and veins. The authors reported a case of a 45-year-old woman who was admitted in hospital with refractory fever, cough and progressive dyspnea despite of receiving broad-spectrum antibiotics. Computed tomography (CT) of the lung showed bilateral patchy ground-glass opacities with some pleural effusion in the left lung. A CT-guided percutaneous lung biopsy was ...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Xiao D, Fu C, Long X, Liu W, Chen C, Zhou J, Fan S Tags: Int J Clin Exp Pathol Source Type: research

Metachronous bilateral adrenocortical functional adenomas causing adrenocorticotropic hormone-independent Cushing's syndrome.
Abstract Metachronous bilateral adrenocortical adenomas causing adrenocorticotropic hormone-independent Cushing's syndrome is a surgical case that scarcely occurs. A 38-year-old woman diagnosed with bilateral adrenocortical adenomas one by one in 2006 and 2013. Both of the two adenomas were functional and caused typical Cushingoid symptoms. The patient underwent a laparoscopic adrenolectomy in 2006 and a laparoscopic adrenocortical adenoma resection in 2013. After surgery, the symptoms of Cushing's syndrome withdrew and the woman started steroid replacement therapy as a following treatment. PMID: 25197412 [Pu...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Cheng K, Cao W, Dai J, Huang X, Huang B, Su H, Sun F Tags: Int J Clin Exp Pathol Source Type: research

Placental mesenchymal dysplasia: a case of a normal-appearing fetus with intrauterine growth restriction.
Abstract In this paper, we described a placenta with vesicular lesions in a 23-year-old woman (1-gravid) who visited our hospital at 13 weeks of gestation on prenatal routine examination. Ultrasound findings showed multiple vesicular lesions which gradually increased as the pregnancy advanced, and a live normal-appearing fetus which was confirmed of IUGR at 30 weeks of gestation in her uterus. Throughout gestation, the maternal serum β-human chorionic gonadotropin level keeps normal, but the serum alpha-fetoprotein was higher than average. The patient delivered an 1800-g female without obvious anomalies at 35...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Li H, Li L, Tang X, Yang F, Yang KX Tags: Int J Clin Exp Pathol Source Type: research

Detection of trichodysplasia spinulosa-associated polyomavirus in a fatal case of myocarditis in a seven-month-old girl.
Abstract Trichodysplasia spinulosa-associated polyomavirus (TSV) was identified in a seven-month-old girl with myocarditis. The number of TSV genomes detected was higher in the heart than in the other organs. The full-length TSV genome was cloned from the heart. This suggests a possible role of TSV infection in the pathogenesis of myocarditis in infants. PMID: 25197415 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Tsuzuki S, Fukumoto H, Mine S, Sato N, Mochizuki M, Hasegawa H, Sekizuka T, Kuroda M, Matsushita T, Katano H Tags: Int J Clin Exp Pathol Source Type: research

Ectopic thyroid tissue surrounding the right laryngeal nerve: a case report.
Abstract Ectopic thyroid tissue (ETT) is a rare developmental anomaly of the thyroid tissue which is defined as the presence of thyroid tissue in locations other than the pretracheal area. However, ectopic thyroid tissue in the lateral neck surrounding the recurrent laryngeal nerve is unusually found. Here we describe a case of a 64-year-old woman who was found bilateral thyroid goiter by the ultrasound examination. The total thyroidectomy plus a modified radical neck dissection was performed. Surprisingly we also found a nodule surrounding the right recurrent laryngeal nerve at the same time. Nevertheless the dia...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: He B, Li P, Yang K, Shan Y Tags: Int J Clin Exp Pathol Source Type: research

Small cell malignant melanoma of the anus: a case report with review of the literature.
PMID: 25197417 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Ishida M, Iwai M, Kagotani A Tags: Int J Clin Exp Pathol Source Type: research

Circulating CD62P small microparticles levels are increased in hypertension.
Abstract The study aims to find a new biomarker in hypertension. Our study is the first time to demonstrate that the CD62P small microparticle (diameter is
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Hu SS, Zhang HG, Zhang QJ, Xiu RJ Tags: Int J Clin Exp Pathol Source Type: research

Bone marrow transplantation reverses new-onset immunoinflammatory diabetes in a mouse model.
This study aimed to investigate whether bone marrow transplantation could reverse hyperglycemia in diabetic mice and whether high-dose total body irradiation followed by high-dose bone marrow mononuclear cell infusion could improve the efficiency of bone marrow transplantation in treating diabetic mice. Diabetic mice after multiple low doses of streptozotocin injection were irradiated followed by infusion with approximately 1×10(7) bone marrow mononuclear cells intravenously. Before and after bone marrow transplantation, fasting blood glucose, intraperitoneal glucose tolerance test, serum insulin, pancreatic histolog...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Lv CL, Wang J, Xie T, Ouyang J Tags: Int J Clin Exp Pathol Source Type: research

Primary cutaneous γδ-T-cell lymphoma (CGD-TCL) with unilateral lower extremity swelling as first-onset symptom: a rare case report.
We report the case of a 42-year-old man who first presented with a swelling in the extremities and subsequent appeared subcutaneous nodule over the body. In order to clarify the diagnosis, a biopsy of subcutaneous nodule for pathology had been done. CGD-TCL was diagnosed by histopathology, immunophenotype, in situ hybridization and analysis of TCRγ genes rearrangement. The patient was treated with chemotherapeutic regimens-CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone). After one period of chemotherapy, subcutaneous nodules became small, even disappeared, swelling and ulcer in the left pedal gone ...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Li D, Huang L, Guo B, Wen Q, Wang W, Luo J, Fan S Tags: Int J Clin Exp Pathol Source Type: research

Identification of neuroanatomic circuits from spinal cord to stomach in mouse: retrograde transneuronal viral tracing study.
Abstract To determine the spinal innervation and neuronal connections is important for studying gastric carbohydrate metabolism and motor responses. Neurons involved in the efferent control of the stomach were identified following visualization of pseudorabies virus (PRV)-614 retrograde tracing. PRV-614 was injected into the ventral stomach wall in 13 adult C57BL/6J strain male mice. On the fifth day postinjection, animals were humanely sacrificed, and spinal cords were removed and sectioned, and processed for PRV visualization. The virus injected into the ventral stomach wall was specifically transported to the t...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Ye DW, Liu C, Tian XB, Xiang HB Tags: Int J Clin Exp Pathol Source Type: research

Retrograde tracing of medial vestibular nuclei connections to the kidney in mice.
In this study, the medial vestibular nuclei (MVe) of 10 adult male C57BL/6J strain mice were mapped retrograde using injections of pseudorabies virus (PRV)-614. The virus, injected into the kidney, was specifically transported to the medial vestibular nuclei (MVe). We used a fluorescence immunohistochemistry to characterize the chemical neuroanatomical substrate of MVe innervating the kidney in the mouse. At five days after PRV-614 injection in the kidney, PRV-614 infected neurons were retrogradely labeled in MVeMC and MVePC; PRV-614/tyrosine hydroxylase (TH) double-labeled neurons located predominantly in MVeMC and not in...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Hao Y, Tian XB, Liu C, Xiang HB Tags: Int J Clin Exp Pathol Source Type: research

Preliminary application of hybrid operation in the treatment of carotid artery stenosis in patients with complex ischemic cerebrovascular diseases.
In conclusion, one-stop hybrid operation plays an important role in treating complex stenosis cerebrovascular diseases. PMID: 25197423 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Zhang L, Xing T, Geng F, Du L, Wang J Tags: Int J Clin Exp Pathol Source Type: research

Tetraploidy acute promyelocytic leuemia with double t(15;17)/PML-RARA, a case report with review of literature.
Abstract Acute promyelocytic leukemia (APL) with tetraploidy chromosome harboring t(15;17)(q23;a21) is extremely rare. To date, there are 14 such cases reports that describe this entity, mostly found in Eastern hemisphere. Herein we described a 51-year-old man with a diagnosis of tetraploid acute promyelocytic leukemia with double (15;17) translocations and compare the prototypically clinicopathologic, genetic and molecular findings with those reported in the literature. PMID: 25197424 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Dalia SM, Horna P, Zhang L Tags: Int J Clin Exp Pathol Source Type: research

Cerium promotes bone marrow stromal cells migration and osteogenic differentiation via Smad1/5/8 signaling pathway.
In conclusion, our results support the notion that Ce promoted migration and osteogenic differentiation of BMSCs by Smad1/5/8 signaling pathway. PMID: 25197425 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Hu Y, Du Y, Jiang H, Jiang GS Tags: Int J Clin Exp Pathol Source Type: research

Hepatic fat accumulation and regulation of FAT/CD36: an effect of hepatic irradiation.
IA Abstract Irradiation is known to induce inflammation and affect fat metabolic pathways. The current study investigates hepatic fat accumulation and fatty acid transportation in a rat model of single dose liver irradiation (25-Gy). Rat livers were selectively irradiated in-vivo (25-Gy), sham-irradiated rats served as controls. Hepatic lipids were studied by colorimetric assays in liver and serum. Intracellular lipids, protein and mRNA were studied by Nile red staining, immunohistology, Western Blot analysis and RT-PCR in liver, respectively. Changes in FAT/CD36 expression were studied in-vitro in a human monocy...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Martius G, Alwahsh SM, Rave-Fränk M, Hess CF, Christiansen H, Ramadori G, Malik IA Tags: Int J Clin Exp Pathol Source Type: research

"Int J Clin Exp Pathol"[ta]; +124 new citations
124 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[ta] These pubmed results were generated on 2014/08/19PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 19, 2014 Category: Pathology Tags: Report Source Type: research

Solitary fibrous tumor of the kidney with focus on clinical and pathobiological aspects.
Abstract Renal solitary fibrous tumor (SFT) is a rare, and a large scale study on this topic is lacking to date. In this article, we summarize the previously reported cases. The symptoms and signs resemble those of renal cell carcinoma, including hematuria, flank/abdominal/lumbar pain and palpable abdominal mass. Grossly, the tumor demonstrates a well-circumscribed solid mass. Microscopically, the tumor consists of fusiform or ovoid spindle cells and a various amounts of collagen bundles with patternless, storiform, or fascicular arrangements with an occasional hemangiopericytomatous pattern. Immunohistochemically...
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Kuroda N, Ohe C, Sakaida N, Uemura Y, Inoue K, Nagashima Y, Hes O, Michal M Tags: Int J Clin Exp Pathol Source Type: research

Indoleamine 2,3-dioxygenase-1 (IDO1) in human endometrial stromal cells induces macrophage tolerance through interleukin-33 in the progression of endometriosis.
Abstract In the peritoneal fluid, macrophages and their secretory cytokines are essential for endometriosis, but the factors that favor their involvement in the endometriosis-associated inflammatory response are still elusive. Given the anomalous expression of indoleamine 2,3-dioxygenase-1 (IDO1) in endometrial stromal cells (ESCs) and its potentially important roles in immune modulation, we aimed to determine the effects of IDO1 in ESCs on macrophages and the mechanism of those effects. Normal ESCs and ectopic ESCs transfected with the SD11-IDO1 shRNA (short hairpin RNA) or vector-only plasmid SD11 were subsequen...
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Mei J, Xie XX, Li MQ, Wei CY, Jin LP, Li DJ, Zhu XY Tags: Int J Clin Exp Pathol Source Type: research

Decreased expression of a novel lncRNA CADM1-AS1 is associated with poor prognosis in patients with clear cell renal cell carcinomas.
In this study, we investigated the expression pattern of a novel lncRNA CADM1-AS1 in ccRCC by quantitative real time PCR. The results showed that CADM1-AS1 expression was down-regulated in tumor tissues in 64 patients with ccRCC compared with adjacent non-tumor tissues. Furthermore, the expression of CADM1-AS1 was positively correlated with the expression of mRNA CADM1 in ccRCC specimens (R = 0.611, P
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Yao J, Chen Y, Wang Y, Liu S, Yuan X, Pan F, Geng P Tags: Int J Clin Exp Pathol Source Type: research

Characterization of karyopherins in androgen receptor intracellular trafficking in the yeast model.
CONCLUSIONS: These results suggest that while AR nuclear import relies on karyopherin activity, AR nuclear export and/or cytoplasmic localization may require other undefined mechanisms. PMID: 25031696 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Nguyen MM, Harmon RM, Wang Z Tags: Int J Clin Exp Pathol Source Type: research

Effect of Nrf2 on rat ovarian tissues against atrazine-induced anti-oxidative response.
Abstract The environmental persistence and bioaccumulation of herbicide atrazine may pose a significant threat to human health. In this experiment, Wistar rats were treated by 5, 25 and 125 mg·kg(-1) atrazine respectively for 28 days, and the oxidative stress responses as well as the activations of Nrf2 signaling pathway in ovarian tissues induced by atrazine were observed. The results showed that after be treated by atrazine, the proportion of atretic follicles in the rat ovary were increased, the contents of NO and MDA in the tissue homogenates were increased, the over-expressed Nrf2 transferred into the ...
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Zhao F, Li K, Zhao L, Liu J, Suo Q, Zhao J, Wang H, Zhao S Tags: Int J Clin Exp Pathol Source Type: research

Comparative analysis of arterial spin labeling and dynamic susceptibility contrast perfusion imaging for quantitative perfusion measurements of brain tumors.
Abstract We comparatively analyzed the difference between three-dimensional arterial spin labeling (3D-ASL) and the conventional dynamic susceptibility contrast (DSC) perfusion imaging in the setting of assessing brain tumor perfusion in 28 patients with proved brain tumors. All patients were scheduled with standard MRI, 3D-ASL and DSC scannings on a GE DISCOVERY MR 750 system. Maximal relative tumor perfusion was obtained based on the region of interest (ROI) method. A close correlation between 3D-ASL and DSC perfusion imaging was noted as manifested by the absence of significant differences between ASL nTBF and ...
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Jiang J, Zhao L, Zhang Y, Zhang S, Yao Y, Qin Y, Wang CY, Zhu W Tags: Int J Clin Exp Pathol Source Type: research

Gnathic osteosarcomas, experience of four institutions from Turkey.
Abstract Osteosarcoma is the most frequent primary gnathic sarcoma. Neither the etiology nor the variables effecting the prognosis are fully known due mostly to the rarity of gnathic osteosarcomas. To date a considerable number of clinicopathologic features have been suggested in the evaluation of gnathic osteosarcomas. Still there is a need to experience on several aspects of management. The aim of this study is to report a series of 33 cases of osteosarcoma involving either mandible or maxilla. The clinical, radiological and histopathological features of our cases have usually been non-specific and the most freq...
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Yildiz FR, Avci A, Dereci O, Erol B, Celasun B, Gunhan O Tags: Int J Clin Exp Pathol Source Type: research

Brain edema and protein expression of c-Fos and c-Jun in the brain after diffused brain injury.
Abstract OBJECTIVE: To investigate brain edema and protein expression of c-Fos and c-Jun in brain after diffuse brain injury, and to investigate the pathological change after brain injury, which may provide evidence for the clinical treatment of diffused brain injury. METHODS: Marmarou method was used to establish the diffuse brain injury in rats. RESULTS: After diffused brain injury, brain water content increased at 1 h, reached the peak at 1 d and remained at a high level at 7 d when compared with control group. One day after injury, diffuse subarachnoid hemorrhage was observed in the brain. HE stainin...
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Zheng W, Niu L, Zhang C, Zhu C, Xie F, Cao C, Li G Tags: Int J Clin Exp Pathol Source Type: research

Curcumin induces apoptosis in breast cancer cells and inhibits tumor growth in vitro and in vivo.
This study was designed to investigate its antitumor effect and underlying mechanisms in human breast cancer MDA-MB-231 and MCF-7 cells. The MTT assay was used to evaluate cell viability, and flow cytometry, acridine orange staining and transmission electron microscopy were used to detect apoptosis for cultured cells. The protein expression in cells was evaluated by western blot analysis. Breast tumors were established by subcutaneous injection of MDA-MB-231 cells in nude BALB/c mice, and curcumin was administered to the mice. The size of tumors was monitored and the weight of tumors was examined. The exposure of breast ca...
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Lv ZD, Liu XP, Zhao WJ, Dong Q, Li FN, Wang HB, Kong B Tags: Int J Clin Exp Pathol Source Type: research

Astrocytic expression of cannabinoid type 1 receptor in rat and human sclerotic hippocampi.
Abstract Cannabinoid type 1 receptor (CB1R), which is traditionally located on axon terminals, plays an important role in the pathology of epilepsy and neurodegenerative diseases by modulating synaptic transmission. Using the pilocarpine model of chronic spontaneous recurrent seizures, which mimics the main features of mesial temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS) in humans, we examined the expression of CB1R in hippocampal astrocytes of epileptic rats. Furthermore, we also examined the expression of astrocytic CB1R in the resected hippocampi from patients with medically refractory mesial TLE...
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Meng XD, Wei D, Li J, Kang JJ, Wu C, Ma L, Yang F, Zhu GM, Ou-Yang TP, Liu YY, Jiang W Tags: Int J Clin Exp Pathol Source Type: research