Cystic lymphangioma-like adenomatoid tumor of the adrenal gland: report of a rare case and review of the literature.
Abstract Adenomatoid tumors (AT) are uncommon, benign tumors of mesothelial origination most frequently encountered in the genital tracts of both sexes. Their occurrences in the extragenital sites are much rarer and could elicit a variety of differential diagnosis both clinically and morphologically. With regard to the adrenal gland, to the best knowledge of us, only 31 cases of AT have been reported in the English literature. Several histologic growth patterns have been documented in AT, among which cystic type is the least common one. We herein present a further case of AT arising in the adrenal of a 62-year-old...
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Zhao M, Li C, Zheng J, Yan M, Sun K, Wang Z Tags: Int J Clin Exp Pathol Source Type: research

Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) of the ileum in a 35-year-old Japanese woman.
Abstract MALT LYMPHOMA OF THE ILEUM IS EXTREMELY RARE: only several cases have been reported. A 34-year-old woman presented abdominal pain and melena. Colorectal and small intestinal endoscopes revealed multiple tumors and ulcers of the entire ileum. Biopsy was taken. Histologically, the biopsy consisted of 6 tissue specimens taken from the various sites of the ileum. All the tissue specimens showed infiltration of small atypical cells resembling centrocyte-like cells (CLC). Immunoblastic cells were scattered, though the number was scant. Monocytoid, plasma cell differentiation, and germinal centers were seen. Lym...
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Terada T Tags: Int J Clin Exp Pathol Source Type: research

Carcinoid tumor of the lung with massive ossification: report of a case showing the evidence of osteomimicry and review of the literature.
We describe here the case of a 29-year-old female with the radiological finding of a single bony nodular lesion. Pathological examination of the surgically resected specimen led to the diagnosis of carcinoid tumor of the lung with massive ossification. Although histological features showed the tumor of low grade malignancy, subcarinal and right hilar lymph nodes were found to be positive for metastasis. Further immunohistochemical analysis revealed that the tumor cells expressed the osteogenic inducer protein, bone morphogenic protrein-2 [BMP-2] and osteoblastic marker protein, osteocalcin. We interpreted this to mean that...
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Tsubochi H, Endo S, Oda Y, Dobashi Y Tags: Int J Clin Exp Pathol Source Type: research

Mucinous borderline tumor involving fallopian tube: case report and review of the literature.
We report the case of a 74-year-old woman with a primary mucinous borderline tumor of the fallopian tube coexisting with an ovarian mucinous borderline tumor. Data were obtained through histopathologic study of the excised surgical specimen. p53, estrogen receptor (ER) and PAX8 expression were evaluated by immunohistochemistry on the available right fallopian tube and ovary. Both the ovarian and fallopian tube borderline ovarian tumors were negative for p53, ER and PAX8. However, the staining pattern highlighted the transition from a normal ciliated cell to neoplastic epithelia in the fallopian tube fimbria. This is the fi...
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Liu F, Wei J, Shen D, Liu J Tags: Int J Clin Exp Pathol Source Type: research

Cutaneous pseudolymphoma: a case report with an immunohistochemical study.
Abstract Cutaneous pseudolymphoma (C-PSL) is defined as reactive polyclonal benign lymphoproliferative process predominantly composed of either B-cells or T-cells, localized or disseminated. It heals spontaneously after cessation of the causative factor (e.g. drugs) or after non-aggressive treatment. The author herein presents a case of C-PSL with an immunohistochemical study. A 78-year-old man consulted our hospital because of slightly itching skin swelling on the arm. He denied insect bite and traumatic injury. His usual intake drugs were drugs of hypertension, hyperlipidemia, diabetes mellitus, and emotional di...
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Terada T Tags: Int J Clin Exp Pathol Source Type: research

Good response of malignant pleural effusion from carcinoma of unknown primary site to the anti-tuberculosis therapy: a case report.
Conclusion We reported a rare case of successfully treating malignant pleural effusion caused by squamous cell carcinoma of unknown primary site with the anti-tuberculosis combined. This report provides useful evidences for that the anti-tubercular agents may have potential anticancer activity in some carcinomas. PMID: 23638233 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Gu Q, Hu C, Qu J Tags: Int J Clin Exp Pathol Source Type: research

CD10-positive malignant spindle cell tumor of the lip in a child: a malignant myoepithelioma?
Abstract A 9-year-old girl consulted to our hospital because of lower lip tumor. Excision of the tumor was performed. Histologically, the tumor consisted of cellular spindle and round cells with hyperchromatic nuclei and nucleoli. Mitotic figure and apoptotic bodies were scattered. Immunohistochemically, the tumor cells were strongly and diffusely positive for CD10 and vimentin. The tumor was focally positive for S100 protein, α-smooth muscle actin, PDGFRA, HER2/neu, p53, and CD68. The Ki-67 labeling was 20%. In contrast, the tumor cells were negative for pancytokeratins (AE1/3, CAM5.2, WSS, KL-1, HNF116), c...
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Terada T Tags: Int J Clin Exp Pathol Source Type: research

Peutz-Jeghers syndrome and family survey: a case report.
We report on an 18-year-old Chinese male who complained with pigmentation on face and extremities for over 10 years. Colonoscopy revealed more than ten polyps from transverse colon to rectum. The family survey included 15 family members from three generations, and 6 PJSs (4 males and 2 females) were found. This case is reported because of its rarity of Peutz-Jeghers syndrome and the survey of family history. PMID: 23638235 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Li Y, Zeng Q, Liao Z, Zhang G, Xiao R, Wen H Tags: Int J Clin Exp Pathol Source Type: research

Primary hepatosplenic CD5-positive diffuse large B-cell lymphoma: a case report with literature review.
We report a case of CD5(+) DLBCL with primary involvement of the spleen and liver, and no distinct mass lesions or lymphadenopathy. The patient had stage IV disease with bone marrow involvement by lymphoma. The lymphoma cells showed characteristic portal and intrasinusoidal pattern of infiltrate in the liver. The literature was reviewed and the clinicopathologic features of 7 similar reported cases were summarized. All cases share the common features of hepatosplenomegaly without mass lesions, exclusive red pulp infiltrate with a diffuse and cordal pattern in the spleen, portal and intrasinusoidal pattern of infiltrate in ...
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Zhang X, Sun M, Zhang L, Shao H Tags: Int J Clin Exp Pathol Source Type: research

Primary pure squamous cell carcinoma of the endometrium: a case report.
Abstract Because primary pure squamous cell carcinoma (SCC) of the endometrium is very rare and its frequency is unknown, the author reviewed 142 archival hysterectomy specimens of endometrial cancers. As the results, one case of primary pure SCC was found. Thus, the frequency of SCC of the endometrium was 0.7% of all endometrial malignancies in our institution. The patient was a 72-year-old woman presenting with uterine bleeding. Uterine curettage biopsy and uterine discharge cytology revealed SCC. No malignancy was seen in cervical biopsy. Radical hysterectomy, bilateral salpingo-oophorectomy, omentectomy and ly...
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Terada T, Tateoka K Tags: Int J Clin Exp Pathol Source Type: research

Successful delivery after IVF-ET in an abdominal cocoon patient: case report and literature review.
We report the case of a 29-year-old infertile Chinese woman with AC, who successfully got twin pregnancy and delivery through in vitro fertilization (IVF) and embryo transfer (ET). And this review discusses the current concepts of its pathogenesis, diagnosis and treatments. AC might lead to tubal infertility and IVF-ET would be the most effective remedy for the patients desiring pregnancy. PMID: 23638238 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Hu D, Wang R, Xiong T, Zhang HW Tags: Int J Clin Exp Pathol Source Type: research

Comparative expression profiling for human endoplasmic reticulum-resident aminopeptidases 1 and 2 in normal kidney versus distinct renal cell carcinoma subtypes.
Abstract Altered expression of the ER-resident aminopeptidases ERAP1 and ERAP2 might play an important role in shaping the MHC class I-presented peptide repertoire, but their function in tumors has not been determined in detail. Thus, the expression of ERAP1, ERAP2 and HLA class I heavy chain (HC) was analysed in various renal tumor types and corresponding kidney parenchyma by immunohistochemistry. Additionally, comparative expression profilings of untreated versus interferon (IFN)-γ-treated RCC cell lines were performed applying qRT-PCR, Western blot and/or flow cytometry. Normal kidney tissues showed stron...
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Stoehr CG, Buettner-Herold M, Kamphausen E, Bertz S, Hartmann A, Seliger B Tags: Int J Clin Exp Pathol Source Type: research

Immune cascades in human intervertebral disc: the pros and cons.
Abstract The unique structural hallmark of the intervertebral disc has made its central composition, the nucleus pulposus (NP), excluded from the immunologic tolerance. Consequently, the intervertebral disc is identified as an immune-privileged organ. Traditionally, local detrimental immune activities caused by NP at the lesion sites of the disc are noted as a significant factor contributing to disc degeneration. However, given the beneficial activities of immune cells in other immune-privileged sites on basis of current evidence, the degenerate disc might need the assistance of a subpopulation of immune cells to ...
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Sun Z, Zhang M, Zhao XH, Liu ZH, Gao Y, Samartzis D, Wang HQ, Luo ZJ Tags: Int J Clin Exp Pathol Source Type: research

Peripheral Th17/Treg imbalance in patients with atherosclerotic cerebral infarction.
CONCLUSIONS: Th17/Treg cells were imbalanced in ACI patients, and ox-LDL may contribute to this imbalance and lead to the occurrence of ACI suggesting their pathogenetic role in ACI. PMID: 23696918 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Li Q, Wang Y, Yu F, Wang YM, Zhang C, Hu C, Wu Z, Xu X, Hu S Tags: Int J Clin Exp Pathol Source Type: research

Trophoblasts-derived chemokine CCL24 promotes the proliferation, growth and apoptosis of decidual stromal cells in human early pregnancy.
Abstract Chemokine CCL24 is the second member of eotaxins, a group of eosinophils' selectively chemoattractants. Via binding to its only receptor CCR3, CCL24 mainly mediates atopic disorders, parasitic infections and systemic diseases. It is well-known that CCR3 is expressed at the maternal-fetal interface; nevertheless whether CCL24 is located there and which role CCL24/CCR3 axis played is unclear. In this article, we assessed the expression of CCL24 and CCR3 in decidual stromal cells (DSCs) and trophoblasts, investigated the effects of DSCs-trophoblasts contact and pregnancy-associated hormones on the expression...
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Li H, Huang YH, Li MQ, Meng YH, Chen X, Shao J, Tang CL, Du MR, Jin LP, Li DJ Tags: Int J Clin Exp Pathol Source Type: research

Smooth muscles and stem cells of embryonic guts express KIT, PDGFRRA, CD34 and many other stem cell antigens: suggestion that GIST arise from smooth muscles and gut stem cells.
Abstract Gastrointestinal stromal tumor (GIST) is believed to original from interstitial cells of (ICC) present in Auerbach's nerve plexus. GIST frequently shows gain-of-function mutations of KIT and PDGFRA. In practical pathology, GIST is diagnosed by positive immunostaining or KIT and/or CD34. The author herein demonstrates that human embryonic gastrointestinal tract smooth muscles (HEGITSM) and human embryonic stem gastrointestinal cells (HEGISC) consistently express KIT, CD34, NCAM, PDGFRA and other stem cell (SC) antigens NSE, synaptophysin, chromogranin, bcl-2, ErbB, and MET throughout the embryonic developm...
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Terada T Tags: Int J Clin Exp Pathol Source Type: research

Pathomorphological changes of bone marrow adipocytes in process of steroid-associated osteonecrosis.
CONCLUSION: In the process of ON, extravascular fat deposition is characterized by increased small adipocytes at the early stage and hypertrophy of adipocytes at the late stage. PMID: 23696921 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Sheng H, Sheng CJ, Cheng XY, Zhang G, Lee KM, Leung KS, Qu S, Qin L Tags: Int J Clin Exp Pathol Source Type: research

Solid-pseudopapillary neoplasm (SPN) of the pancreas: case series and literature review on an enigmatic entity.
We report our experience with four cases of SPN of the pancreas. All four patients were female with an age range of 15-42 years (mean age: 24.5 years). Two patients presented with abdominal pain, one with abdominal mass and one with acute abdominal signs following blunt trauma. Tumor's size ranged from 1 to 16 cm (mean size: 5.5 cm). Two tumors were diagnosed preoperatively through percutaneous core needle biopsy and two underwent surgery without preoperative diagnosis because of high suspicion of SPN based on clinical and radiological findings. By immunohistochemistry, all cases stained strongly for vimentin, progesterone...
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Vassos N, Agaimy A, Klein P, Hohenberger W, Croner RS Tags: Int J Clin Exp Pathol Source Type: research

KAI1/CD82 and CyclinD1 as biomarkers of invasion, metastasis and prognosis of laryngeal squamous cell carcinoma.
This study aimed to investigate the expressions and significance of KAI1/CD82 and CyclinD1 in laryngeal squamous cell carcinoma (LSCC). METHODS: Real-time quantitative PCR (Q-PCR) and Western blot assay were employed to detect the expressions of KAI1/CD82 and CyclinD1 in the laryngeal tissues of 86 LSCC patients, 32 patients with laryngeal polyp and 38 patients with laryngeal leukoplakia, and the influence of both proteins on the clinicopathological features and survival of LSCC patients. RESULTS: The changes in mRNA and protein expressions of KAI1/CD82 and CyclinD1 were consistent in three groups, and the expres...
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Zhang B, Liu W, Li L, Lu J, Liu M, Sun Y, Jin D Tags: Int J Clin Exp Pathol Source Type: research

Primary central nervous system lymphoma in immunocompetent individuals: a single center experience.
CONCLUSION: In this study, we failed to demonstrate a relationship between different clinicopathological variables and OS of patients. Prospective studies with large patient series are needed to investigate other potential prognostic factors. PMID: 23696924 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Aki H, Uzunaslan D, Saygin C, Batur S, Tuzuner N, Kafadar A, Ongoren S, Oz B Tags: Int J Clin Exp Pathol Source Type: research

Accumulation of the mutations in basal core promoter of hepatitis B virus subgenotype C1 increase the risk of hepatocellular carcinoma in Southern China.
Abstract UNLABELLED: Hepatitis B virus (HBV) genotype C is associated with the development of hepatocellular carcinoma (HCC). In addition, HBV subgenotype C1 is the major subgenotype in Southern China. The aim of this study was to investigate whether there was the specific mutation patterns in HBV/C1 associated with Southern Chinese patients with HCC. METHODS: Mutations in HBV basal core promoter (BCP) and their association with HCC were assessed in a matched cross-sectional control study of 102 HCC and 105 chronic hepatitis (CH) patients (from Guangdong, China) infected with HBV/C1. Functional analysis of HB...
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Li W, Chen G, Yu X, Shi Y, Peng M, Wei J Tags: Int J Clin Exp Pathol Source Type: research

Evaluation of Argonaute protein as a predictive marker for human clear cell renal cell carcinoma.
CONCLUSIONS: In summary, our present study clarify that the aberrant expression of Argonaute in human RCC is possibly involved with tumorigenesis and development, and the Argonaute protein could act as a potential biomarker for prognosis assessment of renal cancer. Related mechanism is worthy of further investigation. PMID: 23696926 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Li W, Liu M, Feng Y, Xu YF, Che JP, Wang GC, Zheng JH, Gao HJ Tags: Int J Clin Exp Pathol Source Type: research

Mir-375 enhances ruthenium-derived compound Rawq01 induced cell death in human ovarian cancer.
CONCLUSION: Mir-375 can enhance Rawq01 induced cell death in human ovarian cancer both in vitro and in vivo. PMID: 23696927 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Shao X, Mei W, Weng W, Qin J, Zhou J, Liu J, Cheng J Tags: Int J Clin Exp Pathol Source Type: research

Expression analysis of leukocytes attracting cytokines in chronic histiocytic intervillositis of the placenta.
Abstract UNLABELLED: Chronic histiocytic intervillositis of the placenta (CHI) is a rare and potentially recurrent disease. Characteristically it shows accumulation of CD68+ cells in the intervillous space but no destructive tissue infiltration. An immunopathological background is likely but it is unknown what attracts circulating monocytes to the placenta. METHODS: We analysed the expression profile of 102 inflammation- and angiogenesis-associated genes with real-time reverse transcriptase-polymerase chain reaction (RT-PCR) in 16 placentas: CHI (n = 5) and, as controls, villitis of unknown aetiology (VUE, n ...
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Freitag L, von Kaisenberg C, Kreipe H, Hussein K Tags: Int J Clin Exp Pathol Source Type: research

Determination of whole transcription profiles and specific pathways in invasive ductal breast carcinoma.
This study aimed to detect the whole transcript expression of approximately 35,000 target genes in Thai breast cancer patients, using Affymetrix GeneChip(®) Exon 1.0 Sense Target Arrays. Analysis revealed that the differential expression profiles of 928 genes (423 up-regulated and 505 down-regulated genes) were 2-fold or greater (unpaired t-test, p
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Arnutti P, Kotepui M, Asanprakit W, Punyarit P, Chavalitshewinkoon-Petmitr P, Harnroongroj T, Petmitr S Tags: Int J Clin Exp Pathol Source Type: research

Phosphorylated c-Src is a novel predictor for recurrence in cervical squamous cell cancer patients.
CONCLUSION: Our present study suggests that Src signaling may play essential role in cervical cancer progression. Phospho-Src expression may be considered as a prognostic marker to predict recurrence in CSCC. PMID: 23696930 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Hou T, Xiao J, Zhang H, Gu H, Feng Y, Li J Tags: Int J Clin Exp Pathol Source Type: research

Autopsy findings of fatal cryptogenic organizing pneumonia.
In conclusion, the author reported an autopsy case of fatal COP. PMID: 23696931 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Terada T Tags: Int J Clin Exp Pathol Source Type: research

Correlation of ECM1 expression level with the pathogenesis and metastasis of laryngeal carcinoma.
Abstract OBJECTIVE: To investigate the expression of extracellular matrix protein 1 (ECM1) in benign laryngeal lesions, precancerous lesions and malignant laryngeal lesions and analyze the clinical significance of ECM1 changes in the pathogenesis and metastasis of laryngeal carcinoma. METHODS: A total of 46 patients with laryngeal lesions were recruited with a median age of 48.2 years (range: 33-67 years). Among these patients, 29 had laryngeal carcinoma (12 with metastasis and 17 without metastasis), 8 had benign laryngeal lesions and 9 had precancerous laryngeal lesions (laryngeal leukoplakia). Immunofluore...
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Gu M, Guan J, Zhao L, Ni K, Li X, Han Z Tags: Int J Clin Exp Pathol Source Type: research

Primary pure signet-ring cell carcinoma of the extrapulmonary left main bronchus: a case report with an immunohistochemical study.
In conclusion, the author reported the first case of primary SRCA of the extrapulmonary left main bronchus near the tracheal bifurcation with an extensive immunohistochemical study. PMID: 23696933 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Terada T Tags: Int J Clin Exp Pathol Source Type: research

Genetic distribution and association analysis of DRD2 gene polymorphisms with major depressive disorder in the Chinese Han population.
In this study, a total of 338 unrelated adult Chinese Han population, including 224 healthy volunteers and 114 patients with major depressive disorder, were recruited. DRD2 polymorphisms (Taq1A and -141C ins/del) were detected using restriction fragment length polymorphism (RFLP) analysis and the C957T were detected by sequencing directly. As a result, three polymorphisms were identified in Chinese Han population and all were common SNP. However, we could detect no evidence of genetic association between 3 markers in DRD2 and major depressive disorder in the Chinese Han population. To conclude, this result suggests that Ta...
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: He M, Yan H, Duan ZX, Qu W, Gong HY, Fan ZL, Kang JY, Li BC, Wang JM Tags: Int J Clin Exp Pathol Source Type: research

Urinary bladder urothelial carcinoma with expression of KIT and PDGFRA and showing diverse differentiations into plasmacytoid, clear cell, acantholytic, nested, and spindle variants, and into adenocarcinoma, signet-ring cell carcinoma, small cell carcinoma, large cell carcinoma, and pleomorphic carcinoma.
Abstract Various tumors can arise in the urinary bladder (UB); most common is urothelial carcinoma (UC). UC of the UB have many variants. Other types of carcinomas such as adenocarcinoma (AC) and small cell carcinoma (SmCC) can occur in UB carcinomas. Expression of KIT and PDGFRA has not been reported. A 66-year-old man admitted to our hospital because of hematuria. Cystoscopy revealed papillary invasive tumor and a transurethral bladder tumorectomy (TUR-BT) was performed. The TUR-BT showed UC, AC, SmCC, large cell carcinoma (LCC), and pleomorphic carcinoma (PC). The UC component showed plasmacytoid, spindle, nest...
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Terada T Tags: Int J Clin Exp Pathol Source Type: research

Does progesterone-induced endometrial withdrawal bleed before ovulation induction have negative effects on IUI outcomes in patients with polycystic ovary syndrome?
In conclusion, our study showed that progesterone exerted a negative effect on endometrial development, which seemed to be associated with reduced pregnancy results in ovulation induction with IUI cycles. PMID: 23696936 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Dong X, Zheng Y, Liao X, Xiong T, Zhang H Tags: Int J Clin Exp Pathol Source Type: research

Primary cutaneous small cell carcinoma; a case report with differential diagnosis.
Abstract Primary cutaneous small cell carcinoma (PC-SmCC) is extremely rare; only two cases have been reported in the world literatures. A 79-year-old woman presented a small cutaneous tumor in the face. Physical examination showed a tumor measuring 1.0x.08x0.6 cm in the shallow skin of the face. Excisional skin biopsy was performed. The biopsy showed complete excision of the tumor. The tumor was located in the shallow dermis and no connections to epidermis were seen. The tumor was invasive into subcutaneous tissue and surrounding dermis. The tumor was very hypercellular tumor composed of small cells with scant cy...
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Terada T Tags: Int J Clin Exp Pathol Source Type: research

Pseudomyxoma cutis; a new entity.
Abstract Pseudomyxoma (PM) implies an accumulation of a large amount of mucins which show myxomatous appearances. PM Peritonei (PMP) is famous and the only example of PM. PMP means excessive accumulation of mucins and mucin-secreting cells in the peritoneal cavity. The causes of PMP are mostly mucinous tumors, both benign and malignant, of ovaries and vermiform appendix. The author experienced excessive accumulation of mucins and mucin-producing cells in the subcutis and deep soft tissue. This situation very resembled PMP. Thus, the author termed the lesion as PM cutis (PMC). A 57-year-old man admitted to our hosp...
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Terada T Tags: Int J Clin Exp Pathol Source Type: research

Pathologic diagnosis of large cell neuroendocrine carcinoma of the lung in an axillary lymph node: a case report with immunohistochemical and molecular genetic studies.
Abstract The author herein reports a large cell neuroendocrine carcinoma (LCNEC) of the lung diagnosed in an axillary lymph node without clinical data, with an emphasis of KIT and PDGFRA. A 64-year-old woman presented with axillary and cervical lymph nodes swelling. An excisional biopsy of an axillary lymph node was performed under the clinical diagnosis of malignant lymphoma. The HE section showed a presence of large malignant cells arranged in a medullary pattern. The tumor cells had nucleoli. The HE diagnosis was large cell lymphoma or metastatic undifferentiated carcinoma, in particular large cell carcinoma of...
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Terada T Tags: Int J Clin Exp Pathol Source Type: research

A case of renal angiomyolipoma with intracardiac extension and asymptomatic pulmonary embolism.
Abstract ANGIOMYOLIPOMA (AML) IS THE MOST COMMON BENIGN TUMOR OF THE KIDNEY, WHICH IS COMPOSED OF A MIXTURE OF THREE TISSUE COMPONENTS: blood vessels, smooth muscle and adipose cells. Occasionally, AML may extend into the renal vein or the vena cava, but so far at least, intracardiac extension was rarely reported. We herein present one case of renal AML with intracardiac extension and pulmonary embolism simultaneously in a 52-year-old Chinese female patient. Contrast-enhanced computed tomography revealed a well-demarcated heterogeneous mass in the right kidney which extended into the right atrium through the right...
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Li X, Li Q, Miao Y, Xu H, Liu Y, Qiu X, Wang EH Tags: Int J Clin Exp Pathol Source Type: research

Cutaneous hybrid tumor composed of epidermal cyst and cystic pilomatricoma expressing p53 and high Ki-67 labeling.
In conclusion, the fifth case of hybrid tumor composed of epidermal cyst and pilomatricoma was presented. PMID: 23696941 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Terada T Tags: Int J Clin Exp Pathol Source Type: research

Successful treatment with recombinant thrombomodulin for B-cell lymphoma-associated hemophagocytic syndrome complicated by disseminated intravascular coagulation.
We report here a 47-year-old male with the diagnosis of high-grade B-cell lymphoma and hemophagocytosis accompanying disseminated intravascular coagulation (DIC). Lymphoma-associated hemophagocytic syndrome (LAHS) is a life-threatening disorder, and LAHS secondary to B-cell lymphoma is relatively rare compared to that secondary to T- or NK/T-cell lymphoma in Western countries. T- or NK/T-cell LAHS is sometimes combined with DIC, which makes patients' outcomes even worse, but few reports of B-cell LAHS accompanying DIC has been published so far. We successfully treated a patient with this condition with recombinant thrombom...
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Uni M, Yoshimi A, Maki H, Maeda D, Nakazaki K, Nakamura F, Fukayama M, Kurokawa M Tags: Int J Clin Exp Pathol Source Type: research

Retroperitoneal fibrosis associated with renal cel carcinoma.
PMID: 23696943 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Terada T Tags: Int J Clin Exp Pathol Source Type: research

Cardiac leiomyosarcoma, a case report.
Abstract In this case report we present the history of a patient admitted with recurrent pulmonary edema. Transesophageal chocardiography showed a tumour in the left atrium, occluding the ostium of the mitral valve and mimicking intermittent mitral stenosis. Cardiac surgery followed by pathological examination revealed that the tumour was a leiomyosarcoma. Images from the echocardiography as well as the pathological findings are shown and discussed. The present case report illustrates that atrial tumors comprise also sarcomas, suggesting the use of careful, rapid diagnostic procedures and treatment to prevent diss...
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Andersen RE, Kristensen BW, Gill S Tags: Int J Clin Exp Pathol Source Type: research

Capillary cavernous hemangioma of the lymph node.
PMID: 23696945 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Terada T Tags: Int J Clin Exp Pathol Source Type: research

Novel detection of pancreatic and duodenal homeobox 1 autoantibodies (PAA) in human sera using luciferase immunoprecipitation systems (LIPS) assay.
In conclusion, we have developed a liquid-phase, non-radioactive, sensitive and specific LIPS assay to detect PAA in human sera, providing a useful tool for evaluating the clinical relevance of PAA. PMID: 23696946 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - May 26, 2013 Category: Pathology Authors: Donelan W, Wang H, Li SW, Pittman D, Li Y, Han S, Sun Y, Carter C, Atkinson M, Reeves W, Winter WE, Yang LJ Tags: Int J Clin Exp Pathol Source Type: research

Study on the clinical significance of Argonaute2 expression in colonic carcinoma by tissue microarray.
CONCLUSION: Abnormal expression of Argonaute2 (EIF2C2) may be correlated with colon tumorigenesis. PMID: 23411422 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - February 21, 2013 Category: Pathology Authors: Wang YX, Zhang XY, Zhang BF, Yang CQ, Gao HJ Tags: Int J Clin Exp Pathol Source Type: research

Indoleamine 2,3-dioxygenase-1 (IDO1) enhances survival and invasiveness of endometrial stromal cells via the activation of JNK signaling pathway.
Abstract Evidence for an immunosuppressive function of indoleamine 2,3-dioxygenase (IDO) has been accumulating. However, the unusual distribution of IDO1 in gynecologic cancer cells suggests that modulating immunity may not its only function. To clarify the physiological importance of IDO1 in endometriosis, a tumor-like benign disease, we have investigated the potential mechanism by which IDO1 modulated endometrial stromal cells (ESCs) proliferation and invasion. ESCs were obtained from 16 control women (normal) and 14 patients with ovarian endometrioma, then the normal ESCs were treated with plasmid pEGFP-N1-IDO1...
Source: International Journal of Clinical and Experimental Pathology - February 21, 2013 Category: Pathology Authors: Mei J, Li MQ, Ding D, Li DJ, Jin LP, Hu WG, Zhu XY Tags: Int J Clin Exp Pathol Source Type: research

Small cell neuroendocrine carcinoma of the esophagus: report of 6 cases with immunohistochemical and molecular genetic analysis of KIT and PDGFRA.
Abstract Small cell neuroendocrine carcinoma of the esophagus (SCNECE) is a very rare, but a highly aggressive tumor. Six cases of SCNECE (0.25%) were found in the 2,438 archival pathologic specimens of esophagus in the last 20 years in our pathology laboratory. The ages ranged from 62 years to 81 years with a mean of 73 years. All cases were male. The presenting symptoms were dysphagia in 5 cases and vomiting in 1 case. The locations were lower esophagus in 4 cases and middle esophagus in 2 cases. Endoscopically, the tumor was ulcerated in 3 cases and polypoid in 3 cases. All the 6 patients were treated by chemor...
Source: International Journal of Clinical and Experimental Pathology - February 21, 2013 Category: Pathology Authors: Terada T Tags: Int J Clin Exp Pathol Source Type: research

Diverticulitis of multiple diverticulosis of the terminal ileum.
We report a case of diverticulitis of multiple diverticula of the terminal ileum. A 67-year-old Japanese woman consulted to our hospital because of abdominal pain and melena. A blood laboratory revealed severe anemia increased CRP (11.21 mg/dl). The upper and lower gastrointestinal endoscopic examination revealed no significant changes. The colon was free from diverticulum. CT demonstrated two tumors in the small intestine. PET identified a few shadows identical to the tumors detected by CT. The clinical diagnosis was small intestinal tumors, particularly malignant lymphoma. Operation was performed, and it revealed multipl...
Source: International Journal of Clinical and Experimental Pathology - February 21, 2013 Category: Pathology Authors: Terada T Tags: Int J Clin Exp Pathol Source Type: research

Fibrous dysplasia of the inferior turbinate.
We report a case of monostotic FD developed only in the inferior turbinate in a 29-year-old woman. To the best of our knowledge, it is the second report of monostotic FD involving the inferior turbinate in the medical literature. We, therefore, report this rare case with a review of literature. PMID: 23411641 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - February 21, 2013 Category: Pathology Authors: Park HJ, Cho MS, Lee SS Tags: Int J Clin Exp Pathol Source Type: research

Therapeutic effect of 188Re-MAG3-depreotide on non-small cell lung cancer in vivo and in vitro.
CONCLUSION: 188Re-MAG3-depreotide can inhibit the proliferation and invasion of A549 cells and SPC-A1 cells. Treatment with 7.4MBq 188Re-MAG3-depreotide via tail vein can significantly suppress the in vivo cancer growth and induce the apoptosis of cancer cells. These findings demonstrate that 188Re-MAG3-depreotide can induce the apoptosis of NSCLC cells and directly kill the NSCLC cells, which provide evidence for the radiotherapy of NSCLC. PMID: 23411669 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - February 21, 2013 Category: Pathology Authors: Yu F, Lv M, Cai H, Li D, Yuan X, Lv Z Tags: Int J Clin Exp Pathol Source Type: research

Inflammatory aortic aneurysm: possible manifestation of IgG4-related sclerosing disease.
In this study, we investigate the hypothesis that IgG4-related autoimmune reaction is involved in the formation of inflammatory aortic aneurysms (IAA). We obtained 23 cases of IAA and 11 cases of atherosclerotic aortic aneurysms (AAA) as control group. We evaluated the expression of IgG4 in both IAA study cases and AAA control cases. In addition, immunohistochemical expression of C-Kit, CD21, CD34, S-100 protein, SMA, vimentin, p53, beta-catenin, and ALK-1, and EBV-LMP1 expression by in situ hybridization were performed only in IAA cases. Of the 23 patients, 20 were males and 3 were females (M: F ratio 6.7:1); age ranged f...
Source: International Journal of Clinical and Experimental Pathology - February 21, 2013 Category: Pathology Authors: Raparia K, Molina CP, Quiroga-Garza G, Weilbaecher D, Ayala AG, Ro JY Tags: Int J Clin Exp Pathol Source Type: research

Acute kidney injury and inflammatory immune reconstitution syndrome in mixed genotype (A/E) hepatitis B virus co-infection in HIV-associated lymphoma.
We report a first case of HIV-associated lymphoma (HAL) presenting with acute kidney injury (AKI) and inflammatory immune reconstitution syndrome (IRIS). A 39-year-old male, treated with nonsteroidal anti-inflammatory drugs (NSAIDs) for one month prior to admission, developed AKI, left testicular tumor, and recurrent swelling of the right parotid gland. A resected testicular tumor exhibited features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma. Renal biopsy showed hydro-degeneration of renal tubules, interstitial inflammatory cells, and a small number of lymphoma cells in the sub-capsule, compati...
Source: International Journal of Clinical and Experimental Pathology - February 21, 2013 Category: Pathology Authors: Tajima K, Kohno K, Shiono Y, Suzuki I, Kato Y, Hiroshima Y, Yamamoto M, Ohtake H, Iwaba A, Yamakawa M, Kato T Tags: Int J Clin Exp Pathol Source Type: research