Extrarenal Wilms tumor of the recto-vaginal septum with < em > BRCA2 < /em > gene mutation: a case report
In this report, we present an unusual case of ERWT situated in the recto-vaginal septum of a 49-year-old woman, accompanied by a concurrent BRCA2 gene mutation. After the tumor's second recurrence, the patient experienced symptomatic relief after administering poly (ADP-ribose) polymerase (PARP) inhibitor therapy. Given the limited exposure and understanding of optimal treatment strategies for this distinct tumor, there is a definite need to accumulate further clinical experiences and insight. Consequently, we propose that genetic testing be considered in cases involving tumor recurrence or metastasis, since this may offer...
Source: International Journal of Clinical and Experimental Pathology - November 16, 2023 Category: Pathology Authors: Qijun Chen Kaixuan Yang Xiao Tang Source Type: research

Immune-related gene prognostic index (IRGPI) for lung adenocarcinoma predicts patient prognosis and immunotherapy response
CONCLUSION: The IRGPI may be a biomarker for determining the prognosis of patients and whether they respond favorably to ICB therapy.PMID:37970331 | PMC:PMC10641371 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - November 16, 2023 Category: Pathology Authors: Zheng Zhu Wei Feng Xiao-Yan Tan Pin-Chao Gu Wei Song Hai-Tao Ma Source Type: research

Angiotensin-converting enzyme - human amniotic mesenchymal stem cells improve pulmonary vascular remodeling in rats with pulmonary hypertension by promoting angiogenesis and counteracting inflammation
CONCLUSION: These results suggest that ACE2-hAMSCs can repair pulmonary vascular endothelial cell injury caused by pulmonary hypertension by promoting angiogenesis and anti-inflammatory ability. This shows that ACE2-hAMSCs have stronger ability to improve pulmonary vascular remodeling than hAMSCs alone.PMID:37970332 | PMC:PMC10641367 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - November 16, 2023 Category: Pathology Authors: Changfang Wu Hao Liu Mingchuan Ba Jie Zha Zhen Gao Lijun Li Peiyuan Xu Minfei Li Fusheng Cai Mingjie Chen Xiaona Wu Lin Guo Hongzhe Zhang Source Type: research

Radiologic and clinicopathologic features of eosinophilic solid and cystic renal cell carcinoma: report of two cases and review of literature
We describe two ESC RCC cases diagnosed at our institution. Both cases occurred in female patients, ages of 33 and 64, respectively. Both patients had no evidence of TSC and both lesions were found incidentally, by imaging studies, at an early stage. Macroscopic and microscopic findings in both neoplasms were classic. One case was analyzed by molecular testing and TSC2 gene mutation was detected. Both cases had focal positivity of CD10 and Cathepsin K by IHC. Both tumors were stage pT1a at diagnosis and the patients remained free of disease after resection. It has been proposed that TSC1/2 can be a molecular marker for ESC...
Source: International Journal of Clinical and Experimental Pathology - November 16, 2023 Category: Pathology Authors: Jiejing Yin Dina Zenezan Khanh Duy Doan Alisa Nobee Shuanzeng Wei Mehri Mollaee Daniela M Proca Source Type: research

Protective effect of mesenchymal stem cell-conditioned medium on hepatic cell apoptosis after acute liver injury [Retraction]
Int J Clin Exp Pathol. 2023 Oct 15;16(10):314. eCollection 2023.ABSTRACT[This retracts the article on p. 831 in vol. 6, PMID: 23638214.].PMID:37970334 | PMC:PMC10641368 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - November 16, 2023 Category: Pathology Source Type: research

Adult cerebral high-grade glioneuronal tumor with perivascular or pseudopapillary growth co-existing with low-grade tumor: a case report
Int J Clin Exp Pathol. 2023 Oct 15;16(10):294-302. eCollection 2023.ABSTRACTAn unusual, small cell-predominant, high-grade glioneuronal tumor in the occipital lobe of a 49-year-old man that co-existed with a low-grade tumor is reported. The tumor consisted of two distinct components: the major component was a dense proliferation of primitive small cells showing bidirectional neuronal and glial differentiation; and the minor component consisted of a proliferation of well-differentiated astrocytes intermingled with mature neuronal cells. In the former component, perivascular pseudorosette-like or pseudopapillary growth remin...
Source: International Journal of Clinical and Experimental Pathology - November 16, 2023 Category: Pathology Authors: Masayuki Shintaku Makoto Ohta Hideo Chihara Hideaki Yokoo Yuri Noda Koji Tsuta Source Type: research

Extrarenal Wilms tumor of the recto-vaginal septum with < em > BRCA2 < /em > gene mutation: a case report
In this report, we present an unusual case of ERWT situated in the recto-vaginal septum of a 49-year-old woman, accompanied by a concurrent BRCA2 gene mutation. After the tumor's second recurrence, the patient experienced symptomatic relief after administering poly (ADP-ribose) polymerase (PARP) inhibitor therapy. Given the limited exposure and understanding of optimal treatment strategies for this distinct tumor, there is a definite need to accumulate further clinical experiences and insight. Consequently, we propose that genetic testing be considered in cases involving tumor recurrence or metastasis, since this may offer...
Source: International Journal of Clinical and Experimental Pathology - November 16, 2023 Category: Pathology Authors: Qijun Chen Kaixuan Yang Xiao Tang Source Type: research

Immune-related gene prognostic index (IRGPI) for lung adenocarcinoma predicts patient prognosis and immunotherapy response
CONCLUSION: The IRGPI may be a biomarker for determining the prognosis of patients and whether they respond favorably to ICB therapy.PMID:37970331 | PMC:PMC10641371 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - November 16, 2023 Category: Pathology Authors: Zheng Zhu Wei Feng Xiao-Yan Tan Pin-Chao Gu Wei Song Hai-Tao Ma Source Type: research

Angiotensin-converting enzyme - human amniotic mesenchymal stem cells improve pulmonary vascular remodeling in rats with pulmonary hypertension by promoting angiogenesis and counteracting inflammation
CONCLUSION: These results suggest that ACE2-hAMSCs can repair pulmonary vascular endothelial cell injury caused by pulmonary hypertension by promoting angiogenesis and anti-inflammatory ability. This shows that ACE2-hAMSCs have stronger ability to improve pulmonary vascular remodeling than hAMSCs alone.PMID:37970332 | PMC:PMC10641367 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - November 16, 2023 Category: Pathology Authors: Changfang Wu Hao Liu Mingchuan Ba Jie Zha Zhen Gao Lijun Li Peiyuan Xu Minfei Li Fusheng Cai Mingjie Chen Xiaona Wu Lin Guo Hongzhe Zhang Source Type: research

Radiologic and clinicopathologic features of eosinophilic solid and cystic renal cell carcinoma: report of two cases and review of literature
We describe two ESC RCC cases diagnosed at our institution. Both cases occurred in female patients, ages of 33 and 64, respectively. Both patients had no evidence of TSC and both lesions were found incidentally, by imaging studies, at an early stage. Macroscopic and microscopic findings in both neoplasms were classic. One case was analyzed by molecular testing and TSC2 gene mutation was detected. Both cases had focal positivity of CD10 and Cathepsin K by IHC. Both tumors were stage pT1a at diagnosis and the patients remained free of disease after resection. It has been proposed that TSC1/2 can be a molecular marker for ESC...
Source: International Journal of Clinical and Experimental Pathology - November 16, 2023 Category: Pathology Authors: Jiejing Yin Dina Zenezan Khanh Duy Doan Alisa Nobee Shuanzeng Wei Mehri Mollaee Daniela M Proca Source Type: research

Protective effect of mesenchymal stem cell-conditioned medium on hepatic cell apoptosis after acute liver injury [Retraction]
Int J Clin Exp Pathol. 2023 Oct 15;16(10):314. eCollection 2023.ABSTRACT[This retracts the article on p. 831 in vol. 6, PMID: 23638214.].PMID:37970334 | PMC:PMC10641368 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - November 16, 2023 Category: Pathology Source Type: research

Adult cerebral high-grade glioneuronal tumor with perivascular or pseudopapillary growth co-existing with low-grade tumor: a case report
Int J Clin Exp Pathol. 2023 Oct 15;16(10):294-302. eCollection 2023.ABSTRACTAn unusual, small cell-predominant, high-grade glioneuronal tumor in the occipital lobe of a 49-year-old man that co-existed with a low-grade tumor is reported. The tumor consisted of two distinct components: the major component was a dense proliferation of primitive small cells showing bidirectional neuronal and glial differentiation; and the minor component consisted of a proliferation of well-differentiated astrocytes intermingled with mature neuronal cells. In the former component, perivascular pseudorosette-like or pseudopapillary growth remin...
Source: International Journal of Clinical and Experimental Pathology - November 16, 2023 Category: Pathology Authors: Masayuki Shintaku Makoto Ohta Hideo Chihara Hideaki Yokoo Yuri Noda Koji Tsuta Source Type: research

Extrarenal Wilms tumor of the recto-vaginal septum with < em > BRCA2 < /em > gene mutation: a case report
In this report, we present an unusual case of ERWT situated in the recto-vaginal septum of a 49-year-old woman, accompanied by a concurrent BRCA2 gene mutation. After the tumor's second recurrence, the patient experienced symptomatic relief after administering poly (ADP-ribose) polymerase (PARP) inhibitor therapy. Given the limited exposure and understanding of optimal treatment strategies for this distinct tumor, there is a definite need to accumulate further clinical experiences and insight. Consequently, we propose that genetic testing be considered in cases involving tumor recurrence or metastasis, since this may offer...
Source: International Journal of Clinical and Experimental Pathology - November 16, 2023 Category: Pathology Authors: Qijun Chen Kaixuan Yang Xiao Tang Source Type: research

Immune-related gene prognostic index (IRGPI) for lung adenocarcinoma predicts patient prognosis and immunotherapy response
CONCLUSION: The IRGPI may be a biomarker for determining the prognosis of patients and whether they respond favorably to ICB therapy.PMID:37970331 | PMC:PMC10641371 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - November 16, 2023 Category: Pathology Authors: Zheng Zhu Wei Feng Xiao-Yan Tan Pin-Chao Gu Wei Song Hai-Tao Ma Source Type: research

Angiotensin-converting enzyme - human amniotic mesenchymal stem cells improve pulmonary vascular remodeling in rats with pulmonary hypertension by promoting angiogenesis and counteracting inflammation
CONCLUSION: These results suggest that ACE2-hAMSCs can repair pulmonary vascular endothelial cell injury caused by pulmonary hypertension by promoting angiogenesis and anti-inflammatory ability. This shows that ACE2-hAMSCs have stronger ability to improve pulmonary vascular remodeling than hAMSCs alone.PMID:37970332 | PMC:PMC10641367 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - November 16, 2023 Category: Pathology Authors: Changfang Wu Hao Liu Mingchuan Ba Jie Zha Zhen Gao Lijun Li Peiyuan Xu Minfei Li Fusheng Cai Mingjie Chen Xiaona Wu Lin Guo Hongzhe Zhang Source Type: research