Angiofibroma of soft tissue: clinicopathologic study of 2 cases of a recently characterized benign soft tissue tumor.
This report serves to broaden the morphologic spectrum of angiofibroma of soft tumor. Awareness of this tumor is important to prevent misdiagnosis as other more aggressive soft tissue tumor. PMID: 24133600 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - October 20, 2013 Category: Pathology Authors: Zhao M, Sun K, Li C, Zheng J, Yu J, Jin J, Xia W Tags: Int J Clin Exp Pathol Source Type: research

Primary bone carcinosarcoma of the fibula with chondrosarcoma and squamous cell carcinoma components.
In this report, we describe the third documented de novo case of carcinosarcoma of the bone. A 59-year-old Japanese female presented with a painful tumor in her right lower leg. Plane radiography revealed an osteolytic destructive lesion with periosteal reaction and mineralization in the right fibula. Resection of the fibula tumor was performed under a clinical diagnosis of chondrosarcoma. Histopathological study revealed that the tumor was comprised of three components. The main component was proliferation of small round to short spindle cells (approximately 50%), and the remaining components were chondrosarcoma (30%) and...
Source: International Journal of Clinical and Experimental Pathology - October 20, 2013 Category: Pathology Authors: Ishida M, Kodama N, Takemura Y, Iwai M, Yoshida K, Kagotani A, Matsusue Y, Okabe H Tags: Int J Clin Exp Pathol Source Type: research

Biclonal light chain gammopathy with aberrant CD33 expression in secondary plasma cell leukemia.
We present a case of a secondary plasma cell leukemia arising from plasma cell myeloma with dual expression of lambda and kappa light chains along with aberrant expression of CD33, CD20, and dim CD56. This case emphasizes the importance of recognizing aberrant immunophenotypes in plasma cell leukemias and represents the first reported case of biclonal light chain expression in a secondary plasma cell leukemia. PMID: 24133602 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - October 20, 2013 Category: Pathology Authors: Gentry M, Pettenati M, Pang CS Tags: Int J Clin Exp Pathol Source Type: research

Desmoplastic fibroma of the scapula with fluorodeoxyglucose uptake on positron emission tomography: a case report and literature review.
We present a case of desmoplastic fibroma (DF) arising from the right scapula that was incidentally identified by fluorodeoxyglucose-positron emission tomography (FDG-PET) imaging performed to evaluate the presence of metastasis due to a history of surgical treatment for endometrioid adenocarcinoma. A 65-year-old woman was admitted to our hospital for consultation about a bone lesion in the right scapula although she was asymptomatic. FDG-PET revealed moderate focal (18)F-FDG uptake in the right scapula with a maximal standardized uptake value of 3.2. The lower angle of the scapula was unclear on plain radiology. Needle bi...
Source: International Journal of Clinical and Experimental Pathology - October 20, 2013 Category: Pathology Authors: Okubo T, Saito T, Takagi T, Torigoe T, Suehara Y, Akaike K, Yao T, Kaneko K Tags: Int J Clin Exp Pathol Source Type: research

Methotrexate-related Epstein-Barr virus-associated lymphoproliferative disorder occurring in the gingiva of a patient with rheumatoid arthritis.
Abstract It is well recognized that patients with immunodeficiency have a high risk of development of lymphoproliferative disorders (LPDs), and Epstein-Barr virus (EBV) is associated with the occurrence of LPDs. Methotrexate (MTX) is one of the common cause of iatrogenic-associated LPD, and approximately 40-50% of MTX-related LPD cases occur in extranodal sites. However, the occurrence of MTX-related LPD in the gingiva is extremely rare. Herein, we report the fourth documented case of MTX-related EBV-associated LPD occurring in the gingiva of a patient with rheumatoid arthritis (RA). A 76-year-old Japanese female ...
Source: International Journal of Clinical and Experimental Pathology - October 20, 2013 Category: Pathology Authors: Ishida M, Hodohara K, Yoshii M, Okuno H, Horinouchi A, Nakanishi R, Harada A, Iwai M, Yoshida K, Kagotani A, Yoshida T, Okabe H Tags: Int J Clin Exp Pathol Source Type: research

Xanthomatous meningioma: a case report with review of the literature.
In this report, we describe the fifth documented case of xanthomatous meningioma and review its clinicopathological features. A 76-year-old Japanese male presented with dizziness. Magnetic resonance imaging demonstrated a well-circumscribed tumor in the left parasagittal to frontal region with attachment of the dura mater. Histopathological examination of the resected specimen revealed proliferation of polygonal to spindle cells with eosinophilic cytoplasm and bland round to oval nuclei. Whorl formation and psammomas were scattered, and mitotic figures were rarely seen. A peculiar finding was the presence of extensive xant...
Source: International Journal of Clinical and Experimental Pathology - October 20, 2013 Category: Pathology Authors: Ishida M, Fukami T, Nitta N, Iwai M, Yoshida K, Kagotani A, Nozaki K, Okabe H Tags: Int J Clin Exp Pathol Source Type: research

Paraganglioma of the vulva: a case report and review of the literature.
Abstract Paraganglioma is a neuroendocrine neoplasm, which is extremely rare in the vulva and only one case has been reported. Here we present a case of vulvar paraganglioma in a 48-year-old woman and a literature review. The patient found a lump located in the genitals below the symphysis pubis 3 months before presentation when she complained that the lump was increasing in size. A 3.2 cm x 2.3 cm x 1.5 cm nodule was excised from subcutaneous soft tissue in the vulva. Microscopy showed a diversity of cell morphologies and structures in the rich vascular network of the tumor separated the chief cells into round ce...
Source: International Journal of Clinical and Experimental Pathology - October 20, 2013 Category: Pathology Authors: Liu YQ, Yue JQ Tags: Int J Clin Exp Pathol Source Type: research

Malignant perivascular epithelioid cell tumor of the retroperitoneum.
In conclusion, the malignant PEComas of the retroperitoneum is a very rare neoplasm with unique morphological and immunohistochemical characteristics. It should be differentiated from other epithelioid cell tumors of the retroperitoneum. PMID: 24133607 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - October 20, 2013 Category: Pathology Authors: Wu JH, Zhou JL, Cui Y, Jing QP, Shang L, Zhang JZ Tags: Int J Clin Exp Pathol Source Type: research

Synovial sarcoma of the neck masquerading as a malignant second branchial cleft cyst.
We report a case of a young patient with synovial sarcoma, clinically masquerading as cystic mass of the neck and malignant second branchial cleft cyst. The pathological diagnosis of the sarcoma was confirmed by a multimodality diagnostic protocol, including histological, immunohistochemical and molecular genetic analysis. The patient underwent complete surgical excision followed by postoperative radiotherapy and recovered well. PMID: 24133608 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - October 20, 2013 Category: Pathology Authors: Teng YS, Lin ZH, Li Y, Cao XL, Lin FC, Xiang JJ Tags: Int J Clin Exp Pathol Source Type: research

Metastatic Crohn's disease accompanying granulomatous vasculitis and lymphangitis in the vulva.
Abstract Metastatic Crohn's disease (CD) is an extremely rare extragastrointestinal manifestation of CD, and is characterized histopathologically by the presence of non-caseating granulomatous inflammation. Granulomatous vasculitis and lymphangitis have rarely been documented in metastatic CD. Herein, we report the first documented case of metastatic CD accompanied by both granulomatous vasculitis and lymphangitis in the vulva. A 35-year-old Japanese female with CD presented with multiple small nodules in her vulva. Biopsy was performed under a clinical diagnosis of genital warts. A histopathological study reveale...
Source: International Journal of Clinical and Experimental Pathology - October 20, 2013 Category: Pathology Authors: Ishida M, Iwai M, Yoshida K, Kagotani A, Okabe H Tags: Int J Clin Exp Pathol Source Type: research

Encephalomalacic dysplastic mass lesion associated with vascular abnormalities in an elderly man. Is this "acquired" focal cortical dysplasia?
We present here a case of mass-forming FCD type IIIc with very unusual vasculopathies. The patient, a 75-year-old man, presented with a seizure and left-sided weakness. MRI showed a right frontal intra-axial mass (4 cm in diameter). He had significant multiple cardiovascular risk factors and a history of melanoma and bladder cancer. Craniotomy was performed for excision of the suspected neoplasm. Histologically, the cortex showed transition from normal, laminar cortical architecture to marked architectural abnormality with irregular areas of encephalomalacia, with intervening, almost nodular regions of "preserved"...
Source: International Journal of Clinical and Experimental Pathology - October 20, 2013 Category: Pathology Authors: Takei H, Bhattacharjee MB Tags: Int J Clin Exp Pathol Source Type: research

Sinomenine protects mice against ischemia reperfusion induced renal injury by attenuating inflammatory response and tubular cell apoptosis.
Abstract Sinomenine (SIN) is a purified alkaloid from the Chinese herb Sinomenium acutum. Previous studies demonstrated that SIN possesses anti-inflammatory and anti-apoptotic properties. We thus in the present report conducted studies to examine its impact on ischemia reperfusion (IR) induced renal injury. Precondition of mice with 200 mg/kg of SIN provided significant protection for mice against IR-induced renal injury as manifested by the attenuated serum creatinine (Cre) and blood urea nitrogen (BUN) along with less severity for histological changes and tubular cell apoptosis. In line with these results, treat...
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Zhao Z, Guan R, Song S, Zhang M, Liu F, Guo M, Guo W, Yu Q, Zhang L, Wang Q Tags: Int J Clin Exp Pathol Source Type: research

Inflammatory thoracic aortic aneurysm (lymphoplasmacytic thoracic aortitis): a 13-year-experience at a German Heart Center with emphasis on possible role of IgG4.
CONCLUSION: IgG4-rich sclerosing lymphoplasmacytic thoracic aortitis is a constant histological feature of thoracic IAA. Normal serum IgG4 in most patients, predilection for women and absence of other features of IgG4-RD all suggest a tissue-specific localized autoimmunological process and argue against a systemic disorder. The relationship (if any) of IgG4-rich lymphoplasmacytic thoracic aortitis in those patients with IAA lacking other organ manifestations or an elevated serum IgG4 level to systemic IgG4-RD remains unclear and merit further studies. PMID: 24040436 [PubMed - in process] (Source: International Journal...
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Agaimy A, Weyand M, Strecker T Tags: Int J Clin Exp Pathol Source Type: research

Investigation of splicing changes and post-translational processing of LMNA in sporadic inclusion body myositis.
Abstract Some features of sporadic inclusion body myositis (s-IBM) suggest that there is acceleration of the normal ageing process in muscle tissue. LMNA encodes the nuclear lamina proteins lamin A/C through alternative splicing, and aberrant splicing of exon 11 leads to the premature ageing disease, Hutchinson-Gilford progeria syndrome. Progerin, the pathogenic isoform expressed in HGPS tissues, has also been detected at low levels in tissues of normal individuals with aging. We therefore investigated the alternative splicing of LMNA gene transcripts, and the post-translational processing of prelamin A, in s-IBM ...
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Luo YB, Mitrpant C, Johnsen R, Fabian V, Needham M, Fletcher S, Wilton SD, Mastaglia FL Tags: Int J Clin Exp Pathol Source Type: research

Array analysis for potential biomarker of gemcitabine identification in non-small cell lung cancer cell lines.
Abstract Gemcitabine is one of the most widely used drugs for the treatment of advanced Non-small cell lung cancer (NSCLC), but modest objective response rate of patients to gemcitabine makes it necessary to identify novel biomarkers for patients who can benefit from gemcitabine-based therapy and to improve the effect of clinical therapy. In this work, 3 NSCLC cell lines displaying different sensitivities to gemcitabine were applied for mRNA and microRNA (miR) expression chips to figure out the biomarkers for gemcitabine sensitivity. Genes whose expression increased dramatically in sensitive cell lines were mainly...
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Zhang HH, Zhang ZY, Che CL, Mei YF, Shi YZ Tags: Int J Clin Exp Pathol Source Type: research

The differential expression of TGF-β1, ILK and wnt signaling inducing epithelial to mesenchymal transition in human renal fibrogenesis: an immunohistochemical study.
In conclusion, the type II EMT process in humans is thought to be an adaptive response of TECs to chronic injury and is regulated by interconnections of TGF-β/Smad, integrin/integrin-linked kinase (ILK) and wnt/β-catenin signaling pathways. PMID: 24040439 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Kim MK, Maeng YI, Sung WJ, Oh HK, Park JB, Yoon GS, Cho CH, Park KK Tags: Int J Clin Exp Pathol Source Type: research

Limited therapeutic efficacy of thrombopoietin on the regeneration of steatotic livers.
In conclusion, TPO slightly prevents acute liver damage after resection in obese mice, but fails to significantly enhance regeneration of fatty livers. PMID: 24040440 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Abshagen K, Mertens F, Eipel C, Vollmar B Tags: Int J Clin Exp Pathol Source Type: research

AMPK activity is down-regulated in endothelial cells of GHS-R(-/-) mice.
Abstract Ghrelin/GHS-R axis is known as its role in stimulating growth hormone release. Besides, it is also implicated in the regulation of atherosclerosis (AS), a chronic vascular disease that has been recognized as the main cause of coronary heart disease and cerebrovascular disease. It has been reported that both Ghrelin and AMPK play protective roles in AS by inhibiting the inflammatory response as well as cell proliferation. However, it remains unclear whether AMPK pathway is involved in Ghrelin/GHS-R-mediated inhibition of the inflammatory response and cell proliferation in AS. Here, we established the GHS-R...
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Zhang M, Fang WY, Qu XK, Yuan F, Wang WG, Fei J, Wang ZG Tags: Int J Clin Exp Pathol Source Type: research

IL-22 secreted by decidual stromal cells and NK cells promotes the survival of human trophoblasts.
In this study, we demonstrated that co-culture of decidual stromal cells (DSCs) and decidual natural killer (dNK) cells resulted in increased secretion of IL-22, compared to culture of DSCs or dNK cells alone. The trophoblast cell line, HTR8/SVneo, expresses IL-22 receptor α1 (IL-22R1). Combinant human (rh) IL-22 significantly promoted the proliferation and viability, and inhibited the apoptosis of HTR8/SVneo cells. By Western blotting and immunohistochemistry, we confirmed that villi expressed IL-22R1, and the villi from unexplained spontaneous miscarriage patients expressed reduced levels of IL-22R1 than those from...
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Wang Y, Xu B, Li MQ, Li DJ, Jin LP Tags: Int J Clin Exp Pathol Source Type: research

Expression of dishevelled gene in Hirschsprung's disease.
CONCLUSION: The study showed an association of DVL-1 and DVL-3 with HSCR, it may play an important role in the pathogenesis of HSCR. PMID: 24040443 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Chen D, Mi J, Wu M, Wang W, Gao H Tags: Int J Clin Exp Pathol Source Type: research

Growth inhibitory effect of Cucurbitacin E on breast cancer cells.
Conclusions Cucurbitacin E (CuE) could inhibit the growth of human breast cancer cells in vitro. CuE induced both apoptosis and cell cycle arrest probably through the inhibition of STAT3 function. Lose-dose CuE significantly enhanced the growth inhibitory effect of cisplatin on breast cancer cells, further indicating the potential clinical values of CuE for the prevention or treatment of human breast cancer. PMID: 24040444 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Lan T, Wang L, Xu Q, Liu W, Jin H, Mao W, Wang X, Wang X Tags: Int J Clin Exp Pathol Source Type: research

Assessing the role of IL-35 in colorectal cancer progression and prognosis.
Abstract Despite the recent realization of Interleukin (IL)-35 in tumorigenesis, its exact impact on colorectal cancer (CRC) progression and prognosis, however, is yet to be elucidated clearly. We thus in the present report conducted comparative analysis of IL-35 levels between CRC patients and matched control subjects. IL-35 is highly expressed in all CRC tissues, which can be detected in vast majority of colorectal cancer cells. IL-35 levels in CRC lysates and serum samples are highly correlated to the severity of malignancy and the clinical stage of tumor. Particularly, a significant reduction for serum IL-35 w...
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Zeng JC, Zhang Z, Li TY, Liang YF, Wang HM, Bao JJ, Zhang JA, Wang WD, Xiang WY, Kong B, Wang ZY, Wu BH, Chen XD, He L, Zhang S, Wang CY, Xu JF Tags: Int J Clin Exp Pathol Source Type: research

Cellular retinol binding protein 1 could be a tumor suppressor gene in cervical cancer.
CONCLUSIONS: The data indicates that, both activating and inactivating changes in the CRBP1 gene could be significant events in the development and progression of CC, and the lack of expression of the CRBP1 protein could be related with to the development of CC. We believe that there is enough evidence to consider to CRBP1 gene as a tumor suppressor gene for CC. PMID: 24040446 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Mendoza-Rodriguez M, Arreola H, Valdivia A, Peralta R, Serna H, Villegas V, Romero P, Alvarado-Hernández B, Paniagua L, Marrero-Rodríguez D, Meraz MA, Salcedo M Tags: Int J Clin Exp Pathol Source Type: research

miRNA-9 expression is upregulated in the spinal cord of G93A-SOD1 transgenic mice.
Abstract The pathogenesis of amyotrophic lateral sclerosis (ALS) remains unclear. Accumulating evidence indicates that various miRNAs expressed in a spatially and temporally controlled manner in the nervous system have an important function in the development of neurodegenerative diseases. The present study aimed to determine the expression and cellular distribution of miRNA-9 in the spinal cord of G93A-SOD1 mutant mice at different time points (post-natal 95, 108 and 122 d). miRNA expression was evaluated by microarray analysis; differentially expressed miRNAs were validated by RT-qPCR. The cellular distribution ...
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Zhou F, Guan Y, Chen Y, Zhang C, Yu L, Gao H, Du H, Liu B, Wang X Tags: Int J Clin Exp Pathol Source Type: research

Value of epithelioid morphology and PDGFRA immunostaining pattern for prediction of PDGFRA mutated genotype in gastrointestinal stromal tumors (GISTs).
Abstract AIMS: Genotyping is a prerequisite for tyrosine kinase inhibitor therapy in high risk and malignant GIST. About 10% of GISTs are wild-type for KIT but carry PDGFRA mutations. Applying the traditional approach, mutation analysis of these cases is associated with higher costs if all hotspots regions in KIT (exon 9, 11, 13, 17) are performed at first. Our aim was to evaluate the predictive value of a combined histomorphological-immunohistochemical pattern analysis of PDGFRA-mutated GISTs to efficiently direct KIT and PDGFRA mutation analysis. METHODS: The histomorphology and PDGFRA immunostaining patter...
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Agaimy A, Otto C, Braun A, Geddert H, Schaefer IM, Haller F Tags: Int J Clin Exp Pathol Source Type: research

FIZZ1 could enhance the angiogenic ability of rat aortic endothelial cells.
This study aimed to explore the effects of FIZZ1 on the angiogenic ability of cultured rat aortic endothelial cells (RAECs) and the potential mechanism. The RAECs were cultured in the extracellular matrix (ECM) supplemented with 10% fetal bovine serum (FBS). Matrigel assay was used to detect the angiogenic ability of the RAECs and Agilent Rat Microarray containing 41,000 genes/ESTs was used to screen the differentially expressed genes of the RAECs after they were treated with FIZZ1 (5 x 10(-9)~2 x 10(-8) mol/L). The results were verified using RT-PCR method. We found that FIZZ1 markedly enhanced the angiogenic ability of R...
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Li X, Yang Y, Fang J, Zhang H Tags: Int J Clin Exp Pathol Source Type: research

Increased expression of EphA1 protein in prostate cancers correlates with high Gleason score.
Abstract The erythropoietin-producing hepatocellular (Eph) family of receptor tyrosine kinases regulates a multitude of physiological and pathological processes. EphA1 is the first member of Eph superfamily and is involved in carcinogenesis. The aim of this study was to investigate the expression of EphA1 in prostate cancers cell lines and the tissues, then explore the correlation with the clinicopathologic parameters. The EphA1 transcript expression in prostate cancer cell lines was detected by Quantitative real-time PCR. The expression of EphA1 protein in 138 prostate cancer tissue samples and 21 benign prostate...
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Peng L, Wang H, Dong Y, Ma J, Wen J, Wu J, Wang X, Zhou X, Wang J Tags: Int J Clin Exp Pathol Source Type: research

Immunochemiluminescent detection of galectin-3 in tumoral tissue from prostate.
Carvalho LB Abstract This work proposes a chemiluminescent quantitative method for galectin-3 (Gal3) detection in prostate tissues. Monoclonal antibody anti-Gal3 was conjugated to acridinium ester (AE) and the complex formed with Gal3 in the prostate tissue was chemiluminescently detected. The light emission (expressed in Relative Light Unit-RLU) showed mean values higher for benign prostatic hyperplasia than normal tissues and adenocarcinoma. These differences showed to be statistically significant (p
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Araújo-Filho JL, Melo-Junior MR, Beltrão EI, de Lima LR, Antunes CB, de Carvalho LB Tags: Int J Clin Exp Pathol Source Type: research

Pigmented squamous intraepithelial neoplasia of the esophagus.
Abstract Squamous cell carcinoma (SCC) usually lacks melanocytes within the tumor. A few reports have documented invasive SCC or SCC in situ (intraepithelial neoplasia, IEN) with melanocytic hyperplasia within the tumor, referred to as pigmented SCC, in some organs. However, case series of pigmented SCC or IEN of the esophagus have not yet been reported. This is the first study to analyze the incidence and clinicopathological features of pigmented SCC or IEN of the esophagus. We reviewed 18 surgically-resected and 122 endoscopically-resected esophageal specimens, including 79 cases of IEN. Three cases of pigmented...
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Ishida M, Mochizuki Y, Iwai M, Yoshida K, Kagotani A, Okabe H Tags: Int J Clin Exp Pathol Source Type: research

Immunohistochemical evaluation of cardiac connexin43 in rats exposed to low-frequency noise.
CONCLUSIONS: LFN induces modifications on cardiac Cx43 in rats. The Cx43 reduction observed in our study suggests that LFN may induce an arrhythmogenic substrate and opens a new investigational area concerning the effects of LFN on the heart. PMID: 24040453 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Antunes E, Borrecho G, Oliveira P, Brito J, Aguas A, Martins Dos Santos J Tags: Int J Clin Exp Pathol Source Type: research

Screening for EGFR and KRAS mutations in non-small cell lung carcinomas using DNA extraction by hydrothermal pressure coupled with PCR-based direct sequencing.
This study assessed the feasibility of using this method to screen for exons 18-21 of EGFR and exon 2 of KRAS gene mutations in surgical resection and core needle biopsy specimens from 251 NSCLC patients. EGFR mutations were identified in 140 (55.8%) NSCLC patients (118 in adenocarcinoma, 11 in squamous cell carcinoma, 7 in adenocarcinoma and 4 in NSCLC-not otherwise specified), including four novel substitutions (L718M, A743V, L815P, V819E). EGFR mutations were frequently present in female patients (72 of 113, 63.7%) and NSCLC with adenocarcinoma component (125/204, 61.3%) with statistical significance. Twenty-one patient...
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Liu Y, Wu BQ, Zhong HH, Hui P, Fang WG Tags: Int J Clin Exp Pathol Source Type: research

Pigmented pilomatricoma: an underrecognized variant.
In this study, we analyzed the incidence and clinicopathological features of pigmented pilomatricoma. Fifty-seven consecutive pilomatricoma cases from 53 Japanese patients were examined in this study. In fourteen cases (24.6%), pigmentation was observed in pilomatricoma. This variant equally affected in males and females, and the common locations were the upper arm and face. Proliferation of dendritic melanocytes was observed within basaloid cell nests in all cases, and melanin pigment was also present within the cytoplasm of the basaloid cells in 11 cases. Melanin pigment was also present in the shadow cells in 7 cases. T...
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Ishida M, Okabe H Tags: Int J Clin Exp Pathol Source Type: research

The association of Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 gene with the metabolic characteristics in Chinese women with polycystic ovary syndrome.
CONCLUSION: PPARγ2 gene Pro12Ala polymorphism was not supposed to be susceptible genes in PCOS. However, in PCOS patients, the PPAR-gamma Pro12Ala polymorphism may modulate the concentrations of serum fasting TG levels and fat-deposition in abdomen, respectively. PMID: 24040456 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Yang J, Gong H, Liu W, Tao T Tags: Int J Clin Exp Pathol Source Type: research

Comparison of the GnRH agonist and antagonist protocol on the same patients in assisted reproduction during controlled ovarian stimulation cycles.
Abstract Despite the fact that both gonadotropin-releasing hormone (GnRH) agonist and antagonist protocol are effective in suppressing the incidence of premature luteinizing hormone (LH) surges through reversibly blocking the secretion of pituitary gonadotropins, the exact impact of these two distinctive protocols on the clinical setting of patients for in vitro fertilization and embryo transfer (IVF-ET) treatment, however, remained controversial. We thus in the present report conducted a retrospective study to compare the impact of GnRH agonist and antagonist protocol on the same patients during controlled ovaria...
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Lai Q, Zhang H, Zhu G, Li Y, Jin L, He L, Zhang Z, Yang P, Yu Q, Zhang S, Xu JF, Wang CY Tags: Int J Clin Exp Pathol Source Type: research

The impact of endometriosis on IVF/ICSI outcomes.
This study suggests that IVF/ICSI yielded similar pregnancy outcomes in patients with different stages of endometriosis and patients with tubal infertility. Therefore, IVF/ICSI can be considered as an effective approach for managing endometriosis-associated infertility. PMID: 24040458 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Dong X, Liao X, Wang R, Zhang H Tags: Int J Clin Exp Pathol Source Type: research

Primary sacral non-germinal center type diffuse large B-cell lymphoma with MYC translocation: a case report and a review of the literature.
Abstract An 85-year-old man presented with pain and numbness in the left buttock, and physical examination revealed an approximately 7 cm mass extending from the first to the third sacral vertebrae; biopsy of the mass led to the diagnosis of CD10-negative, BCL6-weakly positive, MUM1-positive, non-germinal center (non-GC) type diffuse large B-cell lymphoma (DLBCL). Furthermore, serological testing showed negative results for Epstein-Barr virus (EBV) infection, and fluorescence in situ hybridization (FISH) revealed a MYC translocation. Radiographs showed no remarkable osteolytic bone destruction, and the patient was...
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Shimada A, Sugimoto KJ, Wakabayashi M, Imai H, Sekiguchi Y, Nakamura N, Sawada T, Ota Y, Komatsu N, Noguchi M Tags: Int J Clin Exp Pathol Source Type: research

Primary ductal adenocarcinoma of the lacrimal sac: the first reported case.
This report is the first to demonstrate that mTOR pathway proteins, which are central proteins involved in carcinogenesis, are activated in ductal adenocarcinoma. Therefore, mTOR inhibitor may be a potential candidate for treatment of this highly aggressive carcinoma. PMID: 24040460 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Ishida M, Iwai M, Yoshida K, Kagotani A, Kohzaki H, Arikata M, Shimizu T, Okabe H Tags: Int J Clin Exp Pathol Source Type: research

Composite hemangioendothelioma arising from the kidney: case report with review of the literature.
Abstract Reported herein is a medical curiosities vascular tumor primary arising from the kidney and exhibiting unique histopathological features. A 32-year-old woman underwent a total nephrectomy of right kidney because of a mass localized in the inferior pole. Distinct from other vascular lesions, on histology the tumor had a peculiar composite pattern, consisting of benign and malignant vascular components, which were haphazardly intermixed without any definite margins. The malignant component was composed of epithelioid hemangioendothelioma (45%) and angiosarcoma (50%) with moderate differentiation. Immunohist...
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Zhang J, Wu B, Zhou GQ, Zhang RS, Wei X, Yu B, Lu ZF, Ma HH, Shi QL, Zhou XJ Tags: Int J Clin Exp Pathol Source Type: research

Endobronchial metastasis from hepatocellular carcinoma - a case description with literature review.
Abstract Endobronchial metastases from hepatocellular carcinoma are very rare. Up to date, no more than 7 cases were reported. The authors present a case of 20-year old female with metastatic hepatocellular carcinoma to superior lobar bronchus. Examination of cytological and small biopsy specimens obtained from bronchoscopy revealed characteristic microscopic features and immunohistochemical profile of hepatocellular carcinoma. PMID: 24040462 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Szumera-Ciećkiewicz A, Olszewski WT, Piech K, Głogowski M, Prochorec-Sobieszek M Tags: Int J Clin Exp Pathol Source Type: research

Gangliocytic paraganglioma of the appendix with features suggestive of malignancy, a rare case report and review of the literature.
We report a case of appendicial paraganglioma in a 40 year old female who presented with acute appendicitis and underwent laparoscopic appendectomy. To the best of our knowledge this is the first reported case of appendicial gangliocytic paraganglioma with features suggestive of malignancy in the modern literature. Van Eeden S. et al. reported the first case of appendicial paraganglioma in a 47 year old man who also presented with acute appendicitis. The appendectomy specimen showed a distended appendix with thickened wall, and a 1.3 cm mucosal based yellow lesion. Microscopically this lesion was centered in the submucosa ...
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Abdelbaqi MQ, Tahmasbi M, Ghayouri M Tags: Int J Clin Exp Pathol Source Type: research

Sporadic hemangioblastoma of the kidney with PAX2 and focal CD10 expression: report of a case.
In this study, we presented an additional case of renal hemangioblastoma, which demonstrates PAX2 and focal CD10 expression. Histologically, the tumor consisted of sheets of oval or polygonal cells and a prominent vascular network. The tumor cells varied in size, and possessed pale or eosinophilic cytoplasm that sometimes contained sharply delineated fine vacuoles. The tumor cell nuclei with inconspicuous nucleoli showed moderate nuclear atypia and pleomorphism. Focal areas of stromal hyalinization and sclerosis were detected. On account of its strong or moderate immunoreactivity for the a-inhibin, S100, NSE, and EGFR, the...
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Jiang JG, Rao Q, Xia QY, Tu P, Lu ZF, Shen Q, Zhang RS, Yu B, Zhou XJ, Shi SS, Shi QL Tags: Int J Clin Exp Pathol Source Type: research

Lymphoid papillary hyperplasia of the palatine tonsil: a Chinese case report.
Abstract Lymphoid papillary hyperplasia is a rare abnormality of the tonsils with a predilection for affecting young Asian girls. Herein, we report a 31-year-old Chinese woman presented as right lateral recurrent tonsillar hypertrophy with odynophagia and dysphagia over the past 5 years, worsening over a period of for half a year. Clinically, this lesion was similar to papillomatosis or lymphoid polyposis. However, histopathologic study showed a distinctive form of lymphoid hyperplasia with considerable distinct finger-like projections composed of many phyllodes which contained remarkable follicular lymphoid hyper...
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Zhao M, Yu J, Li C Tags: Int J Clin Exp Pathol Source Type: research

The first reported case of pigmented Bartholin duct cyst.
PMID: 24040466 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 17, 2013 Category: Pathology Authors: Ishida M, Iwai M, Yoshida K, Kagotani A, Okabe H Tags: Int J Clin Exp Pathol Source Type: research

In vitro apoptosis effects of GnRHII on endometrial stromal cells from patients with endometriosis.
Abstract PURPOSE: To study the effect of gonadotropin-releasing hormone II (GnRHII) on the cell apoptosis of ectopic, eutopic and normal endometrial stromal cells cultured in vitro from endometriosis patients, and to provide theoretical basis for exploring new treatments for endometriosis (EMs). METHODS: Ectopic, eutopic and normal endometrial stromal cells were isolated, cultured and identified in vitro, then treated with different concentrations of GnRHII (0, 10(-10) M, 10(-8) M and 10(-6) M). Cell apoptosis was detected by Hoechst staining and flow cytometry. RESULTS: GnRHII increased apoptosis in ect...
Source: International Journal of Clinical and Experimental Pathology - August 14, 2013 Category: Pathology Authors: Huang F, Zou Y, Wang H, Cao J, Yin T Tags: Int J Clin Exp Pathol Source Type: research

Urothelial eddies in papillary urothelial neoplasms: a distinct morphologic pattern with low risk for progression.
Abstract WE ENCOUNTERED AN UNDESCRIBED HISTOLOGIC FEATURE OF PAPILLARY UROTHELIAL NEOPLASMS: "urothelial eddy", which was histologically reminiscent of squamous eddy of irritated follicular keratosis of the skin. A review of 756 patients with transurethral resection of bladder tumor revealed 10 patients (1.3%) of papillary urothelial neoplasms with urothelial eddies. All cases were male with a median age of 65 years. Urothelial eddies were characterized by small ovoid nests of ovoid to spindle cells arranged in an onion-skin pattern with fine cytoplasmic processes within wide intercellular space. The cyt...
Source: International Journal of Clinical and Experimental Pathology - August 9, 2013 Category: Pathology Authors: Kim M, Ro JY, Amin MB, de Peralta-Venturina M, Kwon GY, Park YW, Cho YM Tags: Int J Clin Exp Pathol Source Type: research

Histopathological and functional effects of antimony on the renal cortex of growing albino rat.
In conclusion, this study proposed that continuous oral administration of antimony for 8 and 12 weeks has hazardous toxic effect on the structure and function of the kidney in growing albino rat. Based on the results of the present study, it is recommended to avoid the use of any drinking water contaminated with antimony compounds and forbidden its use in infants and children foods. PMID: 23923065 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 9, 2013 Category: Pathology Authors: Rashedy AH, Solimany AA, Ismail AK, Wahdan MH, Saban KA Tags: Int J Clin Exp Pathol Source Type: research

IL4 and IL-17A provide a Th2/Th17-polarized inflammatory milieu in favor of TGF-β1 to induce bronchial epithelial-mesenchymal transition (EMT).
IL4 and IL-17A provide a Th2/Th17-polarized inflammatory milieu in favor of TGF-β1 to induce bronchial epithelial-mesenchymal transition (EMT). Int J Clin Exp Pathol. 2013;6(8):1481-92 Authors: Ji X, Li J, Xu L, Wang W, Luo M, Luo S, Ma L, Li K, Gong S, He L, Zhang Z, Yang P, Zhou Z, Xiang X, Wang CY Abstract Severe asthma is a chronic airway disease characterized by the Th2/Th17-polarized inflammation along with permanent airway remodeling. Despite past extensive studies, the exact role for Th2 and Th17 cytokines in asthmatic pathoetiology, particularly in the pathogenesis of bronchial epithelial-mes...
Source: International Journal of Clinical and Experimental Pathology - August 9, 2013 Category: Pathology Authors: Ji X, Li J, Xu L, Wang W, Luo M, Luo S, Ma L, Li K, Gong S, He L, Zhang Z, Yang P, Zhou Z, Xiang X, Wang CY Tags: Int J Clin Exp Pathol Source Type: research

RAF1-MEK1-ERK/AKT axis may confer NSCLC cell lines resistance to erlotinib.
Abstract The fact that advanced NSCLC patients with wild type (wt) EGFR can benefit from erlotinib therapy makes it critical to find out biomarkers for effective selection of patients and improving the therapy effects. In present study, 3 NSCLC cell lines (U1752, Calu-6 and NCI-H292) with wt EGFR and different sensitivities to erlotinib were used for microarray analysis. The differential basal gene expression between 2 NSCLC cell lines was analyzed, about 353 genes were expression-altered with higher than 2-fold changes between Calu-6 and U1752. And Ingenuity Pathway Analysis (IPA) showed that these genes were mai...
Source: International Journal of Clinical and Experimental Pathology - August 9, 2013 Category: Pathology Authors: Xu ZH, Hang JB, Hu JA, Gao BL Tags: Int J Clin Exp Pathol Source Type: research

Effect of intra-cisternal application of kainic acid on the spinal cord and locomotor activity in rats.
Abstract Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease of idiopathic etiology. Glutamate excitotoxicity is one of the proposed hypotheses causing progressive death of motor neurons. We aimed to develop an experimental animal model of this disease to enhance the knowledge of pathophysiological mechanism of ALS. Male Wistar rats were infused with Kainic acid (KA) intra-cisternally for 5 days at the dosage of 50 fmol/day and 150 fmol/day. Locomotor activity, sensory function and histological changes in cervical and lumbar sections of spinal cord were evaluated. Glial Fibrillary Acidic Protein (GF...
Source: International Journal of Clinical and Experimental Pathology - August 9, 2013 Category: Pathology Authors: Mitra NK, Goh TE, Bala Krishnan T, Nadarajah VD, Vasavaraj AK, Soga T Tags: Int J Clin Exp Pathol Source Type: research

Inhibition of GAP-43 by propentofylline in a rat model of neuropathic pain.
Abstract Neural plasticity within the spinal nociceptive network may be fundamental to the chronic nature of neuropathic pain. The relation of growth-associated protein-43 (GAP-43), a protein involved in the nerve fiber growth and sprouting, to pain hypersensitivity has been investigated. Glial activation and inflammatory cytokines released by microglia and astrocytes are considered to be involved in the neural sprouting and plasticity. In the present study, the anti-nociception effect of propentofylline, a glial modulating agent, was investigated in a rat chronic constriction injury (CCI) model aiming to explore ...
Source: International Journal of Clinical and Experimental Pathology - August 9, 2013 Category: Pathology Authors: Wu F, Miao X, Chen J, Liu Z, Tao Y, Yu W, Sun Y Tags: Int J Clin Exp Pathol Source Type: research