Higher ambient temperature is associated with worsening of HbA1c levels in a Saudi population
Int J Clin Exp Pathol. 2021 Aug 15;14(8):881-891. eCollection 2021.ABSTRACTBACKGROUND: Ambient temperature is predicted to rise in Saudi Arabia, and how this will impact the health of its population has not been investigated. Saudi Arabia is one of the top ten countries with the highest prevalence of diabetes. The current study investigates the correlation between ambient temperature and HbA1c levels in a group of Saudis in Riyadh.METHODS: Age, gender, and HbA1c data for six years were obtained from patients' records. The maximum daily temperature of Riyadh city for the same period was obtained.RESULTS: A total of 168,614 ...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Abdullah S Alghamdi Abdulaziz Alqadi Fayez Alghamdi Richard O Jenkins Parvez I Haris Source Type: research

Molecular alterations differentiate microinvasive carcinoma from ductal carcinoma in situ and invasive breast carcinoma: retrospective analysis of a large single-center series
Int J Clin Exp Pathol. 2021 Aug 15;14(8):892-901. eCollection 2021.ABSTRACTMicroinvasive carcinoma (MIC) of the breast is a rare lesion. The clinicopathologic features and biologic behavior of MIC are unclear. Whether MIC is a distinct entity or an interim stage in the progression from ductal carcinoma in situ (DCIS) to invasive breast carcinoma (IBC) remains to be determined. A retrospective review of clinicopathologic features and analysis of the expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2), and Ki-67 in patients with MIC (90 cases), DCIS (268 cases) a...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Yan Zhang Ying Wu Lei-Jun Huo Shan-Shan Yan Dong-Dong Wang Hong-Yi Gao Source Type: research

A new approach using a numerical diagnostic criterion for vitiligo diagnosis with HMB-45 and Melan-A staining
This study aims to investigate the usefulness of the Melan-A and homatropine methyl bromide-45 (HMB-45) markers in identifying melanocytes and to evaluate cut-off values for the diagnosis of vitiligo. We also aim to identify the role of remaining melanocytes when using HMB-45. We counted and confirmed melanocytes and melanin in the samples using a high-magnification microscope. The Melan-A, HMB-45, and Fontana-Masson staining methods were utilized. Descriptive statistical analysis of quantitative traits was performed. For the comparison of the two diagnostic tools, receiver operating characteristic curve and the area under...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Nuri Na Joonsoo Park Source Type: research

Effects of acrylonitrile on apoptosis of rat cerebral nerve cells
In this study, we established a rat model of acrylonitrile poisoning with administration by gavage, aiming to determine the influence of acrylonitrile on rat cerebral nerve cells. Transmission electron microscopy observation and TdT-mediated dUTP nick-end labelling (TUNEL) staining were used to explore preliminarily the apoptotic changes of cerebral nerve cells. The pathogenesis revealed by transmission electron microscopy indicated that apoptosis in the control group was more serious than that of the exposure groups. The results of TUNEL staining showed the apoptotic rate was significantly higher in the control group than...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Xiaoxu Gu Chunhua Xu Xiuju Li Tingting Yu Wei Fan Jimin Shi Bing Li Wencai Guan Xiaohui Zhou Yuanling Zhou Source Type: research

Erratum: Role of ursolic acid chalcone, a synthetic analogue of ursolic acid, in inhibiting the properties of CD133(+) sphere-forming cells in liver stem cells
Int J Clin Exp Pathol. 2021 Aug 15;14(8):915-917. eCollection 2021.ABSTRACT[This corrects the article on p. 1427 in vol. 8, PMID: 25973027.].PMID:34527135 | PMC:PMC8414432 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Rui-Xin Lin Lu-Lu Gong Li-Mei Fan Zhong-Kai Zhao Shu-Li Yang Source Type: research

Erratum: Glycyrrhizic acid inhibits leukemia cell growth and migration via blocking AKT/mTOR/STAT3 signaling
Int J Clin Exp Pathol. 2021 Aug 15;14(8):918-919. eCollection 2021.ABSTRACT[This corrects the article on p. 5175 in vol. 8, PMID: 26191214.].PMID:34527136 | PMC:PMC8414430 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Si-Qi He Meng Gao Yun-Feng Fu Ya-Nan Zhang Source Type: research

Circular RNA La-related protein 4 inhibits cell proliferation, migration, and invasion and sponges microRNA-367 in non-small cell lung cancer
In conclusion, circRNA LARP4 is downregulated, suppresses cell proliferation, migration, and invasion, and acts as a sponge of oncogene miR-367 in NSCLC.PMID:34527128 | PMC:PMC8414429 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Ying Wang Jing Zhu Xuepeng Li Jinhua Xu Ying Xin Ying Liu Source Type: research

Knockdown of E2F4 suppresses the growth of ovarian cancer cells through the cell cycle pathway
In this study, we investigated the underlying molecular mechanism of E2F4 in human ovarian cancer cells (OCC). E2F4 expression was demonstrated by quantitative real time polymerase chain reaction (qRT-PCR) in OCC. The alterations of expression values were determined using 2(-ΔΔCt) method. The effects of suppressing E2F4 on cell proliferation, migration, and differentiation were evaluated by cell proliferation assay, colony formation assay and wound healing assay in vitro. Overexpression of E2F4 was found at both mRNA and protein levels in OCC. Small interfering RNA was used to suppress E2F4 expression. Depletio...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Jaein Kim Ga Won Yim Dae Woo Lee Young Tae Kim Young Joo Lee Yeo Jin Rhee Source Type: research

Small cell carcinoma of the brain without apparent extracranial origin in the same intracranial region one year following resection of malignant glioma
Int J Clin Exp Pathol. 2021 Aug 15;14(8):875-880. eCollection 2021.ABSTRACTPrimary small cell carcinoma (SCC) of the brain is rare, and there have been no reports of small cell carcinoma located at the resection site of a glioma without extracranial tumours. Herein, we report a case of brain SCC in the same intracranial region from which a malignant glioma had been surgically resected a year prior. The patient, a 68-year-old male, had headaches as a symptom, and brain CT and MRI revealed a hyperdense region measuring 5.5×5 centimetres. Blood test results showed no significant changes. H&E staining suggested that ...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Jiaying Yang Lei Wang Yongjun Yao Jie Liu Jinju Yang Source Type: research

Higher ambient temperature is associated with worsening of HbA1c levels in a Saudi population
Int J Clin Exp Pathol. 2021 Aug 15;14(8):881-891. eCollection 2021.ABSTRACTBACKGROUND: Ambient temperature is predicted to rise in Saudi Arabia, and how this will impact the health of its population has not been investigated. Saudi Arabia is one of the top ten countries with the highest prevalence of diabetes. The current study investigates the correlation between ambient temperature and HbA1c levels in a group of Saudis in Riyadh.METHODS: Age, gender, and HbA1c data for six years were obtained from patients' records. The maximum daily temperature of Riyadh city for the same period was obtained.RESULTS: A total of 168,614 ...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Abdullah S Alghamdi Abdulaziz Alqadi Fayez Alghamdi Richard O Jenkins Parvez I Haris Source Type: research

Molecular alterations differentiate microinvasive carcinoma from ductal carcinoma in situ and invasive breast carcinoma: retrospective analysis of a large single-center series
Int J Clin Exp Pathol. 2021 Aug 15;14(8):892-901. eCollection 2021.ABSTRACTMicroinvasive carcinoma (MIC) of the breast is a rare lesion. The clinicopathologic features and biologic behavior of MIC are unclear. Whether MIC is a distinct entity or an interim stage in the progression from ductal carcinoma in situ (DCIS) to invasive breast carcinoma (IBC) remains to be determined. A retrospective review of clinicopathologic features and analysis of the expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2), and Ki-67 in patients with MIC (90 cases), DCIS (268 cases) a...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Yan Zhang Ying Wu Lei-Jun Huo Shan-Shan Yan Dong-Dong Wang Hong-Yi Gao Source Type: research

A new approach using a numerical diagnostic criterion for vitiligo diagnosis with HMB-45 and Melan-A staining
This study aims to investigate the usefulness of the Melan-A and homatropine methyl bromide-45 (HMB-45) markers in identifying melanocytes and to evaluate cut-off values for the diagnosis of vitiligo. We also aim to identify the role of remaining melanocytes when using HMB-45. We counted and confirmed melanocytes and melanin in the samples using a high-magnification microscope. The Melan-A, HMB-45, and Fontana-Masson staining methods were utilized. Descriptive statistical analysis of quantitative traits was performed. For the comparison of the two diagnostic tools, receiver operating characteristic curve and the area under...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Nuri Na Joonsoo Park Source Type: research

Effects of acrylonitrile on apoptosis of rat cerebral nerve cells
In this study, we established a rat model of acrylonitrile poisoning with administration by gavage, aiming to determine the influence of acrylonitrile on rat cerebral nerve cells. Transmission electron microscopy observation and TdT-mediated dUTP nick-end labelling (TUNEL) staining were used to explore preliminarily the apoptotic changes of cerebral nerve cells. The pathogenesis revealed by transmission electron microscopy indicated that apoptosis in the control group was more serious than that of the exposure groups. The results of TUNEL staining showed the apoptotic rate was significantly higher in the control group than...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Xiaoxu Gu Chunhua Xu Xiuju Li Tingting Yu Wei Fan Jimin Shi Bing Li Wencai Guan Xiaohui Zhou Yuanling Zhou Source Type: research

Erratum: Role of ursolic acid chalcone, a synthetic analogue of ursolic acid, in inhibiting the properties of CD133(+) sphere-forming cells in liver stem cells
Int J Clin Exp Pathol. 2021 Aug 15;14(8):915-917. eCollection 2021.ABSTRACT[This corrects the article on p. 1427 in vol. 8, PMID: 25973027.].PMID:34527135 | PMC:PMC8414432 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Rui-Xin Lin Lu-Lu Gong Li-Mei Fan Zhong-Kai Zhao Shu-Li Yang Source Type: research

Erratum: Glycyrrhizic acid inhibits leukemia cell growth and migration via blocking AKT/mTOR/STAT3 signaling
Int J Clin Exp Pathol. 2021 Aug 15;14(8):918-919. eCollection 2021.ABSTRACT[This corrects the article on p. 5175 in vol. 8, PMID: 26191214.].PMID:34527136 | PMC:PMC8414430 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Si-Qi He Meng Gao Yun-Feng Fu Ya-Nan Zhang Source Type: research

Circular RNA La-related protein 4 inhibits cell proliferation, migration, and invasion and sponges microRNA-367 in non-small cell lung cancer
In conclusion, circRNA LARP4 is downregulated, suppresses cell proliferation, migration, and invasion, and acts as a sponge of oncogene miR-367 in NSCLC.PMID:34527128 | PMC:PMC8414429 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Ying Wang Jing Zhu Xuepeng Li Jinhua Xu Ying Xin Ying Liu Source Type: research

Knockdown of E2F4 suppresses the growth of ovarian cancer cells through the cell cycle pathway
In this study, we investigated the underlying molecular mechanism of E2F4 in human ovarian cancer cells (OCC). E2F4 expression was demonstrated by quantitative real time polymerase chain reaction (qRT-PCR) in OCC. The alterations of expression values were determined using 2(-ΔΔCt) method. The effects of suppressing E2F4 on cell proliferation, migration, and differentiation were evaluated by cell proliferation assay, colony formation assay and wound healing assay in vitro. Overexpression of E2F4 was found at both mRNA and protein levels in OCC. Small interfering RNA was used to suppress E2F4 expression. Depletio...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Jaein Kim Ga Won Yim Dae Woo Lee Young Tae Kim Young Joo Lee Yeo Jin Rhee Source Type: research

Small cell carcinoma of the brain without apparent extracranial origin in the same intracranial region one year following resection of malignant glioma
Int J Clin Exp Pathol. 2021 Aug 15;14(8):875-880. eCollection 2021.ABSTRACTPrimary small cell carcinoma (SCC) of the brain is rare, and there have been no reports of small cell carcinoma located at the resection site of a glioma without extracranial tumours. Herein, we report a case of brain SCC in the same intracranial region from which a malignant glioma had been surgically resected a year prior. The patient, a 68-year-old male, had headaches as a symptom, and brain CT and MRI revealed a hyperdense region measuring 5.5×5 centimetres. Blood test results showed no significant changes. H&E staining suggested that ...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Jiaying Yang Lei Wang Yongjun Yao Jie Liu Jinju Yang Source Type: research

Higher ambient temperature is associated with worsening of HbA1c levels in a Saudi population
Int J Clin Exp Pathol. 2021 Aug 15;14(8):881-891. eCollection 2021.ABSTRACTBACKGROUND: Ambient temperature is predicted to rise in Saudi Arabia, and how this will impact the health of its population has not been investigated. Saudi Arabia is one of the top ten countries with the highest prevalence of diabetes. The current study investigates the correlation between ambient temperature and HbA1c levels in a group of Saudis in Riyadh.METHODS: Age, gender, and HbA1c data for six years were obtained from patients' records. The maximum daily temperature of Riyadh city for the same period was obtained.RESULTS: A total of 168,614 ...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Abdullah S Alghamdi Abdulaziz Alqadi Fayez Alghamdi Richard O Jenkins Parvez I Haris Source Type: research

Molecular alterations differentiate microinvasive carcinoma from ductal carcinoma in situ and invasive breast carcinoma: retrospective analysis of a large single-center series
Int J Clin Exp Pathol. 2021 Aug 15;14(8):892-901. eCollection 2021.ABSTRACTMicroinvasive carcinoma (MIC) of the breast is a rare lesion. The clinicopathologic features and biologic behavior of MIC are unclear. Whether MIC is a distinct entity or an interim stage in the progression from ductal carcinoma in situ (DCIS) to invasive breast carcinoma (IBC) remains to be determined. A retrospective review of clinicopathologic features and analysis of the expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2), and Ki-67 in patients with MIC (90 cases), DCIS (268 cases) a...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Yan Zhang Ying Wu Lei-Jun Huo Shan-Shan Yan Dong-Dong Wang Hong-Yi Gao Source Type: research

A new approach using a numerical diagnostic criterion for vitiligo diagnosis with HMB-45 and Melan-A staining
This study aims to investigate the usefulness of the Melan-A and homatropine methyl bromide-45 (HMB-45) markers in identifying melanocytes and to evaluate cut-off values for the diagnosis of vitiligo. We also aim to identify the role of remaining melanocytes when using HMB-45. We counted and confirmed melanocytes and melanin in the samples using a high-magnification microscope. The Melan-A, HMB-45, and Fontana-Masson staining methods were utilized. Descriptive statistical analysis of quantitative traits was performed. For the comparison of the two diagnostic tools, receiver operating characteristic curve and the area under...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Nuri Na Joonsoo Park Source Type: research

Effects of acrylonitrile on apoptosis of rat cerebral nerve cells
In this study, we established a rat model of acrylonitrile poisoning with administration by gavage, aiming to determine the influence of acrylonitrile on rat cerebral nerve cells. Transmission electron microscopy observation and TdT-mediated dUTP nick-end labelling (TUNEL) staining were used to explore preliminarily the apoptotic changes of cerebral nerve cells. The pathogenesis revealed by transmission electron microscopy indicated that apoptosis in the control group was more serious than that of the exposure groups. The results of TUNEL staining showed the apoptotic rate was significantly higher in the control group than...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Xiaoxu Gu Chunhua Xu Xiuju Li Tingting Yu Wei Fan Jimin Shi Bing Li Wencai Guan Xiaohui Zhou Yuanling Zhou Source Type: research

Erratum: Role of ursolic acid chalcone, a synthetic analogue of ursolic acid, in inhibiting the properties of CD133(+) sphere-forming cells in liver stem cells
Int J Clin Exp Pathol. 2021 Aug 15;14(8):915-917. eCollection 2021.ABSTRACT[This corrects the article on p. 1427 in vol. 8, PMID: 25973027.].PMID:34527135 | PMC:PMC8414432 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Rui-Xin Lin Lu-Lu Gong Li-Mei Fan Zhong-Kai Zhao Shu-Li Yang Source Type: research

Erratum: Glycyrrhizic acid inhibits leukemia cell growth and migration via blocking AKT/mTOR/STAT3 signaling
Int J Clin Exp Pathol. 2021 Aug 15;14(8):918-919. eCollection 2021.ABSTRACT[This corrects the article on p. 5175 in vol. 8, PMID: 26191214.].PMID:34527136 | PMC:PMC8414430 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Si-Qi He Meng Gao Yun-Feng Fu Ya-Nan Zhang Source Type: research

Circular RNA La-related protein 4 inhibits cell proliferation, migration, and invasion and sponges microRNA-367 in non-small cell lung cancer
In conclusion, circRNA LARP4 is downregulated, suppresses cell proliferation, migration, and invasion, and acts as a sponge of oncogene miR-367 in NSCLC.PMID:34527128 | PMC:PMC8414429 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Ying Wang Jing Zhu Xuepeng Li Jinhua Xu Ying Xin Ying Liu Source Type: research

Knockdown of E2F4 suppresses the growth of ovarian cancer cells through the cell cycle pathway
In this study, we investigated the underlying molecular mechanism of E2F4 in human ovarian cancer cells (OCC). E2F4 expression was demonstrated by quantitative real time polymerase chain reaction (qRT-PCR) in OCC. The alterations of expression values were determined using 2(-ΔΔCt) method. The effects of suppressing E2F4 on cell proliferation, migration, and differentiation were evaluated by cell proliferation assay, colony formation assay and wound healing assay in vitro. Overexpression of E2F4 was found at both mRNA and protein levels in OCC. Small interfering RNA was used to suppress E2F4 expression. Depletio...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Jaein Kim Ga Won Yim Dae Woo Lee Young Tae Kim Young Joo Lee Yeo Jin Rhee Source Type: research

Small cell carcinoma of the brain without apparent extracranial origin in the same intracranial region one year following resection of malignant glioma
Int J Clin Exp Pathol. 2021 Aug 15;14(8):875-880. eCollection 2021.ABSTRACTPrimary small cell carcinoma (SCC) of the brain is rare, and there have been no reports of small cell carcinoma located at the resection site of a glioma without extracranial tumours. Herein, we report a case of brain SCC in the same intracranial region from which a malignant glioma had been surgically resected a year prior. The patient, a 68-year-old male, had headaches as a symptom, and brain CT and MRI revealed a hyperdense region measuring 5.5×5 centimetres. Blood test results showed no significant changes. H&E staining suggested that ...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Jiaying Yang Lei Wang Yongjun Yao Jie Liu Jinju Yang Source Type: research

Higher ambient temperature is associated with worsening of HbA1c levels in a Saudi population
Int J Clin Exp Pathol. 2021 Aug 15;14(8):881-891. eCollection 2021.ABSTRACTBACKGROUND: Ambient temperature is predicted to rise in Saudi Arabia, and how this will impact the health of its population has not been investigated. Saudi Arabia is one of the top ten countries with the highest prevalence of diabetes. The current study investigates the correlation between ambient temperature and HbA1c levels in a group of Saudis in Riyadh.METHODS: Age, gender, and HbA1c data for six years were obtained from patients' records. The maximum daily temperature of Riyadh city for the same period was obtained.RESULTS: A total of 168,614 ...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Abdullah S Alghamdi Abdulaziz Alqadi Fayez Alghamdi Richard O Jenkins Parvez I Haris Source Type: research

Molecular alterations differentiate microinvasive carcinoma from ductal carcinoma in situ and invasive breast carcinoma: retrospective analysis of a large single-center series
Int J Clin Exp Pathol. 2021 Aug 15;14(8):892-901. eCollection 2021.ABSTRACTMicroinvasive carcinoma (MIC) of the breast is a rare lesion. The clinicopathologic features and biologic behavior of MIC are unclear. Whether MIC is a distinct entity or an interim stage in the progression from ductal carcinoma in situ (DCIS) to invasive breast carcinoma (IBC) remains to be determined. A retrospective review of clinicopathologic features and analysis of the expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2), and Ki-67 in patients with MIC (90 cases), DCIS (268 cases) a...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Yan Zhang Ying Wu Lei-Jun Huo Shan-Shan Yan Dong-Dong Wang Hong-Yi Gao Source Type: research

A new approach using a numerical diagnostic criterion for vitiligo diagnosis with HMB-45 and Melan-A staining
This study aims to investigate the usefulness of the Melan-A and homatropine methyl bromide-45 (HMB-45) markers in identifying melanocytes and to evaluate cut-off values for the diagnosis of vitiligo. We also aim to identify the role of remaining melanocytes when using HMB-45. We counted and confirmed melanocytes and melanin in the samples using a high-magnification microscope. The Melan-A, HMB-45, and Fontana-Masson staining methods were utilized. Descriptive statistical analysis of quantitative traits was performed. For the comparison of the two diagnostic tools, receiver operating characteristic curve and the area under...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Nuri Na Joonsoo Park Source Type: research

Effects of acrylonitrile on apoptosis of rat cerebral nerve cells
In this study, we established a rat model of acrylonitrile poisoning with administration by gavage, aiming to determine the influence of acrylonitrile on rat cerebral nerve cells. Transmission electron microscopy observation and TdT-mediated dUTP nick-end labelling (TUNEL) staining were used to explore preliminarily the apoptotic changes of cerebral nerve cells. The pathogenesis revealed by transmission electron microscopy indicated that apoptosis in the control group was more serious than that of the exposure groups. The results of TUNEL staining showed the apoptotic rate was significantly higher in the control group than...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Xiaoxu Gu Chunhua Xu Xiuju Li Tingting Yu Wei Fan Jimin Shi Bing Li Wencai Guan Xiaohui Zhou Yuanling Zhou Source Type: research

Erratum: Role of ursolic acid chalcone, a synthetic analogue of ursolic acid, in inhibiting the properties of CD133(+) sphere-forming cells in liver stem cells
Int J Clin Exp Pathol. 2021 Aug 15;14(8):915-917. eCollection 2021.ABSTRACT[This corrects the article on p. 1427 in vol. 8, PMID: 25973027.].PMID:34527135 | PMC:PMC8414432 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Rui-Xin Lin Lu-Lu Gong Li-Mei Fan Zhong-Kai Zhao Shu-Li Yang Source Type: research

Erratum: Glycyrrhizic acid inhibits leukemia cell growth and migration via blocking AKT/mTOR/STAT3 signaling
Int J Clin Exp Pathol. 2021 Aug 15;14(8):918-919. eCollection 2021.ABSTRACT[This corrects the article on p. 5175 in vol. 8, PMID: 26191214.].PMID:34527136 | PMC:PMC8414430 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Si-Qi He Meng Gao Yun-Feng Fu Ya-Nan Zhang Source Type: research

Circular RNA La-related protein 4 inhibits cell proliferation, migration, and invasion and sponges microRNA-367 in non-small cell lung cancer
In conclusion, circRNA LARP4 is downregulated, suppresses cell proliferation, migration, and invasion, and acts as a sponge of oncogene miR-367 in NSCLC.PMID:34527128 | PMC:PMC8414429 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Ying Wang Jing Zhu Xuepeng Li Jinhua Xu Ying Xin Ying Liu Source Type: research

Knockdown of E2F4 suppresses the growth of ovarian cancer cells through the cell cycle pathway
In this study, we investigated the underlying molecular mechanism of E2F4 in human ovarian cancer cells (OCC). E2F4 expression was demonstrated by quantitative real time polymerase chain reaction (qRT-PCR) in OCC. The alterations of expression values were determined using 2(-ΔΔCt) method. The effects of suppressing E2F4 on cell proliferation, migration, and differentiation were evaluated by cell proliferation assay, colony formation assay and wound healing assay in vitro. Overexpression of E2F4 was found at both mRNA and protein levels in OCC. Small interfering RNA was used to suppress E2F4 expression. Depletio...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Jaein Kim Ga Won Yim Dae Woo Lee Young Tae Kim Young Joo Lee Yeo Jin Rhee Source Type: research

Small cell carcinoma of the brain without apparent extracranial origin in the same intracranial region one year following resection of malignant glioma
Int J Clin Exp Pathol. 2021 Aug 15;14(8):875-880. eCollection 2021.ABSTRACTPrimary small cell carcinoma (SCC) of the brain is rare, and there have been no reports of small cell carcinoma located at the resection site of a glioma without extracranial tumours. Herein, we report a case of brain SCC in the same intracranial region from which a malignant glioma had been surgically resected a year prior. The patient, a 68-year-old male, had headaches as a symptom, and brain CT and MRI revealed a hyperdense region measuring 5.5×5 centimetres. Blood test results showed no significant changes. H&E staining suggested that ...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Jiaying Yang Lei Wang Yongjun Yao Jie Liu Jinju Yang Source Type: research

Higher ambient temperature is associated with worsening of HbA1c levels in a Saudi population
Int J Clin Exp Pathol. 2021 Aug 15;14(8):881-891. eCollection 2021.ABSTRACTBACKGROUND: Ambient temperature is predicted to rise in Saudi Arabia, and how this will impact the health of its population has not been investigated. Saudi Arabia is one of the top ten countries with the highest prevalence of diabetes. The current study investigates the correlation between ambient temperature and HbA1c levels in a group of Saudis in Riyadh.METHODS: Age, gender, and HbA1c data for six years were obtained from patients' records. The maximum daily temperature of Riyadh city for the same period was obtained.RESULTS: A total of 168,614 ...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Abdullah S Alghamdi Abdulaziz Alqadi Fayez Alghamdi Richard O Jenkins Parvez I Haris Source Type: research

Molecular alterations differentiate microinvasive carcinoma from ductal carcinoma in situ and invasive breast carcinoma: retrospective analysis of a large single-center series
Int J Clin Exp Pathol. 2021 Aug 15;14(8):892-901. eCollection 2021.ABSTRACTMicroinvasive carcinoma (MIC) of the breast is a rare lesion. The clinicopathologic features and biologic behavior of MIC are unclear. Whether MIC is a distinct entity or an interim stage in the progression from ductal carcinoma in situ (DCIS) to invasive breast carcinoma (IBC) remains to be determined. A retrospective review of clinicopathologic features and analysis of the expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2), and Ki-67 in patients with MIC (90 cases), DCIS (268 cases) a...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Yan Zhang Ying Wu Lei-Jun Huo Shan-Shan Yan Dong-Dong Wang Hong-Yi Gao Source Type: research

A new approach using a numerical diagnostic criterion for vitiligo diagnosis with HMB-45 and Melan-A staining
This study aims to investigate the usefulness of the Melan-A and homatropine methyl bromide-45 (HMB-45) markers in identifying melanocytes and to evaluate cut-off values for the diagnosis of vitiligo. We also aim to identify the role of remaining melanocytes when using HMB-45. We counted and confirmed melanocytes and melanin in the samples using a high-magnification microscope. The Melan-A, HMB-45, and Fontana-Masson staining methods were utilized. Descriptive statistical analysis of quantitative traits was performed. For the comparison of the two diagnostic tools, receiver operating characteristic curve and the area under...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Nuri Na Joonsoo Park Source Type: research

Effects of acrylonitrile on apoptosis of rat cerebral nerve cells
In this study, we established a rat model of acrylonitrile poisoning with administration by gavage, aiming to determine the influence of acrylonitrile on rat cerebral nerve cells. Transmission electron microscopy observation and TdT-mediated dUTP nick-end labelling (TUNEL) staining were used to explore preliminarily the apoptotic changes of cerebral nerve cells. The pathogenesis revealed by transmission electron microscopy indicated that apoptosis in the control group was more serious than that of the exposure groups. The results of TUNEL staining showed the apoptotic rate was significantly higher in the control group than...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Xiaoxu Gu Chunhua Xu Xiuju Li Tingting Yu Wei Fan Jimin Shi Bing Li Wencai Guan Xiaohui Zhou Yuanling Zhou Source Type: research

Erratum: Role of ursolic acid chalcone, a synthetic analogue of ursolic acid, in inhibiting the properties of CD133(+) sphere-forming cells in liver stem cells
Int J Clin Exp Pathol. 2021 Aug 15;14(8):915-917. eCollection 2021.ABSTRACT[This corrects the article on p. 1427 in vol. 8, PMID: 25973027.].PMID:34527135 | PMC:PMC8414432 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Rui-Xin Lin Lu-Lu Gong Li-Mei Fan Zhong-Kai Zhao Shu-Li Yang Source Type: research

Erratum: Glycyrrhizic acid inhibits leukemia cell growth and migration via blocking AKT/mTOR/STAT3 signaling
Int J Clin Exp Pathol. 2021 Aug 15;14(8):918-919. eCollection 2021.ABSTRACT[This corrects the article on p. 5175 in vol. 8, PMID: 26191214.].PMID:34527136 | PMC:PMC8414430 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Si-Qi He Meng Gao Yun-Feng Fu Ya-Nan Zhang Source Type: research

Circular RNA La-related protein 4 inhibits cell proliferation, migration, and invasion and sponges microRNA-367 in non-small cell lung cancer
In conclusion, circRNA LARP4 is downregulated, suppresses cell proliferation, migration, and invasion, and acts as a sponge of oncogene miR-367 in NSCLC.PMID:34527128 | PMC:PMC8414429 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Ying Wang Jing Zhu Xuepeng Li Jinhua Xu Ying Xin Ying Liu Source Type: research

Knockdown of E2F4 suppresses the growth of ovarian cancer cells through the cell cycle pathway
In this study, we investigated the underlying molecular mechanism of E2F4 in human ovarian cancer cells (OCC). E2F4 expression was demonstrated by quantitative real time polymerase chain reaction (qRT-PCR) in OCC. The alterations of expression values were determined using 2(-ΔΔCt) method. The effects of suppressing E2F4 on cell proliferation, migration, and differentiation were evaluated by cell proliferation assay, colony formation assay and wound healing assay in vitro. Overexpression of E2F4 was found at both mRNA and protein levels in OCC. Small interfering RNA was used to suppress E2F4 expression. Depletio...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Jaein Kim Ga Won Yim Dae Woo Lee Young Tae Kim Young Joo Lee Yeo Jin Rhee Source Type: research

Small cell carcinoma of the brain without apparent extracranial origin in the same intracranial region one year following resection of malignant glioma
Int J Clin Exp Pathol. 2021 Aug 15;14(8):875-880. eCollection 2021.ABSTRACTPrimary small cell carcinoma (SCC) of the brain is rare, and there have been no reports of small cell carcinoma located at the resection site of a glioma without extracranial tumours. Herein, we report a case of brain SCC in the same intracranial region from which a malignant glioma had been surgically resected a year prior. The patient, a 68-year-old male, had headaches as a symptom, and brain CT and MRI revealed a hyperdense region measuring 5.5×5 centimetres. Blood test results showed no significant changes. H&E staining suggested that ...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Jiaying Yang Lei Wang Yongjun Yao Jie Liu Jinju Yang Source Type: research

Higher ambient temperature is associated with worsening of HbA1c levels in a Saudi population
Int J Clin Exp Pathol. 2021 Aug 15;14(8):881-891. eCollection 2021.ABSTRACTBACKGROUND: Ambient temperature is predicted to rise in Saudi Arabia, and how this will impact the health of its population has not been investigated. Saudi Arabia is one of the top ten countries with the highest prevalence of diabetes. The current study investigates the correlation between ambient temperature and HbA1c levels in a group of Saudis in Riyadh.METHODS: Age, gender, and HbA1c data for six years were obtained from patients' records. The maximum daily temperature of Riyadh city for the same period was obtained.RESULTS: A total of 168,614 ...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Abdullah S Alghamdi Abdulaziz Alqadi Fayez Alghamdi Richard O Jenkins Parvez I Haris Source Type: research

Molecular alterations differentiate microinvasive carcinoma from ductal carcinoma in situ and invasive breast carcinoma: retrospective analysis of a large single-center series
Int J Clin Exp Pathol. 2021 Aug 15;14(8):892-901. eCollection 2021.ABSTRACTMicroinvasive carcinoma (MIC) of the breast is a rare lesion. The clinicopathologic features and biologic behavior of MIC are unclear. Whether MIC is a distinct entity or an interim stage in the progression from ductal carcinoma in situ (DCIS) to invasive breast carcinoma (IBC) remains to be determined. A retrospective review of clinicopathologic features and analysis of the expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2), and Ki-67 in patients with MIC (90 cases), DCIS (268 cases) a...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Yan Zhang Ying Wu Lei-Jun Huo Shan-Shan Yan Dong-Dong Wang Hong-Yi Gao Source Type: research

A new approach using a numerical diagnostic criterion for vitiligo diagnosis with HMB-45 and Melan-A staining
This study aims to investigate the usefulness of the Melan-A and homatropine methyl bromide-45 (HMB-45) markers in identifying melanocytes and to evaluate cut-off values for the diagnosis of vitiligo. We also aim to identify the role of remaining melanocytes when using HMB-45. We counted and confirmed melanocytes and melanin in the samples using a high-magnification microscope. The Melan-A, HMB-45, and Fontana-Masson staining methods were utilized. Descriptive statistical analysis of quantitative traits was performed. For the comparison of the two diagnostic tools, receiver operating characteristic curve and the area under...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Nuri Na Joonsoo Park Source Type: research

Effects of acrylonitrile on apoptosis of rat cerebral nerve cells
In this study, we established a rat model of acrylonitrile poisoning with administration by gavage, aiming to determine the influence of acrylonitrile on rat cerebral nerve cells. Transmission electron microscopy observation and TdT-mediated dUTP nick-end labelling (TUNEL) staining were used to explore preliminarily the apoptotic changes of cerebral nerve cells. The pathogenesis revealed by transmission electron microscopy indicated that apoptosis in the control group was more serious than that of the exposure groups. The results of TUNEL staining showed the apoptotic rate was significantly higher in the control group than...
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Xiaoxu Gu Chunhua Xu Xiuju Li Tingting Yu Wei Fan Jimin Shi Bing Li Wencai Guan Xiaohui Zhou Yuanling Zhou Source Type: research

Erratum: Role of ursolic acid chalcone, a synthetic analogue of ursolic acid, in inhibiting the properties of CD133(+) sphere-forming cells in liver stem cells
Int J Clin Exp Pathol. 2021 Aug 15;14(8):915-917. eCollection 2021.ABSTRACT[This corrects the article on p. 1427 in vol. 8, PMID: 25973027.].PMID:34527135 | PMC:PMC8414432 (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - September 16, 2021 Category: Pathology Authors: Rui-Xin Lin Lu-Lu Gong Li-Mei Fan Zhong-Kai Zhao Shu-Li Yang Source Type: research