Epstein-Barr virus-positive plasmacytoma in immunocompetent patients: a diagnostic dilemma.
We reported the clinicopathologic and immunophenotypic findings of four patients with EBV-positive plasmacytomas (three cases of extramedullary plasmacytomas, one case of solitary plasmacytoma of bone) with immunocompetent status. These tumors were characterized by a diffuse proliferation of mature appearing plasma cells, which were diffusely positive for EBV encoded RNA (EBER) by in situ hybridization. All the four patients were alive with no evidence of disease at last follow-up. PMID: 32269699 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - April 10, 2020 Category: Pathology Authors: He L, Li Z, Fan X, Shi Q, Wu H, Chen J Tags: Int J Clin Exp Pathol Source Type: research

MiR-22 suppresses the growth and metastasis of bladder cancer cells by targeting E2F3.
In conclusion, miR-22 suppressed cell proliferation, migration, invasion, and EMT in bladder cancer cells by regulating E2F3 expression, providing a novel avenue for treatment of bladder cancer. PMID: 32269700 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - April 10, 2020 Category: Pathology Authors: Guo J, Zhang J, Yang T, Zhang W, Liu M Tags: Int J Clin Exp Pathol Source Type: research

Prognostic value of the number of lymph nodes resected in patients with lymph-node-negative esophageal squamous cell carcinoma.
This study aimed to determine the optimal extent of LN dissection for node-negative ESCC patients. We retrospectively reviewed 481 ESCC patients with node-negative resection and no preoperative therapy. Overall survival (OS) was evaluated by the log-rank test and multivariate Cox regression. The 5-year OS was 51.7% and 64.7% for patients with 1-5 and ≥6 negative LNs resected, respectively (P
Source: International Journal of Clinical and Experimental Pathology - April 10, 2020 Category: Pathology Authors: Xu G, Jin M, Shao Y, Chen Y, Ning Z Tags: Int J Clin Exp Pathol Source Type: research

Kin17 knockdown suppresses the migration and invasion of cervical cancer cells through NF- κB-Snail pathway.
This study aimed to explore roles and mechanisms of kin17 in the migration and invasion of cervical cancer cells. Cervical cancer cell lines HeLa and SiHa with kin17 knockdown were constructed by using recombinant lentiviral vector that carry specific siRNA targeting KIN17 gene. The mRNA and protein levels of kin17 in cells were determined by RT-qPCR and western blotting, respectively. Wound healing assay and transwell assays were performed to assess the migration and invasion abilities of the cancer cells, respectively. The expression of signaling proteins involved in the NF-κB-Snail pathway was analyzed by western ...
Source: International Journal of Clinical and Experimental Pathology - April 10, 2020 Category: Pathology Authors: Zhong M, Liu Z, Wu K, Hong Z, Zhang Y, Qu J, Zhu C, Ou Z, Zeng T Tags: Int J Clin Exp Pathol Source Type: research

GAB2 inhibits chondrocyte apoptosis through PI3K-AKT signaling in osteoarthritis.
Abstract Cartilage degeneration is considered the main pathologic feature of osteoarthritis (OA). Cumulative evidence indicates that chondrocyte apoptosis is associated with cartilage degradation. However, the underlying molecular mechanism of chondrocyte apoptosis remains unclear. Growth factor receptor-bound protein 2 (GAB2), an adaptor protein, belongs to the Gab family and is involved in various biologic processes. Here, we explored the role of GAB2 in the pathogenesis of osteoarthritis (OA). GAB2 expression was markedly increased in OA articular cartilage. GAB2 expression was also increased in an in vitro mod...
Source: International Journal of Clinical and Experimental Pathology - April 10, 2020 Category: Pathology Authors: Cheng Z, Sun W, Ni X, Xu H, Wang Y Tags: Int J Clin Exp Pathol Source Type: research

A case of small well-differentiated hepatocellular carcinoma with marked lymphocytic infiltrate.
Abstract We herein report a case of well-differentiated small hepatocellular carcinoma (HCC) with severe lymphocytic infiltrate (SLI) in a 55-year-old male patient with HCV-related cirrhosis. The patient had been followed-up because of HCV-related cirrhosis. He was found to have two small nodules in S8 by imaging techniques, and he underwent S8 segmentectomy. The resected liver showed two small nodules. Both were encapsulated, well-defined, solid, reddish and expansive nodules with fibrous septa. They measured 8 × 8 mm and 15 × 10 mm, respectively. Histologically, both tumours were pure HCC; the smalle...
Source: International Journal of Clinical and Experimental Pathology - April 10, 2020 Category: Pathology Authors: Iwasaki T, Kubota A, Suzuki M, Terada T Tags: Int J Clin Exp Pathol Source Type: research

The role of fenhexamid on the proliferation of ovarian cancer BG-1 cells [Retraction].
Authors: Abstract [This retracts the article on p. 2025 in vol. 11, PMID: 31938309.]. PMID: 32269705 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - April 10, 2020 Category: Pathology Tags: Int J Clin Exp Pathol Source Type: research

A promising independent prognostic biomarker in colorectal cancer: P2X7 receptor.
In this study, we aimed to investigate the prognostic value of P2X7R and GLUT-1 expression in CRC. We examined P2X7R and GLUT-1 expression in specimens of 196 CRC patients, immunohistochemically. P2X7R expression was higher in patients with poorly differentiated tumors than in those with well differentiated ones (P = 0.001). P2X7R and GLUT-1 overexpression were correlated to TILs (P
Source: International Journal of Clinical and Experimental Pathology - March 28, 2020 Category: Pathology Authors: Calik I, Calik M, Turken G, Ozercan IH Tags: Int J Clin Exp Pathol Source Type: research

Inhibitory effect of siRNA-Annexin A7 on growth, migration, and invasion in BGC823 cells and gastric cancer xenograftsin nude mice.
Abstract OBJECTIVE: To explore the inhibitory effect of siRNA-Annexin A7 on growth, migration, and invasion of transplanted gastric cancer in nude mice. METHODS: The siRNA sequence targeting to human Annexin A7 gene was designed, and based on that a pair of complementary oligonucleotides were synthesized, annealed, and cloned into plasmid pGenesil-1.1 to construct recombinant plasmid siRNA-Annexin A7. Transplanted gastric cancer model was established by injecting s.c. nude mice with human gastric cancer BGC823 cells, and siRNA-Annexin A7 was injected into the tumors formed. The nude mice were observed for cli...
Source: International Journal of Clinical and Experimental Pathology - March 28, 2020 Category: Pathology Authors: Yuan HF, Li Y, Tan BB, Zhao Q, Fan LQ, An ZJ Tags: Int J Clin Exp Pathol Source Type: research

Interaction between CXCR4 and EGFR and downstream PI3K/AKT pathway in lung adenocarcinoma A549 cells and transplanted tumor in nude mice.
Abstract Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality all over the world, particularly in China. Metastasis is the main factor resulting in the poor prognosis of patients with NSCLC. CXCR4 and EGFR have been widely studied due to their critical role in tumor metastasis, but it remains more elusive then the relationship between CXCR4 and EGFR. Studies have demonstrated that many tumors have been found the existence of the "cross-talk" between EGFR and CXCR4 signaling pathways. In this context, we explored the relationship between EGFR and CXCR4 signaling pathways in ...
Source: International Journal of Clinical and Experimental Pathology - March 28, 2020 Category: Pathology Authors: Wu J, Liu Y, Ma Y, Wang R, Ji X, Zhang Y, Du Y Tags: Int J Clin Exp Pathol Source Type: research

MiR-144 affects proliferation and apoptosis of high glucose-induced AC16 cardiomyocytes by regulating CTRP3/JNK signaling.
CONCLUSION: MiR-144 regulates proliferation and apoptosis of HG-induced AC16 cardiomyocytes through targeting the CTRP3/JNK signaling pathway, providing a novel avenue for treatment of DCM. PMID: 32211094 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - March 28, 2020 Category: Pathology Authors: Song Y, Mai H, Lin Y, Wang Y, Wang X, Gu S Tags: Int J Clin Exp Pathol Source Type: research

Toll-like receptor 3 (TLR3) functions as a pivotal target in latent membrane protein 1 (LMP1)-mediated nasopharyngeal carcinoma cell proliferation.
Abstract Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) activation of NF-κB is pivotal for EBV-infected B lymphocyte survival. Herein, we found that LMP1 markedly rescued the suppressed the proliferation of several nasopharyngeal carcinoma (NPC) cell lines caused by a Toll-like receptor 3 (TLR3) ligand poly (I:C). We profiled the expression alterations of TLR3 and LMP1 within these NPC cell lines in response to poly (I:C) treatment, and found a high correlation between them ws found, suggesting potential involvement of TLR3 in LMP1 signaling. Then, cells deficient in TLR3 were used to asse...
Source: International Journal of Clinical and Experimental Pathology - March 28, 2020 Category: Pathology Authors: Zhou L, Hang X, Xie L Tags: Int J Clin Exp Pathol Source Type: research

Clinical value of exhaled breath condensate let-7 in non-small cell lung cancer.
Abstract Non-small cell lung cancer (NSCLC) is one of the most common causes of tumor-associated mortality worldwide. Early diagnosis is the key focus for improving prognosis. In the present study, the association between exhaled breath condensate (EBC) let-7 and NSCLC diagnosis and clinicopathologic characteristics was investigated in order to explore non-invasive simple technological therapeutic methods. The expression levels of let-7 from 180 samples were analyzed using the reverse transcription-quantitative polymerase chain reaction (RT-qPCR), consisting of 30 patients with NSCLC (lung cancer and para-carcinom...
Source: International Journal of Clinical and Experimental Pathology - March 28, 2020 Category: Pathology Authors: Chen JL, Han HN, Lv XD, Ma H, Wu JN, Chen JR Tags: Int J Clin Exp Pathol Source Type: research

Arsenic trioxide inhibits proliferation of retinal pigment epithelium by downregulating expression of extracellular matrix and p27.
Abstract The present study aimed to investigate the effect of arsenic trioxide (ATO) on the proliferation of retinal pigment epithelium (RPE) and its mechanism. RPE cells were cultivated with 0.5-11 μmol/L ATO for 24, 48, and 72 h and their survival and growth were measured by MTT assay. The expression of p27 and proliferating cell nuclear antigen (PCNA) in RPE cells was detected using cell immunofluorescence and western blotting. Dose-dependency was evident in both the experimental and control groups. The 50% inhibitory concentration was obtained at a concentration of 6 mol/L with cells treated for 3 days. The...
Source: International Journal of Clinical and Experimental Pathology - March 28, 2020 Category: Pathology Authors: Su Y, Wang F, Hu Q, Qu Y, Han Y Tags: Int J Clin Exp Pathol Source Type: research

Protective effects of histone deacetylase inhibition by Scriptaid on brain injury in neonatal rat models of cerebral ischemia and hypoxia.
This study investigated the protective effect of HDAC inhibition by Scriptaid after HBID. METHODS: We established the neonatal rat HBID model, and used intraperitoneal injection of HDAC inhibitor scriptaid as a treatment. 7 days after HBID, nuclear magnetic resonance imaging (MRI) was used to detect infarct volume. The otarod test, wire hang test and Morris water maze were used to evaluate the HBID model of neurobehavioral dysfunction. Immunoblotting, immunofluorescence, and quantitative real-time PCR (RT-qPCR) were used to detect gene expression. RESULTS: HDAC inhibition by Scriptaid treatment could not only red...
Source: International Journal of Clinical and Experimental Pathology - March 28, 2020 Category: Pathology Authors: Meng Q, Yang G, Yang Y, Ding F, Hu F Tags: Int J Clin Exp Pathol Source Type: research

Kidney and lung tissue modifications after BDL-induced liver injury in mice are associated with increased expression of IGFBPrP1 and activation of the NF- κB inflammation pathway.
CONCLUSION: Liver injury caused by bile duct ligation can lead to kidney and lung tissue injury in mice. The mechanism of injury may be related to the high expression of liver injury factor IGFBPrP1, transcription factor NF-κB, proinflammatory cytokine TNF-α, and IL-6 in kidney and lung tissue. Moreover, an increased expression level of IGFBPrP1 may be accompanied by the activation of the NF-κB inflammatory pathway. PMID: 32211099 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - March 28, 2020 Category: Pathology Authors: Hu ZH, Kong YY, Ren JJ, Huang TJ, Wang YQ, Liu LX Tags: Int J Clin Exp Pathol Source Type: research

Detection of circulating tumor cell DNA for monitoring advanced gastric cancer.
In this study, the frequency of TP53 was significantly different between the effective and ineffective groups (P = 0.040), and the number of TP53 mutations was more frequent in the ineffective group. Missense mutation was a significant difference between the treatment effect groups (P = 0.026). The number of gene mutations and the change in copy number levels were related to therapeutic effect. Among the ineffective group, there was a significant difference in the number of gene mutations (P = 0.0006). We further divided the number of gene mutations into an increase group and a decrease group, and found that there was a si...
Source: International Journal of Clinical and Experimental Pathology - March 28, 2020 Category: Pathology Authors: Wu R, Shi C, Chen Q, Wu F, Li Q Tags: Int J Clin Exp Pathol Source Type: research

Scutellarin circumvents chemoresistance, promotes apoptosis, and represses tumor growth by HDAC/miR-34a-mediated down-modulation of Akt/mTOR and NF- κB-orchestrated signaling pathways in multiple myeloma.
In this study, we sought to investigate whether scutellarin (STN), a flavonoid, could reduce MM progression, mitigate chemoresistance of MM cells to bortezomib (BTB), and cause MM cell apoptosis in a xenograft mouse model of MM. Epigenetic signalling plays a main role in the modulation of various pathways involved in multiple myeloma progression. At the outset, mechanistic analyses of the MM pathways indicated that key epigenetic molecules including HDAC1/3 and miR-34a were up-modulated and down-modulated respectively, in the MM mice. Besides, the downstream signalling analysis of miR-34a depicted that the c-Met/AKT/mTOR p...
Source: International Journal of Clinical and Experimental Pathology - March 28, 2020 Category: Pathology Authors: Li L, Zheng Y, Zhang W, Hou L, Gao Y Tags: Int J Clin Exp Pathol Source Type: research

Ethyl acetate extract of sappanwood alleviates experimental atherosclerosis in rats through changes in FGF21 and SREBP-2 expression.
This study aimed to examine whether sappanwood ethyl acetate extract (SEAE) alleviates experimental atherosclerosis in rats through FGF21/SREBP-2 signaling. Rats were randomized to six groups (n=10/group): blank control, model, simvastatin (positive control, 4.2 mg/kg/d), and SEAE high-, medium-, and low-dose (2.30, 1.15, and 0.575 g/kg/d, respectively). The high-fat- and vitamin D3-induced rodent model of atherosclerosis was created (except in the blank control group). Aorta and liver underwent histopathologic examination. SREPB-2 and FGF21 expression levels were examined by real-time RT-PCR and western blot. Compared wit...
Source: International Journal of Clinical and Experimental Pathology - March 28, 2020 Category: Pathology Authors: Li Q, Wang H, Zhang C, Tong R, Chen H, Qie R Tags: Int J Clin Exp Pathol Source Type: research

Detection of IDH1 and TERT promoter mutations with droplet digital PCR in diffuse gliomas.
Abstract Mutations in isocitrate dehydrogenase (IDH) and telomerase reverse transcriptase promoter (TERTp) exert a far-reaching influence on clinicopathologic diagnosis and prognosis of glioma. Traditional approaches, such as Sanger sequencing and ARMS, lack sensitivity due to tumor heterogeneity and low tumor purity of glioma samples. Therefore, we propose a highly sensitive detection method for IDH1 and TERTp mutations based on ddPCR technology, named IDH1-TERT-mutation ddPCR (IT-ddPCR). We determined the IDH1 and TERTp mutations of 80 patients by Sanger sequencing, ARMS, and IT-ddPCR in parallel. We detected th...
Source: International Journal of Clinical and Experimental Pathology - March 28, 2020 Category: Pathology Authors: Ge J, Liu MY, Li L, Deng Q, Liu F, Luo Y, Wang L, Yao G, Zhu D, Lu H, Liang M, Deng S, Zhou R, Luo T Tags: Int J Clin Exp Pathol Source Type: research

TTLL12 expression in ovarian cancer correlates with a poor outcome.
In conclusion, this study identified TTLL12 as a potential molecular marker for predicting the invasion and progression of OC. PMID: 32211104 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - March 28, 2020 Category: Pathology Authors: Yang S, Liang Y, Qian H, Li Q Tags: Int J Clin Exp Pathol Source Type: research

Solid pseudopapillary neoplasm (SPN) of the pancreas presenting with ascites misdiagnosed as pancreatic tuberculosis: a case report and literature review.
CONCLUSION: Clinicians should consider the possibility of SPN for pancreatic heterogeneous masses. Multiple diagnostic imaging modalities and EUS-FNA may contribute to the preoperative diagnosis of this disease. PMID: 32211105 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - March 28, 2020 Category: Pathology Authors: Gao BJ, Luo J, Liu Y, Zhong FR, Guo QX, Peng FY, Yang XL, Su S, Li B Tags: Int J Clin Exp Pathol Source Type: research

Primary colorectal diffuse large B-cell lymphoma initially presenting with pleural effusion: report of one case and review of literature.
Abstract Gastrointestinal (GI) diffuse large B-cell lymphoma (DLBCL) is one of the frequently reported histologic subtypes of non-Hodgkin lymphoma (NHL) that occur in the GI tract. However, the presentation of quite different clinical manifestations, morphologic characteristics, immunophenotypes, and molecular biologic features is challenging for its diagnosis. Herein, we describe a rare case of primary colorectal DLBCL that occurred in a 59-year-old immunocompetent Chinese female who attended our respiratory clinic for the third time with an asymptomatic pleural effusion and pleural thickening. In her clinical se...
Source: International Journal of Clinical and Experimental Pathology - March 28, 2020 Category: Pathology Authors: Xu T, Wang L, Zhou L, Wang Z, Zhu Y, Ju F Tags: Int J Clin Exp Pathol Source Type: research

Mixed malignant peripheral nerve sheath tumor in the inguinal region: a case report.
Abstract Malignant peripheral nerve sheath tumor (MPNST) is a rare malignant soft tissue tumor that accounts for approximately 5% of all soft tissue sarcomas. This tumor originates from the peripheral nerves and occurs mainly in the limbs, head and neck, and spine. As a more aggressive tumor, it has higher recurrence and metastasis rates, and patient prognosis is poor. MPNST has a variety of histologic subtypes such as classic MPNST and epithelioid malignant peripheral nerve sheath tumors (EMPNSTs). Due to the diversity of histologic types, these tumors have a high histologic similarity to other benign and maligna...
Source: International Journal of Clinical and Experimental Pathology - March 28, 2020 Category: Pathology Authors: Liu M, Liu S, Zhan J, Chen W, Yang P, Zhou H Tags: Int J Clin Exp Pathol Source Type: research

Clear cell chondrosarcoma of the talus in Von Hippel-Lindau disease: a rare tumor in an unusual location and uncommon co-presentation.
Abstract Von Hippel-Lindau (VHL) disease is an autosomal dominant inherited tumor syndrome. Clear cell chondrosarcoma (CCCS) is a rare variant of chondrosarcoma. Here, we report a case of CCCS in the talus occurring in a patient with VHL disease. A 32-year-old man presented with ankle pain for 2 years. MRI revealed a 4.2 cm mass in the talus, and needle biopsy was performed. The patient underwent curettage but the final diagnosis was CCCS. Adjuvant radiation therapy was performed without additional talectomy and the patient was alive without recurrence for a follow-up period of 2 years. To our knowledge, this is t...
Source: International Journal of Clinical and Experimental Pathology - March 28, 2020 Category: Pathology Authors: Song MJ, Won KY, Park S Tags: Int J Clin Exp Pathol Source Type: research

Primary anorectal malignant melanoma: a case report.
We report a case of a 48-year-old woman with 9 months of rectal swelling and bleeding. Physical examination revealed a mass about 5 × 6 cm on the anterior wall of the rectum, 3 cm from the anal verge, and the patient underwent abdominoperineal resection (APR). After hematoxylin-eosin staining and immunohistochemical staining, it was considered an ARM, which is an aggressive disease with a poor survival. Immunohistochemical staining showed the tumor to be positive for S-100, Melan A, Ki67 proliferative index of 70%, and negative for HMB45. The melanoma had infiltrated the adventitia and metastasized to the (intestinal...
Source: International Journal of Clinical and Experimental Pathology - March 28, 2020 Category: Pathology Authors: Dai JJ, Qu CS, Wang W, Wang YB, Mao XW, Li QS, Chen JF Tags: Int J Clin Exp Pathol Source Type: research

NOX2 is involved in CB2-mediated protection against lung ischemia-reperfusion injury in mice.
In this study, we sought to determine whether JWH133, a selective CB2 receptor agonist, could alleviate lung injury induced by I/R and to examine the role of NOX2 in this process. Here, an I/R model was established using male C57BL/6 mice, by blocking the left pulmonary hilum for 1 h, followed by reperfusion for 2 h. Results showed that pretreatment with JWH133 significantly attenuated I/R-induced lung injury (decreased lung injury scores and wet-to-dry weight ratio and increased oxygenation index), alleviated oxidative stress (increased superoxide dismutase (SOD), and decreased Malondialdehyde (MDA) levels). It also signi...
Source: International Journal of Clinical and Experimental Pathology - March 28, 2020 Category: Pathology Authors: Huang W, Xiong Y, Chen Y, Cheng Y, Wang R Tags: Int J Clin Exp Pathol Source Type: research

Correlation of HER2 codon 655 polymorphism with cardiotoxicity risk in Chinese HER2-positive breast cancer patients undergoing epirubicin/cyclophosphamide followed by docetaxel plus trastuzumab adjuvant chemotherapy.
In conclusion, HER2 codon 655 A>G was an independent predictive factor for increased cardiotoxicity risk in HER2-positive breast cancer patients undergoing EC-D-T adjuvant chemotherapy. PMID: 32211111 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - March 28, 2020 Category: Pathology Authors: Tan L, Su X, Li X, Li H, Hu B Tags: Int J Clin Exp Pathol Source Type: research

Gene-gene interactions between BMP4 and ARHGAP29 among non-syndromic cleft lip only (NSCLO) trios from western Han Chinese population.
CONCLUSIONS: Gene-gene interaction between markers in BMP4 and ARHGAP29 may influence the risk of NSCLO in western Han Chinese population, which might explain the missing heritability for NSCL/P. PMID: 32211112 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - March 28, 2020 Category: Pathology Authors: Wang Y, Shi J, Zheng Q, Shi B, Jia Z Tags: Int J Clin Exp Pathol Source Type: research

A fetus with Kabuki syndrome 2 detected by chromosomal microarray analysis.
CONCLUSIONS: We report a fetus with Kabuki syndrome 2 detected using CMA. It is strongly recommended that CMA be included in prenatal diagnosis in fetuses with growth retardation, cardiovascular and musculoskeletal abnormalities revealed by routine Color Doppler ultrasonography. PMID: 32211113 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - March 28, 2020 Category: Pathology Authors: Lin CZ, Qi BR, Hu JS, Huang XQ Tags: Int J Clin Exp Pathol Source Type: research

Clinicopathologic significance and treatment of ASC-US in cervical cytology.
CONCLUSION: women with ASC-US have a wide range of final pathologic results, and it can be the initial warning of high-grade CIN or cervical cancer. In China, HPV (DNA) testing triage is a useful shunting measure for ASC-US patients, and an immediate colposcopy is a consequential strategy for dealing with ASC-US cytology to increase the detection rate of high-grade cervical lesions or invasive cancer. PMID: 32211114 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - March 28, 2020 Category: Pathology Authors: Abdulaziz AMA, Liu L, Sun Y, You X, Cui B, Han S, Zhang Y Tags: Int J Clin Exp Pathol Source Type: research

Coexistence of micro-inflammatory and macrophage phenotype abnormalities in chronic kidney disease.
Abstract The heterogeneity of macrophages promotes renal fibrosis and plays an important role in the repair of kidney damage. The "microinflammation state" is closely related to accelerated mortality in patients with chronic kidney disease (CKD). The aim of this study was to investigate the relationship between microinflammation and macrophage polarization in CKD. The levels of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in peripheral blood of 30 non-dialysis CKD-5 patients (CKD group) and 20 healthy subjects (Con group) were measure...
Source: International Journal of Clinical and Experimental Pathology - March 28, 2020 Category: Pathology Authors: Wu J, Guo N, Chen X, Xing C Tags: Int J Clin Exp Pathol Source Type: research

Downregulated miR-203 attenuates IL- β, IL-6, and TNF-α activation in TRAF6-treated human renal mesangial and tubular epithelial cells.
Downregulated miR-203 attenuates IL-β, IL-6, and TNF-α activation in TRAF6-treated human renal mesangial and tubular epithelial cells. Int J Clin Exp Pathol. 2020;13(2):324-331 Authors: Zhang L, Zhang X Abstract Circulating microRNAs (miRNAs) are attracting major interest as novel non-invasive biomarkers for human autoimmune diseases including lupus nephritis (LN). A previous study showed that altered miR-203 expression may provide highly diagnostic for systemic lupus erythematosus. However, whether miR-203 is a diagnostic biomarker for LN is still unknown. In the present research, serum sa...
Source: International Journal of Clinical and Experimental Pathology - March 28, 2020 Category: Pathology Authors: Zhang L, Zhang X Tags: Int J Clin Exp Pathol Source Type: research

Long noncoding RNA NORAD regulates lung cancer cell proliferation, apoptosis, migration, and invasion by the miR-30a-5p/ADAM19 axis.
CONCLUSION: NORAD knockdown suppressed cell proliferation, migration and invasion but promoted cell apoptosis in lung cancer cells by regulating miR-30a-5p/ADAM19, providing a possible therapeutic strategy for lung cancer patients. PMID: 32055266 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - February 16, 2020 Category: Pathology Authors: Li J, Xu X, Wei C, Liu L, Wang T Tags: Int J Clin Exp Pathol Source Type: research

Clinical significance of RAD51C and its contribution to ovarian carcinogenesis.
Abstract AIM: The underlying mechanisms of chemoresistance-induced recurrence of ovarian carcinoma are largely unknown. The purpose of this study was to investigate the clinical significance of RAD51C and its role in ovarian tumorigenesis and progression. METHODS: 60 cases of ovarian epithelial tumors (30 benign and 30 malignant tumors, respectively) were enrolled from 2014 to 2016. Immunohistochemistry was used to evaluate RAD51C expression in tumor tissues, and RT-PCR was employed to test RAD51C mRNA levels in SKOV3, A2780, and CAOV3 cell lines. Targeted knockdown of RAD51C was achieved with siRNA to explor...
Source: International Journal of Clinical and Experimental Pathology - February 16, 2020 Category: Pathology Authors: Lu XL, Liu SS, Xiong ZF, Wang F, Li XY, Deng H Tags: Int J Clin Exp Pathol Source Type: research

Lymphadenopathy in POEMS syndrome: a correlation between clinical features and imaging findings.
This study aimed to analyse the features of lymphadenopathy and estimate the role of imaging methods, including computed tomography (CT) and positron emission tomography-CT (PET/CT), in the diagnosis of lymphadenopathy in patients with POEMS syndrome. We conducted a retrospective analysis of 23 patients with confirmed POEMS syndrome. All of the patients received chest and abdominal CT scan and/or superficial ultrasound examinations. Four patients underwent PET/CT examinations, and 6 patients received lymph node biopsies. Enlarged lymph nodes (short diameter ≥ 1 cm) were found in 48% (11/23) of patients, but only 1 patie...
Source: International Journal of Clinical and Experimental Pathology - February 16, 2020 Category: Pathology Authors: Shi XF, Hu SD, Wu LL, Chen XY, Wu JN, Yu XQ, Li DY, Chen M, Liu YC, Zhu Y, Xi XD Tags: Int J Clin Exp Pathol Source Type: research

Potential value of V-domain Ig suppressor of T-cell activation for assessing progn osis in cervical cancer and as a target for therapy.
Abstract V-domain Ig suppressor of T-cell activation (VISTA), which belongs to the B7 family and is expressed predominantly on hematopoetic cells, myeloid, granulocytic and T cells, can suppresses T-cell activation in vivo and vitro. The blockade of VISTA has displayed brilliant results in certain murine tumor models. But to date, little is known about the expression and impact of VISTA in human cervical cancer (CC). To fill this gap of information, we systemically investigated the expression of VISTA on tumor cells, intratumoral immune cells (ICs) and vascular endothelial cells (VECs) in a group of patients with ...
Source: International Journal of Clinical and Experimental Pathology - February 16, 2020 Category: Pathology Authors: Kuang L, He Y Tags: Int J Clin Exp Pathol Source Type: research

Superficial CD34-positive fibroblastic tumor: report of two cases and review of literature.
CONCLUSIONS: SCPFT is a rare low-grade fibroblastic tumor that has typical morphologic features and unique biologic behavior. Familiarity with clinicopathologic characteristics of the tumor contributes to the differential diagnosis of similar tumors. PMID: 32055270 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - February 16, 2020 Category: Pathology Authors: Mao X, Sun YY, Deng ML, Ma T, Yu L Tags: Int J Clin Exp Pathol Source Type: research

Rapid intraoperative immunocytochemistry of central nervous system tumors.
In this study, we chose Cytokeratin-pan, GFAP, and LCA as three immunohistochemical indicators. Intraoperative IHC was done by Novodiax ihcDirect technology combined with Leica Bond auto-staining. Compared with the manual method recommended for the reagents (Novodiax ihcDirect), the results show that auto-staining has better stability and high reproducibility in coloration, which has broad prospects for future application. PMID: 32055271 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - February 16, 2020 Category: Pathology Authors: Zhang X, Liu J, Yan X Tags: Int J Clin Exp Pathol Source Type: research

A ruptured jejunal gastrointestinal stromal tumor with hemoperitoneum mimicking ovarian carcinoma.
CONCLUSION: The authors report an unusual case of ruptured jejunal GIST with hemoperitoneum mimicking ovarian carcinoma. Therefore, GIST, in addition to ovarian cancer, should be considered in patients with an increased serum level of CA-125 and an abdominopelvic mass. PMID: 32055272 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - February 16, 2020 Category: Pathology Authors: Hwang SY, Choi CI, Cho HJ, Kim DH, Hong SB, Choi KU, Suh DS Tags: Int J Clin Exp Pathol Source Type: research

Mouse tail models of secondary lymphedema: fibrosis gradually worsens and is irreversible.
Abstract Although the mouse tail model of secondary lymphedema has been widely used in research, our knowledge regarding some of the characteristic changes in this model is lacking. Therefore, in the current study, we aimed to identify pathologic changes after surgery. Tail lymphedema was created in C57BL/6J mice by disconnecting both superficial and deep lymphatic vessels. The surgery resulted in chronic edema formation with the proliferation of subcutaneous adipose tissue, deposition of fibrotic tissue, and gradual increase in CD4+ T lymphocyte infiltration. Furthermore, dramatic expansion and an increased numbe...
Source: International Journal of Clinical and Experimental Pathology - February 16, 2020 Category: Pathology Authors: Zhou C, Su W, Han H, Li N, Ma G, Cui L Tags: Int J Clin Exp Pathol Source Type: research

Co-expression of HIF-1 and TLR3 is associated with poor prognosis in oral squamous cell carcinoma.
This study investigates the prognostic impact of the expression of hypoxia inducible factor (HIF)-1α and Toll-like receptor (TLR) 3 detected by immunohistochemistry in oral squamous cell carcinoma (OSCC). The study also evaluates the treatment outcome by inhibition of the HIF-1α and TLR 3 pathway (nuclear factor [NF]-κB) in an OSCC transplantation model in nude mice. Statistical analysis of immunohistochemical results with clinical findings that included overall survival outcomes was performed for 90 OSCC patients. Forty nude mice were divided into four groups (control; inhibition of HIF-1α; inhibit...
Source: International Journal of Clinical and Experimental Pathology - February 16, 2020 Category: Pathology Authors: Han S, Yin X, Wang Y, Xu W, Cheng W Tags: Int J Clin Exp Pathol Source Type: research

Discordant lymphoma consisting of mantle cell lymphoma and angioimmunoblastic T cell lymphoma: homology or heterogeneity?
CONCLUSIONS: This is the first report on discordant lymphoma consisting of mantle cell lymphoma and angioimmunoblastic T cell lymphoma. There seems to be no relation these two different kinds of lymphoma, and EBV infection might prompt the development of angioimmunoblastic T cell lymphoma after transplantation. Rash is a common clinical manifestation when T cell lymphoma develops after treatment for MCL. PMID: 32055275 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - February 16, 2020 Category: Pathology Authors: Li Q, Jiang L, Wu S, Wang Y, Wang X, Yu G Tags: Int J Clin Exp Pathol Source Type: research

Effect of antenatal tetramethylpyrazine on lung development and YAP expression in rat model of experimental congenital diaphragmatic hernia.
Abstract The aim of this study was to investigate the therapeutic effects and underlying mechanism of tetramethylpyrazine (TMP) on lung development using a rat model of congenital diaphragmatic hernia (CDH). Nitrofen was used to induce CDH. Pregnant rats were divided into three groups: control, CDH, and CDH+TMP. In the CDH and CDH+TMP, fetuses only with left diaphragmatic hernias were chosen for analysis. Lung and body weight were recorded and lung histologic evaluations, image analysis, and western blot analysis of YAP, p-YAP and LATS1 were performed after lung processing. A markedly abnormal structure was observ...
Source: International Journal of Clinical and Experimental Pathology - February 16, 2020 Category: Pathology Authors: Liao J, Liu W, Zhang L, Li Q, Hou F, Zou P Tags: Int J Clin Exp Pathol Source Type: research

MicroRNA-21 and microRNA-155 promote the progression of Burkitt's lymphoma by the PI3K/AKT signaling pathway.
CONCLUSION: miR-21 and miR-155 promote the progression of Burkitt's lymphoma through PI3K/AKT signaling by targeting C1RL and TCAP. Our findings will provide a novel biomarker and therapeutic strategies for Burkitt's lymphoma. PMID: 32055277 [PubMed] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - February 16, 2020 Category: Pathology Authors: Han B, Wang S, Zhao H Tags: Int J Clin Exp Pathol Source Type: research

Knockdown of eukaryotic translation initiation factor 3 subunit B inhibits cell proliferation and migration and promotes apoptosis by downregulating WNT signaling pathway in acute myeloid leukemia.
Abstract The study aimed to investigate the effect of eukaryotic translation initiation factor 3 subunit B (EIF3B) on cell proliferation, migration, and apoptosis as well as the underlying mechanism in acute myeloid leukemia (AML). EIF3B expression was detected in AML-193, HL-60, OCI-AML2, and KG-1 cell lines and human primary bone marrow mononuclear cells (BMMC). EIF3B knockdown was realized by transfecting EIF3B ShRNA plasmids, and EIF3B knockdown and WNT2 overexpression were established by transfecting EIF3B ShRNA plasmids and WNT2 overexpression plasmids into KG-1 cells. The effect of EIF3B knockdown, and EIF3...
Source: International Journal of Clinical and Experimental Pathology - February 16, 2020 Category: Pathology Authors: Feng Y, Wu L Tags: Int J Clin Exp Pathol Source Type: research

"Int J Clin Exp Pathol"[ta]; +558 new citations
558 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[ta] These pubmed results were generated on 2020/01/25PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - January 25, 2020 Category: Pathology Tags: Report Source Type: research

"Int J Clin Exp Pathol"[ta]; +558 new citations
558 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[ta] These pubmed results were generated on 2020/01/24PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - January 24, 2020 Category: Pathology Tags: Report Source Type: research

"Int J Clin Exp Pathol"[ta]; +422 new citations
422 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[ta] These pubmed results were generated on 2020/01/18PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - January 18, 2020 Category: Pathology Tags: Report Source Type: research

"Int J Clin Exp Pathol"[ta]; +504 new citations
504 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Int J Clin Exp Pathol"[ta] These pubmed results were generated on 2020/01/15PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - January 15, 2020 Category: Pathology Tags: Report Source Type: research