Students & #39; knowledge and views on pharmacogenomic education in the medical curriculum
CONCLUSION: Second-year MBBS students had good knowledge of pharmacogenomics, but knowledge about the application in clinical practice and interpretation of pharmacogenomics was limited. Therefore, we recommend (1) basic pharmacogenomic education at all levels of medical curricula, (2) development of case-based knowledge application modules, (3) regular continuing medical education to update about available screening tools/biomarkers, and (4) patient and public awareness programs so that they receive personalized/precision medicine with optimum efficacy and reduced side effects and health-care costs. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - April 28, 2021 Category: Drugs & Pharmacology Authors: Manju Agrawal Lopamudra Kirtania Anuja Jha Rajesh Hishikar Source Type: research
Determination of in vitro human whole blood-to-plasma ratio of THJ-018 utilizing gas chromatography & #8211;Mass spectrometry
CONCLUSION: The data analysis supports the proposition that the ratio of the plasma to whole blood concentrations (1.56) is a suitable parameter characterizing THJ-018 distribution in whole blood. For toxicological analysis, it would be best to refrain from converting any drug concentration measured in whole blood to that anticipated in plasma or serum; however, toxic and therapeutic concentrations should be determined for the individual specimens collected. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - April 28, 2021 Category: Drugs & Pharmacology Authors: Sachil Kumar Remal Nahar Khleel Alkhibery Abdulsallam Bakdash Mohamed Sultan Mohamed Abdelhady Source Type: research
Denosumab biosimilar in postmenopausal osteoporotic women: A randomized, assessor-blind, active-controlled clinical trial
CONCLUSIONS: Denosumab-biosimilar and denosumab-reference showed biosimilarity in osteoporotic postmenopausal women. Availability of denosumab-biosimilar provides a treatment alternative for patients. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - April 28, 2021 Category: Drugs & Pharmacology Authors: Inderjeet Singh Vinu Jose Ronak Patel Sumit Arora Source Type: research
Therapeutic drug monitoring of olanzapine: Easy and reliable method for clinical correlation
CONCLUSION: Therapeutic drug monitoring must be a part of clinical practice in psychiatric hospitals for optimizing the dose of an individual patient along with the correlation of serum concentration with the clinical assessment scales. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - April 28, 2021 Category: Drugs & Pharmacology Authors: Srinivas Pramod Junutula Sai Kiran Dubasi Sai Geethika Reddy Padide Gireesh Kumar Miryala Manasa Soumya Koppolu Sharvana Bhava Bandaru Sheshagiri Venkateshwarlu Eggadi Source Type: research
Most cherished moments of STAR pharmacologists
Shivprakash Rathnam, Prakash V DiwanIndian Journal of Pharmacology 2021 53(1):1-1 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - April 28, 2021 Category: Drugs & Pharmacology Authors: Shivprakash Rathnam Prakash V Diwan Source Type: research
Efficacy and safety of steroid therapy in COVID-19: A rapid systematic review and Meta-analysis
CONCLUSION: This study guides the use of steroid across patients with different severity categories of COVID-19. Among mechanically ventilated patients, steroid therapy may be beneficial in terms of reduced mortality. Among “severe and critical” patients; steroid therapy was associated with lowered mortality, decreased requirement of mechanical ventilation, and ICU. However, no benefit was observed in “mild to moderate” population. To conclude, among properly selected patient populations (based-upon clinical severity and biomarker status), steroid administration may prove...
Source: Indian Journal of Pharmacology - February 19, 2021 Category: Drugs & Pharmacology Authors: Phulen Sarma Anusuya Bhattacharyya Hardeep Kaur Manisha Prajapat Ajay Prakash Subodh Kumar Seema Bansal Richard Kirubakaran Dibbanti Harikrishna Reddy Gaurav Muktesh Karanvir Kaushal Saurabh Sharma Nishant Shekhar Pramod Avti Prasad Thota Bikash Medhi Source Type: research
Antiviral effect of amiodarone and its possible role in COVID-19: An appraisal
Snehal Lonare, Mythili Hazarika, Chandra Kr DasIndian Journal of Pharmacology 2020 52(6):533-534 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - February 19, 2021 Category: Drugs & Pharmacology Authors: Snehal Lonare Mythili Hazarika Chandra Kr Das Source Type: research
Tacrolimus-induced mania in a patient with nephrotic syndrome
Alok Kumar, Dorchhom Khrime, Vivek RuhelaIndian Journal of Pharmacology 2020 52(6):531-532 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - February 19, 2021 Category: Drugs & Pharmacology Authors: Alok Kumar Dorchhom Khrime Vivek Ruhela Source Type: research
Tropicamide abuse and regulatory measures in a Sudanese hospital
Elhassan Hussein Eltom, Mohanad Kamaleldin Mahmoud Ibrahim, Ekramy Mahmoud ElmorsyIndian Journal of Pharmacology 2020 52(6):529-530 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - February 19, 2021 Category: Drugs & Pharmacology Authors: Elhassan Hussein Eltom Mohanad Kamaleldin Mahmoud Ibrahim Ekramy Mahmoud Elmorsy Source Type: research
Convergence of divergent approaches to control COVID-19
Shivani Desai, Shivani R Sainani, Ketki R Rode, Ramesh R BhondeIndian Journal of Pharmacology 2020 52(6):526-528 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - February 19, 2021 Category: Drugs & Pharmacology Authors: Shivani Desai Shivani R Sainani Ketki R Rode Ramesh R Bhonde Source Type: research
Response to & #8220;A comparative study of alpha-1a blockers (tamsulosin) versus estrogens in the treatment of lower urinary tract symptoms in perimenopausal females & #8221;
Anant PatilIndian Journal of Pharmacology 2020 52(6):524-525 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - February 19, 2021 Category: Drugs & Pharmacology Authors: Anant Patil Source Type: research
Bradyarrhythmia due to mirtazapine overdose: A case of serious adverse event in a suicidal patient
Filiz Baloglu Kaya, Caglar Kuas, Engin Ozakin, Muhammed Evvah Karakilic, Seyhmus KayaIndian Journal of Pharmacology 2020 52(6):520-523
There are a limited number of studies on postoverdose clinical findings of mirtazapine in the literature. Our case presented an unlikely junctional rhythm, which we have not seen in the previous studies, in a patient who had bradycardia and hypotension following mirtazapine intake. A 37-year old male was admitted to the emergency department (ED) after his suicide attempt with 300 mg PO of mirtazapine tablets. He took the drug 2 h prior to his ED visit. He did not have any complaints after ...
Source: Indian Journal of Pharmacology - February 19, 2021 Category: Drugs & Pharmacology Authors: Filiz Baloglu Kaya Caglar Kuas Engin Ozakin Muhammed Evvah Karakilic Seyhmus Kaya Source Type: research
Effectiveness and tolerability of twice daily dosing of deferasirox in unresponsive and intolerant transfusion-dependent beta-thalassemia patients: A narrative review
Tirin Babu, George Mathew Panachiyil, Juny Sebastian, Mandyam Dhati RaviIndian Journal of Pharmacology 2020 52(6):514-519
Chronic iron overload in beta-thalassemia patients after continuous blood transfusions has caused notable morbidity and mortality in these patients. The once-a-day oral iron chelator, deferasirox has established efficacy and bearable safety in adults and pediatric thalassemia patients. It is now extensively used for the management of transfusional hemosiderosis. However, a number of studies have revealed a few patients continued to be none respondent or intolerant toward the once-a-day regimen of defer...
Source: Indian Journal of Pharmacology - February 19, 2021 Category: Drugs & Pharmacology Authors: Tirin Babu George Mathew Panachiyil Juny Sebastian Mandyam Dhati Ravi Source Type: research
Zebrafish: An emerging whole-organism screening tool in safety pharmacology
Vandana S Nikam, Deeksha Singh, Rohan Takawale, Minal R GhanteIndian Journal of Pharmacology 2020 52(6):505-513
During the last two decades, the development in drug discovery is slackening due to drug withdrawal from the market or reported to have postmarket safety events. The vital organ toxicities, especially cardiotoxicity, hepatotoxicity, pulmonary toxicity, and neurotoxicity are the major concerns for high drug attrition rates. The pharmaceutical industry is looking for high throughput, high content analysis based novel assays that would be fast, efficient, reproducible, and cost-effective; would address toxicity, th...
Source: Indian Journal of Pharmacology - February 19, 2021 Category: Drugs & Pharmacology Authors: Vandana S Nikam Deeksha Singh Rohan Takawale Minal R Ghante Source Type: research
Evaluation of the possibility of selective modulation of retinal glucose transporters in diabetic complications: An experimental study
CONCLUSION: This study showed the possibility of selective upregulation of GLUT4 (independent of PPARγ activation) in the retina of diabetic rats using genistein. Selective modulation of retinal glucose transporters as therapeutic target in ocular diabetic complications can be possibly explored. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - February 19, 2021 Category: Drugs & Pharmacology Authors: Kanuj Mishra Madhu Nath Nabanita Halder Thirumurthy Velpandian Source Type: research
