Involvement of the toll-like receptors-2/nuclear factor-kappa B signaling pathway in atherosclerosis induced by high-fat diet and zymosan A in C57BL/6 mice
CONCLUSION: The study is first, to our current knowledge, to demonstrate the involvement of the TLR-2/NF-ƙB signaling pathway in atherosclerosis induced by HFD and Zym in C57BL/6 mice, resulting in increased degradation of LDLR protein, thereby, increasing the serum lipid levels. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 3, 2020 Category: Drugs & Pharmacology Authors: Priyanka Arya Uma Bhandari Source Type: research
Evaluation of diuretic efficacy and antiurolithiatic potential of ethanolic leaf extract of Annona squamosa Linn. in experimental animal models
CONCLUSION: The dose of 500 mg/kg showed a promising diuretic and antiurolithiatic activity. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 3, 2020 Category: Drugs & Pharmacology Authors: Mejo C Korah Junaid Rahman R Rajeswari Haja Sherief V Lalitha S Sengottavelu T Sivakumar Source Type: research
Cytochrome P4502D6 polymorphism in eastern Indian population
CONCLUSIONS: Differences in CYP2D6 activity has treatment implications and may lead to adverse events or therapeutic failure. Phenotyping of subjects receiving CYP2D6 metabolized drugs may help clinicians personalize treatment and avert adverse drug-drug interactions. However, the frequency of the PM phenotype is low in India, and routinely phenotyping for CYP2D6 activity will not be cost-effective. We cannot recommend it at this stage. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 3, 2020 Category: Drugs & Pharmacology Authors: Monalisa Dhuya Murari Mohan Pal Avijit Hazra Suparna Chatterjee Nithya Gogtay Source Type: research
Drug utilization, rationality, and cost analysis of antimicrobial medicines in a tertiary care teaching hospital of Northern India: A prospective, observational study
CONCLUSION: AMMs are being commonly prescribed without confirmation of AMM sensitivity in the hospital. A large proportion of expenditure is being incurred on expensive AMM used in a few number of patients. There is a need for developing a policy for rational use of AMM in the health facility. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 3, 2020 Category: Drugs & Pharmacology Authors: HV Bimba Vandana Roy Angelika Batta Mradul Kumar Daga Source Type: research
Effectiveness of Deferasirox in Pediatric Thalassemia Patients: Experience from a Tertiary Care Hospital of Odisha
CONCLUSIONS: Deferasirox is an effective iron chelator when started at an optimum time and with optimum dose. At least 1 year of deferasirox therapy is needed for a significant lowering of serum ferritin levels of pediatric thalassemia patients on multiple blood transfusions. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 3, 2020 Category: Drugs & Pharmacology Authors: Mousumee Panigrahi Trupti Rekha Swain Rabindra Kumar Jena Ashutosh Panigrahi Nishant Debta Source Type: research
Understanding the challenges and ethical aspects of compassionate use of drugs in emergency situations
Pardeep Kumar Goyal, Roli Mathur, Bikash MedhiIndian Journal of Pharmacology 2020 52(3):163-171 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 3, 2020 Category: Drugs & Pharmacology Authors: Pardeep Kumar Goyal Roli Mathur Bikash Medhi Source Type: research
Sofosbuvir for COVID-19 infection: A potential candidate
Rohit Gupta, Puneet DhamijaIndian Journal of Pharmacology 2020 52(3):232-233 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 3, 2020 Category: Drugs & Pharmacology Authors: Rohit Gupta Puneet Dhamija Source Type: research
Psychiatric implications of the use of hydroxychloroquine in COVID-19 patients
Seema Rani, Sandeep Grover, Aseem Mehra, Swapnajeet SahooIndian Journal of Pharmacology 2020 52(3):229-231 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 3, 2020 Category: Drugs & Pharmacology Authors: Seema Rani Sandeep Grover Aseem Mehra Swapnajeet Sahoo Source Type: research
Indian perspective of remdesivir: A promising COVID-19 drug
Devendra Singh, Himika Wasan, Apoorva Mathur, Yogendra Kumar GuptaIndian Journal of Pharmacology 2020 52(3):227-228 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 3, 2020 Category: Drugs & Pharmacology Authors: Devendra Singh Himika Wasan Apoorva Mathur Yogendra Kumar Gupta Source Type: research
Target/therapies for chronic recurrent erythema nodosum leprosum
Pugazhenthan Thangaraju, Shoban Babu Varthya, Sajitha VenkatesanIndian Journal of Pharmacology 2020 52(3):222-226
A Type 2 lepra reaction or erythema nodosum leprosum is an anticipated complication in the lepromatous spectrum of leprosy cases. It is an example of an immune complex-mediated complement activated disease (Type III hypersensitivity reaction). Hence, we tried to target the inflammatory mediators and the mental stressors for the possible management strategies. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 3, 2020 Category: Drugs & Pharmacology Authors: Pugazhenthan Thangaraju Shoban Babu Varthya Sajitha Venkatesan Source Type: research
Co-abuse of alprazolam augments the hepato-renal toxic effects of methylphenidate
CONCLUSION: The co-abuse of ALZ has amplified the hepato-renal toxic effects of MPH. Therefore, it is a significant concern for public safety, and their co-abuse must be restricted and discouraged. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 3, 2020 Category: Drugs & Pharmacology Authors: Meenu Dutt Ravinder Naik Dharavath Tanzeer Kaur Navpreet Kaur Kanwaljit Chopra Shweta Sharma Source Type: research
Duloxetine-induced hypertensive urgency in type 2 diabetes mellitus with diabetic neuropathy
We present a case of hypertensive urgency in a diabetic patient with painful diabetic neuropathy on duloxetine treatment. The patient's blood pressure was high after taking 1-day dose of duloxetine and the patient was diagnosed with hypertensive urgency. The patient was managed with labetalol, leading to reduction in blood pressure. The patient's medication was switched to telmisartan and metoprolol, which leads to resolution of increased blood pressure. This case report is a possible case of hypertensive urgency after the initiation of duloxetine managed with antihypertensives and resolves with the d...
Source: Indian Journal of Pharmacology - August 3, 2020 Category: Drugs & Pharmacology Authors: Ravindra Shukla Sameer Khasbage Mahendra Kumar Garg Surjit Singh Source Type: research
A rare case of cephalexin-induced acute interstitial nephritis with hypokalemic periodic paralysis
Rajesh Kumar, Amit Kumar Singh, Kavish Sharma, Vandana TalwarIndian Journal of Pharmacology 2020 52(3):210-212
Drug-induced acute interstitial nephritis (AIN) is often encountered in clinical practice. Cephalexin is a first-generation cephalosporin with antimicrobial sensitivity ranging from Gram-positive to Gram-negative organisms. Cephalexin-induced AIN presenting with hypokalemic periodic paralysis (HPP) has been rarely reported. A 34-year-old female with recent history of oral cephalexin intake presented with acute onset paraplegia with deranged renal parameters and hypokalemia. She was treated conservatively with mec...
Source: Indian Journal of Pharmacology - August 3, 2020 Category: Drugs & Pharmacology Authors: Rajesh Kumar Amit Kumar Singh Kavish Sharma Vandana Talwar Source Type: research
Involvement of the toll-like receptors-2/nuclear factor-kappa B signaling pathway in atherosclerosis induced by high-fat diet and zymosan A in C57BL/6 mice
CONCLUSION: The study is first, to our current knowledge, to demonstrate the involvement of the TLR-2/NF-ƙB signaling pathway in atherosclerosis induced by HFD and Zym in C57BL/6 mice, resulting in increased degradation of LDLR protein, thereby, increasing the serum lipid levels. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 3, 2020 Category: Drugs & Pharmacology Authors: Priyanka Arya Uma Bhandari Source Type: research
Evaluation of diuretic efficacy and antiurolithiatic potential of ethanolic leaf extract of Annona squamosa Linn. in experimental animal models
CONCLUSION: The dose of 500 mg/kg showed a promising diuretic and antiurolithiatic activity. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 3, 2020 Category: Drugs & Pharmacology Authors: Mejo C Korah Junaid Rahman R Rajeswari Haja Sherief V Lalitha S Sengottavelu T Sivakumar Source Type: research
