Reporting of adverse events related to medical devices: A single-center experience from a tertiary care institute of national importance in India
Bikash Ranjan Meher, Ashish DashIndian Journal of Pharmacology 2023 55(2):128-132
As frontline health workers, nursing professionals have a crucial role in reporting medical device-associated adverse events (MDAEs). A questionnaire-based study was carried out to evaluate the knowledge, attitude, and practice of senior nursing officers (SNOs), nursing officers (NOs), and nursing students (NSs) toward MDAE. The response rate of the survey was 84% (n = 134). The mean score of knowledge of SNOs, NOs, and NSs was 2.03 ± 0.92, 1.71 ± 0.96, and 1.52 ± 0.82, respectively (...
Source: Indian Journal of Pharmacology - June 7, 2023 Category: Drugs & Pharmacology Authors: Bikash Ranjan Meher Ashish Dash Source Type: research
Impact of sodium-glucose co-transporter 2 inhibitors on renal outcomes in patients of diabetes mellitus: A meta-analysis of landmark renal and cardiovascular outcome trials
Debdipta Bose, Miteshkumar Maurya, Mahanjit KonwarIndian Journal of Pharmacology 2023 55(2):119-127
Sodium-glucose co-transporter 2 inhibitors (SGLT2is) are recommended as the next step therapy for the management of diabetes mellitus. The large clinical trials of SGLT2is demonstrated benefits on various renal endpoints. We conducted this meta-analysis of large trials on cardiovascular and renal safety trials to explore the renoprotective effect of this group of drugs. PubMed, Cochrane CENTRAL, and EMBASE databases were searched with specific keywords till January 19, 2021. Randomized trials of SGLT2is that evaluated the c...
Source: Indian Journal of Pharmacology - June 7, 2023 Category: Drugs & Pharmacology Authors: Debdipta Bose Miteshkumar Maurya Mahanjit Konwar Source Type: research
Proteome architecture of human-induced pluripotent stem cell-derived three-dimensional organoids as a tool for early diagnosis of neuronal disorders
CONCLUSION: The developed 3D model represents the majority of candidate proteins and associated biological mechanisms altered in ALS disease. The study also offers novel protein targets that may uncloud the precise disease pathological mechanism and be considered for future diagnostic and therapeutic purposes for various neurodegenerative disorders. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - June 7, 2023 Category: Drugs & Pharmacology Authors: R Negi A Srivastava AK Srivastava Abhishek Pandeya P Vatsa UA Ansari AB Pant Source Type: research
Raptinal ameliorates 1,2-dimethylhydrazine-induced colon cancer through p53/Bcl2/Bax/caspase-3-mediated apoptotic events in vitro and in vivo
CONCLUSIONS: These findings indicate the raptinal effectively reduces colon cancer by inducing apoptosis through p53/Bcl2/Bax/caspase-3 pathway and suppressing IL-6, TNF-mediated chronic inflammation in the colon cancer microenvironment. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - June 7, 2023 Category: Drugs & Pharmacology Authors: Yongting Lan Yang Yang Abhijit Das Barshana Bhattacharya Souvik Roy Source Type: research
A clinical study on the pattern of antimicrobial drug use and drug resistance in patients with ventilator-associated pneumonia in a tertiary care hospital
CONCLUSION: The organisms had a varied sensitivity and resistance pattern. The clinical outcome was multifactorial and its association with specific antimicrobial agents cannot be drawn. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - June 7, 2023 Category: Drugs & Pharmacology Authors: Abisha Rezia R Vijendra Source Type: research
Variation in normative values of major clinical biochemistry analytes in healthy reproductive-age women in India: A subset of data from a National Indian Council of Medical Research-Polycystic Ovary Syndrome task force study
CONCLUSION: This is the first study generating biochemical RIs data among a large representative sample of healthy reproductive-age women recruited using a robust design across the country. The resource may serve as a reference range for common biochemical analytes for future in this age group. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - June 7, 2023 Category: Drugs & Pharmacology Authors: Mohd Ashraf Ganie Subhankar Chowdhury Vanita Suri Beena Nitin Joshi Prasanta Kumar Bhattacharya Sarita Agarwal Neena Malhotra Rakesh Sahay PK Jabbar Roya Rozati Amlin Shukla Haroon Rashid Rohina Bashir Imtiyaz Wani Abhilash Nair Taruna Katyal Arora Bharat Source Type: research
Do alternatives to animal experimentation replace preclinical research ?
Vidya Mahalmani, Ajay Prakash, Bikash MedhiIndian Journal of Pharmacology 2023 55(2):71-75 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - June 7, 2023 Category: Drugs & Pharmacology Authors: Vidya Mahalmani Ajay Prakash Bikash Medhi Source Type: research
Toxicity of zinc alone or its formulation: An issue that needs attention
Sumanpreet Kaur, Dibyajyoti BanerjeeIndian Journal of Pharmacology 2023 55(1):64-65 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - March 20, 2023 Category: Drugs & Pharmacology Authors: Sumanpreet Kaur Dibyajyoti Banerjee Source Type: research
Nutrivigilance & #8211; The need of the hour
Harshad Malve, Madeline FernandesIndian Journal of Pharmacology 2023 55(1):62-63 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - March 20, 2023 Category: Drugs & Pharmacology Authors: Harshad Malve Madeline Fernandes Source Type: research
Successful management of delayed hyaluronidase hypersensitivity after subtenon & #39;s anesthesia during the COVID-19 pandemic: A rare case report
Bharat Gurnani, Kirandeep KaurIndian Journal of Pharmacology 2023 55(1):59-61
Subtenon's block is commonly used to achieve akinesia, analgesia, and anesthesia for ophthalmic surgeries. This case study detailed a rare hypersensitivity report in a 65-year-old female who had underwent manual small incision cataract surgery under subtenon's anesthesia (STA) in the left eye. On postoperative day 1, she presented with acute onset proptosis, periorbital edema, conjunctival chemosis, and restriction of extraocular movements. The pupillary reaction and dilated fundus examination were normal. A differential di...
Source: Indian Journal of Pharmacology - March 20, 2023 Category: Drugs & Pharmacology Authors: Bharat Gurnani Kirandeep Kaur Source Type: research
Peptides and peptidomimetics as a therapeutic candidate for the treatment of COVID-19: A brief review
In this study, we have reviewed the published literature describing peptide designing, in silico binding mode, antiviral activity, preventive measures, and in vivo assessments. Here, we reported all the results which are promising against SARS-CoV-2 as therapeutic and preventive (vaccine candidates), and their status in the drug development process. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - March 20, 2023 Category: Drugs & Pharmacology Authors: J Kumaravel Harvinder Singh Sukhmeet Kaur Ajay Prakash Bikash Medhi Source Type: research
Efficacy and safety of levamisole in childhood nephrotic syndrome: A meta-analysis
Girish Chandra Bhatt, Bhupeshwari Patel, Rashmi Ranjan Das, Shikha Malik, Martin Bitzan, Nihar Ranjan MishraIndian Journal of Pharmacology 2023 55(1):43-52
Present evidence regarding the efficacy and safety of levamisole in childhood nephrotic syndrome (NS), particularly the steroid-sensitive NS (SSNS), is limited. We searched relevant databases such as PubMed/MEDLINE, Embase, Google Scholar, and Cochrane CENTRAL till June 30, 2020. We included 12 studies for evidence synthesis (5 were clinical trials that included 326 children). The proportion of children without relapses at 6–12 months was higher in the lev...
Source: Indian Journal of Pharmacology - March 20, 2023 Category: Drugs & Pharmacology Authors: Girish Chandra Bhatt Bhupeshwari Patel Rashmi Ranjan Das Shikha Malik Martin Bitzan Nihar Ranjan Mishra Source Type: research
Nephroprotective potential of syringic acid in experimental diabetic nephropathy: Focus on oxidative stress and autophagy
CONCLUSION: Results from this study signify the renoprotective effect of SYA and highlight the modulation of oxidative stress and autophagy mechanisms to mitigate diabetic kidney disease. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - March 20, 2023 Category: Drugs & Pharmacology Authors: Bhoomika Sherkhane Veera Ganesh Yerra Anjana Sharma K Anil Kumar Gundu Chayanika Arruri Vijay Kumar Ashutosh Kumar Source Type: research
Prevalence of CYP2C9 and CYP2C19 variants and the impact on clopidogrel efficacy in patients having CYPC19 & #42;2 variant
CONCLUSIONS: The observed frequencies are not significantly different from that observed in earlier reported studies conducted across India and the world. Antiplatelet activity, as measured using the PAA method, was significantly lesser in patients having the CYP2C19*2 variant. The therapy failure in these patients can lead to serious cardiovascular consequences, and we propose determining the presence of the CYP2C19*2 variant before initiation of clopidogrel therapy. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - March 20, 2023 Category: Drugs & Pharmacology Authors: Meha P Mehta Normi D Gajjar Rutvi J Patel Lipi P Joshi Gaurang B Shah Source Type: research
Comparison of clinical effect of octreotide and pituitrin in treatment of upper gastrointestinal hemorrhage in cirrhosis
CONCLUSION: In the treatment of upper gastrointestinal hemorrhage in cirrhosis, octreotide is superior to pituitrin, with advantages of quick onset, short hemostasis time, and less adverse reactions, which is helpful to control the rebleeding rate and bleeding-related mortality. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - March 20, 2023 Category: Drugs & Pharmacology Authors: Yanli Zhu Yihua Ren Chunmei Li Zhaoming Si Nannan Chi Source Type: research
