Mangiferin ameliorates intracerebroventricular-quinolinic acid-induced cognitive deficits, oxidative stress, and neuroinflammation in Wistar rats
CONCLUSION: The results suggest that MGF offers the neuroprotective potential that may be a promising pharmacological approach to ameliorate cognitive deficits associated with neurodegeneration. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - October 14, 2020 Category: Drugs & Pharmacology Authors: Mandeep Kumar Arora Anglina Kisku Ashok Jangra Source Type: research
A prospective study to assess the medication adherence pattern among hypertensives and to evaluate the use of cellular phone text messaging as a tool to improve adherence to medications in a tertiary health-care center
CONCLUSION: Nonadherence to medication is a global phenomenon to be tackled at the earliest. Our study clearly brings out the importance of improving adherence by regular reminders as messages. Hence, there is a wide scope to avail means to improve the adherence pattern and maximize the health benefits. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - October 14, 2020 Category: Drugs & Pharmacology Authors: Garima Shukla A Tejus R Vishnuprasad Sapna Pradhan MS Prakash Source Type: research
Prescription pattern of antiepileptic drugs in a tertiary care center of India
CONCLUSIONS: Polytherapy is a very common practice in our tertiary care center. Sodium VPA, a highly prescribed AED, results in good control of generalized seizures, whereas focal seizures are well controlled by CBZ alone as well as in combination. The present study highlights the commonly prescribed combinations of AEDs resulting in control of different types of seizures. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - October 14, 2020 Category: Drugs & Pharmacology Authors: Rupa Joshi Manjari Tripathi Pooja Gupta Sheffali Gulati Yogendra Kumar Gupta Source Type: research
Clinical Trials Registry & #8211; India: A decadal perspective
CONCLUSIONS: The CTRI has a strong global presence and has enhanced the transparency of regulatory trials as well as academic research particularly thesis-based work. The latter is expected to help improve standard of research and prevent repetitive research. Additional support from Indian journal editors by strict implementation of prospective registration is crucial for increasing compliance by researchers. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - October 14, 2020 Category: Drugs & Pharmacology Authors: Mendu Vishnu Vardhana Rao Mohua Maulik Atul Juneja Tulsi Adhikari Saurabh Sharma Jyotsna Gupta Yashmin Panchal Neha Yadav Source Type: research
A comparative study of the effect of 10-day esomeprazole containing levofloxacin versus clarithromycin sequential regimens on the treatment of Iranian patients with Helicobacter pylori infection
CONCLUSIONS: Both esomeprazole containing sequential regimens including levofloxacin and clarithromycin showed good eradication rates in spite of significant differences in antimicrobial resistance patterns in vitro. The efficacy of esomeprazole in lowering gastric acidity beside its antimicrobial effect should be considered in H. pylori regimens. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - October 14, 2020 Category: Drugs & Pharmacology Authors: Marjan Mokhtare Mehdi Nikkhah Behdad Behnam Shahram Agah Mansour Bahardoust Mohsen Masoodi Amirhosein Faghihi Source Type: research
Medication errors in neonatal intensive care unit of a tertiary care hospital in South India: A prospective observational study
CONCLUSIONS: MEs were common in NICU setting. The occurrence of life-threatening MEs was minimal. Longer duration of hospital stay, polypharmacy, and babies born outside were significantly associated with occurrence of MEs. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - October 14, 2020 Category: Drugs & Pharmacology Authors: B Prakadeesh Bharathi Jeffrey Pradeep Raj Kevin Saldanha PN Suman Rao D Padmini Devi Source Type: research
Comparison of medication acceptance of intranasal midazolam administered by parents versus doctors in children & #8211; A randomized trial
CONCLUSION: Intranasal midazolam when given by parents produces better preoperative anxiolysis and easier parental separation as compared with administration by a medical staff. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - October 14, 2020 Category: Drugs & Pharmacology Authors: M V. S Satya Prakash S Sivasankar Lenin Babu Elakkumanan VK Mohan Rithu Krishna Kamaladevi Source Type: research
Pattern of clinical research in the era of COVID-19 pandemic: A new learning experience for the present as well as future
Vidya M Mahalmani, Ankita Semwal, Harpinder Kaur, Sukhmeet Kaur, Ajay Prakash, Bikash MedhiIndian Journal of Pharmacology 2020 52(4):249-253 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - October 14, 2020 Category: Drugs & Pharmacology Authors: Vidya M Mahalmani Ankita Semwal Harpinder Kaur Sukhmeet Kaur Ajay Prakash Bikash Medhi Source Type: research
Sofosbuvir for COVID-19 infection: A potential candidate
Rohit Gupta, Puneet DhamijaIndian Journal of Pharmacology 2020 52(3):232-233 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 3, 2020 Category: Drugs & Pharmacology Authors: Rohit Gupta Puneet Dhamija Source Type: research
Psychiatric implications of the use of hydroxychloroquine in COVID-19 patients
Seema Rani, Sandeep Grover, Aseem Mehra, Swapnajeet SahooIndian Journal of Pharmacology 2020 52(3):229-231 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 3, 2020 Category: Drugs & Pharmacology Authors: Seema Rani Sandeep Grover Aseem Mehra Swapnajeet Sahoo Source Type: research
Indian perspective of remdesivir: A promising COVID-19 drug
Devendra Singh, Himika Wasan, Apoorva Mathur, Yogendra Kumar GuptaIndian Journal of Pharmacology 2020 52(3):227-228 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 3, 2020 Category: Drugs & Pharmacology Authors: Devendra Singh Himika Wasan Apoorva Mathur Yogendra Kumar Gupta Source Type: research
Target/therapies for chronic recurrent erythema nodosum leprosum
Pugazhenthan Thangaraju, Shoban Babu Varthya, Sajitha VenkatesanIndian Journal of Pharmacology 2020 52(3):222-226
A Type 2 lepra reaction or erythema nodosum leprosum is an anticipated complication in the lepromatous spectrum of leprosy cases. It is an example of an immune complex-mediated complement activated disease (Type III hypersensitivity reaction). Hence, we tried to target the inflammatory mediators and the mental stressors for the possible management strategies. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 3, 2020 Category: Drugs & Pharmacology Authors: Pugazhenthan Thangaraju Shoban Babu Varthya Sajitha Venkatesan Source Type: research
Co-abuse of alprazolam augments the hepato-renal toxic effects of methylphenidate
CONCLUSION: The co-abuse of ALZ has amplified the hepato-renal toxic effects of MPH. Therefore, it is a significant concern for public safety, and their co-abuse must be restricted and discouraged. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 3, 2020 Category: Drugs & Pharmacology Authors: Meenu Dutt Ravinder Naik Dharavath Tanzeer Kaur Navpreet Kaur Kanwaljit Chopra Shweta Sharma Source Type: research
Duloxetine-induced hypertensive urgency in type 2 diabetes mellitus with diabetic neuropathy
We present a case of hypertensive urgency in a diabetic patient with painful diabetic neuropathy on duloxetine treatment. The patient's blood pressure was high after taking 1-day dose of duloxetine and the patient was diagnosed with hypertensive urgency. The patient was managed with labetalol, leading to reduction in blood pressure. The patient's medication was switched to telmisartan and metoprolol, which leads to resolution of increased blood pressure. This case report is a possible case of hypertensive urgency after the initiation of duloxetine managed with antihypertensives and resolves with the d...
Source: Indian Journal of Pharmacology - August 3, 2020 Category: Drugs & Pharmacology Authors: Ravindra Shukla Sameer Khasbage Mahendra Kumar Garg Surjit Singh Source Type: research
A rare case of cephalexin-induced acute interstitial nephritis with hypokalemic periodic paralysis
Rajesh Kumar, Amit Kumar Singh, Kavish Sharma, Vandana TalwarIndian Journal of Pharmacology 2020 52(3):210-212
Drug-induced acute interstitial nephritis (AIN) is often encountered in clinical practice. Cephalexin is a first-generation cephalosporin with antimicrobial sensitivity ranging from Gram-positive to Gram-negative organisms. Cephalexin-induced AIN presenting with hypokalemic periodic paralysis (HPP) has been rarely reported. A 34-year-old female with recent history of oral cephalexin intake presented with acute onset paraplegia with deranged renal parameters and hypokalemia. She was treated conservatively with mec...
Source: Indian Journal of Pharmacology - August 3, 2020 Category: Drugs & Pharmacology Authors: Rajesh Kumar Amit Kumar Singh Kavish Sharma Vandana Talwar Source Type: research
