LD50 dose fixation of nanohybrid-layered double hydroxide-methotrexate
Akhilesh Mishra, Gayatri Dewangan, Tapan Kumar Mandal, Jui ChkrabortyIndian Journal of Pharmacology 2022 54(5):379-380 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - December 13, 2022 Category: Drugs & Pharmacology Authors: Akhilesh Mishra Gayatri Dewangan Tapan Kumar Mandal Jui Chkraborty Source Type: research
Adverse drug reactions of itolizumab in COVID-19 patient: A case report
Ziauddin Mohammed, Kandi Suryachandra, Manoj P DandekarIndian Journal of Pharmacology 2022 54(5):377-378 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - December 13, 2022 Category: Drugs & Pharmacology Authors: Ziauddin Mohammed Kandi Suryachandra Manoj P Dandekar Source Type: research
Long-lasting effect of belantamab mafodotin in heavily pretreated multiple myeloma
Manuel David Gil-Sierra, Maria Del Pilar Briceño-Casado, Francisco Javier Julia-Luna, Maria Dolores Martinez-MoyaIndian Journal of Pharmacology 2022 54(5):373-376
Belantamab mafodotin (BLMF) is an interesting therapeutic alternative for multiple myeloma (MM) patients pretreated with immunomodulatory drugs, proteasome inhibitors, and anti-CD38 monoclonal antibodies. Scientific evidence on BLMF provides immature data about progression-free survival and overall survival by short follow-up of patients with poor prognoses. Cases with long follow-ups could provide additional information about BLMF. This case reports...
Source: Indian Journal of Pharmacology - December 13, 2022 Category: Drugs & Pharmacology Authors: Manuel David Gil-Sierra Maria Del Pilar Brice & #241;o-Casado Francisco Javier Julia-Luna Maria Dolores Martinez-Moya Source Type: research
Drug development process and COVID-19 pandemic: Flourishing era of outsourcing
Himika Wasan, Devendra Singh, KH Reeta, Pooja Gupta, Yogendra Kumar GuptaIndian Journal of Pharmacology 2022 54(5):364-372
Traditional drug development is a tedious process with involvement of enormous cost and a high attrition rate. Outsourcing drug development services to contract research organizations (CROs) has become an important strategy for cost and risk reduction, capacity building, and data generation. The therapeutic and operational expertise of these CROs has allowed pharmaceutical industry to reduce in-house infrastructure as well as research capacity. Working with specialized CROs has not only increased the ...
Source: Indian Journal of Pharmacology - December 13, 2022 Category: Drugs & Pharmacology Authors: Himika Wasan Devendra Singh KH Reeta Pooja Gupta Yogendra Kumar Gupta Source Type: research
Deployment of iron uptake machineries as targets against drug resistant strains of mycobacterium tuberculosis
Kunal Mohan Gokhale, Aditya Manivannan IyerIndian Journal of Pharmacology 2022 54(5):353-363
Mycobacterium tuberculosis (MTB) requires a perpetual supply of iron for its sustenance. Iron scarcity and its limited availability in the host environment because of an encounter of various sites during the establishment of infection has led to the evolution of strategies for iron uptake, which includes biosynthesis of iron-chelating molecules called siderophores, Heme uptake pathways, recently discovered host iron transport protein receptors like glyceraldehyde-3-phosphate dehydrogenase and the development of machinery for prope...
Source: Indian Journal of Pharmacology - December 13, 2022 Category: Drugs & Pharmacology Authors: Kunal Mohan Gokhale Aditya Manivannan Iyer Source Type: research
Analysis of adverse drug reactions of imatinib in chronic myeloid leukemia patients: An Eastern Indian experience
CONCLUSION: The study revealed that imatinib mesylate, a well tolerated drug, has very few cases of severe ADRs in Indian patients at the chronic stable phase of CML. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - December 13, 2022 Category: Drugs & Pharmacology Authors: Trupti Rekha Swain Siddhartha Goutam Rabindra Kumar Jena Niranjan Rout Source Type: research
Materiovigilance of unidirectional barbed and poliglecaprone 25 nonbarbed sutures used for intraoral incision closure: An open-label prospective study
CONCLUSION: Both types of study sutures were associated with minor severity adverse events when used for the closure of intraoral surgical incisions. Suture extrusion had a probable causal association with barbed suture. Knot unraveling was possibly associated with the nonbarbed suture. Both types of suture materials were equally safe in oral and maxillofacial intraoral surgical incision closure. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - December 13, 2022 Category: Drugs & Pharmacology Authors: Jaspreet Kaur Deo Harmeet Singh Rehan Pravesh Mehra Source Type: research
Evaluation of peripheral lymphocyte subsets in acne vulgaris patients before and after systemic isotretinoin treatment
CONCLUSIONS: NK cell count may be a parameter related to acne severity. Systemic ISO may have an inhibitory effect on naïve T cells. Finally, systemic ISO seems to stimulate mature B-cell proliferation. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - December 13, 2022 Category: Drugs & Pharmacology Authors: Sibel Dogan Gunaydin Ilhan Tezcan Source Type: research
Antitumor effects of polyphenol-rich extract of Euphoria longana seed by vascular endothelial growth factor and transforming growth factor-beta signaling inhibition in experimentally induced oral cancer in rats
CONCLUSION: Our data suggest antitumor activity of Euphoria longana Lam. Extract against 4-NQO induced oral cancer in rats, which could be attributed to alteration in the VEGF and TGF-β signaling axis. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - December 13, 2022 Category: Drugs & Pharmacology Authors: Labhu Lagariya Kinal Soni Jigna Samir Shah Source Type: research
Assessment of prescribing pattern of drugs and completeness of prescriptions as per the World Health Organization prescribing indicators in various Indian tertiary care centers: A multicentric study by Rational Use of Medicines Centers-Indian Council of Medical Research network under National Virtual Centre Clinical Pharmacology activity
CONCLUSION: Most of the parameters in the present study were out of the range of WHO-recommended prescribing indicators. Therefore, effective intervention program, like training, for the promotion of rational drug use practice was recommended to improve the prescribing pattern of drugs and the quality of prescriptions all over the country. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - December 13, 2022 Category: Drugs & Pharmacology Authors: R Joshi B Medhi A Prakash S Chandy J Ranjalkar HR Bright J Basker L Govindraj PK Chugh CD Tripathi DK Badyal S Balakrishnan R Jhaj AK Shukla S Atal A Najmi A Banerjee S Kamat RK Tripathi YC Shetty U Parmar N Rege H Dikshit H Mishra SS Roy S Chatterjee A H Source Type: research
A comparative study of intravenous low doses of dexmedetomidine, fentanyl, and magnesium sulfate for attenuation of hemodynamic response to endotracheal intubation
CONCLUSION: Efficacy of low doses of both dexmedetomidine and fentanyl was equipotent in attenuating response in comparison with MgSO4, and we conclude that dexmedetomidine can serve as an alternative to fentanyl. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - December 13, 2022 Category: Drugs & Pharmacology Authors: Sharmishtha Shukla Reena R Kadni Joel J Chakravarthy K Varghese Zachariah Source Type: research
Imaging techniques in drug development
Shreya Gupta, Ajay Prakash, Bikash MedhiIndian Journal of Pharmacology 2022 54(5):309-313 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - December 13, 2022 Category: Drugs & Pharmacology Authors: Shreya Gupta Ajay Prakash Bikash Medhi Source Type: research
Celecoxib-tramadol co-crystal: Efficacy in acute postoperative pain
Abhijit Sukumaran NairIndian Journal of Pharmacology 2022 54(4):297-298 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - October 6, 2022 Category: Drugs & Pharmacology Authors: Abhijit Sukumaran Nair Source Type: research
Severe progressive dermatomyositis in a patient with metastatic ovarian cancer using bevacizumab
Dilek Menteþoðlu, Sibel Doğan Günaydın, Sibel Ersoy-Evans, Nilgün Atakan, Özay Gököz, Ömer Karadağ, Saadettin KılıçkapIndian Journal of Pharmacology 2022 54(4):295-296 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - October 6, 2022 Category: Drugs & Pharmacology Authors: Dilek Mente þ o ð lu Sibel Do & #287;an G & #252;nayd & #305;n Sibel Ersoy-Evans Nilg & #252;n Atakan & #214;zay G & #246;k & #246;z & #214;mer Karada & #287; Saadettin K & #305;l & #305; & #231;kap Source Type: research
Systems approach to strengthen faculty development program in India to address Competency-Based Medical Education: A roadmap
Indranil Saha, Bobby PaulIndian Journal of Pharmacology 2022 54(4):292-294 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - October 6, 2022 Category: Drugs & Pharmacology Authors: Indranil Saha Bobby Paul Source Type: research
