Comparison of patients using lamivudine, entecavir, and tenofovir according to liver fibrosis markers fibrosis-4 and aspartate aminotransferase-to-platelet ratio index scores
CONCLUSION: Consistent with the study outcome, when we consider FIB regression, tenofovir and entecavir regimens were found more effective than lamivudine. In addition, entecavir was more effective than the other two drugs after the 1st year. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - March 20, 2023 Category: Drugs & Pharmacology Authors: Huseyin Dogus Okan Oguz Karabay Ertugrul Guclu Mustafa Baran Inci Aziz Ogutlu Source Type: research

Efficacy and safety analysis of prucalopride in refractory chronic constipation cases in a tertiary care hospital in Eastern India: A randomized, single-blind, placebo-controlled study
CONCLUSION: Prucalopride is effective in laxative refractory CC cases with a good safety profile. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - March 20, 2023 Category: Drugs & Pharmacology Authors: Suhasini Dehury Sourya Mohapatra Haribhakti Seba Das Siddhartha Goutam Chetna Kaushik Source Type: research

Concept of essential medicines and recent updates
Shreya Gupta, J Kumaravel, Ajay Prakash, Bikash MedhiIndian Journal of Pharmacology 2023 55(1):1-5 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - March 20, 2023 Category: Drugs & Pharmacology Authors: Shreya Gupta J Kumaravel Ajay Prakash Bikash Medhi Source Type: research

Baboon syndrome with lactulose: An apparently inert drug causing a systemic reaction
Diksha Agrawal, Pooja AroraIndian Journal of Pharmacology 2022 54(6):464-465 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - January 31, 2023 Category: Drugs & Pharmacology Authors: Diksha Agrawal Pooja Arora Source Type: research

Intradermal versus intramuscular COVID-19 vaccination aiming at protection for delta variant: cost utility analysis
Rujittika Mungmunpuntipantip, Viroj WiwanitkitIndian Journal of Pharmacology 2022 54(6):462-463 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - January 31, 2023 Category: Drugs & Pharmacology Authors: Rujittika Mungmunpuntipantip Viroj Wiwanitkit Source Type: research

An idiosyncratic reaction of unilateral common peroneal nerve palsy associated with below desired therapeutic range of tacrolimus level in a patient postheart transplantation
We report a 21-year-old patient, who underwent heart transplantation after a suitable donor was identified, and presented with a new-onset right side foot drop on the 10th postoperative day. According to the WHO-Uppsala Monitoring Center causality assessment scale, the likely culprit agent is TAC. Rapid and progressive improvement of foot drop occurred after stopping it and changed over to cyclosporine. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - January 31, 2023 Category: Drugs & Pharmacology Authors: Ayush Srivastava P Ansuman Abhisek Shweta Supriya Pradhan Source Type: research

Paxlovid: A promising drug for the challenging treatment of SARS-COV-2 in the pandemic era
Niraj Niraj, Sonia Shinde Mahajan, Ajay Prakash, Phulen Sarma, Bikash MedhiIndian Journal of Pharmacology 2022 54(6):452-458 Coronavirus infection is a pandemic threat and the most dangerous disease of the 21st century. Despite the rigorous exertion of world-class researchers, there is no perfect cure for it. It has been seen in presently available studies that Paxlovid prevents the progression of diseases and reduces severity in patients tremendously who are at high risk of hospitalization and death. It is a safe oral antiviral drug and has the potential to treat infections from multiple corona variants including omicron...
Source: Indian Journal of Pharmacology - January 31, 2023 Category: Drugs & Pharmacology Authors: Niraj Niraj Sonia Shinde Mahajan Ajay Prakash Phulen Sarma Bikash Medhi Source Type: research

Pharmacological treatment of bipolar disorder in pregnancy: An update on safety considerations
Swarndeep Singh, Raman DeepIndian Journal of Pharmacology 2022 54(6):443-451 Pregnancy in women with bipolar disorder (BD) can be considered a high-risk pregnancy in view of several clinical and pharmacotherapeutic considerations. Pharmacological treatment during pregnancy requires a careful weighing of psychotropic drug exposure against the risk of BD relapse. An untreated bipolar illness can negatively affect the health of mother as well as unborn child in the event of a relapse. Availability of well balanced, latest information on safety of prophylactic drugs for BD is crucial for making informed decisions. The review ...
Source: Indian Journal of Pharmacology - January 31, 2023 Category: Drugs & Pharmacology Authors: Swarndeep Singh Raman Deep Source Type: research

Virtual screening and molecular dynamics simulation study of approved drugs as a binder to the linoleic acid binding site on spike protein of SARS-CoV-2 and double mutant (E484Q and L452R)
CONCLUSION: We have identified 2 ligands (selexipag and pralatrexate) as possible stable binders to the LA binding site in spike trimer (wild and mutant form). Among them, pralatrexate has shown in vitro activity against SARS-CoV-2, validating our study results. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - January 31, 2023 Category: Drugs & Pharmacology Authors: Manisha Prajapat Phulen Sarma Nishant Shekhar Arushi Chauhan Gurjeet Kaur Anusuya Bhattacharyya Pramod Avti Gajendra Choudhary Seema Bansal Saurabh Sharma Hardeep Kaur Subodh Kumar Harvinder Mann Anupam Raja Ashutosh Singh Rahul Singh Amit Raj Sharma Ajay Source Type: research

Evaluation of mechanism(s) of action underlying the antioxidant and antiulcer activity of Sesamum indicum leaves extract in experimental rats
CONCLUSION: Antioxidant, anti-Ulcer, EESIL, and EESIL show antioxidant activity at different concentration. The fallout of the study indicated that the EESIL had improved antiulcer potential due to the decrease in offensive factors and increase in defensive factors. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - January 31, 2023 Category: Drugs & Pharmacology Authors: Shivam Phool Chandra Neetu Sachan Source Type: research

Pharmacovigilance study of amphotericin B for mucormycosis in post-COVID and non-COVID patients at a tertiary care hospital in Eastern India
CONCLUSION: AmphoB deoxycholate use in mucormycosis patients was associated with a high incidence of electrolyte abnormalities and infusion-related reactions. All ADRs subsided with medical management and none were fatal. The safety data generated from this study may be useful in resource-limited settings where the far more expensive liposomal formulation is not being used. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - January 31, 2023 Category: Drugs & Pharmacology Authors: Suparna Chatterjee Manjari Bhattacharjee Avijit Hazra Pradip Mukhopadhyay Biman Kanti Ray Sayan Chatterjee Souvik Dubey Source Type: research

Use of drugs not listed in the National List of Essential Medicines: Findings from a prescription analysis by the Indian Council of Medical Research-Rational Use of Medicines Centres Network in tertiary care hospitals across India
CONCLUSION: This study highlights the extent and pattern of drugs prescribed from outside the NLEM at the tertiary health-care level and the need for training and enhanced awareness among prescribers for greater utilization of the NLEM. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - January 31, 2023 Category: Drugs & Pharmacology Authors: Ratinder Jhaj Aditya Banerjee Nilima Arun Kshirsagar Balakrishnan Sadasivam Sujith J Chandy Heber Rew Bright Preetha Kaur Chugh CD Tripathi Dinesh Kumar Badyal Madhulika Peter Samuel Bikash Medhi Ajay Prakash Rupa Joshi Sandhya Kamat Raakhi Tripathi Urwas Source Type: research

Lasmiditan abortive therapy for episodic migraine in Phase II/III randomized clinical trials: A meta-analysis
CONCLUSION: Lasmiditan demonstrated efficacy as abortive therapy for episodic migraine with central nervous system-related side effects. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - January 31, 2023 Category: Drugs & Pharmacology Authors: Marya Ahsan Ayaz Khurram Mallick Source Type: research

Translational research: Bridging the gap between preclinical and clinical research
Vidya Mahalmani, Shweta Sinha, Ajay Prakash, Bikash MedhiIndian Journal of Pharmacology 2022 54(6):393-396 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - January 31, 2023 Category: Drugs & Pharmacology Authors: Vidya Mahalmani Shweta Sinha Ajay Prakash Bikash Medhi Source Type: research

Atypical presentation of domperidone-induced galactorrhea
Deepthi Yedla, Vijayan SharmilaIndian Journal of Pharmacology 2022 54(5):381-382 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - December 13, 2022 Category: Drugs & Pharmacology Authors: Deepthi Yedla Vijayan Sharmila Source Type: research