Efficacy and safety of steroid therapy in COVID-19: A rapid systematic review and Meta-analysis

CONCLUSION: This study guides the use of steroid across patients with different severity categories of COVID-19. Among mechanically ventilated patients, steroid therapy may be beneficial in terms of reduced mortality. Among “severe and critical” patients; steroid therapy was associated with lowered mortality, decreased requirement of mechanical ventilation, and ICU. However, no benefit was observed in “mild to moderate” population. To conclude, among properly selected patient populations (based-upon clinical severity and biomarker status), steroid administration may prove beneficial in patients with COVID-19.

Source: Indian Journal of Pharmacology - February 19, 2021 Category: Drugs & Pharmacology Authors: Phulen Sarma Anusuya Bhattacharyya Hardeep Kaur Manisha Prajapat Ajay Prakash Subodh Kumar Seema Bansal Richard Kirubakaran Dibbanti Harikrishna Reddy Gaurav Muktesh Karanvir Kaushal Saurabh Sharma Nishant Shekhar Pramod Avti Prasad Thota Bikash Medhi Source Type: research