Thymic stromal lymphopoietin participates in the host response to intra-amniotic inflammation leading to preterm labor and birth
Hum Immunol. 2023 Jul 6:S0198-8859(23)00089-7. doi: 10.1016/j.humimm.2023.06.005. Online ahead of print.ABSTRACTThe aim of this study was to establish the role of thymic stromal lymphopoietin (TSLP) in the intra-amniotic host response of women with spontaneous preterm labor (sPTL) and birth. Amniotic fluid and chorioamniotic membranes (CAM) were collected from women with sPTL who delivered at term (n = 30) or preterm without intra-amniotic inflammation (n = 34), with sterile intra-amniotic inflammation (SIAI, n = 27), or with intra-amniotic infection (IAI, n = 17). Amnion epithelial cells (AEC), Ureaplasma parvum, and Snea...
Source: Human Immunology - July 8, 2023 Category: Allergy & Immunology Authors: Tomi Kanninen Li Tao Roberto Romero Yi Xu Marcia Arenas-Hernandez Jose Galaz Zhenjie Liu Derek Miller Dustyn Levenson Jonathan M Greenberg Jonathan Panzer Justin Padron Kevin R Theis Nardhy Gomez-Lopez Source Type: research
Thymic stromal lymphopoietin participates in the host response to intra-amniotic inflammation leading to preterm labor and birth
Hum Immunol. 2023 Jul 6:S0198-8859(23)00089-7. doi: 10.1016/j.humimm.2023.06.005. Online ahead of print.ABSTRACTThe aim of this study was to establish the role of thymic stromal lymphopoietin (TSLP) in the intra-amniotic host response of women with spontaneous preterm labor (sPTL) and birth. Amniotic fluid and chorioamniotic membranes (CAM) were collected from women with sPTL who delivered at term (n = 30) or preterm without intra-amniotic inflammation (n = 34), with sterile intra-amniotic inflammation (SIAI, n = 27), or with intra-amniotic infection (IAI, n = 17). Amnion epithelial cells (AEC), Ureaplasma parvum, and Snea...
Source: Human Immunology - July 8, 2023 Category: Allergy & Immunology Authors: Tomi Kanninen Li Tao Roberto Romero Yi Xu Marcia Arenas-Hernandez Jose Galaz Zhenjie Liu Derek Miller Dustyn Levenson Jonathan M Greenberg Jonathan Panzer Justin Padron Kevin R Theis Nardhy Gomez-Lopez Source Type: research
Epitopes, paratopes, and other topes 30 years on: Understanding what we are talking about
Hum Immunol. 2023 Jul 3:S0198-8859(23)00097-6. doi: 10.1016/j.humimm.2023.06.006. Online ahead of print.ABSTRACTThe question of which protein antigens, such as HLA class I or class II molecules, will bind, and how well, to a given antibody is often assumed to depend exclusively on the details of protein surface structure. These structures are usually based on static models resulting from X-ray crystallography. While these notions are useful, the ultimate causal factors determining how well a given antigen binds a given antibody are based in thermodynamics and can include atomic mobility and the time-varying conformations o...
Source: Human Immunology - July 5, 2023 Category: Allergy & Immunology Authors: Neil S Greenspan Source Type: research
Epitopes, paratopes, and other topes 30 years on: Understanding what we are talking about
Hum Immunol. 2023 Jul 3:S0198-8859(23)00097-6. doi: 10.1016/j.humimm.2023.06.006. Online ahead of print.ABSTRACTThe question of which protein antigens, such as HLA class I or class II molecules, will bind, and how well, to a given antibody is often assumed to depend exclusively on the details of protein surface structure. These structures are usually based on static models resulting from X-ray crystallography. While these notions are useful, the ultimate causal factors determining how well a given antigen binds a given antibody are based in thermodynamics and can include atomic mobility and the time-varying conformations o...
Source: Human Immunology - July 5, 2023 Category: Allergy & Immunology Authors: Neil S Greenspan Source Type: research
Epitopes, paratopes, and other topes 30 years on: Understanding what we are talking about
Hum Immunol. 2023 Jul 3:S0198-8859(23)00097-6. doi: 10.1016/j.humimm.2023.06.006. Online ahead of print.ABSTRACTThe question of which protein antigens, such as HLA class I or class II molecules, will bind, and how well, to a given antibody is often assumed to depend exclusively on the details of protein surface structure. These structures are usually based on static models resulting from X-ray crystallography. While these notions are useful, the ultimate causal factors determining how well a given antigen binds a given antibody are based in thermodynamics and can include atomic mobility and the time-varying conformations o...
Source: Human Immunology - July 5, 2023 Category: Allergy & Immunology Authors: Neil S Greenspan Source Type: research
Interferon lambda modulates proinflammatory cytokines production in PBMCs from patients with chronic kidney disease
CONCLUSION: High expression of IFNλ was found in CKD patients and was associated with eGFR and disease-related cytokines. More importantly, IFNλ promoted the expression of pro-inflammatory cytokines in PBMCs, suggesting a potential pro-inflammatory role of IFNλ in CKD.PMID:37394297 | DOI:10.1016/j.humimm.2023.06.001 (Source: Human Immunology)
Source: Human Immunology - July 2, 2023 Category: Allergy & Immunology Authors: Yuhao Xia Qiannan Yang Shang Ying Wu Zhicheng Wu Qian Li Jing Du Source Type: research
Interferon lambda modulates proinflammatory cytokines production in PBMCs from patients with chronic kidney disease
CONCLUSION: High expression of IFNλ was found in CKD patients and was associated with eGFR and disease-related cytokines. More importantly, IFNλ promoted the expression of pro-inflammatory cytokines in PBMCs, suggesting a potential pro-inflammatory role of IFNλ in CKD.PMID:37394297 | DOI:10.1016/j.humimm.2023.06.001 (Source: Human Immunology)
Source: Human Immunology - July 2, 2023 Category: Allergy & Immunology Authors: Yuhao Xia Qiannan Yang Shang Ying Wu Zhicheng Wu Qian Li Jing Du Source Type: research
Interferon lambda modulates proinflammatory cytokines production in PBMCs from patients with chronic kidney disease
CONCLUSION: High expression of IFNλ was found in CKD patients and was associated with eGFR and disease-related cytokines. More importantly, IFNλ promoted the expression of pro-inflammatory cytokines in PBMCs, suggesting a potential pro-inflammatory role of IFNλ in CKD.PMID:37394297 | DOI:10.1016/j.humimm.2023.06.001 (Source: Human Immunology)
Source: Human Immunology - July 2, 2023 Category: Allergy & Immunology Authors: Yuhao Xia Qiannan Yang Shang Ying Wu Zhicheng Wu Qian Li Jing Du Source Type: research
Differential NRAMP1gene's D543N genotype frequency: Increased risk of contracting tuberculosis among Venezuelan populations
In conclusion, the results thus indicated that the association between NRAMP1-D543N-A/A genotype and TB in Warao Amerindians could support such allele's role in host susceptibility to Mtb infection.PMID:37380553 | DOI:10.1016/j.humimm.2023.06.003 (Source: Human Immunology)
Source: Human Immunology - June 28, 2023 Category: Allergy & Immunology Authors: Zaida Araujo Milena Camargo Darwin A Moreno P érez Albina Wide Dailobivxon Pacheco Diana D íaz Arévalo Carmen T Celis Giraldo Sandra Salas Jacobus H de Waard Manuel A Patarroyo Source Type: research
Differential NRAMP1gene's D543N genotype frequency: Increased risk of contracting tuberculosis among Venezuelan populations
In conclusion, the results thus indicated that the association between NRAMP1-D543N-A/A genotype and TB in Warao Amerindians could support such allele's role in host susceptibility to Mtb infection.PMID:37380553 | DOI:10.1016/j.humimm.2023.06.003 (Source: Human Immunology)
Source: Human Immunology - June 28, 2023 Category: Allergy & Immunology Authors: Zaida Araujo Milena Camargo Darwin A Moreno P érez Albina Wide Dailobivxon Pacheco Diana D íaz Arévalo Carmen T Celis Giraldo Sandra Salas Jacobus H de Waard Manuel A Patarroyo Source Type: research
Differential NRAMP1gene's D543N genotype frequency: Increased risk of contracting tuberculosis among Venezuelan populations
In conclusion, the results thus indicated that the association between NRAMP1-D543N-A/A genotype and TB in Warao Amerindians could support such allele's role in host susceptibility to Mtb infection.PMID:37380553 | DOI:10.1016/j.humimm.2023.06.003 (Source: Human Immunology)
Source: Human Immunology - June 28, 2023 Category: Allergy & Immunology Authors: Zaida Araujo Milena Camargo Darwin A Moreno P érez Albina Wide Dailobivxon Pacheco Diana D íaz Arévalo Carmen T Celis Giraldo Sandra Salas Jacobus H de Waard Manuel A Patarroyo Source Type: research
Differential NRAMP1gene's D543N genotype frequency: Increased risk of contracting tuberculosis among Venezuelan populations
In conclusion, the results thus indicated that the association between NRAMP1-D543N-A/A genotype and TB in Warao Amerindians could support such allele's role in host susceptibility to Mtb infection.PMID:37380553 | DOI:10.1016/j.humimm.2023.06.003 (Source: Human Immunology)
Source: Human Immunology - June 28, 2023 Category: Allergy & Immunology Authors: Zaida Araujo Milena Camargo Darwin A Moreno P érez Albina Wide Dailobivxon Pacheco Diana D íaz Arévalo Carmen T Celis Giraldo Sandra Salas Jacobus H de Waard Manuel A Patarroyo Source Type: research
Special Issue: 9th International Conference on HLA-G
Hum Immunol. 2023 Jun 24:S0198-8859(23)00088-5. doi: 10.1016/j.humimm.2023.06.004. Online ahead of print.NO ABSTRACTPMID:37365070 | DOI:10.1016/j.humimm.2023.06.004 (Source: Human Immunology)
Source: Human Immunology - June 26, 2023 Category: Allergy & Immunology Authors: Edgardo D Carosella Source Type: research
Special Issue: 9th International Conference on HLA-G
Hum Immunol. 2023 Jun 24:S0198-8859(23)00088-5. doi: 10.1016/j.humimm.2023.06.004. Online ahead of print.NO ABSTRACTPMID:37365070 | DOI:10.1016/j.humimm.2023.06.004 (Source: Human Immunology)
Source: Human Immunology - June 26, 2023 Category: Allergy & Immunology Authors: Edgardo D Carosella Source Type: research
Role of inflammation and immune response in atherosclerosis: Mechanisms, modulations, and therapeutic targets
Hum Immunol. 2023 Jun 21:S0198-8859(23)00086-1. doi: 10.1016/j.humimm.2023.06.002. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs) have emerged as the leading cause of mortality globally, with atherosclerosis being a prominent focus of investigation among medical researchers worldwide. Atherosclerosis is characterized as a disease of the large and medium-sized arteries that is multifocal, accumulative, and immunoinflammatory in nature, resulting from the deposition of lipids. Accumulating evidence suggests that inflammatory responses and immunoregulation play a vital role in the occurrence and development of a...
Source: Human Immunology - June 23, 2023 Category: Allergy & Immunology Authors: Fang Liu Yijun Wang Jiayin Yu Source Type: research
