CXCL1 promotes immune escape in colorectal cancer by autophagy-mediated MHC-I degradation
CONCLUSION: CXCL1 promoted immune escape in CRC by autophagy-mediated MHC-I degradation, suggesting that CXCL1 may be a possible immunotherapeutic target for CRC.PMID:37802708 | DOI:10.1016/j.humimm.2023.09.002 (Source: Human Immunology)
Source: Human Immunology - October 6, 2023 Category: Allergy & Immunology Authors: Jianqiao Kong Song Xu Peng Zhang Yun Zhao Source Type: research
DNA methylation and expression of LGR6 gene in ankylosing spondylitis: A case-control study
CONCLUSION: The present study revealed that LGR6 DNA methylation dysregulation may be involved in the pathogenesis of AS from an epigenetic perspective for the first time, with the aim of providing new directions for biomarker identification and treatment development for AS patients.PMID:37802707 | DOI:10.1016/j.humimm.2023.09.005 (Source: Human Immunology)
Source: Human Immunology - October 6, 2023 Category: Allergy & Immunology Authors: Yujie Deng Wei Xu Man Ni Xiaoya Sun Xinqi Wang Tao Zhang Faming Pan Source Type: research
CXCL1 promotes immune escape in colorectal cancer by autophagy-mediated MHC-I degradation
CONCLUSION: CXCL1 promoted immune escape in CRC by autophagy-mediated MHC-I degradation, suggesting that CXCL1 may be a possible immunotherapeutic target for CRC.PMID:37802708 | DOI:10.1016/j.humimm.2023.09.002 (Source: Human Immunology)
Source: Human Immunology - October 6, 2023 Category: Allergy & Immunology Authors: Jianqiao Kong Song Xu Peng Zhang Yun Zhao Source Type: research
DNA methylation and expression of LGR6 gene in ankylosing spondylitis: A case-control study
CONCLUSION: The present study revealed that LGR6 DNA methylation dysregulation may be involved in the pathogenesis of AS from an epigenetic perspective for the first time, with the aim of providing new directions for biomarker identification and treatment development for AS patients.PMID:37802707 | DOI:10.1016/j.humimm.2023.09.005 (Source: Human Immunology)
Source: Human Immunology - October 6, 2023 Category: Allergy & Immunology Authors: Yujie Deng Wei Xu Man Ni Xiaoya Sun Xinqi Wang Tao Zhang Faming Pan Source Type: research
CXCL1 promotes immune escape in colorectal cancer by autophagy-mediated MHC-I degradation
CONCLUSION: CXCL1 promoted immune escape in CRC by autophagy-mediated MHC-I degradation, suggesting that CXCL1 may be a possible immunotherapeutic target for CRC.PMID:37802708 | DOI:10.1016/j.humimm.2023.09.002 (Source: Human Immunology)
Source: Human Immunology - October 6, 2023 Category: Allergy & Immunology Authors: Jianqiao Kong Song Xu Peng Zhang Yun Zhao Source Type: research
DNA methylation and expression of LGR6 gene in ankylosing spondylitis: A case-control study
CONCLUSION: The present study revealed that LGR6 DNA methylation dysregulation may be involved in the pathogenesis of AS from an epigenetic perspective for the first time, with the aim of providing new directions for biomarker identification and treatment development for AS patients.PMID:37802707 | DOI:10.1016/j.humimm.2023.09.005 (Source: Human Immunology)
Source: Human Immunology - October 6, 2023 Category: Allergy & Immunology Authors: Yujie Deng Wei Xu Man Ni Xiaoya Sun Xinqi Wang Tao Zhang Faming Pan Source Type: research
CXCL1 promotes immune escape in colorectal cancer by autophagy-mediated MHC-I degradation
CONCLUSION: CXCL1 promoted immune escape in CRC by autophagy-mediated MHC-I degradation, suggesting that CXCL1 may be a possible immunotherapeutic target for CRC.PMID:37802708 | DOI:10.1016/j.humimm.2023.09.002 (Source: Human Immunology)
Source: Human Immunology - October 6, 2023 Category: Allergy & Immunology Authors: Jianqiao Kong Song Xu Peng Zhang Yun Zhao Source Type: research
CXCL1 promotes immune escape in colorectal cancer by autophagy-mediated MHC-I degradation
CONCLUSION: CXCL1 promoted immune escape in CRC by autophagy-mediated MHC-I degradation, suggesting that CXCL1 may be a possible immunotherapeutic target for CRC.PMID:37802708 | DOI:10.1016/j.humimm.2023.09.002 (Source: Human Immunology)
Source: Human Immunology - October 6, 2023 Category: Allergy & Immunology Authors: Jianqiao Kong Song Xu Peng Zhang Yun Zhao Source Type: research
DNA methylation and expression of LGR6 gene in ankylosing spondylitis: A case-control study
CONCLUSION: The present study revealed that LGR6 DNA methylation dysregulation may be involved in the pathogenesis of AS from an epigenetic perspective for the first time, with the aim of providing new directions for biomarker identification and treatment development for AS patients.PMID:37802707 | DOI:10.1016/j.humimm.2023.09.005 (Source: Human Immunology)
Source: Human Immunology - October 6, 2023 Category: Allergy & Immunology Authors: Yujie Deng Wei Xu Man Ni Xiaoya Sun Xinqi Wang Tao Zhang Faming Pan Source Type: research
Coronavirus-19 disease risk and protective factors associated with HLA/KIR polymorphisms in Ecuadorian patients residing in Madrid
CONCLUSION: HLA-B*39 alleles might be genetic risk factors for developing COVID-19 in Ecuadorian individuals. In the presence of its ligand C*04, the natural killer-activating receptor KIR2DS4 might also increase the risk of developing COVID-19, while, in the presence of HLA-Bw4 alleles, the inhibitory receptor KIR3DL1 might play a protective role. Patients with COVID-19 who carry HLA-A*24:02 and HLA-DRB1*09:01 alleles might be protected against more severe forms of COVID-19.PMID:37777360 | DOI:10.1016/j.humimm.2023.09.004 (Source: Human Immunology)
Source: Human Immunology - September 30, 2023 Category: Allergy & Immunology Authors: Antonio Balas Miguel Ángel Moreno-Hidalgo Fernando de la Calle-Prieto Jos é Luis Vicario Marta Arsuaga Elena Trigo Rosa de Miguel-Buckley Teresa Bell ón Marta D íaz-Menéndez Source Type: research
Coronavirus-19 disease risk and protective factors associated with HLA/KIR polymorphisms in Ecuadorian patients residing in Madrid
CONCLUSION: HLA-B*39 alleles might be genetic risk factors for developing COVID-19 in Ecuadorian individuals. In the presence of its ligand C*04, the natural killer-activating receptor KIR2DS4 might also increase the risk of developing COVID-19, while, in the presence of HLA-Bw4 alleles, the inhibitory receptor KIR3DL1 might play a protective role. Patients with COVID-19 who carry HLA-A*24:02 and HLA-DRB1*09:01 alleles might be protected against more severe forms of COVID-19.PMID:37777360 | DOI:10.1016/j.humimm.2023.09.004 (Source: Human Immunology)
Source: Human Immunology - September 30, 2023 Category: Allergy & Immunology Authors: Antonio Balas Miguel Ángel Moreno-Hidalgo Fernando de la Calle-Prieto Jos é Luis Vicario Marta Arsuaga Elena Trigo Rosa de Miguel-Buckley Teresa Bell ón Marta D íaz-Menéndez Source Type: research
Coronavirus-19 disease risk and protective factors associated with HLA/KIR polymorphisms in Ecuadorian patients residing in Madrid
CONCLUSION: HLA-B*39 alleles might be genetic risk factors for developing COVID-19 in Ecuadorian individuals. In the presence of its ligand C*04, the natural killer-activating receptor KIR2DS4 might also increase the risk of developing COVID-19, while, in the presence of HLA-Bw4 alleles, the inhibitory receptor KIR3DL1 might play a protective role. Patients with COVID-19 who carry HLA-A*24:02 and HLA-DRB1*09:01 alleles might be protected against more severe forms of COVID-19.PMID:37777360 | DOI:10.1016/j.humimm.2023.09.004 (Source: Human Immunology)
Source: Human Immunology - September 30, 2023 Category: Allergy & Immunology Authors: Antonio Balas Miguel Ángel Moreno-Hidalgo Fernando de la Calle-Prieto Jos é Luis Vicario Marta Arsuaga Elena Trigo Rosa de Miguel-Buckley Teresa Bell ón Marta D íaz-Menéndez Source Type: research
Coronavirus-19 disease risk and protective factors associated with HLA/KIR polymorphisms in Ecuadorian patients residing in Madrid
CONCLUSION: HLA-B*39 alleles might be genetic risk factors for developing COVID-19 in Ecuadorian individuals. In the presence of its ligand C*04, the natural killer-activating receptor KIR2DS4 might also increase the risk of developing COVID-19, while, in the presence of HLA-Bw4 alleles, the inhibitory receptor KIR3DL1 might play a protective role. Patients with COVID-19 who carry HLA-A*24:02 and HLA-DRB1*09:01 alleles might be protected against more severe forms of COVID-19.PMID:37777360 | DOI:10.1016/j.humimm.2023.09.004 (Source: Human Immunology)
Source: Human Immunology - September 30, 2023 Category: Allergy & Immunology Authors: Antonio Balas Miguel Ángel Moreno-Hidalgo Fernando de la Calle-Prieto Jos é Luis Vicario Marta Arsuaga Elena Trigo Rosa de Miguel-Buckley Teresa Bell ón Marta D íaz-Menéndez Source Type: research
Coronavirus-19 disease risk and protective factors associated with HLA/KIR polymorphisms in Ecuadorian patients residing in Madrid
CONCLUSION: HLA-B*39 alleles might be genetic risk factors for developing COVID-19 in Ecuadorian individuals. In the presence of its ligand C*04, the natural killer-activating receptor KIR2DS4 might also increase the risk of developing COVID-19, while, in the presence of HLA-Bw4 alleles, the inhibitory receptor KIR3DL1 might play a protective role. Patients with COVID-19 who carry HLA-A*24:02 and HLA-DRB1*09:01 alleles might be protected against more severe forms of COVID-19.PMID:37777360 | DOI:10.1016/j.humimm.2023.09.004 (Source: Human Immunology)
Source: Human Immunology - September 30, 2023 Category: Allergy & Immunology Authors: Antonio Balas Miguel Ángel Moreno-Hidalgo Fernando de la Calle-Prieto Jos é Luis Vicario Marta Arsuaga Elena Trigo Rosa de Miguel-Buckley Teresa Bell ón Marta D íaz-Menéndez Source Type: research
In silico analysis of missense SNPs in TNFR1a and their possible therapeutic or pathogenic role in immune diseases
In this study, six nsSNPs at five different evolutionary conserved regions are predicted to be detrimental to the structure and/or function of TNFR1a by using numerous computational tools. Their 3D models are also proposed in this study. Besides, they were found to reduce the stability and affect the molecular mechanisms of this protein. Two contrasting possibilities might happen because of these substitutions. One, they might reduce the production of TNFa which is overexpressed in inflammatory diseases, hence can play therapeutic role in such diseases. Second, they might possibly hinder the apoptosis to occur which can ef...
Source: Human Immunology - September 25, 2023 Category: Allergy & Immunology Authors: Maria Arshad Nabeel Noor Zunair Iqbal Hadiqa Jaleel Source Type: research
