Polymorphisms in the CD6-ALCAM axis may modulate psoriasis risk and outcomes
Hum Immunol. 2024 Apr 5:110797. doi: 10.1016/j.humimm.2024.110797. Online ahead of print.ABSTRACTThe fact that CD6, along with its ligand - ALCAM, plays a role in regulating T cell activation makes the genes encoding these molecules promising candidates for research in T cell-mediated diseases such as psoriasis vulgaris (PsV). Our study aimed to determine whether CD6 (rs17824933C>G, rs11230563C>T and rs12360861G>A) and ALCAM (rs6437585C>T, rs11559013G>A) polymorphisms may affect psoriasis susceptibility and severity (assessed by Psoriasis Area and Severity Index (PASI)). Moreover, the presence of HLA-C*06:02...
Source: Human Immunology - April 5, 2024 Category: Allergy & Immunology Authors: Marta Wagner Maciej Sobczy ński Andrzej Wi śniewski Łukasz Matusiak Piotr Ku śnierczyk Monika Jasek Source Type: research
Tolerance in intestinal transplantation
Hum Immunol. 2024 Apr 5:110793. doi: 10.1016/j.humimm.2024.110793. Online ahead of print.ABSTRACTIntestinal transplantation (ITx) is highly immunogenic, resulting in the need for high levels of immunosuppression, with frequent complications along with high rejection rates. Tolerance induction would provide a solution to these limitations. Detailed studies of alloreactive T cell clones as well as multiparameter flow cytometry in the graft and peripheral tissues have provided evidence for several tolerance mechanisms that occur spontaneously following ITx, which might provide targets for further interventions. These include ...
Source: Human Immunology - April 5, 2024 Category: Allergy & Immunology Authors: Megan Sykes Source Type: research
Validation of tag SNPs for multiple sclerosis HLA risk alleles across the 1000 genomes panel
We examined 19 SNPs reported to be in high LD with these alleles in 2,502 healthy subjects included in the 1000 Genomes panel having typed HLA data. Examination of 3 indices (LD R2 values, sensitivity and specificity, minor allele frequency) revealed few SNPs with high tagging performance. All SNPs examined that tag DRB1*15:01 were in perfect LD in the British population; three showed high tagging performance in 4 of the 5 European, and 2 of the 4 American populations. For DQB1*06:02, with no previously validated tag SNPs, we show that rs3135388 has high tagging performance in one South Asian, one American, and one Europea...
Source: Human Immunology - April 4, 2024 Category: Allergy & Immunology Authors: Anne I Boullerne Benjamin Goudey Julien Paganini Michael Erlichster Sujata Gaitonde Douglas L Feinstein Source Type: research
Validation of tag SNPs for multiple sclerosis HLA risk alleles across the 1000 genomes panel
We examined 19 SNPs reported to be in high LD with these alleles in 2,502 healthy subjects included in the 1000 Genomes panel having typed HLA data. Examination of 3 indices (LD R2 values, sensitivity and specificity, minor allele frequency) revealed few SNPs with high tagging performance. All SNPs examined that tag DRB1*15:01 were in perfect LD in the British population; three showed high tagging performance in 4 of the 5 European, and 2 of the 4 American populations. For DQB1*06:02, with no previously validated tag SNPs, we show that rs3135388 has high tagging performance in one South Asian, one American, and one Europea...
Source: Human Immunology - April 4, 2024 Category: Allergy & Immunology Authors: Anne I Boullerne Benjamin Goudey Julien Paganini Michael Erlichster Sujata Gaitonde Douglas L Feinstein Source Type: research
Everolimus treatment enhances inhibitory immune checkpoint molecules' expression in monocyte-derived dendritic cells
CONCLUSION: The findings of this study show that Everolimus can target DCs and affect their phenotype and function in order to shift them toward a partially tolerogenic state. However, additional research is required to gain a comprehensive understanding of the precise impact of Everolimus on the activation status of DCs.PMID:38569354 | DOI:10.1016/j.humimm.2024.110798 (Source: Human Immunology)
Source: Human Immunology - April 3, 2024 Category: Allergy & Immunology Authors: Bahar Naseri Amirhossein Mardi Arezou Khosrojerdi Elham Baghbani Leili Aghebati-Maleki Amirhossein Hatami-Sadr Javad Ahmadian Heris Shabnam Eskandarzadeh Mahshid Kafshdouz Nazila Alizadeh Behzad Baradaran Source Type: research
Role of HLA-G in tumors and upon COVID-19 infection
Hum Immunol. 2024 Mar 29:110792. doi: 10.1016/j.humimm.2024.110792. Online ahead of print.ABSTRACTHLA-G expression of tumors and upon viral infections is involved in their immune escape leading to the evasion from both T and NK cell recognition. The underlying mechanisms of HLA-G expression in both pathophysiologic conditions are broad and range from genetic abnormalities to epigenetic, transcriptional and posttranscriptional regulation. This review summarizes the current knowledge of the frequency, regulation and clinical relevance of HLA-G expression upon neoplastic and viral transformation, its interaction with componen...
Source: Human Immunology - March 30, 2024 Category: Allergy & Immunology Authors: Barbara Seliger Source Type: research
Role of HLA-G in tumors and upon COVID-19 infection
Hum Immunol. 2024 Mar 29:110792. doi: 10.1016/j.humimm.2024.110792. Online ahead of print.ABSTRACTHLA-G expression of tumors and upon viral infections is involved in their immune escape leading to the evasion from both T and NK cell recognition. The underlying mechanisms of HLA-G expression in both pathophysiologic conditions are broad and range from genetic abnormalities to epigenetic, transcriptional and posttranscriptional regulation. This review summarizes the current knowledge of the frequency, regulation and clinical relevance of HLA-G expression upon neoplastic and viral transformation, its interaction with componen...
Source: Human Immunology - March 30, 2024 Category: Allergy & Immunology Authors: Barbara Seliger Source Type: research
Role of HLA-G in tumors and upon COVID-19 infection
Hum Immunol. 2024 Mar 29:110792. doi: 10.1016/j.humimm.2024.110792. Online ahead of print.ABSTRACTHLA-G expression of tumors and upon viral infections is involved in their immune escape leading to the evasion from both T and NK cell recognition. The underlying mechanisms of HLA-G expression in both pathophysiologic conditions are broad and range from genetic abnormalities to epigenetic, transcriptional and posttranscriptional regulation. This review summarizes the current knowledge of the frequency, regulation and clinical relevance of HLA-G expression upon neoplastic and viral transformation, its interaction with componen...
Source: Human Immunology - March 30, 2024 Category: Allergy & Immunology Authors: Barbara Seliger Source Type: research
Role of HLA-G in tumors and upon COVID-19 infection
Hum Immunol. 2024 Mar 29:110792. doi: 10.1016/j.humimm.2024.110792. Online ahead of print.ABSTRACTHLA-G expression of tumors and upon viral infections is involved in their immune escape leading to the evasion from both T and NK cell recognition. The underlying mechanisms of HLA-G expression in both pathophysiologic conditions are broad and range from genetic abnormalities to epigenetic, transcriptional and posttranscriptional regulation. This review summarizes the current knowledge of the frequency, regulation and clinical relevance of HLA-G expression upon neoplastic and viral transformation, its interaction with componen...
Source: Human Immunology - March 30, 2024 Category: Allergy & Immunology Authors: Barbara Seliger Source Type: research
Donor genetic determinant of thymopoiesis, rs2204985, and stem cell transplantation outcome in a multipopulation cohort
CONCLUSION: Weak support for the genetic association between rs2204985, previously also associated with thymus function, and the outcome of SCT could be found in a cohort from four populations.PMID:38553383 | DOI:10.1016/j.humimm.2024.110791 (Source: Human Immunology)
Source: Human Immunology - March 29, 2024 Category: Allergy & Immunology Authors: Julia Nihtil ä Urpu Salmenniemi Maija It älä-Remes Rachel E Crossland David Gallardo Katarzyna Bogunia-Kubik Piotr Łacina Maria Bieniaszewska Sebastian Giebel Kati Hyv ärinen Eliisa Kek äläinen Jarmo Ritari Jukka Partanen Source Type: research
Assessment of chimerism by next generation sequencing: A comparison to STR/qPCR methods
In this study, an insertion/deletion-based multiplex chimerism assay by next generation sequencing (NGS) was evaluated using 5 simulated unrelated donor-recipient combinations from 10 volunteers. Median number of informative markers detected was 8 (range = 5 - 11). The limit of quantitation (LoQ) was determined to be 0.1 % recipient. Assay sample number/batch was 10-20 and total assay time was 19-31 h (manual labor = 2.1 h). Additionally, 50 peripheral blood samples from 5 allo-HSCT recipients (related: N = 4; unrelated: N = 1) were tested by NGS and STR/qPCR. Median number of informative markers detected was 7 (range = 4 ...
Source: Human Immunology - March 29, 2024 Category: Allergy & Immunology Authors: Darren Brow Hiroko Shike Jasmine Kendrick Linnea Pettersson Shin Mineishi David F Claxton Baldeep Wirk Joseph Cioccio Robert J Greiner David Viswanatha Mohamed A Kharfan-Dabaja Zhuo Li Jennifer Tyler Mohamed Elrefaei Source Type: research
Donor genetic determinant of thymopoiesis, rs2204985, and stem cell transplantation outcome in a multipopulation cohort
CONCLUSION: Weak support for the genetic association between rs2204985, previously also associated with thymus function, and the outcome of SCT could be found in a cohort from four populations.PMID:38553383 | DOI:10.1016/j.humimm.2024.110791 (Source: Human Immunology)
Source: Human Immunology - March 29, 2024 Category: Allergy & Immunology Authors: Julia Nihtil ä Urpu Salmenniemi Maija It älä-Remes Rachel E Crossland David Gallardo Katarzyna Bogunia-Kubik Piotr Łacina Maria Bieniaszewska Sebastian Giebel Kati Hyv ärinen Eliisa Kek äläinen Jarmo Ritari Jukka Partanen Source Type: research
Assessment of chimerism by next generation sequencing: A comparison to STR/qPCR methods
In this study, an insertion/deletion-based multiplex chimerism assay by next generation sequencing (NGS) was evaluated using 5 simulated unrelated donor-recipient combinations from 10 volunteers. Median number of informative markers detected was 8 (range = 5 - 11). The limit of quantitation (LoQ) was determined to be 0.1 % recipient. Assay sample number/batch was 10-20 and total assay time was 19-31 h (manual labor = 2.1 h). Additionally, 50 peripheral blood samples from 5 allo-HSCT recipients (related: N = 4; unrelated: N = 1) were tested by NGS and STR/qPCR. Median number of informative markers detected was 7 (range = 4 ...
Source: Human Immunology - March 29, 2024 Category: Allergy & Immunology Authors: Darren Brow Hiroko Shike Jasmine Kendrick Linnea Pettersson Shin Mineishi David F Claxton Baldeep Wirk Joseph Cioccio Robert J Greiner David Viswanatha Mohamed A Kharfan-Dabaja Zhuo Li Jennifer Tyler Mohamed Elrefaei Source Type: research
PIRCHE application major versions 3 and 4 lead to equivalent T cell epitope mismatch scores in solid organ and stem cell transplantation modules
Hum Immunol. 2024 Mar 22:110789. doi: 10.1016/j.humimm.2024.110789. Online ahead of print.ABSTRACTPIRCHE scores in organ and stem cell transplantation have been shown to correlate with increased risk of donor-specific HLA antibodies and graft-versus-host disease, respectively. With advancements of the PIRCHE application server, it is critical to compare the predicted scores with previous versions. This manuscript compares the newly introduced PIRCHE version 4.2 with its predecessor version 3.3, which was widely used in retrospective studies, using a virtual cohort of 10,000 transplant pairs. In the stem cell transplantatio...
Source: Human Immunology - March 23, 2024 Category: Allergy & Immunology Authors: Benedict M Matern Matthias Niemann Source Type: research
Targeting the adenosine signaling pathway in macrophages for cancer immunotherapy
Hum Immunol. 2024 Mar 22:110774. doi: 10.1016/j.humimm.2024.110774. Online ahead of print.ABSTRACTOne of the ways in which macrophages support tumorigenic growth is by producing adenosine, which acts to dampen antitumor immune responses and is generated by both tumor and immune cells in the tumor microenvironment (TME). Two cell surface expressed molecules, CD73 and CD39, boost catalytic adenosine triphosphate, leading to further increased adenosine synthesis, under hypoxic circumstances in the TME. There are four receptors (A1, A2A, A2B, and A3) expressed on macrophages that allow adenosine to perform its immunomodulatory...
Source: Human Immunology - March 23, 2024 Category: Allergy & Immunology Authors: Han Yang Zongliang Zhang Kai Zhao Yulian Zhang Xinbao Yin Guanqun Zhu Zhenlin Wang Xuechuan Yan Xueyu Li Tianzhen He Ke Wang Source Type: research
