Coronavirus-19 disease risk and protective factors associated with HLA/KIR polymorphisms in Ecuadorian patients residing in Madrid
CONCLUSION: HLA-B*39 alleles might be genetic risk factors for developing COVID-19 in Ecuadorian individuals. In the presence of its ligand C*04, the natural killer-activating receptor KIR2DS4 might also increase the risk of developing COVID-19, while, in the presence of HLA-Bw4 alleles, the inhibitory receptor KIR3DL1 might play a protective role. Patients with COVID-19 who carry HLA-A*24:02 and HLA-DRB1*09:01 alleles might be protected against more severe forms of COVID-19.PMID:37777360 | DOI:10.1016/j.humimm.2023.09.004 (Source: Human Immunology)
Source: Human Immunology - September 30, 2023 Category: Allergy & Immunology Authors: Antonio Balas Miguel Ángel Moreno-Hidalgo Fernando de la Calle-Prieto Jos é Luis Vicario Marta Arsuaga Elena Trigo Rosa de Miguel-Buckley Teresa Bell ón Marta D íaz-Menéndez Source Type: research
In silico analysis of missense SNPs in TNFR1a and their possible therapeutic or pathogenic role in immune diseases
In this study, six nsSNPs at five different evolutionary conserved regions are predicted to be detrimental to the structure and/or function of TNFR1a by using numerous computational tools. Their 3D models are also proposed in this study. Besides, they were found to reduce the stability and affect the molecular mechanisms of this protein. Two contrasting possibilities might happen because of these substitutions. One, they might reduce the production of TNFa which is overexpressed in inflammatory diseases, hence can play therapeutic role in such diseases. Second, they might possibly hinder the apoptosis to occur which can ef...
Source: Human Immunology - September 25, 2023 Category: Allergy & Immunology Authors: Maria Arshad Nabeel Noor Zunair Iqbal Hadiqa Jaleel Source Type: research
In silico analysis of missense SNPs in TNFR1a and their possible therapeutic or pathogenic role in immune diseases
In this study, six nsSNPs at five different evolutionary conserved regions are predicted to be detrimental to the structure and/or function of TNFR1a by using numerous computational tools. Their 3D models are also proposed in this study. Besides, they were found to reduce the stability and affect the molecular mechanisms of this protein. Two contrasting possibilities might happen because of these substitutions. One, they might reduce the production of TNFa which is overexpressed in inflammatory diseases, hence can play therapeutic role in such diseases. Second, they might possibly hinder the apoptosis to occur which can ef...
Source: Human Immunology - September 25, 2023 Category: Allergy & Immunology Authors: Maria Arshad Nabeel Noor Zunair Iqbal Hadiqa Jaleel Source Type: research
In silico analysis of missense SNPs in TNFR1a and their possible therapeutic or pathogenic role in immune diseases
In this study, six nsSNPs at five different evolutionary conserved regions are predicted to be detrimental to the structure and/or function of TNFR1a by using numerous computational tools. Their 3D models are also proposed in this study. Besides, they were found to reduce the stability and affect the molecular mechanisms of this protein. Two contrasting possibilities might happen because of these substitutions. One, they might reduce the production of TNFa which is overexpressed in inflammatory diseases, hence can play therapeutic role in such diseases. Second, they might possibly hinder the apoptosis to occur which can ef...
Source: Human Immunology - September 25, 2023 Category: Allergy & Immunology Authors: Maria Arshad Nabeel Noor Zunair Iqbal Hadiqa Jaleel Source Type: research
In silico analysis of missense SNPs in TNFR1a and their possible therapeutic or pathogenic role in immune diseases
In this study, six nsSNPs at five different evolutionary conserved regions are predicted to be detrimental to the structure and/or function of TNFR1a by using numerous computational tools. Their 3D models are also proposed in this study. Besides, they were found to reduce the stability and affect the molecular mechanisms of this protein. Two contrasting possibilities might happen because of these substitutions. One, they might reduce the production of TNFa which is overexpressed in inflammatory diseases, hence can play therapeutic role in such diseases. Second, they might possibly hinder the apoptosis to occur which can ef...
Source: Human Immunology - September 25, 2023 Category: Allergy & Immunology Authors: Maria Arshad Nabeel Noor Zunair Iqbal Hadiqa Jaleel Source Type: research
USP8 targeted by Mir-874-3p promotes trophoblastic cell invasion by stabilizing the expression of ENaC on trophoblast membrane
Hum Immunol. 2023 Sep 21:S0198-8859(23)00322-1. doi: 10.1016/j.humimm.2023.09.001. Online ahead of print.ABSTRACTThe aim of this study was to investigate the role of ubiquitin-specific peptidase 8 (USP8) in human trophoblast cells and its molecular mechanism. Based on the GSE30186 dataset, USP8 was identified as a downregulated gene in pre-eclampsia (PE). Analysis of clinical samples also revealed that USP8 expression at both the mRNA and protein levels in placental tissue from patients with PE was significantly lower than that from healthy pregnant women. Plate clone formation, scratch-wound healing, Transwell, tubule for...
Source: Human Immunology - September 23, 2023 Category: Allergy & Immunology Authors: Suqin Zhang Yanmei Shi Pingping Dong Source Type: research
USP8 targeted by Mir-874-3p promotes trophoblastic cell invasion by stabilizing the expression of ENaC on trophoblast membrane
Hum Immunol. 2023 Sep 21:S0198-8859(23)00322-1. doi: 10.1016/j.humimm.2023.09.001. Online ahead of print.ABSTRACTThe aim of this study was to investigate the role of ubiquitin-specific peptidase 8 (USP8) in human trophoblast cells and its molecular mechanism. Based on the GSE30186 dataset, USP8 was identified as a downregulated gene in pre-eclampsia (PE). Analysis of clinical samples also revealed that USP8 expression at both the mRNA and protein levels in placental tissue from patients with PE was significantly lower than that from healthy pregnant women. Plate clone formation, scratch-wound healing, Transwell, tubule for...
Source: Human Immunology - September 23, 2023 Category: Allergy & Immunology Authors: Suqin Zhang Yanmei Shi Pingping Dong Source Type: research
USP8 targeted by Mir-874-3p promotes trophoblastic cell invasion by stabilizing the expression of ENaC on trophoblast membrane
Hum Immunol. 2023 Sep 21:S0198-8859(23)00322-1. doi: 10.1016/j.humimm.2023.09.001. Online ahead of print.ABSTRACTThe aim of this study was to investigate the role of ubiquitin-specific peptidase 8 (USP8) in human trophoblast cells and its molecular mechanism. Based on the GSE30186 dataset, USP8 was identified as a downregulated gene in pre-eclampsia (PE). Analysis of clinical samples also revealed that USP8 expression at both the mRNA and protein levels in placental tissue from patients with PE was significantly lower than that from healthy pregnant women. Plate clone formation, scratch-wound healing, Transwell, tubule for...
Source: Human Immunology - September 23, 2023 Category: Allergy & Immunology Authors: Suqin Zhang Yanmei Shi Pingping Dong Source Type: research
A meta-analysis of epitopes in prostate-specific antigens identifies opportunities and knowledge gaps
CONCLUSION: CEDAR provides a comprehensive repository of epitopes related to prostate-specific antigens. This inventory of epitope data with its wealth of searchable T cell, B cell and MHC ligand information provides a useful tool for the scientific community. At the same time, we identify significant knowledge gaps that could be addressed by experimental analysis.PMID:37679223 | DOI:10.1016/j.humimm.2023.08.145 (Source: Human Immunology)
Source: Human Immunology - September 7, 2023 Category: Allergy & Immunology Authors: Gabriele Foos Nina Blazeska Morten Nielsen Hannah Carter Zeynep Kosaloglu-Yalcin Bjoern Peters Alessandro Sette Source Type: research
A meta-analysis of epitopes in prostate-specific antigens identifies opportunities and knowledge gaps
CONCLUSION: CEDAR provides a comprehensive repository of epitopes related to prostate-specific antigens. This inventory of epitope data with its wealth of searchable T cell, B cell and MHC ligand information provides a useful tool for the scientific community. At the same time, we identify significant knowledge gaps that could be addressed by experimental analysis.PMID:37679223 | DOI:10.1016/j.humimm.2023.08.145 (Source: Human Immunology)
Source: Human Immunology - September 7, 2023 Category: Allergy & Immunology Authors: Gabriele Foos Nina Blazeska Morten Nielsen Hannah Carter Zeynep Kosaloglu-Yalcin Bjoern Peters Alessandro Sette Source Type: research
A meta-analysis of epitopes in prostate-specific antigens identifies opportunities and knowledge gaps
CONCLUSION: CEDAR provides a comprehensive repository of epitopes related to prostate-specific antigens. This inventory of epitope data with its wealth of searchable T cell, B cell and MHC ligand information provides a useful tool for the scientific community. At the same time, we identify significant knowledge gaps that could be addressed by experimental analysis.PMID:37679223 | DOI:10.1016/j.humimm.2023.08.145 (Source: Human Immunology)
Source: Human Immunology - September 7, 2023 Category: Allergy & Immunology Authors: Gabriele Foos Nina Blazeska Morten Nielsen Hannah Carter Zeynep Kosaloglu-Yalcin Bjoern Peters Alessandro Sette Source Type: research
A meta-analysis of epitopes in prostate-specific antigens identifies opportunities and knowledge gaps
CONCLUSION: CEDAR provides a comprehensive repository of epitopes related to prostate-specific antigens. This inventory of epitope data with its wealth of searchable T cell, B cell and MHC ligand information provides a useful tool for the scientific community. At the same time, we identify significant knowledge gaps that could be addressed by experimental analysis.PMID:37679223 | DOI:10.1016/j.humimm.2023.08.145 (Source: Human Immunology)
Source: Human Immunology - September 7, 2023 Category: Allergy & Immunology Authors: Gabriele Foos Nina Blazeska Morten Nielsen Hannah Carter Zeynep Kosaloglu-Yalcin Bjoern Peters Alessandro Sette Source Type: research
A meta-analysis of epitopes in prostate-specific antigens identifies opportunities and knowledge gaps
CONCLUSION: CEDAR provides a comprehensive repository of epitopes related to prostate-specific antigens. This inventory of epitope data with its wealth of searchable T cell, B cell and MHC ligand information provides a useful tool for the scientific community. At the same time, we identify significant knowledge gaps that could be addressed by experimental analysis.PMID:37679223 | DOI:10.1016/j.humimm.2023.08.145 (Source: Human Immunology)
Source: Human Immunology - September 7, 2023 Category: Allergy & Immunology Authors: Gabriele Foos Nina Blazeska Morten Nielsen Hannah Carter Zeynep Kosaloglu-Yalcin Bjoern Peters Alessandro Sette Source Type: research
A meta-analysis of epitopes in prostate-specific antigens identifies opportunities and knowledge gaps
CONCLUSION: CEDAR provides a comprehensive repository of epitopes related to prostate-specific antigens. This inventory of epitope data with its wealth of searchable T cell, B cell and MHC ligand information provides a useful tool for the scientific community. At the same time, we identify significant knowledge gaps that could be addressed by experimental analysis.PMID:37679223 | DOI:10.1016/j.humimm.2023.08.145 (Source: Human Immunology)
Source: Human Immunology - September 7, 2023 Category: Allergy & Immunology Authors: Gabriele Foos Nina Blazeska Morten Nielsen Hannah Carter Zeynep Kosaloglu-Yalcin Bjoern Peters Alessandro Sette Source Type: research
A meta-analysis of epitopes in prostate-specific antigens identifies opportunities and knowledge gaps
CONCLUSION: CEDAR provides a comprehensive repository of epitopes related to prostate-specific antigens. This inventory of epitope data with its wealth of searchable T cell, B cell and MHC ligand information provides a useful tool for the scientific community. At the same time, we identify significant knowledge gaps that could be addressed by experimental analysis.PMID:37679223 | DOI:10.1016/j.humimm.2023.08.145 (Source: Human Immunology)
Source: Human Immunology - September 7, 2023 Category: Allergy & Immunology Authors: Gabriele Foos Nina Blazeska Morten Nielsen Hannah Carter Zeynep Kosaloglu-Yalcin Bjoern Peters Alessandro Sette Source Type: research
