Decoding the contextual duality of CD40 functions
Hum Immunol. 2023 Aug 16:S0198-8859(23)00310-5. doi: 10.1016/j.humimm.2023.08.142. Online ahead of print.ABSTRACTPreviously, we established that as a function of its mode of interaction with its ligand or cellular conditions such as membrane lipids, preexisting signaling intermediates activation status, a transmembrane receptor, as represented here with CD40, can induce counteractive cellular responses. Using CD40-binding peptides, recombinant mutated CD40-ligands, and an agonistic antibody, we have established the functional duality of CD40. CD40 builds up two constitutionally different signalosomes on lipid raft and non-...
Source: Human Immunology - August 18, 2023 Category: Allergy & Immunology Authors: Syamdas Bandyopadhyay Dhiraj Gurjar Bhaskar Saha Neelam Bodhale Source Type: research
Decoding the contextual duality of CD40 functions
Hum Immunol. 2023 Aug 16:S0198-8859(23)00310-5. doi: 10.1016/j.humimm.2023.08.142. Online ahead of print.ABSTRACTPreviously, we established that as a function of its mode of interaction with its ligand or cellular conditions such as membrane lipids, preexisting signaling intermediates activation status, a transmembrane receptor, as represented here with CD40, can induce counteractive cellular responses. Using CD40-binding peptides, recombinant mutated CD40-ligands, and an agonistic antibody, we have established the functional duality of CD40. CD40 builds up two constitutionally different signalosomes on lipid raft and non-...
Source: Human Immunology - August 18, 2023 Category: Allergy & Immunology Authors: Syamdas Bandyopadhyay Dhiraj Gurjar Bhaskar Saha Neelam Bodhale Source Type: research
Decoding the contextual duality of CD40 functions
Hum Immunol. 2023 Aug 16:S0198-8859(23)00310-5. doi: 10.1016/j.humimm.2023.08.142. Online ahead of print.ABSTRACTPreviously, we established that as a function of its mode of interaction with its ligand or cellular conditions such as membrane lipids, preexisting signaling intermediates activation status, a transmembrane receptor, as represented here with CD40, can induce counteractive cellular responses. Using CD40-binding peptides, recombinant mutated CD40-ligands, and an agonistic antibody, we have established the functional duality of CD40. CD40 builds up two constitutionally different signalosomes on lipid raft and non-...
Source: Human Immunology - August 18, 2023 Category: Allergy & Immunology Authors: Syamdas Bandyopadhyay Dhiraj Gurjar Bhaskar Saha Neelam Bodhale Source Type: research
Decoding the contextual duality of CD40 functions
Hum Immunol. 2023 Aug 16:S0198-8859(23)00310-5. doi: 10.1016/j.humimm.2023.08.142. Online ahead of print.ABSTRACTPreviously, we established that as a function of its mode of interaction with its ligand or cellular conditions such as membrane lipids, preexisting signaling intermediates activation status, a transmembrane receptor, as represented here with CD40, can induce counteractive cellular responses. Using CD40-binding peptides, recombinant mutated CD40-ligands, and an agonistic antibody, we have established the functional duality of CD40. CD40 builds up two constitutionally different signalosomes on lipid raft and non-...
Source: Human Immunology - August 18, 2023 Category: Allergy & Immunology Authors: Syamdas Bandyopadhyay Dhiraj Gurjar Bhaskar Saha Neelam Bodhale Source Type: research
Decoding the contextual duality of CD40 functions
Hum Immunol. 2023 Aug 16:S0198-8859(23)00310-5. doi: 10.1016/j.humimm.2023.08.142. Online ahead of print.ABSTRACTPreviously, we established that as a function of its mode of interaction with its ligand or cellular conditions such as membrane lipids, preexisting signaling intermediates activation status, a transmembrane receptor, as represented here with CD40, can induce counteractive cellular responses. Using CD40-binding peptides, recombinant mutated CD40-ligands, and an agonistic antibody, we have established the functional duality of CD40. CD40 builds up two constitutionally different signalosomes on lipid raft and non-...
Source: Human Immunology - August 18, 2023 Category: Allergy & Immunology Authors: Syamdas Bandyopadhyay Dhiraj Gurjar Bhaskar Saha Neelam Bodhale Source Type: research
Decoding the contextual duality of CD40 functions
Hum Immunol. 2023 Aug 16:S0198-8859(23)00310-5. doi: 10.1016/j.humimm.2023.08.142. Online ahead of print.ABSTRACTPreviously, we established that as a function of its mode of interaction with its ligand or cellular conditions such as membrane lipids, preexisting signaling intermediates activation status, a transmembrane receptor, as represented here with CD40, can induce counteractive cellular responses. Using CD40-binding peptides, recombinant mutated CD40-ligands, and an agonistic antibody, we have established the functional duality of CD40. CD40 builds up two constitutionally different signalosomes on lipid raft and non-...
Source: Human Immunology - August 18, 2023 Category: Allergy & Immunology Authors: Syamdas Bandyopadhyay Dhiraj Gurjar Bhaskar Saha Neelam Bodhale Source Type: research
Diminished Interleukin-7 receptor expression on T-cell subsets in tuberculosis patients
Hum Immunol. 2023 Aug 12:S0198-8859(23)00309-9. doi: 10.1016/j.humimm.2023.08.141. Online ahead of print.ABSTRACTImmunopathology in human tuberculosis affects T-cell phenotype and functions. Previous studies identified impaired T-cell sensitivity to Interleukin (IL)-7 accompanied by lower IL-7 receptor α-chain (IL-7Rα) expression in patients with acute tuberculosis. In the present study, we characterized affected T-cell subsets and determined the influence of tuberculosis disease severity and treatment response. Tuberculosis patients (n = 89) as well as age- and gender-matched asymptomatic contacts (controls, n = 47) wer...
Source: Human Immunology - August 14, 2023 Category: Allergy & Immunology Authors: Isaac Acheampong Difery Minadzi Ernest Adankwah Wilfred Aniagyei Monika M Vivekanandan Augustine Yeboah Joseph F Arthur Millicent Lamptey Mohammed K Abass Francis Kumbel Francis Osei-Yeboah Amidu Gawusu Edwin F Laing Linda Batsa Debrah Dorcas O Owusu Alex Source Type: research
Diminished Interleukin-7 receptor expression on T-cell subsets in tuberculosis patients
Hum Immunol. 2023 Aug 12:S0198-8859(23)00309-9. doi: 10.1016/j.humimm.2023.08.141. Online ahead of print.ABSTRACTImmunopathology in human tuberculosis affects T-cell phenotype and functions. Previous studies identified impaired T-cell sensitivity to Interleukin (IL)-7 accompanied by lower IL-7 receptor α-chain (IL-7Rα) expression in patients with acute tuberculosis. In the present study, we characterized affected T-cell subsets and determined the influence of tuberculosis disease severity and treatment response. Tuberculosis patients (n = 89) as well as age- and gender-matched asymptomatic contacts (controls, n = 47) wer...
Source: Human Immunology - August 14, 2023 Category: Allergy & Immunology Authors: Isaac Acheampong Difery Minadzi Ernest Adankwah Wilfred Aniagyei Monika M Vivekanandan Augustine Yeboah Joseph F Arthur Millicent Lamptey Mohammed K Abass Francis Kumbel Francis Osei-Yeboah Amidu Gawusu Edwin F Laing Linda Batsa Debrah Dorcas O Owusu Alex Source Type: research
Diminished Interleukin-7 receptor expression on T-cell subsets in tuberculosis patients
Hum Immunol. 2023 Aug 12:S0198-8859(23)00309-9. doi: 10.1016/j.humimm.2023.08.141. Online ahead of print.ABSTRACTImmunopathology in human tuberculosis affects T-cell phenotype and functions. Previous studies identified impaired T-cell sensitivity to Interleukin (IL)-7 accompanied by lower IL-7 receptor α-chain (IL-7Rα) expression in patients with acute tuberculosis. In the present study, we characterized affected T-cell subsets and determined the influence of tuberculosis disease severity and treatment response. Tuberculosis patients (n = 89) as well as age- and gender-matched asymptomatic contacts (controls, n = 47) wer...
Source: Human Immunology - August 14, 2023 Category: Allergy & Immunology Authors: Isaac Acheampong Difery Minadzi Ernest Adankwah Wilfred Aniagyei Monika M Vivekanandan Augustine Yeboah Joseph F Arthur Millicent Lamptey Mohammed K Abass Francis Kumbel Francis Osei-Yeboah Amidu Gawusu Edwin F Laing Linda Batsa Debrah Dorcas O Owusu Alex Source Type: research
Diminished Interleukin-7 receptor expression on T-cell subsets in tuberculosis patients
Hum Immunol. 2023 Aug 12:S0198-8859(23)00309-9. doi: 10.1016/j.humimm.2023.08.141. Online ahead of print.ABSTRACTImmunopathology in human tuberculosis affects T-cell phenotype and functions. Previous studies identified impaired T-cell sensitivity to Interleukin (IL)-7 accompanied by lower IL-7 receptor α-chain (IL-7Rα) expression in patients with acute tuberculosis. In the present study, we characterized affected T-cell subsets and determined the influence of tuberculosis disease severity and treatment response. Tuberculosis patients (n = 89) as well as age- and gender-matched asymptomatic contacts (controls, n = 47) wer...
Source: Human Immunology - August 14, 2023 Category: Allergy & Immunology Authors: Isaac Acheampong Difery Minadzi Ernest Adankwah Wilfred Aniagyei Monika M Vivekanandan Augustine Yeboah Joseph F Arthur Millicent Lamptey Mohammed K Abass Francis Kumbel Francis Osei-Yeboah Amidu Gawusu Edwin F Laing Linda Batsa Debrah Dorcas O Owusu Alex Source Type: research
Th1 or Th2 cytokines are correlated with Tregs and T cell subsets and pregnancy outcomes in patients with autoimmune thyroid disease during early, middle, late pregnancy, and postpartum period
Hum Immunol. 2023 Aug 8:S0198-8859(23)00111-8. doi: 10.1016/j.humimm.2023.07.002. Online ahead of print.ABSTRACTAutoimmune thyroid disease (AITD) is a T lymphocytes-mediated autoimmune disorder affecting pregnant women. The current study sought to determine the correlations between T helper-1 (Th1)/T helper-2 (Th2) cytokines and regulatory T cells (Tregs) and T cell subsets and pregnancy outcomes in AITD patients during early pregnancy (T1), middle pregnancy (T2), late pregnancy (T3), and postpartum period (PP). A total of 60 patients with Graves' disease, 60 patients with Hashimoto's thyroiditis, and 30 healthy pregnant w...
Source: Human Immunology - August 10, 2023 Category: Allergy & Immunology Authors: Mei Zhong Hui Chen Jiao Lan Chunyong Lan Lan Liang Jingming Yu Hua Zhong Xing Zhou Jie Lu Xiaoyan Tan Wensheng Lu Source Type: research
Th1 or Th2 cytokines are correlated with Tregs and T cell subsets and pregnancy outcomes in patients with autoimmune thyroid disease during early, middle, late pregnancy, and postpartum period
Hum Immunol. 2023 Aug 8:S0198-8859(23)00111-8. doi: 10.1016/j.humimm.2023.07.002. Online ahead of print.ABSTRACTAutoimmune thyroid disease (AITD) is a T lymphocytes-mediated autoimmune disorder affecting pregnant women. The current study sought to determine the correlations between T helper-1 (Th1)/T helper-2 (Th2) cytokines and regulatory T cells (Tregs) and T cell subsets and pregnancy outcomes in AITD patients during early pregnancy (T1), middle pregnancy (T2), late pregnancy (T3), and postpartum period (PP). A total of 60 patients with Graves' disease, 60 patients with Hashimoto's thyroiditis, and 30 healthy pregnant w...
Source: Human Immunology - August 10, 2023 Category: Allergy & Immunology Authors: Mei Zhong Hui Chen Jiao Lan Chunyong Lan Lan Liang Jingming Yu Hua Zhong Xing Zhou Jie Lu Xiaoyan Tan Wensheng Lu Source Type: research
Th1 or Th2 cytokines are correlated with Tregs and T cell subsets and pregnancy outcomes in patients with autoimmune thyroid disease during early, middle, late pregnancy, and postpartum period
Hum Immunol. 2023 Aug 8:S0198-8859(23)00111-8. doi: 10.1016/j.humimm.2023.07.002. Online ahead of print.ABSTRACTAutoimmune thyroid disease (AITD) is a T lymphocytes-mediated autoimmune disorder affecting pregnant women. The current study sought to determine the correlations between T helper-1 (Th1)/T helper-2 (Th2) cytokines and regulatory T cells (Tregs) and T cell subsets and pregnancy outcomes in AITD patients during early pregnancy (T1), middle pregnancy (T2), late pregnancy (T3), and postpartum period (PP). A total of 60 patients with Graves' disease, 60 patients with Hashimoto's thyroiditis, and 30 healthy pregnant w...
Source: Human Immunology - August 10, 2023 Category: Allergy & Immunology Authors: Mei Zhong Hui Chen Jiao Lan Chunyong Lan Lan Liang Jingming Yu Hua Zhong Xing Zhou Jie Lu Xiaoyan Tan Wensheng Lu Source Type: research
Th1 or Th2 cytokines are correlated with Tregs and T cell subsets and pregnancy outcomes in patients with autoimmune thyroid disease during early, middle, late pregnancy, and postpartum period
Hum Immunol. 2023 Aug 8:S0198-8859(23)00111-8. doi: 10.1016/j.humimm.2023.07.002. Online ahead of print.ABSTRACTAutoimmune thyroid disease (AITD) is a T lymphocytes-mediated autoimmune disorder affecting pregnant women. The current study sought to determine the correlations between T helper-1 (Th1)/T helper-2 (Th2) cytokines and regulatory T cells (Tregs) and T cell subsets and pregnancy outcomes in AITD patients during early pregnancy (T1), middle pregnancy (T2), late pregnancy (T3), and postpartum period (PP). A total of 60 patients with Graves' disease, 60 patients with Hashimoto's thyroiditis, and 30 healthy pregnant w...
Source: Human Immunology - August 10, 2023 Category: Allergy & Immunology Authors: Mei Zhong Hui Chen Jiao Lan Chunyong Lan Lan Liang Jingming Yu Hua Zhong Xing Zhou Jie Lu Xiaoyan Tan Wensheng Lu Source Type: research
Study of association between antibodies to non-HLA kidney self-antigens and progression to chronic immune injury after kidney transplantation
CONCLUSIONS: Humoral immune responses to either KSAg alone or in combination with donor-specific anti-HLA antibodies are not associated with progression to CII at 1 and 2 years after kidney transplantation.PMID:37507262 | DOI:10.1016/j.humimm.2023.07.006 (Source: Human Immunology)
Source: Human Immunology - July 28, 2023 Category: Allergy & Immunology Authors: Sumi Nair Ranjithkumar Ravichandran Raymond Heilman Andr és Jaramillo Matthew Buras Bruce Kaplan Yoshihiro Itabashi Daniel Ramon Katrin Hacke Byron Smith Thalachallour Mohanakumar Source Type: research
