The inhibition of ADAM17 in cord blood stem cell-derived CD16 < sup > + < /sup > NK cells to enhance their cytotoxicity against acute lymphoblastic leukemia cells
Hum Immunol. 2024 Feb 29:110769. doi: 10.1016/j.humimm.2024.110769. Online ahead of print.ABSTRACTFortunately, ample efforts are being made to find the best strategy to improve the anti-leukemia capacity of NK cells for treating different types of cancer. Despite the favorable ADCC capacity of functional CD16 + NK cells for immunotherapy, when NK cells face leukemia cells, the CD16 receptor is cleaved during the process mediated by a disintegrin and metalloproteinase-17(ADAM17). Reduced CD16 expression on NK cells weakens their cytotoxicity against leukemia cells. In addition, the expression of the CD47 receptor is high in...
Source: Human Immunology - March 1, 2024 Category: Allergy & Immunology Authors: Behnaz Valipour Seyedeh Momeneh Mohammadi Ali Abedelahi Hojjatollah Nozad Charoudeh Source Type: research
Including the liver in the visceral allograft: Impact on donor-specific anti-HLA antibodies and long-term outcomes
In conclusion, liver-containing visceral allografts have superior short- and long-term outcomes compared with liver-free allografts. De novo DSA develop early and frequently after VTx performed without B cell-depleting induction therapy, but the exact role of DSA in the pathogenesis of rejection remains unclear.PMID:38418315 | DOI:10.1016/j.humimm.2024.110767 (Source: Human Immunology)
Source: Human Immunology - February 28, 2024 Category: Allergy & Immunology Authors: Dace Abele Markus G äbel Mihai Oltean Jonas Varkey Johan M ölne Nils Ekwall Helena Borg Hanna Jacobsson Jan Holgersson Gustaf Herlenius Source Type: research
Including the liver in the visceral allograft: Impact on donor-specific anti-HLA antibodies and long-term outcomes
In conclusion, liver-containing visceral allografts have superior short- and long-term outcomes compared with liver-free allografts. De novo DSA develop early and frequently after VTx performed without B cell-depleting induction therapy, but the exact role of DSA in the pathogenesis of rejection remains unclear.PMID:38418315 | DOI:10.1016/j.humimm.2024.110767 (Source: Human Immunology)
Source: Human Immunology - February 28, 2024 Category: Allergy & Immunology Authors: Dace Abele Markus G äbel Mihai Oltean Jonas Varkey Johan M ölne Nils Ekwall Helena Borg Hanna Jacobsson Jan Holgersson Gustaf Herlenius Source Type: research
Including the liver in the visceral allograft: Impact on donor-specific anti-HLA antibodies and long-term outcomes
In conclusion, liver-containing visceral allografts have superior short- and long-term outcomes compared with liver-free allografts. De novo DSA develop early and frequently after VTx performed without B cell-depleting induction therapy, but the exact role of DSA in the pathogenesis of rejection remains unclear.PMID:38418315 | DOI:10.1016/j.humimm.2024.110767 (Source: Human Immunology)
Source: Human Immunology - February 28, 2024 Category: Allergy & Immunology Authors: Dace Abele Markus G äbel Mihai Oltean Jonas Varkey Johan M ölne Nils Ekwall Helena Borg Hanna Jacobsson Jan Holgersson Gustaf Herlenius Source Type: research
The increasing need for ABO blood group genotyping and quality assurance implications for laboratory implementation
Hum Immunol. 2024 Feb 23:110766. doi: 10.1016/j.humimm.2024.110766. Online ahead of print.ABSTRACTABO blood group antigens are critical determinants of immunologic self and non-self and are ubiquitously expressed on all cellular tissues. Antibodies against non-self ABO antigens are naturally present and can mediate pathologic reactions against incompatible transfused blood cells and transplanted tissues. Laboratory testing for ABO antigens and isoagglutinins is essential for safe and effective transfusion and transplantation. Testing for ABO antigens has traditionally depended on serologic testing. However, there is increa...
Source: Human Immunology - February 24, 2024 Category: Allergy & Immunology Authors: Amena Usmani Gerald P Morris Cathi Murphey Source Type: research
The increasing need for ABO blood group genotyping and quality assurance implications for laboratory implementation
Hum Immunol. 2024 Feb 23:110766. doi: 10.1016/j.humimm.2024.110766. Online ahead of print.ABSTRACTABO blood group antigens are critical determinants of immunologic self and non-self and are ubiquitously expressed on all cellular tissues. Antibodies against non-self ABO antigens are naturally present and can mediate pathologic reactions against incompatible transfused blood cells and transplanted tissues. Laboratory testing for ABO antigens and isoagglutinins is essential for safe and effective transfusion and transplantation. Testing for ABO antigens has traditionally depended on serologic testing. However, there is increa...
Source: Human Immunology - February 24, 2024 Category: Allergy & Immunology Authors: Amena Usmani Gerald P Morris Cathi Murphey Source Type: research
The increasing need for ABO blood group genotyping and quality assurance implications for laboratory implementation
Hum Immunol. 2024 Feb 23:110766. doi: 10.1016/j.humimm.2024.110766. Online ahead of print.ABSTRACTABO blood group antigens are critical determinants of immunologic self and non-self and are ubiquitously expressed on all cellular tissues. Antibodies against non-self ABO antigens are naturally present and can mediate pathologic reactions against incompatible transfused blood cells and transplanted tissues. Laboratory testing for ABO antigens and isoagglutinins is essential for safe and effective transfusion and transplantation. Testing for ABO antigens has traditionally depended on serologic testing. However, there is increa...
Source: Human Immunology - February 24, 2024 Category: Allergy & Immunology Authors: Amena Usmani Gerald P Morris Cathi Murphey Source Type: research
The increasing need for ABO blood group genotyping and quality assurance implications for laboratory implementation
Hum Immunol. 2024 Feb 23:110766. doi: 10.1016/j.humimm.2024.110766. Online ahead of print.ABSTRACTABO blood group antigens are critical determinants of immunologic self and non-self and are ubiquitously expressed on all cellular tissues. Antibodies against non-self ABO antigens are naturally present and can mediate pathologic reactions against incompatible transfused blood cells and transplanted tissues. Laboratory testing for ABO antigens and isoagglutinins is essential for safe and effective transfusion and transplantation. Testing for ABO antigens has traditionally depended on serologic testing. However, there is increa...
Source: Human Immunology - February 24, 2024 Category: Allergy & Immunology Authors: Amena Usmani Gerald P Morris Cathi Murphey Source Type: research
The role of immune system in atherosclerosis: Molecular mechanisms, controversies, and future possibilities
Hum Immunol. 2024 Feb 17:110765. doi: 10.1016/j.humimm.2024.110765. Online ahead of print.ABSTRACTNumerous cardiovascular disorders have atherosclerosis as their pathological underpinning. Numerous studies have demonstrated that, with the aid of pattern recognition receptors, cytokines, and immunoglobulins, innate immunity, represented by monocytes/macrophages, and adaptive immunity, primarily T/B cells, play a critical role in controlling inflammation and abnormal lipid metabolism in atherosclerosis. Additionally, the finding of numerous complement components in atherosclerotic plaques suggests yet again how heavily the i...
Source: Human Immunology - February 18, 2024 Category: Allergy & Immunology Authors: Tianle Zhang Chenxu Pang Mengxin Xu Qianqian Zhao Zhijie Hu Xijuan Jiang Maojuan Guo Source Type: research
The role of immune system in atherosclerosis: Molecular mechanisms, controversies, and future possibilities
Hum Immunol. 2024 Feb 17:110765. doi: 10.1016/j.humimm.2024.110765. Online ahead of print.ABSTRACTNumerous cardiovascular disorders have atherosclerosis as their pathological underpinning. Numerous studies have demonstrated that, with the aid of pattern recognition receptors, cytokines, and immunoglobulins, innate immunity, represented by monocytes/macrophages, and adaptive immunity, primarily T/B cells, play a critical role in controlling inflammation and abnormal lipid metabolism in atherosclerosis. Additionally, the finding of numerous complement components in atherosclerotic plaques suggests yet again how heavily the i...
Source: Human Immunology - February 18, 2024 Category: Allergy & Immunology Authors: Tianle Zhang Chenxu Pang Mengxin Xu Qianqian Zhao Zhijie Hu Xijuan Jiang Maojuan Guo Source Type: research
The role of immune system in atherosclerosis: Molecular mechanisms, controversies, and future possibilities
Hum Immunol. 2024 Feb 17:110765. doi: 10.1016/j.humimm.2024.110765. Online ahead of print.ABSTRACTNumerous cardiovascular disorders have atherosclerosis as their pathological underpinning. Numerous studies have demonstrated that, with the aid of pattern recognition receptors, cytokines, and immunoglobulins, innate immunity, represented by monocytes/macrophages, and adaptive immunity, primarily T/B cells, play a critical role in controlling inflammation and abnormal lipid metabolism in atherosclerosis. Additionally, the finding of numerous complement components in atherosclerotic plaques suggests yet again how heavily the i...
Source: Human Immunology - February 18, 2024 Category: Allergy & Immunology Authors: Tianle Zhang Chenxu Pang Mengxin Xu Qianqian Zhao Zhijie Hu Xijuan Jiang Maojuan Guo Source Type: research
The role of immune system in atherosclerosis: Molecular mechanisms, controversies, and future possibilities
Hum Immunol. 2024 Feb 17:110765. doi: 10.1016/j.humimm.2024.110765. Online ahead of print.ABSTRACTNumerous cardiovascular disorders have atherosclerosis as their pathological underpinning. Numerous studies have demonstrated that, with the aid of pattern recognition receptors, cytokines, and immunoglobulins, innate immunity, represented by monocytes/macrophages, and adaptive immunity, primarily T/B cells, play a critical role in controlling inflammation and abnormal lipid metabolism in atherosclerosis. Additionally, the finding of numerous complement components in atherosclerotic plaques suggests yet again how heavily the i...
Source: Human Immunology - February 18, 2024 Category: Allergy & Immunology Authors: Tianle Zhang Chenxu Pang Mengxin Xu Qianqian Zhao Zhijie Hu Xijuan Jiang Maojuan Guo Source Type: research
The role of immune system in atherosclerosis: Molecular mechanisms, controversies, and future possibilities
Hum Immunol. 2024 Feb 17:110765. doi: 10.1016/j.humimm.2024.110765. Online ahead of print.ABSTRACTNumerous cardiovascular disorders have atherosclerosis as their pathological underpinning. Numerous studies have demonstrated that, with the aid of pattern recognition receptors, cytokines, and immunoglobulins, innate immunity, represented by monocytes/macrophages, and adaptive immunity, primarily T/B cells, play a critical role in controlling inflammation and abnormal lipid metabolism in atherosclerosis. Additionally, the finding of numerous complement components in atherosclerotic plaques suggests yet again how heavily the i...
Source: Human Immunology - February 18, 2024 Category: Allergy & Immunology Authors: Tianle Zhang Chenxu Pang Mengxin Xu Qianqian Zhao Zhijie Hu Xijuan Jiang Maojuan Guo Source Type: research
A comprehensive review on the role of T cell subsets and CAR-T cell therapy in Aspergillus fumigatus infection
Hum Immunol. 2024 Feb 12:110763. doi: 10.1016/j.humimm.2024.110763. Online ahead of print.ABSTRACTUnderstanding the immune response to Aspergillus fumigatus, a common cause of invasive fungal infections (IFIs) in immunocompromised individuals, is critical for developing effective treatments. Tcells play a critical role in the immune response to A. fumigatus, with different subsets having distinct functions. Th1 cells are important for controlling fungal growth, while Th2 cells can exacerbate infection. Th17 cells promote the clearance of fungi indirectly by stimulating the production of various antimicrobial peptides from ...
Source: Human Immunology - February 13, 2024 Category: Allergy & Immunology Authors: Abozar Nasiri-Jahrodi Mehdi Barati Hasan Namdar Ahmadabad Hamid Badali Hamid Morovati Source Type: research
A comprehensive review on the role of T cell subsets and CAR-T cell therapy in Aspergillus fumigatus infection
Hum Immunol. 2024 Feb 12:110763. doi: 10.1016/j.humimm.2024.110763. Online ahead of print.ABSTRACTUnderstanding the immune response to Aspergillus fumigatus, a common cause of invasive fungal infections (IFIs) in immunocompromised individuals, is critical for developing effective treatments. Tcells play a critical role in the immune response to A. fumigatus, with different subsets having distinct functions. Th1 cells are important for controlling fungal growth, while Th2 cells can exacerbate infection. Th17 cells promote the clearance of fungi indirectly by stimulating the production of various antimicrobial peptides from ...
Source: Human Immunology - February 13, 2024 Category: Allergy & Immunology Authors: Abozar Nasiri-Jahrodi Mehdi Barati Hasan Namdar Ahmadabad Hamid Badali Hamid Morovati Source Type: research
