Combined imputation of HLA genotype and self-identified race leads to better donor-recipient matching
We present MR-GRIMM "Multi-Race Graph IMputation and Matching" that simultaneously imputes the race/ethnic category and HLA genotype using a SIRE based prior. Additionally, we propose a novel method to impute HLA typing inconsistent with current haplotype frequencies. The performance of MR-GRIMM was validated using a dataset of 170,000 donor-recipient pairs. MR-GRIMM has an average 20 % lower matching error (1-AUC) than single-race imputation. The recall metric (sensitivity) of the race/ethnic category imputation from HLA was measured by comparing the imputed donor race with the donor-provided SIRE. Accuracies of 0.74 and ...
Source: Human Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Sapir Israeli Loren Gragert Abeer Madbouly Pradeep Bashyal Joel Schneider Martin Maiers Yoram Louzoun Source Type: research
Kinetics of Torque Teno virus in heart transplant patients
We report data on a large cohort of heart transplant patients and contribute to the understanding of how TTV behaves in transplant patients. Despite not finding an association with rejection, our results provide important insights into the kinetics of TTV levels after transplantation, which may be useful in future studies of immune function in heart transplant patients.PMID:37867096 | DOI:10.1016/j.humimm.2023.110720 (Source: Human Immunology)
Source: Human Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Randi Berg Tor S Clemmensen Mikkel S Petersen Lone J H Mogensen Mette Christiansen Katrine Rolid Kari Nytr øen Bjarne K M øller Lars Gullestad Hans Eiskj ær Pernille Koefoed-Nielsen Source Type: research
Combined imputation of HLA genotype and self-identified race leads to better donor-recipient matching
We present MR-GRIMM "Multi-Race Graph IMputation and Matching" that simultaneously imputes the race/ethnic category and HLA genotype using a SIRE based prior. Additionally, we propose a novel method to impute HLA typing inconsistent with current haplotype frequencies. The performance of MR-GRIMM was validated using a dataset of 170,000 donor-recipient pairs. MR-GRIMM has an average 20 % lower matching error (1-AUC) than single-race imputation. The recall metric (sensitivity) of the race/ethnic category imputation from HLA was measured by comparing the imputed donor race with the donor-provided SIRE. Accuracies of 0.74 and ...
Source: Human Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Sapir Israeli Loren Gragert Abeer Madbouly Pradeep Bashyal Joel Schneider Martin Maiers Yoram Louzoun Source Type: research
Kinetics of Torque Teno virus in heart transplant patients
We report data on a large cohort of heart transplant patients and contribute to the understanding of how TTV behaves in transplant patients. Despite not finding an association with rejection, our results provide important insights into the kinetics of TTV levels after transplantation, which may be useful in future studies of immune function in heart transplant patients.PMID:37867096 | DOI:10.1016/j.humimm.2023.110720 (Source: Human Immunology)
Source: Human Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Randi Berg Tor S Clemmensen Mikkel S Petersen Lone J H Mogensen Mette Christiansen Katrine Rolid Kari Nytr øen Bjarne K M øller Lars Gullestad Hans Eiskj ær Pernille Koefoed-Nielsen Source Type: research
Combined imputation of HLA genotype and self-identified race leads to better donor-recipient matching
We present MR-GRIMM "Multi-Race Graph IMputation and Matching" that simultaneously imputes the race/ethnic category and HLA genotype using a SIRE based prior. Additionally, we propose a novel method to impute HLA typing inconsistent with current haplotype frequencies. The performance of MR-GRIMM was validated using a dataset of 170,000 donor-recipient pairs. MR-GRIMM has an average 20 % lower matching error (1-AUC) than single-race imputation. The recall metric (sensitivity) of the race/ethnic category imputation from HLA was measured by comparing the imputed donor race with the donor-provided SIRE. Accuracies of 0.74 and ...
Source: Human Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Sapir Israeli Loren Gragert Abeer Madbouly Pradeep Bashyal Joel Schneider Martin Maiers Yoram Louzoun Source Type: research
Kinetics of Torque Teno virus in heart transplant patients
We report data on a large cohort of heart transplant patients and contribute to the understanding of how TTV behaves in transplant patients. Despite not finding an association with rejection, our results provide important insights into the kinetics of TTV levels after transplantation, which may be useful in future studies of immune function in heart transplant patients.PMID:37867096 | DOI:10.1016/j.humimm.2023.110720 (Source: Human Immunology)
Source: Human Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Randi Berg Tor S Clemmensen Mikkel S Petersen Lone J H Mogensen Mette Christiansen Katrine Rolid Kari Nytr øen Bjarne K M øller Lars Gullestad Hans Eiskj ær Pernille Koefoed-Nielsen Source Type: research
Combined imputation of HLA genotype and self-identified race leads to better donor-recipient matching
We present MR-GRIMM "Multi-Race Graph IMputation and Matching" that simultaneously imputes the race/ethnic category and HLA genotype using a SIRE based prior. Additionally, we propose a novel method to impute HLA typing inconsistent with current haplotype frequencies. The performance of MR-GRIMM was validated using a dataset of 170,000 donor-recipient pairs. MR-GRIMM has an average 20 % lower matching error (1-AUC) than single-race imputation. The recall metric (sensitivity) of the race/ethnic category imputation from HLA was measured by comparing the imputed donor race with the donor-provided SIRE. Accuracies of 0.74 and ...
Source: Human Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Sapir Israeli Loren Gragert Abeer Madbouly Pradeep Bashyal Joel Schneider Martin Maiers Yoram Louzoun Source Type: research
Kinetics of Torque Teno virus in heart transplant patients
We report data on a large cohort of heart transplant patients and contribute to the understanding of how TTV behaves in transplant patients. Despite not finding an association with rejection, our results provide important insights into the kinetics of TTV levels after transplantation, which may be useful in future studies of immune function in heart transplant patients.PMID:37867096 | DOI:10.1016/j.humimm.2023.110720 (Source: Human Immunology)
Source: Human Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Randi Berg Tor S Clemmensen Mikkel S Petersen Lone J H Mogensen Mette Christiansen Katrine Rolid Kari Nytr øen Bjarne K M øller Lars Gullestad Hans Eiskj ær Pernille Koefoed-Nielsen Source Type: research
Combined imputation of HLA genotype and self-identified race leads to better donor-recipient matching
We present MR-GRIMM "Multi-Race Graph IMputation and Matching" that simultaneously imputes the race/ethnic category and HLA genotype using a SIRE based prior. Additionally, we propose a novel method to impute HLA typing inconsistent with current haplotype frequencies. The performance of MR-GRIMM was validated using a dataset of 170,000 donor-recipient pairs. MR-GRIMM has an average 20 % lower matching error (1-AUC) than single-race imputation. The recall metric (sensitivity) of the race/ethnic category imputation from HLA was measured by comparing the imputed donor race with the donor-provided SIRE. Accuracies of 0.74 and ...
Source: Human Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Sapir Israeli Loren Gragert Abeer Madbouly Pradeep Bashyal Joel Schneider Martin Maiers Yoram Louzoun Source Type: research
Kinetics of Torque Teno virus in heart transplant patients
We report data on a large cohort of heart transplant patients and contribute to the understanding of how TTV behaves in transplant patients. Despite not finding an association with rejection, our results provide important insights into the kinetics of TTV levels after transplantation, which may be useful in future studies of immune function in heart transplant patients.PMID:37867096 | DOI:10.1016/j.humimm.2023.110720 (Source: Human Immunology)
Source: Human Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Randi Berg Tor S Clemmensen Mikkel S Petersen Lone J H Mogensen Mette Christiansen Katrine Rolid Kari Nytr øen Bjarne K M øller Lars Gullestad Hans Eiskj ær Pernille Koefoed-Nielsen Source Type: research
Combined imputation of HLA genotype and self-identified race leads to better donor-recipient matching
We present MR-GRIMM "Multi-Race Graph IMputation and Matching" that simultaneously imputes the race/ethnic category and HLA genotype using a SIRE based prior. Additionally, we propose a novel method to impute HLA typing inconsistent with current haplotype frequencies. The performance of MR-GRIMM was validated using a dataset of 170,000 donor-recipient pairs. MR-GRIMM has an average 20 % lower matching error (1-AUC) than single-race imputation. The recall metric (sensitivity) of the race/ethnic category imputation from HLA was measured by comparing the imputed donor race with the donor-provided SIRE. Accuracies of 0.74 and ...
Source: Human Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Sapir Israeli Loren Gragert Abeer Madbouly Pradeep Bashyal Joel Schneider Martin Maiers Yoram Louzoun Source Type: research
Kinetics of Torque Teno virus in heart transplant patients
We report data on a large cohort of heart transplant patients and contribute to the understanding of how TTV behaves in transplant patients. Despite not finding an association with rejection, our results provide important insights into the kinetics of TTV levels after transplantation, which may be useful in future studies of immune function in heart transplant patients.PMID:37867096 | DOI:10.1016/j.humimm.2023.110720 (Source: Human Immunology)
Source: Human Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Randi Berg Tor S Clemmensen Mikkel S Petersen Lone J H Mogensen Mette Christiansen Katrine Rolid Kari Nytr øen Bjarne K M øller Lars Gullestad Hans Eiskj ær Pernille Koefoed-Nielsen Source Type: research
Combined imputation of HLA genotype and self-identified race leads to better donor-recipient matching
We present MR-GRIMM "Multi-Race Graph IMputation and Matching" that simultaneously imputes the race/ethnic category and HLA genotype using a SIRE based prior. Additionally, we propose a novel method to impute HLA typing inconsistent with current haplotype frequencies. The performance of MR-GRIMM was validated using a dataset of 170,000 donor-recipient pairs. MR-GRIMM has an average 20 % lower matching error (1-AUC) than single-race imputation. The recall metric (sensitivity) of the race/ethnic category imputation from HLA was measured by comparing the imputed donor race with the donor-provided SIRE. Accuracies of 0.74 and ...
Source: Human Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Sapir Israeli Loren Gragert Abeer Madbouly Pradeep Bashyal Joel Schneider Martin Maiers Yoram Louzoun Source Type: research
Kinetics of Torque Teno virus in heart transplant patients
We report data on a large cohort of heart transplant patients and contribute to the understanding of how TTV behaves in transplant patients. Despite not finding an association with rejection, our results provide important insights into the kinetics of TTV levels after transplantation, which may be useful in future studies of immune function in heart transplant patients.PMID:37867096 | DOI:10.1016/j.humimm.2023.110720 (Source: Human Immunology)
Source: Human Immunology - October 22, 2023 Category: Allergy & Immunology Authors: Randi Berg Tor S Clemmensen Mikkel S Petersen Lone J H Mogensen Mette Christiansen Katrine Rolid Kari Nytr øen Bjarne K M øller Lars Gullestad Hans Eiskj ær Pernille Koefoed-Nielsen Source Type: research
DNA methylation and expression of LGR6 gene in ankylosing spondylitis: A case-control study
CONCLUSION: The present study revealed that LGR6 DNA methylation dysregulation may be involved in the pathogenesis of AS from an epigenetic perspective for the first time, with the aim of providing new directions for biomarker identification and treatment development for AS patients.PMID:37802707 | DOI:10.1016/j.humimm.2023.09.005 (Source: Human Immunology)
Source: Human Immunology - October 6, 2023 Category: Allergy & Immunology Authors: Yujie Deng Wei Xu Man Ni Xiaoya Sun Xinqi Wang Tao Zhang Faming Pan Source Type: research
