Combined loss of CDH1 and downstream regulatory sequences drive early-onset diffuse gastric cancer and increase penetrance of hereditary diffuse gastric cancer
ConclusionIn this work, we demonstrated that regulatory elements lying down-stream ofCDH1 are part of a chromatin network that controlCDH1 expression and influence cell transcriptome and associated signalling pathways, likely explaining high disease penetrance and very young cancer-onset. This study highlights the importance of incorporating scientific –technological updates and clinical guidelines in routine diagnosis, given their impact in timely genetic diagnosis and disease prevention.Graphical abstract (Source: Gastric Cancer)
Source: Gastric Cancer - May 30, 2023 Category: Gastroenterology Source Type: research
Oncological impact of unexpected horizontal tumor spread in gastric cancer that requires total gastrectomy
ConclusionsΔPM > 8 mm is related to several clinicopathological characteristics and is an independent risk factor for poorer survival and peritoneal metastasis but not local recurrence. ΔPM > 8 mm combined with circumferential involvement or esophageal invasion is associated with relatively poor survival outcomes. (Source: Gastric Cancer)
Source: Gastric Cancer - May 29, 2023 Category: Gastroenterology Source Type: research
SPRY4 inhibits and sensitizes the primary KIT mutants in gastrointestinal stromal tumors (GISTs) to imatinib
ConclusionsOur results suggested that SPRY4 acts as negative feedback of primary KIT mutants in GISTs by inhibiting KIT expression and activation. It can increase the sensitivity of primary KIT mutants to imatinib. In contrast, secondary KIT mutants are resistant to the inhibition of SPRY4. (Source: Gastric Cancer)
Source: Gastric Cancer - May 24, 2023 Category: Gastroenterology Source Type: research
The methylation level of a single cancer risk marker gene reflects methylation burden in gastric mucosa
ConclusionsThe methylation level of a single marker gene reflects the methylation burden, which includes driver gene methylation, and thus accurately predicts cancer risk. (Source: Gastric Cancer)
Source: Gastric Cancer - May 23, 2023 Category: Gastroenterology Source Type: research
The risk of osteoporotic fracture in gastric cancer survivors: total gastrectomy versus subtotal gastrectomy versus endoscopic treatment
ConclusionGastric cancer survivors who underwent TG had an increased osteoporotic fracture risk than did SG or ESD/EMR in these patients. The amount of gastric resection and accompanying metabolic changes seemed to mediate such risk. Additional research is needed to establish an optimal strategy for each type of surgery. (Source: Gastric Cancer)
Source: Gastric Cancer - May 20, 2023 Category: Gastroenterology Source Type: research
Evaluation of the widths of the mucosal strips in pathological examination of specimens of endoscopic submucosal dissection for early gastric cancer
ConclusionEvaluation of the appropriate cut-width is important and should be discussed from the standpoint of labor costs and lost opportunities to search for molecular markers in ESD materials. (Source: Gastric Cancer)
Source: Gastric Cancer - May 11, 2023 Category: Gastroenterology Source Type: research
Clinical and endoscopic features of metachronous gastric cancer with possible lymph node metastasis after endoscopic submucosal dissection and Helicobacter pylori eradication
ConclusionsDuring surveillance endoscopy after gastric ESD andH. pylori eradication, the posterior wall should be carefully examined to detect MGCs early. Lower BMI may be associated with the development of MGCs with possible LNM. (Source: Gastric Cancer)
Source: Gastric Cancer - May 9, 2023 Category: Gastroenterology Source Type: research
Body weight loss as a prognostic and predictive factor in previously treated patients with metastatic gastric cancer: post hoc analyses of the randomized phase III TAGS trial
ConclusionsIn TAGS, early BWL was a strong negative prognostic factor for OS in patients with mGC/GEJC receiving third- or later-line treatment. (Source: Gastric Cancer)
Source: Gastric Cancer - April 28, 2023 Category: Gastroenterology Source Type: research
