Expression of chemokine receptor CCR7 is a negative prognostic factor for patients with gastric cancer: a meta-analysis
Abstract Background The prognostic significance of CC chemokine receptor type 7 (CCR7) for survival of patients with gastric cancer remains controversial. To investigate the impacts of CCR7 on clinicopathological findings and survival outcome in gastric cancer, we performed a meta-analysis. Methods A comprehensive search in PubMed, Embase, the Cochrane Library, and the CNKI database (1966 to November 2015) was undertaken for relevant studies. The relative risk and hazard ratios with their 95 % confidence intervals were used as measures to inves...
Source: Gastric Cancer - March 16, 2016 Category: Gastroenterology Source Type: research

Gastric polyps diagnosed by double-contrast upper gastrointestinal barium X-ray radiography mostly arise from the Helicobacter pylori -negative stomach with low risk of gastric cancer in Japan
Abstract Background Double-contrast upper gastrointestinal barium X-ray radiography (UGI-XR) is a method broadly used for gastric cancer screening in Japan. Gastric polyp is one of the most frequent findings detected by UGI-XR, but how to handle it remains controversial. Methods Gastric polyps of the 17,264 generally healthy subjects in Japan who underwent UGI-XR or upper gastrointestinal endoscopy (UGI-ES) in 2010 were analyzed. Results Of the 6,433 UGI-XR examinees (3,405 men and 3,028 women, 47.4 ±&n...
Source: Gastric Cancer - March 14, 2016 Category: Gastroenterology Source Type: research

Minimally invasive surgery for gastric cancer: the American experience
This study assesses the impact of minimally invasive surgery on oncologic and perioperative outcomes in the management of gastric cancer in the USA. Methods From the American College of Surgeons and American Cancer Society National Cancer Data Base, we identified 6427 patients who underwent gastrectomy for cancer from 2010 to 2012. Treatment groups were categorized with an intention-to-treat paradigm as robotic, laparoscopic, and open surgery. Univariate and multivariate analyses were performed to estimate the impact of the surgical approach on oncologic and perioperative outcomes. ...
Source: Gastric Cancer - March 9, 2016 Category: Gastroenterology Source Type: research

Adjuvant capecitabine plus oxaliplatin after D2 gastrectomy in Japanese patients with gastric cancer: a phase II study
Conclusions The feasibility of adjuvant XELOX in Japanese patients with resected gastric cancer is similar to that observed in South Korean, Chinese, and Taiwanese patients in the Capecitabine and Oxaliplatin Adjuvant Study in Stomach Cancer (CLASSIC) study. Based on findings from this study and the CLASSIC study, the XELOX regimen can be considered an adjuvant treatment option for Japanese gastric cancer patients who have undergone curative resection. (Source: Gastric Cancer)
Source: Gastric Cancer - March 8, 2016 Category: Gastroenterology Source Type: research

Surgical resection of hepatic metastases from gastric cancer: outcomes from national series in England
The objectives of this national study were to examine the short-term safety and long-term survival benefit associated with surgical resection of hepatic metastases from gastric cancer. Methods Patients from the Hospital Episode Statistics database were classified by disease and treatment approach. Gastric cancer: 1. Without liver metastases treated by gastrectomy (GG). 2. With liver metastases treated by gastrectomy and hepatectomy (GGH). 3. With liver metastases treated by gastrectomy without hepatectomy (GGNH). 4. With liver metastases treated with no surgery (GNS). Propensity scor...
Source: Gastric Cancer - March 3, 2016 Category: Gastroenterology Source Type: research

A rising trend in the incidence of advanced gastric cancer in young Hispanic men
Conclusions The APC of the incidence of gastric cancer in young Hispanic men places it among the top cancers with rising incidence in the USA. This is concomitant with increased incidence of advanced disease at presentation. This major public health concern warrants additional research to determine the cause of the increasing incidence in this group. (Source: Gastric Cancer)
Source: Gastric Cancer - February 29, 2016 Category: Gastroenterology Source Type: research

Proposal of a new stage grouping of gastric cancer for TNM classification: International Gastric Cancer Association staging project
Conclusions For the next revision of AJCC classification, we propose a new stage grouping based on a large, worldwide data collection. (Source: Gastric Cancer)
Source: Gastric Cancer - February 20, 2016 Category: Gastroenterology Source Type: research

Tumor-associated macrophages in gastric cancer: more than bystanders in tumor microenvironment
(Source: Gastric Cancer)
Source: Gastric Cancer - February 19, 2016 Category: Gastroenterology Source Type: research

Impact of insulin-like growth factor-1 receptor and amphiregulin expression on survival in patients with stage II/III gastric cancer enrolled in the Adjuvant Chemotherapy Trial of S-1 for Gastric Cancer
Conclusion IGF1R gene expression was associated with poor outcomes after curative resection of stage II/III gastric cancer, whereas AREG gene expression was associated with good outcomes. No significant interaction effect on survival was evident between S-1 treatment and gene expression. (Source: Gastric Cancer)
Source: Gastric Cancer - February 16, 2016 Category: Gastroenterology Source Type: research

Relationship between socioeconomic status and accessibility for endoscopic resection among gastric cancer patients: using National Health Insurance Cohort in Korea: poverty and endoscopic resection
Conclusion In conclusion, we suggest that although universal health insurance in Korea has covered EMR treatment since August 2011, patients from the lowest income group are less likely to receive this treatment. Thus, we need to detect more eligible early-stage gastric cancer and treatment for individuals of low socioeconomic status. (Source: Gastric Cancer)
Source: Gastric Cancer - February 16, 2016 Category: Gastroenterology Source Type: research

Feasibility of weekly intraperitoneal versus intravenous paclitaxel therapy delivered from the day of radical surgery for gastric cancer: a preliminary safety analysis of the INPACT study, a randomized controlled trial
Conclusions Intraperitoneal administration of PTX from the day of gastrectomy did not result in a higher incidence of surgical complications and adverse reactions when compared with intravenous administration of PTX. (Source: Gastric Cancer)
Source: Gastric Cancer - February 15, 2016 Category: Gastroenterology Source Type: research

Monitoring the HER2 copy number status in circulating tumor DNA by droplet digital PCR in patients with gastric cancer
Abstract Background We previously demonstrated the potential of circulating tumor DNA (ctDNA) for the amplification of detecting HER2 in patients with gastric cancer (GC). In the present study, we focused on the clinical courses of patients who developed recurrence with GC, and investigated the potential clinical utility of the ddPCR-based HER2 copy number (CN) as a marker for the temporal and/or spatial heterogeneities of GC during treatment progress. Method We enrolled 30 healthy volunteers and 60 patients with GC who underwent surgery, including 17 pa...
Source: Gastric Cancer - February 13, 2016 Category: Gastroenterology Source Type: research

Nishi Memorial Award in Gastric Cancer
(Source: Gastric Cancer)
Source: Gastric Cancer - February 3, 2016 Category: Gastroenterology Source Type: research

Mismatch repair deficiency may affect clinical outcome through immune response activation in metastatic gastric cancer patients receiving first-line chemotherapy
Conclusions Our analysis confirms the favorable prognosis of metastatic gastric cancer patients with a defective MMR system and suggests that expression of TILs might also be linked to better outcome. Because of the correlation between defective MMR status and measures of immune system activity, this group of patients would be the best candidates for novel immunotherapy-based therapies. (Source: Gastric Cancer)
Source: Gastric Cancer - January 21, 2016 Category: Gastroenterology Source Type: research

Epigenetic inactivation of FAT4 contributes to gastric field cancerization
Conclusions FAT4 was methylation-silenced in GCs. Its methylation in gastric mucosae was associated with H. pylori infection and likely contributed to epigenetic field cancerization. (Source: Gastric Cancer)
Source: Gastric Cancer - January 20, 2016 Category: Gastroenterology Source Type: research

CD4 + regulatory T cells in gastric cancer mucosa are proliferating and express high levels of IL-10 but little TGF-β
Conclusion We demonstrate strong proliferation among regulatory CD4+ FOXP3+ CD25high T cells in the gastric cancer mucosa. These local Treg express a suppressive cytokine profile characterized by high IL-10 and low TGF-β and IFN-γ production. (Source: Gastric Cancer)
Source: Gastric Cancer - January 18, 2016 Category: Gastroenterology Source Type: research

Prospero homeobox 1 mediates the progression of gastric cancer by inducing tumor cell proliferation and lymphangiogenesis
Conclusions These results indicate that PROX1 mediates the progression of gastric cancer by inducing tumor cell proliferation and lymphangiogenesis. (Source: Gastric Cancer)
Source: Gastric Cancer - January 12, 2016 Category: Gastroenterology Source Type: research

The efficacy and safety of S-1-based regimens in the first-line treatment of advanced gastric cancer: a systematic review and meta-analysis
Conclusions S-1 is effective and tolerable as first-line therapy for advanced gastric cancer in both Asian and Western countries. (Source: Gastric Cancer)
Source: Gastric Cancer - January 11, 2016 Category: Gastroenterology Source Type: research

Postoperative bleeding after gastric endoscopic submucosal dissection in patients receiving antithrombotic therapy
Conclusions Because heparin alternative therapy significantly increases the risk of post-ESD bleeding and may not decrease the risk of thromboembolic events, other options should be considered for patients receiving anticoagulation therapy. (Source: Gastric Cancer)
Source: Gastric Cancer - January 11, 2016 Category: Gastroenterology Source Type: research

Risk factor analysis for involvement of resection margins in gastric and esophagogastric junction cancer: an Italian multicenter study
Conclusions Survival after gastrectomy is negatively affected by positive RMs. IFS analysis should be routinely used in patients with a high risk of positive RMs, especially in diffuse pattern cancers. (Source: Gastric Cancer)
Source: Gastric Cancer - January 5, 2016 Category: Gastroenterology Source Type: research

Comparison the sixth and seventh editions of the AJCC staging system for T1 gastric cancer: a long-term follow-up study of 2124 patients
Conclusions The classifications in the sixth and seventh editions of the AJCC staging system have a limitation for T1 gastric cancer (early gastric cancer). (Source: Gastric Cancer)
Source: Gastric Cancer - January 5, 2016 Category: Gastroenterology Source Type: research

Laparoscopic gastrectomy for remnant gastric cancer: a comprehensive review and case series
Conclusion Proficiency in advanced laparoscopic surgical techniques, such as proper adhesiolysis and stable laparoscopic anastomosis, will allow laparoscopic gastrectomy for remnant gastric cancer to be performed with satisfactory short-term results. This minimally invasive approach can be one treatment option for remnant gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - December 23, 2015 Category: Gastroenterology Source Type: research

HER2 testing in paired biopsy and excision specimens of gastric cancer: the reliability of the scoring system and the clinicopathological factors relevant to discordance
We examined HER2 expression in 180 paired endoscopic biopsy and surgical excision specimens of gastric cancers via immunohistochemistry (IHC). Equivocal IHC results (IHC 2+) were resolved by HER2 fluorescence in situ hybridization (FISH). The relationships of several clinical and pathological features with discordant HER2 results in paired specimens were determined. Results Fourteen biopsy specimens and surgical specimens (7.8 %) were HER2-positive. Discordant HER2 IHC scores were observed in 90 paired specimens (50 %) and 8 paired specimens (4.4 %) had discordant ...
Source: Gastric Cancer - December 23, 2015 Category: Gastroenterology Source Type: research

Partially covered self-expandable metallic stent for postoperative benign strictures associated with laparoscopy-assisted gastrectomy
Conclusions A PCSEMS may be a feasible and effective option for management of benign anastomotic strictures after LAG which could avoid secondary surgery. (Source: Gastric Cancer)
Source: Gastric Cancer - December 23, 2015 Category: Gastroenterology Source Type: research

MET-targeted therapy for gastric cancer: the importance of a biomarker-based strategy
Abstract The MET protooncogene encodes the receptor tyrosine kinase c-MET (MET). Aberrant activation of MET signaling occurs in a subset of advanced malignancies, including gastric cancer, and promotes tumor cell growth, survival, migration, and invasion as well as tumor angiogenesis, suggesting its potential importance as a therapeutic target. MET can be activated by two distinct pathways that are dependent on or independent of its ligand, hepatocyte growth factor (HGF), with the latter pathway having been attributed mostly to MET amplification in gastric cancer. Preclinical evidence has suggested that interrupti...
Source: Gastric Cancer - December 21, 2015 Category: Gastroenterology Source Type: research

Signature of cytokines and angiogenic factors (CAFs) defines a clinically distinct subgroup of gastric cancer
Conclusion Serum CAF profiling differentiated GC patient groups. A high 11-CAF signature could identify GC patients with a poor prognosis when treated with standard chemotherapy who need urgent new treatment strategies. (Source: Gastric Cancer)
Source: Gastric Cancer - December 17, 2015 Category: Gastroenterology Source Type: research

Does remnant gastric cancer really differ from primary gastric cancer? A systematic review of the literature by the Task Force of Japanese Gastric Cancer Association
In conclusion, although no prospective cohort study has yet evaluated the clinical significance of remnant gastric cancer, our literature review suggests that remnant gastric cancer does not adversely affect patient prognosis and postoperative course. (Source: Gastric Cancer)
Source: Gastric Cancer - December 14, 2015 Category: Gastroenterology Source Type: research

Phase 2 study of adjuvant chemotherapy with docetaxel, capecitabine, and cisplatin in patients with curatively resected stage IIIB–IV gastric cancer
Conclusions Adjuvant DXP is feasible and effective for patients with stage IIIB–IV GC. A phase 3 study comparing triplet and doublet regimens for these patients is ongoing. (Source: Gastric Cancer)
Source: Gastric Cancer - December 11, 2015 Category: Gastroenterology Source Type: research

Effects of administration of a proton pump inhibitor before endoscopic submucosal dissection for differentiated early gastric cancer with ulcer
Abstract Background In ulcerative early gastric cancer, improvement and exacerbation of ulceration repeat as a malignant cycle. Moreover, early gastric cancer combined with ulcer is associated with a low curative resection rate and high risk of adverse events. The aim of this study was to investigate the ulcer healing rate and clinical outcomes with the administration of a proton pump inhibitor before endoscopic submucosal dissection for differentiated early gastric cancer with ulcer. Methods A total of 136 patients with differentiated early gastric ...
Source: Gastric Cancer - December 11, 2015 Category: Gastroenterology Source Type: research

Revisiting a dogma: similar survival of patients with small bowel and gastric GIST. A population-based propensity score SEER analysis
Conclusions Contrary to common belief, OS and CSS of patients with small bowel GIST are not statistically different from those of patients with gastric GIST when adjustment is made for confounding variables on a population-based level. The prognosis of patients with nongastric GIST is worse because of a colonic and extravisceral GIST location. These findings have implications regarding adjuvant treatment of GIST patients. Hence, the dogma that small bowel GIST patients have worse prognosis than gastric GIST patients and therefore should receive adjuvant treatment to a greater extent must be revisited. (Source: Gastric Cancer)
Source: Gastric Cancer - December 9, 2015 Category: Gastroenterology Source Type: research

Is conversion therapy possible in stage IV gastric cancer: the proposal of new biological categories of classification
Abstract Conversion therapy for gastric cancer (GC) has been the subject of much recent attention. It is defined as a surgical treatment aiming at an R0 resection after chemotherapy for tumors that were originally unresectable or marginally resectable for technical and/or oncological reasons. However, the indications for resection remain to be clarified. In the present review, we focus on the biology and heterogeneous characteristics of stage IV GC and propose new categories of classification. Stage IV GC patients can be divided based on the absence (categories 1 and 2) or presence (categories 3 and 4) of macrosco...
Source: Gastric Cancer - December 7, 2015 Category: Gastroenterology Source Type: research

Glucose transporters 1, 3, 6, and 10 are expressed in gastric cancer and glucose transporter 3 is associated with UICC stage and survival
Abstract Background Due to proliferation and increased metabolism, cancer cells have high glucose requirements. The glucose uptake of cells is influenced by a group of membrane proteins denoted the glucose transporter family (Glut-1 to -12). Whereas increased expression and a negative correlation with survival have been described for Glut-1 in several types of cancer, the impact of other glucose transporters on tumor biology is widely unknown. Methods In this retrospective study, gastric cancer specimens of 150 patients who underwent total gastrectomy be...
Source: Gastric Cancer - December 7, 2015 Category: Gastroenterology Source Type: research

Phase II study of adjuvant chemotherapy of S-1 plus oxaliplatin for patients with stage III gastric cancer after D2 gastrectomy
Conclusions S-1 and oxaliplatin therapy is suggested to be manageable and safe with optimal dose reduction and delay in selected patients for stage III gastric cancer after D2 gastrectomy, and warrants further evaluation in larger studies. (Source: Gastric Cancer)
Source: Gastric Cancer - December 1, 2015 Category: Gastroenterology Source Type: research

A new stage of our journal
(Source: Gastric Cancer)
Source: Gastric Cancer - December 1, 2015 Category: Gastroenterology Source Type: research

Tumor-associated macrophages of the M2 phenotype contribute to progression in gastric cancer with peritoneal dissemination
Conclusions Intraperitoneal TAMs in gastric cancer patients with peritoneal dissemination were polarized to the M2 phenotype, and could contribute to tumor proliferation and progression. Therefore, intraperitoneal TAMs are expected to be a promising target in the treatment of peritoneal dissemination in gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - November 30, 2015 Category: Gastroenterology Source Type: research

Pre- and post-ESD discrepancies in clinicopathologic criteria in early gastric cancer: the NECA–Korea ESD for Early Gastric Cancer Prospective Study (N-Keep)
Abstract Background Discrepancies in the clinicopathologic parameters pre- and post-endoscopic submucosal dissection (ESD) sometimes necessitate additional surgical resection. The aim of this study was to assess such discrepancies in clinicopathologic parameters before and after ESD in the context of reducing the risk of failure of curative ESD. Methods Data on 712 early gastric cancer patients were prospectively collected from 12 university hospitals nationwide. The inclusion criteria were differentiated carcinoma
Source: Gastric Cancer - November 30, 2015 Category: Gastroenterology Source Type: research

Auxiliary diagnosis of lymph node metastasis in early gastric cancer using quantitative evaluation of sentinel node radioactivity
Conclusion In early gastric cancer patients, a high RI count from an SN was correlated with lymph node metastasis. Therefore, RI counting may aid efficient pathological diagnosis and focused lymph node dissection. (Source: Gastric Cancer)
Source: Gastric Cancer - November 30, 2015 Category: Gastroenterology Source Type: research

Erratum to: Clinicopathological factors associated with HER2 status in gastric cancer: results from a prospective multicenter observational cohort study in a Japanese population (JFMC44-1101)
(Source: Gastric Cancer)
Source: Gastric Cancer - November 30, 2015 Category: Gastroenterology Source Type: research

Is signet-ring cell carcinoma a specific entity among gastric cancers?
Conclusion In comparison to non-SRC adenocarcinoma, the SRC type has a worse prognosis, different prognostic factors, and is only poorly sensitive to perioperative chemotherapy. Non-SRC and SRC adenocarcinomas should be considered different entities in future therapeutic trials. (Source: Gastric Cancer)
Source: Gastric Cancer - November 25, 2015 Category: Gastroenterology Source Type: research

Gastric cancer in the East and West: what should we learn from each other?
(Source: Gastric Cancer)
Source: Gastric Cancer - November 21, 2015 Category: Gastroenterology Source Type: research

Investigation of each histological type in undifferentiated early gastric cancer and validity of diagnosis of the disease range
(Source: Gastric Cancer)
Source: Gastric Cancer - November 19, 2015 Category: Gastroenterology Source Type: research

Mass-spectrometry-based quantitation of Her2 in gastroesophageal tumor tissue: comparison to IHC and FISH
Abstract Background Trastuzumab has shown a survival benefit in cases of Her2-positive gastroesophageal cancer (GEC). Immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) currently determine eligibility for trastuzumab-based therapy. However, these low-throughput assays often produce discordant or equivocal results. Methods We developed a targeted proteomic assay based on selected reaction monitoring mass spectrometry (SRM-MS) and quantified levels (amol/μg) of Her2-SRM protein in cell lines (n = 27) and GEC tissues (n&nb...
Source: Gastric Cancer - November 18, 2015 Category: Gastroenterology Source Type: research

Phase II trial of dacomitinib in patients with HER2-positive gastric cancer
Conclusions Dacomitinib functions as a single agent in HER2-positive GC patients with a tolerable safety profile. HER2 ECD and sECAD have the potential to be biomarkers for patient selection in a panHER inhibition strategy for HER2-positive GC. (ClinicalTrials.gov: NCT01152853). (Source: Gastric Cancer)
Source: Gastric Cancer - November 18, 2015 Category: Gastroenterology Source Type: research

Incidence of lymph node metastasis in intramucosal gastric cancer measuring 30 mm or less, with ulceration; mixed, predominantly differentiated-type histology; and no lymphovascular invasion: a multicenter retrospective study
Conclusion The results of this retrospective study indicate that the risk of lymph node metastasis was less than 1 % among patients with the criteria defined here, considered to be criteria for noncurative resection as per the current guidelines, and suggest that observation alone without additional surgery may result in a good outcome. (Source: Gastric Cancer)
Source: Gastric Cancer - November 17, 2015 Category: Gastroenterology Source Type: research

Epstein–Barr virus positivity, not mismatch repair-deficiency, is a favorable risk factor for lymph node metastasis in submucosa-invasive early gastric cancer
Abstract Background Epstein–Barr virus (EBV)-associated gastric cancer (GC) and microsatellite-instability-high GC are associated with a low prevalence of regional lymph node metastasis (LNM). To evaluate the feasibility of endoscopic treatment of EBV-associated and/or microsatellite-instability-high early GC (EGC), we analyzed the risk factors for LNM using a large series (n = 756) of submucosa-invasive (SM) EGC. Methods EBV-encoded RNA in situ hybridization (EBER ISH) and immunohistochemistry for four mismatch repair (MMR) proteins (MLH...
Source: Gastric Cancer - November 16, 2015 Category: Gastroenterology Source Type: research

Clinical significance of the anterosuperior lymph nodes along the common hepatic artery identified by sentinel node mapping in patients with gastric cancer
Conclusions We found that SN No. 8a seemed to have lymphatic flow not only from the r-GA basin, but also from the l-GA basin or r-GEA basin. When SN No. 8a are detected, we should be careful to perform function-preserving surgery, even in SN-negative cases. (Source: Gastric Cancer)
Source: Gastric Cancer - November 6, 2015 Category: Gastroenterology Source Type: research

Portomesenteric vein thrombosis after gastric surgery
Conclusions PMVT after gastric surgery was associated with advanced cancer stage, combined splenectomy, and synchronous malignancy, but it was not related to laparoscopy or DVT. Significant differences in the natural course of PMVT were not found between the treatment group and observation group. (Source: Gastric Cancer)
Source: Gastric Cancer - November 5, 2015 Category: Gastroenterology Source Type: research

Improved survival in resected oesophageal and gastric adenocarcinomas over a decade: the Royal Marsden experience 2001–2010
Conclusion This study comprehensively describes the improvement in survival outcomes in a major UK referral centre over a 10-year period, identifying potentially relevant factors such as increased number of R0 resections and higher lymph node yield. (Source: Gastric Cancer)
Source: Gastric Cancer - November 5, 2015 Category: Gastroenterology Source Type: research

Robotic gastrectomy for elderly gastric cancer patients: comparisons with robotic gastrectomy in younger patients and laparoscopic gastrectomy in the elderly
This study aimed to investigate the feasibility and safety of robotic gastrectomy in elderly gastric cancer patients. Methods Patients who underwent laparoscopic or robotic gastrectomy from 2003 to 2010 in a single high-volume center were included in this study. We retrospectively compared preoperative characteristics, perioperative factors, and oncological parameters among an elderly (≥70 years old) robotic gastrectomy group (n = 49), a younger (
Source: Gastric Cancer - November 5, 2015 Category: Gastroenterology Source Type: research

Subgroup analyses of the safety and efficacy of ramucirumab in Japanese and Western patients in RAINBOW: a randomized clinical trial in second-line treatment of gastric cancer
Conclusions Safety profiles of the ramucirumab plus paclitaxel arm were similar between populations, though there was a higher incidence of neutropenia in Japanese patients. Progression-free survival and objective response rate improvements were observed for ramucirumab plus paclitaxel in both populations. ClinicalTrials.gov identifier: NCT01170663 (Source: Gastric Cancer)
Source: Gastric Cancer - October 28, 2015 Category: Gastroenterology Source Type: research