Incidence and risk factors of tuberculosis in patients following gastrectomy or endoscopic submucosal dissection: a cohort analysis of country-level data
ConclusionsPatients who underwent gastrectomy or ESD had an increased risk of TB, and this risk was correlated with the scope of gastrectomy. Considering the low rate of LTBI diagnostic tests and increased risk of TB in the study cohorts, more specific and practical guidelines for TB management are required for gastric cancer patients. (Source: Gastric Cancer)
Source: Gastric Cancer - January 25, 2023 Category: Gastroenterology Source Type: research
Suppression of galectin-4 attenuates peritoneal metastasis of poorly differentiated gastric cancer cells
ConclusionsWe clarified the role of galectin-4 in the development of peritoneal dissemination of poorly differentiated gastric cancer cells. Our data highlight the diagnostic and therapeutic potential of galectin-4 in the peritoneal dissemination of gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - January 25, 2023 Category: Gastroenterology Source Type: research
Evaluating the efficacy of post-operative chemotherapy after curative resection of stage IV gastric cancer with synchronous oligo metastasis: a multicenter retrospective study
ConclusionsCurative resection followed by post-operative chemotherapy in patients with GC with synchronous oligo-metastasis showed favorable survival. (Source: Gastric Cancer)
Source: Gastric Cancer - January 25, 2023 Category: Gastroenterology Source Type: research
Artificial intelligence-guided discovery of gastric cancer continuum
ConclusionsA Boolean implication network enabled the identification of hitherto undefined continuum states during GC initiation. The developed model could now serve as a starting point for rationalizing candidate therapeutic targets to intercept GC progression. (Source: Gastric Cancer)
Source: Gastric Cancer - January 24, 2023 Category: Gastroenterology Source Type: research
Risk assessment of metachronous gastric cancer development using OLGA and OLGIM systems after endoscopic submucosal dissection for early gastric cancer: a long-term follow-up study
ConclusionsHigh OLGA and OLGIM stages are independent risk factors for metachronous gastric cancer, with the OLGIM staging system being a better predictor. Patients with OLGIM stages 0 ~ II are a subgroup that may benefit more fromHelicobacter pylori eradication. (Source: Gastric Cancer)
Source: Gastric Cancer - January 6, 2023 Category: Gastroenterology Source Type: research
HRCT1, negatively regulated by miR-124-3p, promotes tumor metastasis and the growth of gastric cancer by activating the ERBB2-MAPK pathway
ConclusionsThe upregulated expression of HRCT1 predicts poor survival for patients with gastric cancer. HRCT1 promotes tumor progression by activating the ERBB2-MAPK pathway. HRCT1, negatively regulated by miR-124-3p, may be a potential therapeutic target for patients with gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - January 5, 2023 Category: Gastroenterology Source Type: research
Morpho-functional analysis of patient-derived xenografts reveals differential impact of gastric cancer and chemotherapy on the tumor ecosystem, affecting immune check point, metabolism, and sarcopenia
ConclusionOur PDX models are representative for the heterogeneity and complexity of human tumors, with differences in structure, histology, muscle atrophy, and the different biomarkers making them valuable for the analyses of the impact of platinum drugs or new therapies on the tumor and its microenvironment. (Source: Gastric Cancer)
Source: Gastric Cancer - December 19, 2022 Category: Gastroenterology Source Type: research
CD44v3 is a marker of invasive cancer stem cells driving metastasis in gastric carcinoma
ConclusionCD44v3 is a marker of a subpopulation of CSCs with metastatic properties in GC. The identification of metastasis-initiating cells in GC represents a major advance for further development of anti-metastatic therapeutic strategies. (Source: Gastric Cancer)
Source: Gastric Cancer - December 18, 2022 Category: Gastroenterology Source Type: research
A deep-learning based system using multi-modal data for diagnosing gastric neoplasms in real-time (with video)
ConclusionsThe multi-modal model constructed by feature-level fusion showed the best performance. ENDOANGEL-MM identified gastric neoplasms with good accuracy and has a potential role in real-clinic. (Source: Gastric Cancer)
Source: Gastric Cancer - December 15, 2022 Category: Gastroenterology Source Type: research
