ARID1A deficiency is targetable by AKT inhibitors in HER2-negative gastric cancer
ConclusionsThe effect of AKT inhibitors on cell proliferation and survival is affected by HER2 status, providing a rationale for exploring targeted therapy using AKT inhibitors in ARID1A-deficient/HER2-negative GC. (Source: Gastric Cancer)
Source: Gastric Cancer - February 22, 2023 Category: Gastroenterology Source Type: research
Improved survival after laparoscopic compared to open gastrectomy for advanced gastric cancer: a Swedish population-based cohort study
ConclusionsLaparoscopic gastrectomy can be safely preformed for advanced gastric cancer and is associated with improved overall survival compared to open surgery. (Source: Gastric Cancer)
Source: Gastric Cancer - February 19, 2023 Category: Gastroenterology Source Type: research
Clinical relevance of PD-1 positive CD8 T-cells in gastric cancer
ConclusionThis is one of the largest GC cohorts of mIHC combined with analysis of multiple datasets providing orthogonal validation of the clinical relevance of PD-1+CD8+ T-cells being associated with improved OS. CD8PD-1high tumors have distinct features of an immunologically active, T-cell inflamed TME. (Source: Gastric Cancer)
Source: Gastric Cancer - February 12, 2023 Category: Gastroenterology Source Type: research
Exosomal hsa-let-7g-3p and hsa-miR-10395-3p derived from peritoneal lavage predict peritoneal metastasis and the efficacy of neoadjuvant intraperitoneal and systemic chemotherapy in patients with gastric cancer
ConclusionPL-derived exosomes in GC contain large amounts of microRNAs related to PM. Moreover, hsa-let-7g-3p and hsa-miR-10395-3p could be used as biomarkers predicting PM and NIPS efficacy and are involved in GC metastasis and chemoresistance. (Source: Gastric Cancer)
Source: Gastric Cancer - February 4, 2023 Category: Gastroenterology Source Type: research
Comparison of perioperative outcomes between bipolar sealing, ultrasonic shears and a hybrid device during laparoscopic gastrectomy for early gastric cancer: a prospective, multicenter, randomized study
ConclusionBP showed a lower postoperative CRP level and less IBL than US and HB, suggesting less collateral thermal damage and better sealing function. Surgeons may consider this when selecting EBDs for laparoscopic surgery. (Source: Gastric Cancer)
Source: Gastric Cancer - February 3, 2023 Category: Gastroenterology Source Type: research
Required esophageal resection length beyond the tumor boundary to ensure a negative proximal margin for gastric cancer with gross esophageal invasion or esophagogastric junction cancer
ConclusionsRequired esophageal resection lengths to ensure a pathologically negative PM for gastric cancer with gross EI or EGJ cancer are proposed. (Source: Gastric Cancer)
Source: Gastric Cancer - February 1, 2023 Category: Gastroenterology Source Type: research
Incidence and risk factors of tuberculosis in patients following gastrectomy or endoscopic submucosal dissection: a cohort analysis of country-level data
ConclusionsPatients who underwent gastrectomy or ESD had an increased risk of TB, and this risk was correlated with the scope of gastrectomy. Considering the low rate of LTBI diagnostic tests and increased risk of TB in the study cohorts, more specific and practical guidelines for TB management are required for gastric cancer patients. (Source: Gastric Cancer)
Source: Gastric Cancer - January 25, 2023 Category: Gastroenterology Source Type: research
Suppression of galectin-4 attenuates peritoneal metastasis of poorly differentiated gastric cancer cells
ConclusionsWe clarified the role of galectin-4 in the development of peritoneal dissemination of poorly differentiated gastric cancer cells. Our data highlight the diagnostic and therapeutic potential of galectin-4 in the peritoneal dissemination of gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - January 25, 2023 Category: Gastroenterology Source Type: research
Evaluating the efficacy of post-operative chemotherapy after curative resection of stage IV gastric cancer with synchronous oligo metastasis: a multicenter retrospective study
ConclusionsCurative resection followed by post-operative chemotherapy in patients with GC with synchronous oligo-metastasis showed favorable survival. (Source: Gastric Cancer)
Source: Gastric Cancer - January 25, 2023 Category: Gastroenterology Source Type: research
