Preoperative chemotherapy in gastric cancer: expanding the indications, limiting the overuse
(Source: Gastric Cancer)
Source: Gastric Cancer - December 6, 2014 Category: Gastroenterology Source Type: research

Third international conference of the European Union Network of Excellence on gastric and esophagogastric junction cancer, Cologne, Germany, June 2012
Abstract In 2012 the European Union Network of Excellence on gastric and esophagogastric junction cancer (EUNE) held its third conference in Cologne, Germany. The main themes discussed included translational research, standard and audit, early diagnosis, development of surgical treatment, adequate surgery for EGJ cancer, adjuvant and neoadjuvant treatment, prevention of peritoneal carcinomatosis and finally education and training. The meeting was attended by 150 experts from 18 different countries. (Source: Gastric Cancer)
Source: Gastric Cancer - December 6, 2014 Category: Gastroenterology Source Type: research

Bevacizumab plus capecitabine and cisplatin in Chinese patients with inoperable locally advanced or metastatic gastric or gastroesophageal junction cancer: randomized, double-blind, phase III study (AVATAR study)
Conclusions Addition of bevacizumab to capecitabine–cisplatin in Chinese patients with advanced gastric cancer did not improve outcomes in AVATAR. There was no difference in OS between the two arms and PFS was similar in both arms. Safety findings were as previously experienced with bevacizumab, including AVAGAST; no new safety signals were reported. (Source: Gastric Cancer)
Source: Gastric Cancer - December 6, 2014 Category: Gastroenterology Source Type: research

The course of gastric cancer following surgery is associated with genetic variations of the interleukin-1 receptor antagonist and interleukin-1β
Conclusion Genetic variations in the IL-1β and IL-1RN genes influence disease progression in gastric cancer. Screening for these genetic variations might help to stratify therapies for gastric cancer patients in the future. (Source: Gastric Cancer)
Source: Gastric Cancer - December 6, 2014 Category: Gastroenterology Source Type: research

Erratum to: Is a clear benefit in survival enough to modify patient access to the surgery service? A retrospective analysis in a cohort of gastric cancer patients
(Source: Gastric Cancer)
Source: Gastric Cancer - December 6, 2014 Category: Gastroenterology Source Type: research

A new stage of sentinel node navigation surgery in early gastric cancer
Abstract Sentinel node (SN) navigation surgery is expected to realize organ- and function-preserving surgery with SN mapping, and has been applied in operations for breast cancer and melanoma. But there has been no definite evidence for the SN concept in gastric cancer. A prospective multicenter trial to confirm the SN concept for gastric cancer conducted by the Japan Society of Sentinel Node Navigation Surgery reported that the SN detection rate, sensitivity of positive SNs, and accuracy of nodal status are 97.5 % (387/397), 93 % (53/57), and 99 % (383/387), respectively. A detailed analysis of the...
Source: Gastric Cancer - November 30, 2014 Category: Gastroenterology Source Type: research

Prognostic implications of immunosuppressive protein expression in tumors as well as immune cell infiltration within the tumor microenvironment in gastric cancer
In this study, 243 patients with curatively resected GC were included. The levels of immunosuppressive protein expression [programmed cell death 1 ligand 1 (PD-L1), cytotoxic T-lymphocyte antigen 4 (CTLA-4), and indoleamine 2,3-dioxygenase (IDO)] in tumors and the densities of immune cells [CD3(+), CD4(+), CD8(+), or PD-1(+) cells] within the tumor microenvironment were measured using immunohistochemical analysis. Results Positive PD-L1, CTLA-4, and IDO expression was observed in 43.6, 65.8, and 47.7 % of the patients, respectively. Expression of PD-L1, CTLA-4, and IDO was relat...
Source: Gastric Cancer - November 26, 2014 Category: Gastroenterology Source Type: research

Prognostic factors in metastatic gastric cancer: results of a population-based, retrospective cohort study in Ontario
Conclusion This study provides supporting evidence for patient, disease and healthcare system prognostic factors in metastatic gastric cancer. Future work investigating the role of emerging molecular and biologic information will need to take these established prognostic factors into consideration. (Source: Gastric Cancer)
Source: Gastric Cancer - November 25, 2014 Category: Gastroenterology Source Type: research

Theoretical therapeutic impact of lymph node dissection on adenocarcinoma and squamous cell carcinoma of the esophagogastric junction
Conclusions Nodal dissection achieved by proximal gastrectomy and lower esophagectomy should be the minimal requirement for junctional cancer regardless of the histology, considering the therapeutic value indices for the relevant lymph node stations. (Source: Gastric Cancer)
Source: Gastric Cancer - November 21, 2014 Category: Gastroenterology Source Type: research

Carnoy’s solution increases the number of examined lymph nodes following gastrectomy for adenocarcinoma: a randomized trial
Abstract Background Pathological examination of a minimum of 16 lymph nodes is recommended following surgery for gastric adenocarcinoma, despite this a longer survival is expected when 30 or more lymph nodes are examined. Small lymph nodes are difficult to identify, and fat-clearing solutions have been proposed to improve this, but there is no evidence of their clinical benefit. Methods Fifty D2 subtotal gastrectomy specimens were randomized for fixation in Carnoy’s solution (CS) or 10 % neutral buffered formalin (NBF), with subsequent fa...
Source: Gastric Cancer - November 20, 2014 Category: Gastroenterology Source Type: research

Epithelial–mesenchymal transition confers resistance to selective FGFR inhibitors in SNU-16 gastric cancer cells
Conclusion In conclusion, we provide experimental evidence that EMT-mediated resistance might emerge in gastric cancer patients following treatment with FGFR inhibitors, and mubritinib or AUY922 treatment may be an alternative therapeutic strategy for these patients. (Source: Gastric Cancer)
Source: Gastric Cancer - November 19, 2014 Category: Gastroenterology Source Type: research

Application of reduced-port laparoscopic total gastrectomy in gastric cancer preserving the pancreas and spleen
Conclusions We have shown that RPLTG could be an acceptable and satisfactory procedure for the treatment of gastric cancer requiring total gastrectomy for surgeons sufficiently experienced in CLATG. (Source: Gastric Cancer)
Source: Gastric Cancer - November 15, 2014 Category: Gastroenterology Source Type: research

Gastric cancer: past progress and present challenges
(Source: Gastric Cancer)
Source: Gastric Cancer - October 25, 2014 Category: Gastroenterology Source Type: research

Estimation of subepithelial lateral extent in submucosal early gastric cancer: retrospective histological analysis
Abstract Background Endoscopic full-thickness resection (EFTR) is expected to make possible minimally invasive local resection of early gastric cancer (EGC). However, no consensus exists regarding how far an optimal safety margin should be set in determining the resection area by endoscopy. We aimed to investigate the optimal lateral margin of EGC which could be a candidate for EFTR by measuring the subepithelial extent (SE) of tumors. Methods In 60 surgically resected submucosal EGCs 4 cm or smaller, 595 prepared slides which showed lateral tumor b...
Source: Gastric Cancer - October 21, 2014 Category: Gastroenterology Source Type: research

Risk factors for synchronous or metachronous tumor development after endoscopic resection of gastric neoplasms
Conclusions For tumors located in the antrum and accompanied by intestinal metaplasia, meticulous endoscopic evaluation with close follow-up after endoscopic resection is recommended. (Source: Gastric Cancer)
Source: Gastric Cancer - October 18, 2014 Category: Gastroenterology Source Type: research

Inhibition of β-catenin and STAT3 with a curcumin analog suppresses gastric carcinogenesis in vivo
Conclusion β-Catenin and STAT3 can be pharmacologically inhibited in vivo with a curcumin analog, which effectively inhibits β-catenin and STAT3. (Source: Gastric Cancer)
Source: Gastric Cancer - October 18, 2014 Category: Gastroenterology Source Type: research

HER2 amplification detected in the circulating DNA of patients with gastric cancer: a retrospective pilot study
Conclusion Our preliminary data demonstrated the potential clinical use of circulating cfDNA to detect HER2 amplification as a therapeutic marker to detect and monitor HER2 CN status for effective molecular targeted therapy in patients with GC. (Source: Gastric Cancer)
Source: Gastric Cancer - October 17, 2014 Category: Gastroenterology Source Type: research

A newly modified esophagogastrostomy with a reliable angle of His by placing a gastric tube in the lower mediastinum in laparoscopy-assisted proximal gastrectomy
Conclusions The modified EG technique has advantages over the JI technique because of its simplicity and low incidence of residual food and bile reflux. The next step would be to explore this technique further by a prospective multi-institutional study to confirm the reproducibility of its benefits. Miniabstract: The modified EG technique has advantages over the JI technique because of its simplicity, high rate of laparoscopy use, and low incidence of gastroesophageal reflux. (Source: Gastric Cancer)
Source: Gastric Cancer - October 16, 2014 Category: Gastroenterology Source Type: research

Integrins α v β 3 and α v β 5 as prognostic, diagnostic, and therapeutic targets in gastric cancer
Conclusion The expression of αvβ3 and αvβ5 in at least one tumor component in all GC samples is an interesting new result that should form a basis for further investigations; for example, regarding selective integrin antagonists and the value of αvβ3 and αvβ5 as putative prognostic biomarkers. Moreover, both markers might be helpful in the routine classification of GC subtypes. (Source: Gastric Cancer)
Source: Gastric Cancer - October 15, 2014 Category: Gastroenterology Source Type: research

The positive impact of surgeon specialization on survival for gastric cancer patients after surgery with curative intent
Conclusion GC patients treated by specialized surgeons tended to have a better prognosis and lower locoregional recurrence rate. Surgeon specialization was an independent prognostic factor for GC patients after surgery. GC should be treated by specialized surgeons in large-volume centers. (Source: Gastric Cancer)
Source: Gastric Cancer - October 15, 2014 Category: Gastroenterology Source Type: research

Follow-up endoscopy for benign-appearing gastric ulcers has no additive value in detecting malignancy
Abstract Objective To determine the diagnostic accuracy of endoscopic follow-up for gastric ulcers. Methods All cases of gastric ulcers diagnosed at our teaching hospital between September 2005 and November 2011 were reviewed. The cases were selected by using ENDOBASE, an endoscopy documentation system. The characteristics of the ulcers and their histology were analysed. Results During the study period 321 cases with a gastric ulcer were diagnosed, including 214 benign ulcers (67 %) and 107 malignant ulcers (3...
Source: Gastric Cancer - October 14, 2014 Category: Gastroenterology Source Type: research

Erratum to: Impact of the expression of thymidylate synthase and dihydropyrimidine dehydrogenase genes on survival in stage II/III gastric cancer
(Source: Gastric Cancer)
Source: Gastric Cancer - October 7, 2014 Category: Gastroenterology Source Type: research

Clinical characteristics and outcomes for gastric cancer patients aged 18–30 years
Abstract Background There is little known about the clinicopathological features and the predictors of survival in extremely young adult patients aged 18–30 years. The aim of this study was to identify clinicopathological features and clinical outcomes for the overall population and for a resectable subgroup of gastric cancer patients aged 18–30 years. Methods From January 2004 to December 2010, 207 patients aged between 18 and 30 years old were diagnosed with gastric cancer and treated at the Asan Medical Center. Clinic...
Source: Gastric Cancer - September 25, 2014 Category: Gastroenterology Source Type: research

Deregulation of the cell polarity protein Lethal giant larvae 2 (Lgl2) correlates with gastric cancer progression
Abstract Background We investigated the roles of Lethal giant larvae 2 (Lgl2), an epithelial cell polarity protein, during gastric carcinogenesis and gastric cancer (GC) progression and evaluated the correlation of Lgl2 with epithelial-mesenchymal transition (EMT) markers. Methods Lgl2 protein and mRNA expression were determined by immunohistochemistry and mRNA in situ hybridization in a large series of GC and preneoplastic lesions. Additionally, expression of 7 EMT markers was examined by immunohistochemistry. Res...
Source: Gastric Cancer - September 25, 2014 Category: Gastroenterology Source Type: research

Comments on “Omentum-preserving gastrectomy for advanced gastric cancer: a propensity-matched retrospective cohort study”
(Source: Gastric Cancer)
Source: Gastric Cancer - September 25, 2014 Category: Gastroenterology Source Type: research

Non-anesthesiologist administrated propofol (NAAP) during endoscopic submucosal dissection for elderly patients with early gastric cancer
Abstract Background Propofol is rapidly increasing in use in many countries because endoscopists and patients report greater satisfaction with propofol than with conventional sedatives. However, propofol infusion during lengthy endoscopic procedures in elderly patients is still controversial. We investigated the safety of gastroenterologist-guided propofol sedation in elderly patients who underwent gastric endoscopic submucosal dissection (ESD) at a single center. Methods We reviewed 121 medical records of patients who underwent gastric ESD. We co...
Source: Gastric Cancer - September 25, 2014 Category: Gastroenterology Source Type: research

Pre-treatment neutrophil to lymphocyte ratio as a prognostic marker to predict chemotherapeutic response and survival outcomes in metastatic advanced gastric cancer
Abstract Background Several studies have shown that the neutrophil to lymphocyte ratio (NLR) in peripheral blood is a prognostic factor of various cancers. However, there is limited information on the clinical and prognostic significance of NLR in patients with metastatic advanced gastric cancer (AGC). Therefore, we examined whether the NLR can be used as a prognostic marker for predicting chemotherapeutic response and survival outcomes in metastatic AGC patients who are receiving palliative chemotherapy. Method A total of 268 patients diagnosed w...
Source: Gastric Cancer - September 25, 2014 Category: Gastroenterology Source Type: research

Importance of formalin fixing conditions for HER2 testing in gastric cancer: immunohistochemical staining and fluorescence in situ hybridization
Conclusions The time to and length of fixation of tumor specimens can affect HER2 IHC and FISH scores. The fixative used can affect IHC results. (Source: Gastric Cancer)
Source: Gastric Cancer - September 25, 2014 Category: Gastroenterology Source Type: research

Risk factors for submucosal and lymphovascular invasion in gastric cancer looking indicative for endoscopic submucosal dissection
Abstract Background Submucosal and lymphovascular (SM/LV) invasions of early gastric cancer (EGC) are difficult to diagnose accurately prior to endoscopic submucosal dissection (ESD), and are occasionally found in resected specimens, requiring additional gastrectomy and lymph node dissection. We performed a retrospective study to determine the risk factors for SM/LV invasions. Methods We analyzed clinicopathological data (age, sex, cancer location, gross morphology, multifocality, tumor size, histological differentiation, depth of invasion, an...
Source: Gastric Cancer - September 25, 2014 Category: Gastroenterology Source Type: research

Secondary endoscopic submucosal dissection for residual or recurrent tumors after gastric endoscopic submucosal dissection
Conclusions Early sESD is more reliable than late sESD as a therapeutic strategy for salvaging residual tumors and for preventing recurrence. However, if a tumor has already recurred, late sESD remains useful. (Source: Gastric Cancer)
Source: Gastric Cancer - September 25, 2014 Category: Gastroenterology Source Type: research

Stratified phase II trial to establish the usefulness of the collagen gel droplet embedded culture-drug sensitivity test (CD-DST) for advanced gastric cancer
Abstract Background We conducted a multicenter phase II trial to assess the suitability of three types of chemotherapy (docetaxel plus S-1, irinotecan plus S-1, or S-1 alone) for patients with advanced gastric cancer by means of the collagen gel droplet embedded culture-drug sensitivity test (CD-DST). To our knowledge, this is the first multicenter clinical trial that has employed CD-DST to choose anticancer agents for the treatment of advanced gastric cancer. Methods Subjects (n = 64) were patients with advanced or recurrent gastric can...
Source: Gastric Cancer - September 25, 2014 Category: Gastroenterology Source Type: research

Prognostic impact of RING box protein-1 (RBX1) expression in gastric cancer
Abstract Background RING box protein-1 (RBX1) is an essential component of the E3 ubiquitin ligase Skp1/Cullin/RBX1/F-box protein complex. Although an altered expression of RBX1 has been reported in several human cancers, the role of RBX1 in gastric cancer remains unknown. Methods We investigated the RBX1 expression in primary gastric cancer tissues from 145 patients by immunohistochemistry, and explored its clinical relevance and prognostic value. Furthermore, the effect of RBX1 expression on cancer cell proliferation was analyzed in vitro using ...
Source: Gastric Cancer - September 25, 2014 Category: Gastroenterology Source Type: research

Hereditary diffuse gastric cancer in a Japanese family with a large deletion involving CDH1
We present here a Japanese family with HDGC identified by comparative genomic hybridization (CGH) analysis. A 55-year-old woman was treated with completion gastrectomy for multiple SRCCs, and pathological examination revealed approximately 200 foci of SRCC with loss of E-cadherin expression. Her 30-year-old son had surveillance endoscopy and was found to have multiple SRCCs. He underwent total gastrectomy, and 32 foci of SRCC with loss of E-cadherin expression were histologically found. Although no point mutations were detected in CDH1 by sequencing, CGH revealed a 275-kb deletion involving exons 7–16 of CDH1 in both...
Source: Gastric Cancer - September 25, 2014 Category: Gastroenterology Source Type: research

Diagnostic performance and limitations of magnifying narrow-band imaging in screening endoscopy of early gastric cancer: a prospective multicenter feasibility study
Conclusions With a refined strategy considering its limitations, M-NBI can act as an “optical biopsy” in screening endoscopies. (Source: Gastric Cancer)
Source: Gastric Cancer - September 25, 2014 Category: Gastroenterology Source Type: research

Phase I trials in patients with relapsed, advanced upper gastrointestinal carcinomas: experience in a specialist unit
Conclusion Phase I clinical trials can be considered a reasonable option in selected patients with relapsed UGIC. The use of objective prognosticators may improve selection and risk/benefit profile of patients. (Source: Gastric Cancer)
Source: Gastric Cancer - September 25, 2014 Category: Gastroenterology Source Type: research

Efficacy and tolerability of chemotherapy with modified dose-dense TCF regimen (TCF-dd) in locally advanced or metastatic gastric cancer: final results of a phase II trial
Conclusions The TCF-dd regimen in locally advanced or MGC is confirmed to be feasible and very active and needs to be further tested in randomized studies. (Source: Gastric Cancer)
Source: Gastric Cancer - September 25, 2014 Category: Gastroenterology Source Type: research

Clinical management of esophagogastroduodenoscopy by clinicians under the former guidelines of the Japan Gastroenterological Endoscopy Society for patients taking anticoagulant and antiplatelet medications
Conclusion We revealed the low impact of the 2005 JGES guidelines on the management of antithrombotic drugs. Our physicians have reasonably decided to continue antithrombotic drugs before EGD according to the risk of thromboembolism. (Source: Gastric Cancer)
Source: Gastric Cancer - September 25, 2014 Category: Gastroenterology Source Type: research

A new way to experience the International Gastric Cancer Association Congress: the Web Round Tables
Abstract In an attempt to attract a wider diversity of professionals to the 10th International Gastric Cancer Association Congress (IGCC) held in June 2013, the Scientific Committee of the conference organized a number of pre-congress Web Round Tables to discuss cutting-edge topics relating to gastric cancer treatment. Twenty Web Round Tables, each coordinated by a different chairman, were proposed on the IGCC Website 1 year before the congress. Each chairman identified a number of studies related to the theme of his/her Round Table and invited corresponding authors to send an update of their conclusions in ...
Source: Gastric Cancer - September 25, 2014 Category: Gastroenterology Source Type: research

Early-onset diffuse gastric cancer associated with a de novo large genomic deletion of CDH1 gene
Abstract A 41-year-old man with no familial history of gastric cancer was diagnosed as with intramucosal early gastric cancer. Two months after the first endoscopic submucosal dissection for signet-ring cell carcinoma (SRCC), the appearance of previously unrecognized multiple erosions of SRCC was noticed. Pathological examination after a total gastrectomy and Roux-en-Y reconstruction with D2 lymph node dissection were performed. Postoperative pathological examination revealed 90 and more lesions, which tempted the attending pathologist to refer to genetic tests for the predisposition though the patient had n...
Source: Gastric Cancer - September 25, 2014 Category: Gastroenterology Source Type: research

Docetaxel, oxaliplatin, and capecitabine combination chemotherapy for metastatic gastric cancer
Conclusions DOC is an effective and tolerated first-line treatment, and the lower dose of docetaxel and oxaliplatin used in this study compared with other similar regimens does not seem to hamper the antitumor activity. (Source: Gastric Cancer)
Source: Gastric Cancer - September 25, 2014 Category: Gastroenterology Source Type: research

Naso-gastric or naso-jejunal decompression after partial distal gastrectomy for gastric cancer. Final results of a multicenter prospective randomized trial
Abstract Background Only a few, small, monocentric randomized controlled trials (RCTs) have compared routine vs. no placement of a nasogastric or nasojejunal tube decompression (NG/NJT) in patients undergoing partial distal gastrectomy (PDG) for gastric cancer. However, to our knowledge, no multicenter prospective RCT has analyzed the role of decompression after both the Billroth II (BII) procedure and Roux-en-Y (RY) gastrojejunostomy. The aim of this study was to determine whether NG/NJT prevents the consequences of postoperative ileus after PDG for gastric cancer after both BII...
Source: Gastric Cancer - September 25, 2014 Category: Gastroenterology Source Type: research

Erratum to: Importance of formalin fixing conditions for HER2 testing in gastric cancer: immunohistochemical staining and fluorescence in situ hybridization
(Source: Gastric Cancer)
Source: Gastric Cancer - September 25, 2014 Category: Gastroenterology Source Type: research